membrane structure lecture 4 chapter 10. lipid classification phosphoglycerides sphingolipids...
TRANSCRIPT
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MEMBRANE STRUCTURE
LECTURE 4CHAPTER 10
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LIPID CLASSIFICATION
• PHOSPHOGLYCERIDES• SPHINGOLIPIDS• STEROIDS
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PHOSPHOGLYCERIDES
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SPHINGOLIPIDS
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STEROIDS
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MEMBRANE BILAYER
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BILAYER STRUCTURE OF BIOMEMBRANRANES
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FORMATION OF PURE PHOSPHOLIPID BILAYERS
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PROPERTIES OF MEMBRANES
• HYDROPHOBIC CORE IS AN IMPERMEABLE BARRIER
• STABILITY – Van der Waals interaction, and hydrophobic interaction stabilize the fatty acyl groups whereas ionic and hydrogen bonds stabilize the polar head groups
• PHOSPHOLIPID BILAYERS SPONTANEOUSLY FORM CLOSED SEALED COMPARTMENTS
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MEMBRANE BUDDING AND FUSION
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CYTOSOLIC AND EXOPLASMIC FACES ARE CONSERVED
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LIPID COMPOSITION IN THE EXOPLASMIC AND CYTOSOLIC FACES
OF THE MEMBRANES
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HOW LIPIDS AFFECT CURVATURE AND THICKNESS OF MEMBRANES
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PHOSPHOLIPID BILAYER- lateral and rotational movement
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FRAP EXPERIMENTS
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FRAP EXPERIMENT (cont’d)
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MEMBRANE PROTEINS
• INTEGRAL or TRANS – MEMBRANE PROTEINS• LIPID-ANCHORED MEMBRANE PROTEINS• PERIPHERAL MEMBRANE PROTEINS
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Integral membrane proteins
• Contain membrane spanning α- helices• 20-25 hydrophobic uncharged amino acids
(3.75 nm)• Segment is perpendicular to the membrane or
is at an oblique angle• Amino peptide bonds in the interior of the α-
helix• Hydrophobic side chains interact with fatty
acyl groups
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GLYCOPHORIN A – single pass integral membrane protein
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Multipass Transmembrane Protein
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Multiple membrane spanning β strands
• Porins• Gram-negative bacteris, outer membrane of
mitochondria and chloroplasts• Trimers of identical subunits• Each subunit – 16 beta strands that twist to
form a barrel-shaped structure• Barrel - Hydrophilic interior and hydrophobic
exterior
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Single subunit of outer membrane Porin from E.coli
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PERIPHERAL MEMBRANE PROTEINS
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HOW IS BLOOD GROUP DETERMINED?
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Mechanism of action of Phospholipase A
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SOLUBILIZATION OF MEMBRANES
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BINDING OF FATTY ACID TO THE FATTY –ACID-BINDING PROTEIN
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PHOSPHOLIPID BIOSYNTHESIS
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CHOLESTEROL BIOSYNTHESIS
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MECHANISM OF CHOLESTEROL AND PHOSPHOLIPID TRANSPORT