Melt Electrospinning Writing: An Emerging Technique to Fabricate Three-Dimensional Structures for

Tissue Engineering Paul Dalton

Adjunct Associate Professor Institute of Health and Biomedical Innovation

Queensland University of Technology, AUSTRALIA

Acknowledgements Queensland University of

Technology, Australia

• Dietmar W. Hutmacher • Toby Brown • Tim Dargaville • Brooke Farrugia • Anna Slotosch • Laure Thibaudeau • Lourdes Muerza Cascante • Elena Juan Puardo • Annika Reitz

University of Würzburg, Germany

• Jürgen Groll • Tomasz Jungst

Funding

• CSIRO • EU Project “Hydrozones”

www.daltonlab.com

Home 3D Printing

3D Printed Clinical Products

• Melt Extrusion Direct Writing Technology • FDA-Approved Implants

Custom 3D Printed Scaffolds

Probst FA et al. (2010) Handchir Mikrochir Plast Chir, 42, 369.

Melt Electrospinning Writing

Farrugia et al. Biofabrication, 5, 025001.

Additive Manufacturing

(3D Printing)

Filament Resolution New Materials Required

Chaotic Deposition Solvent Process Cell Invasiveness

Melt Electrospinning Writing Accurate Placement of Small Diameter Fibers

Solvent Free Polymers with History of Medical Use

Scaffold Fabrication for TE

Dalton et al. (2007) Polymer, 48, 6823.

Stage Movement & Viscous Threads

Square Wave Pattern

Electrospinning Writing & Layering

Brown et al. (2011) Advanced Materials, 23, 5651-57.

Melt Electrospinning Writing

100µm

100µm

Writing onto Cylinders

100 μm

30° 60°45° 2 mm2 mm 2 mm

Brown et al. (2012) Biointerphases, 7, 13.

Tubular Scaffolds

Brown et al. (2012) Biointerphases, 7, 13.

Tissue Engineering Research

Tissue Engineered Products

Valley of Death Funding: Venture Capital?, SBIR?, Corporate Partnerships? Basic Research Funding:

NIH, NSF, DOD, etc. Commercialization Funding: Large Companies, Private Equity

Insurance Reimbursed Clinical Products

Regulatory Approval Pre-Clinical Studies: ISO/FDA Guided

Bench Tests: Large Targeted Animal Studies:

Design/Manufacturing: Design, History, Input GMP Manufacturing:

Surgeon Acceptance

CLINICAL TRIALS: Basic In Vivo Research: Small Animal Model; Rudimentary Biologic/ Scaffold Constructs

Basic In Vitro Research: Cell Isolation; Material Synthesis

The Valley of Death

Summary of Melt Electrospinning Writing • Distinct Process

• Inexpensive

• Good Resolution

• High Scaffold Porosity

• Solvent Free Process

• Clinical Potential

Literature

• Dalton et al. (2013), Biomaterials Science, 1, 171. • Hutmacher & Dalton (2011), Chemistry: An Asian Journal,

6, 44-56. • Farrugia et al. (2013) Biofabrication, 5, 025001. • Brown et al. (2012) Biointerphases, 7, 13. • Brown et al. (2011) Advanced Materials, 23, 5651-57. • Dalton et al. (2008) Biomedical Materials, 3, 034139. • Dalton et al. (2007) Polymer, 48, 6823. • Dalton et al. (2006) Biomacromolecules, 7, 686.

www.daltonlab.com

Melt Electrospinning Writing: An Emerging Technique to Fabricate Three-Dimensional Structures for Tissue EngineeringAcknowledgementsSlide Number 3Slide Number 4Home 3D Printing3D Printed Clinical ProductsCustom 3D Printed ScaffoldsMelt Electrospinning WritingScaffold Fabrication for TESlide Number 10Stage Movement & Viscous ThreadsSquare Wave PatternElectrospinning Writing & LayeringSlide Number 14Melt Electrospinning WritingSlide Number 16Slide Number 17Slide Number 18Writing onto CylindersWriting on CylindersTubular ScaffoldsSlide Number 22Summary of Melt Electrospinning WritingLiterature