Type of anaemia in

which erythroblasts in

the bone marrow show a

characterstics

abnormality-maturation

of nucleus delayed

relative to that of

cytoplasm.

This is due to defect in

DNA synthesis.

Usually caused by

deficiency of vitB12 and

Folate.

• VitB12 Deficiency

• Folic Acid Deficiency

• Sources Meat,fish Green

Vegetable

• Daily 2-5ug 50-100ug

• Requirments

• Places of ileum Duodenum

Absorptions and small

intestine

• Inadequate production of intrinsic factor

Pernicious Anemia

• Inadequate releasing of VitB12 from food

Partial Gastrectomy

• Terminal ileum disease

Vegetarians

Drugs(Neomycin,Nitrous oxide)

Small bowel disease

Alcoholism

Pregnancy

Chronic hemolysis

Malignancy

• Due to orotic aciduria

• Due to alcohol,therapy with

hydroxyurea,cystosine arabinoside.