8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 1/15

MEDICAL IMPORTANCE OF CULICOIDES 

A) Vector of pathogen(Disease transmitter)

1) Filarial infection(Mansonella spp )• They are transmitted by biting midge and generally regarded as

non-pathogenic.

•Mansonella perstans is widely transmitted by Culicoides sp. in Africa

& South America.

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 2/15

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 3/15

•Mansonella streptocerca  transmitted is restricted in Africa.

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 4/15

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 5/15

M. ozzardi  transmitted by C. furens is restricted in South

America and usually endemic to beach areas in Caribbean.

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 6/15

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 7/15

Clinical  picture :

• fever

• headache

• eosinophilia rash

• pruritus

• abdominal pain

• arthralgia

-headache -headache 

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 8/15

 2)Arbovirus(Oropouche fever)

• They are transmitted by biting C.paraensis in Brazil, Trinidad

and Colombia

• They are disease non fatal

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 9/15

• Two distinct life cycle

-epidemic urban cycle in which human is primary host

-silent maintenance cycle in which forest animal are vertebrae

host

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 10/15

Clinical picture

-headache

-arthralgia-photophobia

-myalgia

-nausea

-meningitis (rare)

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 11/15

B)Culicoides as etiological agent of

disease(Causing disesase)

1)Bite :

• Annoyance and disturb sleep

• Allergic reactions( injection of saliva into skin)

• Skin lesion (inflammation and dermatitis)

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 12/15

Treatment

1) Filarial infection (Mansonella spp)

• M.perstants-Mebendazole 100 mg & Ivermectin 150ug/kg per single dose

• M.streptocerca-Diethylcarbamazine

• M.ozzardi –Ivermectin 150ug/kg per single dose

2)Arbovirus( Oropouche virus)

• No specific therapy as no vaccine available

C t

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 13/15

Contro

•Eradicate the population and their breeding place by suitable insecticide

•Removal of vector larva habitat such as rotting cacao husks , trunk of felled banana

plants

•Repellent consist DEET (diethytoluamide)

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 14/15

• Avoid of infestation by taking these precaution

-Installation of window and door screen with a mesh size smaller

-Clothing impregnated with DEET or permethrin

2)Arbovirus (Oropouche fever)

-refrain from sternuous activites

-retire to bed

-consult their physician

8/13/2019 Medical Importance of Culicoides

http://slidepdf.com/reader/full/medical-importance-of-culicoides 15/15

Reference

http://www.byron.nsw.gov.au/protect-yourself-from-biting-midges-sand-flies http://www.fehd.gov.hk/english/safefood/pest-post-midges.html http://en.wikipedia.org/wiki/Culicoides  http://extension.entm.purdue.edu/publichealth/insects/bitingmidge.html  http://entnemdept.ufl.edu/creatures/aquatic/biting_midges.htm  http://www.cfsph.iastate.edu/BRMForProducers/English/RouteSpecificInformation/biting_midge_control.pdf  http://www.public.health.wa.gov.au/cproot/2658/2/11177_BitingMidges_23658_web.pdf  http://books.google.com.eg/books?id=6R1v9o-uaI4C&pg=PA169&lpg=PA169&dq=biting+midges+causing+diseases&source=bl&ots=6l29irQwtR&sig=D-yvMtK-qPYCbxeqtPcLoCaESTw&hl=en&sa=X&ei=ZIuzUrz9H_C00QXGgIEw&ved=0CFgQ6AEwCDgK#v=onepage&q=biting%20midges%20causing%20diseases&f=false http://books.google.com.eg/books?id=AB39e6KZ8MMC&pg=PA217&lpg=PA217&d

q=mansonella+spp+in+human+by+culicoides&source=bl&ots=t0xa03vnDL&sig=nXizDtF7P5ShtiJwxDmjlCli3sE&hl=en&sa=X&ei=kxG4UoG9DcSU0QXp_IGgDg&ved=0CGMQ6AEwCA#v=onepage&q=mansonella%20spp%20in%20human%20by%20culicoides&f=false