medication reconciliation as a patient safety practice ...€¦ · unintended medication changes at...
TRANSCRIPT
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Medication Reconciliation as a Patient Safety Practice During Transitions of Care
Janice L. Kwan, MD, MPH, FRCPC Division of General Internal Medicine
Mount Sinai Hospital, University of Toronto
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Recorded Version
Agency for Healthcare Research and Quality
http://ce.ahrq.gov/pcor/
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Disclosures
This Webinar has been funded and developed by the Agency for Healthcare Research and Quality (AHRQ); there has been no outside commercial support.
Presenter(s)/staff have no conflicts of interest or relevant financial relationships to disclose.
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Requirements for Successful Completion
Be present for the entire Webinar.
Complete the online evaluation and posttest within 30 days of the Webinar.
Pass the posttest with a grade of 75% or higher.
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Designation Statements
• The Postgraduate Institute for Medicine designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
• This educational activity for 1.0 contact hour is provided by Postgraduate Institute for Medicine. It is designated for 0.0 contact hours of pharmacotherapy credit for Advance Practice Registered Nurses.
• Postgraduate Institute for Medicine designates this continuing education activity for 1.0 contact hour (0.1 CEUs) of the Accreditation Council for Pharmacy Education. (Universal Activity Number - 0809-9999-14-222-L01-P) Type of Activity: Knowledge.
• Hayes, Inc. is approved as a provider of nurse practitioner continuing education by the American Association of Nurse Practitioners: AANP Provider Number 140928. This program has been approved for 1.0 contact hours of continuing education.
• This program has been pre-approved by The Commission for Case Manager Certification to provide continuing education credit to CCM® board certified case managers. This program has been approved for 1.0 clock hours of continuing education.
• Sponsored by Hayes, Inc., a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc. This program is designated for Certified Health Education Specialists (CHES) and/or Master Certified Health Education Specialists (MCHES) to receive up to 1.0 total Category I continuing education contact hours. Maximum advanced-level continuing education contact hours available are 1.0.
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Accreditation Statements
• This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Postgraduate Institute for Medicine and Hayes. The Postgraduate Institute for Medicine is accredited by the ACCME to provide continuing medical education for physicians.
• Postgraduate Institute for Medicine is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
• Postgraduate Institute for Medicine is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.
• The CCMC, accredited by the National Commission for Certifying Agencies, has reviewed this activity and consents that, upon successful completion of the activity, those eligible will be awarded CCM credits.
• Hayes, Inc. is approved as a provider of nurse practitioner continuing education by the American Association of Nurse Practitioners: AANP Provider Number 140928.
• This program was planned in accordance with National Commission for Health Education Credentialing, Inc. (NCHEC) CE Standards and Policies and NCHEC Commercial Support Standards.
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Agency for Healthcare Research and Quality (AHRQ)
To produce evidence to make health care safer, higher quality, more accessible, equitable, and affordable, and to work with the U.S. Department of Health and Human Services and other partners to make sure that the evidence is understood and used.
www.ahrq.gov
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Learning Objectives
1 • Define medication reconciliation as a formal patient safety
practice.
2 • Identify four sources of medication information.
3 • Describe what is known about potential harms associated with
unintended medication changes at care transitions.
4 • Describe the steps outlined in the MATCH toolkit for evaluating,
designing, and implementing medication reconciliation processes.
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Introduction
Janice L. Kwan, MD, MPH,
FRCPC
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Introduction to Patient Safety
Preoperative and
Anesthesia Checklists
Preventing Pressure
Ulcers
Preventing Health Care– Associated Infections
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What Will We Cover?
• Unintended medication discrepancies
• Medication reconciliation interventions
• Beneficial effects of medication reconciliation
• Harms associated with medication reconciliation
• Implementation and in what context
• Effect of context on effectiveness
• Cost
• MATCH toolkit to implement in your practice
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Case Study: Medication Reconciliation
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Evaluation
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Case Study: Medication Reconciliation
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Discrepancy
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Case Study: Medication Reconciliation
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Resolution
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A Note about Clinical Pharmacists
• Most of the evidence includes the use of clinical pharmacists
• Accreditation standards do NOT require use of pharmacists
• Medication reconciliation in practice may not achieve the same effects
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What is the Patient Safety Issue?
• Transitions in care
► Admission and discharge from acute care hospital
► Changes in setting within a hospital
• Errors in medications result from
► Poor communication
► Inadvertent information loss
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Unintentional Medication Discrepancies
• Unintentional Medication Discrepancy
► Example: Physician unaware of the full list of preadmission medications.
► Example: Physician does not have accurate information on the most recent dose.
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Incidence of Medication Discrepancies
• Up to 67% of patients upon admission to hospitals*
• Internal hospital transfers may result in slightly higher rates
► Example: Transfer from intensive care unit to ward
• ≥40% of patients at hospital discharge
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*Tam VC, Knowles SR, Cornish PL, et al. Frequency, type and clinical importance of medication history errors at admission to hospital: a systematic review. CMAJ. 2005 Aug 30;173(5):510-5. PMID 16129874.
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Risk for Unintentional Discontinuation
Population
Ontario, Canada
Admitted
Patients
Intensive Care Unit
Other Unit
Not Admitted
Control
19
Risk of Unintentional Discontinuation
>
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Clinical Risk
• Estimated proportion of all discrepancies likely to cause clinical problems: ► Wide range: 11%-59%
• Omissions ► Key medications inappropriately
not started or continued
► 46%-56% of all discrepancies
• Commissions ► Discontinued medications
inadvertently re-started
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What is Medication Reconciliation?
• Formal, systematic strategy to overcome medication information communication challenges. • Aims to reduce unintended medication discrepancies that occur at transitions in care. • Health care providers work with patients and families to ensure accurate information. 21
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Best Possible Medication History
• More comprehensive than routine medication history • Systematic process for interviewing patient and family • Review of at least one reliable source of information
► Central medication database ► Medication vials ► Contact with community pharmacy
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What are the Effects of Medication Reconciliation?
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Outcomes • Clinically significant
discrepancies • Emergency department visits • Hospital readmission
Harms of medication
reconciliation interventions
Patients undergoing
transitions of care
Medication reconciliation interventions
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Systematic Review Methods
• MEDLINE
• Embase
• Cochrane
• Reference lists
Literature Search
• Clinically significant discrepancies
• Hospital utilization
Assessed for Eligibility
•Meta-analysis
•Qualitative synthesis
Evidence Synthesis
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Included Studies
Study Points of Care Transitions Outcomes
Author, year (N=18)
Hospital Admission Discharge Home In-Hospital Transfer Clinically Significant
Discrepancies Emergency
Department Visits Hospitalization w/in
30 days
Coffey, 2009 X X
Cornish, 2005 X X
Gleason, 2004 X X
Gleason, 2010 X X
Kripalani, 2012 X X X
Lee, 2010 X X
Pippins, 2008 X X
Stone, 2010 X X
Vira, 2006 X X X
Wong, 2008 X X
Schnipper, 2009 X X X X
Dedhia, 2009 X X X
Jack, 2009 X X X
Koehler, 2009 X X X X
Kramer, 2009 X X X X
Schnipper, 2006 X X X
Showalter, 2011 X X X
Walker, 2009 X X X
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The Intervention Components
BPMH w/ admission reconciliation
Discharge reconciliation w/
prescribing physician
Discharge reconciliation is interprofessional
Electronically generated discharge
prescription
Attention to broader medication
issues
Pharmacist-led medication
counseling prior to discharge
Communicating medication changes
to community pharmacy
Post-discharge follow-up phone call
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Defining Clinically Significant Unintended Medication Discrepancies
• Clinically significant discrepancies
►All unintentional discrepancies that were not considered “trivial,” “minor,” or “unlikely to cause harm”
►Corresponds to potential adverse drug events
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Clinically Significant Unintended Medication Discrepancies
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Median and Interquartile Range for the Number of Clinically Significant Unintended Medication Discrepancies per Patient
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Clinically Significant Unintended Discrepancies
Proportion of clinically significant unintended discrepancies
► Mean = 35.1%
► Heterogeneous (I2=92%)
► Range = 15%-54%
► Median = 34%
► IQR = 28%-49%
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Patients with Clinically Significant Unintended Discrepancies
Proportion of patients with clinically significant unintended discrepancies
► Mean = 39.3%
► Heterogeneous (I2=95%)
► Range = 15%-60%
► Median = 45%
► IQR = 31%-56%
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Preventable Adverse Drug Events
178 pts
Discharged
Intervention Medication
reconciliation
Counseling by pharmacist
Follow-up phone call w/in 5 days
1% Preventable adverse
drug events
Control Counseling by nurse
Pharmacists reviewed
medication orders
11% Preventable adverse
drug events
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Preventable Adverse Drug Events
• Cluster randomized controlled trial ► 14 medical teams ► 2 hospitals
• Intervention ► Web-based app using electronic medical record (EMR)
o EMR included ambulatory visits
► Created preadmission medication list
• Results ► Hospital A: adjusted relative risk for potential adverse drug events =
0.72 (95% CI, 0.52-0.99) – Statistically significant ► Hospital B: adjusted relative risk for potential adverse drug events =
0.87 (95% CI, 0.57-1.32) – Not statistically significant
• Discussion ► Authors attribute difference between 2 hospitals to variation in the
degree to which they integrated the intervention
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Hospital Utilization
• Emergency department visits or readmission within 30 days:
► Proportion of patients (9 studies) o Median 28% (IQR, 20%-32%)
► Rate of utilization (7 studies) o Median 30% (IQR, 22%-31%)
o No statistically significant difference between intervention and control groups
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Hospital Utilization
• Emergency department visits or readmission within 30 days:
► Reduced by 23% compared with controls o 95% CI, 5%-37%; I2=24%
Statistically significant
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NOTE: Pooled result of 3 studies driven by one intensive intervention comprised several efforts aimed at reducing readmissions.
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Hospital Utilization at 12 Months
• Readmission rates at 12 months:
► Study not included in meta-analysis
► 16% reduction in all hospital visits in intervention group – Statistically significant
► Intervention included:
o Pharmacists identifying drug-related problems beyond unintended discrepancies
o Pharmacists delivering counseling to patients at admission and discharge
o Pharmacists telephoning patients 2 months after discharge
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A Comment on Measuring Hospital Utilization
• Is 30 days after discharge long enough?
• Inadvertent discontinuation of certain medications may result in adverse effects requiring hospital utilization in the long term, but not necessarily within 30 days.
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What are the Harms of Medication Reconciliation?
Transition in care
Mistake in medication
reconciliation
Mistake in patient record
Potential clinical effect
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What are the Harms of Medication Reconciliation?
• Reliance on pharmacists
• Clinical pharmacists in short supply
• Risk of taking pharmacist away from other important patient safety practices
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How has the patient safety practice been implemented?
…and in what context?
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Bronze Level
Bronze
Best Possible Medication History (BPMH) with admission reconciliation
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Silver Level
Bronze
Silver
Bronze level +
Discharge reconciliation by prescribing physician
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Gold Level
Bronze Silver
Gold
Silver level +
Discharge reconciliation is interprofessional
Electronically generated discharge summary and prescriptions
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Platinum Level
Bronze
Silver
Gold
Platinum
Gold level +
Attention to broader medication issues
Appropriateness of medication choices
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Diamond Level
Bronze
Silver
Gold
Platinum
Diamond
Platinum +
Pharmacist counseling
Communicating directly with patient’s pharmacy
Follow-up phone call to patient
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Effect of Context on Effectiveness
• No studies assessed effect of context on effectiveness
• Review limited to:
► Hospital setting
► Interventions including a clinical pharmacist
• Medication reconciliation interventions have only been assessed in academically affiliated hospitals using clinical pharmacists
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Are There Any Data About Costs?
• Cost-effectiveness of 5 pharmacist-led strategies
► £10,000 = $16,272 per quality-adjusted life-year (2009 exchange rate)
► Limit: Assumptions about reduction in actual vs potential adverse drug events
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Applicability
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Limitations of the Evidence
• Discrepancy in findings from 2 RCTs
► 1 reported reduction in preventable adverse drug events
► 1 reported mixed results o Statistically significant reduction at
one site but not the other
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Limitations of the Evidence
• Judgment about potential clinical importance of medication discrepancy
► Inter-rater reliability
► Speculation about: o Potential risk
o Likelihood that the discrepancy will persist
o How long the discrepancy will persist before being detected
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What Did We Learn From This Review?
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Serious Adverse Drug Events
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• Variation in frequency of non-trivial discrepancies
• Extremely severe discrepancies rarely reported
• Post-discharge adverse drug events could be related to drug monitoring, NOT medication reconciliation
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Preventable Adverse Drug Events
• Potential adverse drug events
► Significant reduction at 1 of 2 study hospitals
• 30 days after discharge
► Reduction in preventable adverse drug events
► No difference in total adverse drug events
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Hospital Utilization
• No reduction in hospital utilization within 30 days
• May result in reduction when bundled with other interventions aimed at improving transitions in care
• May reduce utilization in long term
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How Can I Implement Medication Reconciliation in My Practice?
Available at:
http://www.ahrq.gov/professionals/quality-patient-safety/patient-safety-resources/resources/match/
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How to Use This Toolkit
1 • Building the Project Foundation: Gaining Leadership Support Within the Organization
2 • Building the Project Foundation: Project Teams and Scope
3 • Developing Change: Designing the Medication Reconciliation Process
4
• Developing and Pilot Testing Change: Implementing the Medication Reconciliation Process
5 • Education and Training
6 • Assessment and Process Evaluation
7 • High-Risk Situations for Medication Reconciliation
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MATCH Work Plan
Work Plan available at:
http://www.ahrq.gov/professionals/quality-patient-safety/patient-safety-
resources/resources/match/matchap.html
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Chapter 1: Building the Project Foundation: Gaining Leadership Support
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Medication reconciliation is a
patient safety issue
Resource justification to produce a
successful project
Linking medication reconciliation with
other initiatives
Talking Points
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Chapter 2: Building the Project Foundation: Project Teams and Scope
Identify and assemble interdisciplinary team
Create a flowchart of the current medication reconciliation process
Develop a project charter or work plan for improvements
Establish a measurement strategy
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Chapter 3: Developing Change: Designing the Process
Guiding principles “One Source of Truth” Defining roles and
responsibilities
Integrating medication
reconciliation into the existing workflow
Flowcharting the design
Designing the process
Examples of electronic, paper-based, or hybrid
systems 59
Tools for Designing a Medication Reconciliation Process
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Chapter 4: Developing and Pilot Testing Change: Implement the Process
• Pilot test the solution:
► Implement on a small scale
► Receive input
► Identify major gaps within the process
► Confirm utility within current workflow
► Weaknesses can be addressed before facility-wide implementation
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Chapter 5: Education and Training
• Multidisciplinary training supported by key leaders:
► Promotes team approach
► Creates appreciation of interdependency of each discipline
► Defines roles and responsibilities
► Ensures consistent training for all disciplines
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Chapter 5: Education and Training – Overarching Message
1 • Obtain, document, and verify current medication list
2 • Compare this list with medication ordered
3 • Ensure that any discrepancies are appropriate and intentional
4 • Resolve unintended discrepancies with supporting documentation
5 • Communicate medication information during transitions in care
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Chapter 6: Assessment and Process Evaluation
• Audit critical to assess adoption
• Perform at all transitions of care
• Involve each discipline
• Audit can be: ► Electronic or manual
► Prospective or retrospective
• Quantity audit assesses: ► Adoption
► Adherence
• Quality audit assesses: ► Impact on patient safety
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Chapter 7: High-Risk Situations for Medication Reconciliation
• Patients at increased risk for medication reconciliation errors:
► Limited health literacy
► Cognitive impairment
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High-Risk Situations: Health Literacy
• Patients with limited health literacy: ► Difficulty processing information about
health and health care encounters
► Difficulty adhering to a medication regimen
► Difficulty providing an accurate medication history
► Difficulty understanding prescription instructions and warning labels
► At discharge, changes to prior medications or new medications may require more targeted efforts from clinicians
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High-Risk Situations: Cognitive Impairment
• Cognitive impairment may pose challenges: ► When obtaining medication history from patient upon
admission
► When providing medication education and counseling to patient at discharge
• Screening for cognitive impairment: ► Mini-Mental State Examination (MMSE)
o Takes ~ 10 minutes to administer
o http://www.minimental.com
► Mini-Cog o Takes less than 5 minutes to administer
o 3-item recall test for memory and simply scored clock-drawing test
o www.alz.org/documents_custom/minicog.pdf 66
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CONCLUSIONS
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Conclusions of the Systematic Review
• Where to direct resources?
• Almost all evaluated interventions involved the use of clinical pharmacists
• Studies with high-risk patients
► Did not report higher rates of clinically significant unintentional discrepancies
► Did not show larger effects on readmissions
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Conclusions of the Systematic Review
• Results could reflect ► Limited number of studies
► Limitations of the high-risk criteria used
• High-risk patients may take large numbers of medications ► Regimens may remain stable
► Regimens may be well-known
► Direct risk factor may be frequent or recent changes o This would be ascertained through a
thorough medication history, like BPMH
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Implementing Change in Your Practice
• Medication reconciliation process should:
► Encompass all areas where patient transitions occur
o Admission, transfer, and discharge
► Follow your patients in the post-acute setting or at home
► Involve all caregiver disciplines
► Be integrated into caregiver daily workflow
► Have the support of facility leadership
• Interventions and improvements must be appropriately implemented as process gaps are identified, and these corrections should be measured for the effectiveness of your patient safety improvement efforts.
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Available at:
http://www.ahrq.gov/professionals/quality-patient-safety/patient-safety-resources/resources/match/
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Using the MATCH Toolkit
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Wrap-up
• To obtain credit:
► Login to your CME University account: http://ahrq.cmeuniversity.com/course/disclaimer/111240
►Complete the online evaluation and posttest within 30 days of the Webinar.
► Pass the posttest with a grade of 75% or higher.
If you have any problems, please contact us at [email protected] or by phone at 267-498-7926
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Next Live Webinar: June 24, 2015; 1:00 PM – 2:00 PM EDT
Topic: Obtaining Informed Consent from Patients and Ensuring Documentation of Patients’ Preferences for Life-Sustaining Treatment
Presenters: Kristina Cordasco, MD, MPH, MSHS, and Sydney Dy, MD