mediterranean school of oncology cinbo consorzio interuniversitario nazionale pre la bioncologia
TRANSCRIPT
Mediterranean School of OncologyCINBO
Consorzio Interuniversitario Nazionale pre la Bioncologia
Individuazione del bersaglio molecolareIndividuazione del bersaglio molecolare
Gene profiling
BINOMIO MOLECOLARE DIAGNOSTICO E TERAPEUTICO: STATO DELL’ARTE E PROSPETTIVE FUTURE
Nuovi bersagli molecolari e loro applicazioni
Bersagli molecolari selezionatiBersagli molecolari selezionati: consolidati e nuoviconsolidati e nuovi
Apoptosi, TRAILFattori di crescita e loro recettoriProteasomaAngiogenesiRegolazione trascrizionale ed epigenetica come bersaglio terapeuticoMicro RNA: the New World
Applicazioni nei tumori solidi e ematologiciApplicazioni nei tumori solidi e ematologici
Mammella, Tratto GE, Polmone, Apparato Genitale Femminile, Mieloma, APL
Gene Profiling in the Prognostic Evaluation
Lung
Breast
Ovary
Receptor-type TK signalling
Survival Growth Angiogenesis
Block of VEGF or EGFR in Cancer Treatment
Science Aug 2004
Science June 2004
Mutations of EGFR are pathogenetic and Mutations of EGFR are pathogenetic and treatment sensitizingtreatment sensitizing
From Kaufmann & Vaux, Oncogene, 22: 7414, 2003
Alterations of apoptotic pathways in human cancerAlterations of apoptotic pathways in human cancer
NF-kB: a fundamental role in cancer pathogenesis, a target in cancer therapy
Cytoplasmic nuclear transitionCytoplasmic nuclear transition
A proteasome based regulation
Proteasome inhibitors: Velcade(bortezomib)
The proteasome as a target of cancer therapyThe proteasome as a target of cancer therapy
Retinoic acid induces differentiation of APL blastsRetinoic acid induces differentiation of APL blastsExpressing PML/RARExpressing PML/RAR
1010-6-6 M M(or RA 10-9 M)
1983
Altered gene methylation in cancer
1989
Hypermethylation of a tumor suppressor gene in cancer
Chromatin remodelling by deacetylation in human cancer
1998
Clinical trials with demethylating and deacetylase inhibiting agents
2003
Altered histone methylation in human cancer
2002
Landmarks in cancer epigeneticsLandmarks in cancer epigenetics
Many HDAC InhibitorsMany HDAC Inhibitorsare entering are entering clinical trialsclinical trials
Chromatin remodelling in gene regulationChromatin remodelling in gene regulation
Micro-RNA: the future?