membrane transport iii chapter 11. selectivity of a k + channel
TRANSCRIPT
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Membrane Transport III
Chapter 11
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Selectivity of a K+ channel
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DVD Clip 45
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DVD clip 48
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Patch Clamp Recording
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Patch Clamp Recording
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Patch Clamp Measurements of single voltage gated Na+ channel
3 experiments on the same patch
cumulative of 144 experiments
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Resting Chemical Synapse
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Active Chemical Synapse
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Neuromuscular Junction in a Frog
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Three Conformations of Acetyl Choline receptor at the neuromuscular junction
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DVD Clip 49
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Ion Channels at Neuromuscular Junction
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Motor Neuron Cell body in the Spinal Chord
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Motor Neuron Cell body in the Spinal Chord
thousands of axon terminals are stained red by antibody that recognizes a protein in synaptic vesicles
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Chapter 12
Intracellular Compartments and Protein Sorting
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Major Intracellular compartments of an animal cell
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Volumes of major intracellular compartments in a liver cell
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Relative amount of membrane types in 2 cell types
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Complex Cortical Network of Endoplasmic Reticulum
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Cross section of liver cell
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Topological relationships between compartments of a eukaryotic cell
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Roadmap ofprotein trafficinside cell
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Two ways in which a sorting signal can bebuilt into a protein
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Some typical signal sequences
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Nuclear Pore complexes perforate the nuclear envelope
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Nuclear pore complexes
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Nuclear side of the nuclear envelope
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Face on view of nuclear complexes without the membrane
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Side view of 2 nuclear pore complexes
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Transport through nuclear pore complexes occurs through free diffusion and active
transport
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Nuclear import signal direst proteins to the nucleus
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Single amino acid mutation in signal will prevent import into the nucleus
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Nuclear import receptors bind to nuclear porins and nuclear localization signal of cargo protein
Different nuclear localization signals bind different import receptors
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Ran GTP provides energy for nuclear protein import
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Ran-GTP controls cargo loading and unloading