Melt Electrohydrodynamic Writing: An emerging technique for 3D

printing

Paul Dalton Adjunct Associate Professor

Institute of Health and Biomedical Innovation Queensland University of Technology, AUSTRALIA

www.daltonlab.com

3D Printed Gun

Cody Wilson, University of Texas

3D Printed Clinical Products

Probst FA et al. (2010) Handchir Mikrochir Plast Chir, 42, 369.

Peripheral Nerve Injury

Current Composite Structures

Melt Electrohydrodynamic Writing Melt Electrospinning Writing

Dalton et al. (2007) Polymer, 48, 6823.

Melt Electrohydrodynamic Writing

Electrohydrodynamic Writing & Layering

Brown et al. (2011) Advanced Materials, 23, 5651-57.

Melt Electrohydrodynamic Writing

Farrugia et al. Biofabrication, 5, 025001.

100µm

Scaffold Only Constructs

Writing onto Cylinders

30° 60°45° 2 mm2 mm 2 mm

Brown et al. (2012) Biointerphases, 7, 13. 100 μm

Tubular Scaffolds

Brown et al. (2012) Biointerphases, 7, 13.

Writing on Cylinders

Non-Linear Deposition

Tissue Engineering Research

Tissue Engineered Products

Valley of Death Funding: Venture Capital?, SBIR?, Corporate Partnerships? Basic Research Funding:

NIH, NSF, DOD, etc. Commercialization Funding: Large Companies, Private Equity

Insurance Reimbursed Clinical Products

Regulatory Approval Pre-Clinical Studies: ISO/FDA Guided

Bench Tests: Large Targeted Animal Studies:

Design/Manufacturing: Design, History, Input GMP Manufacturing:

Surgeon Acceptance

CLINICAL TRIALS: Basic In Vivo Research: Small Animal Model; Rudimentary Biologic/ Scaffold Constructs

Basic In Vitro Research: Cell Isolation; Material Synthesis

The Valley of Death

Summary of Melt Electrohydrdynamic Writing

• Distinct Process

• Inexpensive

• Good Resolution

• High Scaffold Porosity

• Solvent Free Process

• Clinical Potential

Acknowledgements Queensland University of

Technology, Australia

• Toby Brown • Brooke Farrugia • Tim Dargaville • Dietmar Hutmacher • Anna Slotosch • Laure Thibaudeau • Lourdes Muerza Cascante • Elena Juan Puardo • Annika Reitz

University of Würzburg

• Jürgen Groll • Tomasz Jungst

DWI an der RWTH

• Martin Moeller • Dirk Grafahrend • Kristina Klinkhammer

www.daltonlab.com

Literature

• Dalton et al. (2013), Biomaterials Science, 1, 171. • Hutmacher & Dalton (2011), Chemistry: An Asian Journal,

6, 44-56. • Farrugia et al. (2013) Biofabrication, 5, 025001. • Brown et al. (2012) Biointerphases, 7, 13. • Brown et al. (2011) Advanced Materials, 23, 5651-57. • Dalton et al. (2008) Biomedical Materials, 3, 034139. • Dalton et al. (2007) Polymer, 48, 6823.

www.daltonlab.com www.meltelectrospinning.org

Melt Electrohydrodynamic Writing: An emerging technique for 3D printingSlide Number 2Slide Number 33D Printed Gun3D Printed Clinical ProductsSlide Number 6Peripheral Nerve InjuryCurrent Composite StructuresSlide Number 9Slide Number 10Slide Number 11Melt Electrohydrodynamic WritingSlide Number 13Electrohydrodynamic Writing & LayeringMelt Electrohydrodynamic WritingSlide Number 16Slide Number 17Scaffold Only ConstructsWriting onto CylindersTubular ScaffoldsWriting on CylindersNon-Linear DepositionSlide Number 23Slide Number 24Summary of Melt Electrohydrdynamic WritingAcknowledgementsLiterature