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Univ.-Prof. Dr. rer. nat. Tobias Bopp (B4)

Date of Birth: 28.07.1977, male Nationality: German Current Position: W2 Professor, Molecular Immunology

Contact: Institute for Immunology

Universitätsmedizin Mainz Langenbeckstr. 1, 55131 Mainz Tel.: +49 (0) 6131-176175 Fax: +49 (0) 6131-176202 Email:boppt@uni-mainz.de

EDUCATION:

1997 – 2003 Biology (Diploma), Johannes Gutenberg-University, Mainz, Germany

2003 – 2006 Dr. rer. nat., Institute for Immunology, Johannes Gutenberg-University, Mainz, (Prof. E. Schmitt)

PROFESSIONAL EXPERIENCE:

2006 – 2008 Postdoctoral Fellow, Institute for Immunology, Johannes Gutenberg-University, Mainz, (Prof. E. Schmitt)

2008 – 2011 Groupleader, Institute for Immunology, Johannes Gutenberg-University, Mainz, (Prof. H. Schild)

2011 Offer of the W2-Professorship "Molecular Immunology" Institute for Immunology, University Medical Center Mainz, Johannes Gutenberg University Mainz

AWARDS/GRANTS/HONORS:

2007-2009 Promotion by the Carl-Zeiss-Foundation 2008 Boehringer Ingelheim Award 2010 Fritz-und-Ursula_Melchers Award of the DGfI 2012 Auswahlsymposium zum Paul Ehrlich- und Ludwig Darmstaedter

Nachwuchspreis

RESEARCH AREAS:

Molecular mechanisms of T helper cell differentiation, Regulatory T cells and immune regulation, effector mechanisms in Asthma

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Selected Publications oft he last five years Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, Klein M, Schild H,

Schmitt E*, Stassen M.* NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells.

J Exp Med. 2005 Jan 17;201(2):181-7. * Authors contributed equally. Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD,

Bopp T, Schmitt E, Klein-Hessling S, Serfling E, Hamann A, Huehn J. Epigenetic control of the foxp3 locus in regulatory T cells.

PLoS Biol. 2007 Feb;5(2):e38. Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Heib V,

Becker M, Kubach J, Schmitt S, Stoll S, Schild H, Staege MS, Stassen M, Jonuleit H, Schmitt E. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression.

J Exp Med. 2007 Jun 11;204(6):1303-10. Staudt V*, Bothur E*, Lingnau K, Reuter S, Klein M, Grebe N, Gerlitzki B, Hoffmann M,

Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E*, and Bopp T* Interferon-regulatory factor 4 is essentially involved in the developmental program of T helper 9 cells.

Immunity. 2010 Aug 27;33(2):192-202. * Authors contributed equally. Vaeth M*, Gogishvili T*, Bopp T*, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots

A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, and Bodor J. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cells c1 (NFATc1).

PNAS 2011 Jan 24. * Authors contributed equally.