mesotherapeutic solution with biomimetic peptides, growth hormones for hair loss ...geosmatic.com...

CONFIDENTIAL, ONLY FOR COMPANY PURPOSE

Mesotherapeutic solution

with Biomimetic Peptides, Growth Hormones

for Hair Loss Management in Men, Women


Introduction on hair loss

• The importance of hair in our lives cannot be overstated...

• Whether men or women lose their hair, they lose much more

than their natural, youthful appearance. People also lose their

self‐esteem and self‐confidence…

• Hair loss (alopecia) is a common problem affecting both men

and women.

• The most common one is androgenetic alopecia (AGA) which

represent 95% of all hair loss


The causes of hair loss

Although causes of hair loss are still not yet fully understood, it can be the results of several factors.

Causes: Genetic;Hormonal changes or imbalances (childbirth, menopause); Improper nutrition (deficiency in certain vitamins and minerals); Stress;Diseases like diabetes or lupus; Medications (drugs or chemotherapy); Seasonal changes;Aging & Photo‐aging.

Hair loss can be permanent or temporary

Affects both men and women although men experience a much greater degree of loss (notably around the temples and the vertex) than women, but following menopause it may affect 75% of women older than 65 years.


Hair ScienceHair appear much more complex that they look.

They are composed of 2 structures:

‐Above the skin = hair shaft

‐Beneath the skin = hair follicle

At the base of the follicle is the dermal papilla &

ECM.

As papilla & ECM new cells grow, they push the

previous cells upwards to form the hair.

The dermal papilla plays a crucial role in the

dermal‐epidermal interactions

and is of great importance for the hair formation

and growth cycle.


Hair ScienceWe carries ±100 000 hair follicles. Each follicle can grow many hairs over a lifetime (±20 times).

The hair follicle growth cycle has 3 distinct phases:

‐Anagen: (Growth phase 70 – 85% hair). Hair are growing for 2‐ 6 years.

‐Catagen: (Transition phase – 1‐2%). The hair bulb separates from the dermal papilla, the hair follicle migrates toward the scalp and remain in this phase for 2‐3 weeks.

‐Telogen: (Resting phase – 100 days). Hair stay attached to the follicle and fall out to be replaced by the next hair in anagen phase (papilla & follicle join together again & new hair begins to form).


•No hormonal dysfunction

•ECM proteins integrity

•No inflammation

•↑ DHT : shorthens Anagen phase → Miniaturization of follicles

•Loss of ECM proteins renewal → Follicle size reduction & loss of hair anchoring

•Inflammation → Disruption of hair cycle

Sheath

Follicle miniaturization

Follicle

Improper anchoring

Hair thinning

Normal hair growth cycleAltered hair growth cycle (↓ Anagen + ↑ Telogen) Hair loss

No more follicle

Hair Loss: How it works?


Mechanism of action in details:

‐DHT Modulation‐ECM Integrity‐Inflammation


Effect of Dihydrotestoterone (DHT)

Miniaturization of the follicles

Producing progressively shorter, finer hairs

Hair loss

Testosterone DHT (dihydrotestosterone)

DHT is formed by the action of the enzyme 5‐‐reductase on testosterone. DHT causes hair loss by shortening the growth phase of the hair cycle, causing miniaturization (decreased size) of the follicles, and producing progressively shorter and finer hairs.

5‐ reductase

DHT shortens the hair growth cycle (shorter anagen phase)

DHT

DHTDHT


Effect of Loss of ECM integrity

Hair follicles size is determined by:

‐the volume of its dermal papilla‐the volume of the extracellular matrix .

Healthy dermal papilla will produce good ECM proteins such as collagen type III and anchoring fibers such as laminin and collagen VII which will favor a good hair anchoring in the bulb surrounding tissue.

If improper ECM renewal, hair will eventually lack vigor and will thin.

Cycle after cycle, the follicle becomes smaller and finally, miniaturized and fall.


Effect of Inflammation

Production of pro‐inflammatory cytokines

Alteration of the ECM

Hair follicle degradation

ChemicalsStresses

(internal / external)

HAIR LOSS

Androgenetic alopecia (AGA)

Hormones (DHT)

AgingClimatic variations


Induces growth, revitalizes hair follicles and enhances blood circulation


Xtra Hair Restorer

• A combination of our traditional active ingredients

(Hyaluronic acid, Vitamins and Amino Acids) and

Biomimetic Peptides.

• This product contains no hormonal ingredients and

can therefore be used by patients of both sexes.

• It increases the thickness and volume to hair,

strengthens hair and makes them more durable.


6 Biomimetic Peptide

• Biomimetic peptides act on the innermost mechanisms of cell physiology, such as

biocatalysts, participates in the intracellular concentration activates metabolic

processes and cause general biostimulation of skin.

• Biomimetic peptides are SynthShort chains of amino-acids responsible for the

proliferation and differentiation of cells

• They act as Growth factors

• They are responsible for cellular processes including wound healing

• They also Stimulate production of elastin & collagen

• They are structurally identical to those found in human skin which means they can

intervene in physiological mechanisms with a highly specific overall action.


Acetyl-decapeptide - 3

• This is a basic growth factor of fibroblasts.

• It promotes cell proliferation and prevents apoptosis.

• It lengthens the lifespan of skin cells and modulates collagen synthesis.

Evolution of the % of keratinocytes after treatment using Acetyl -Decapetide - 3 over a period of72 hrs.


Decapeptide - 4

• This increases elasticity and encourages collagen and elastin synthesis.

• It has a general anti-aging and healing effect

• It has total rejuvenating and anti-inflammatory

effects.


Octapeptide-2• This regulates the proliferation of keratinocytes and fibroblasts.

• It accelerates hair growth and delays cell apoptosis.

• It activates the hair follicles as well as stimulating growth and strengthening hair.

Effects on hair growth after five days of treatment using the peptide: Increased amount of hair, increased length and thicker hair shaft.


Apigenin + Biotinoyl tripeptide - 1

• Protect and restore the structure of the hair follicle are used in

alopecia.

• Increases microcirculation around the hair follicle atrophy and retard

aging and hair follicle.


Morphological Observation. This study was carried out after the peptides were applied to the hair follicle for a period of 14 days


The anagen / telogen ratio increased 46 %


Copper tripeptide - 1

• it slows down hair loss.

• Strengthens hair by stimulating hair follicles, promotes hair growth

and thickness.

• Activates blood circulation.


13 Essential Vitamins

• These cofactors play an essential role in the various cell metabolic processes; they have a pronounced antioxidant effect and act as precursors for collagen synthesis.

• They participate in the production of ATP and in the reactions necessary for the synthesis of nucleic acids.

• Generally speaking, they act as biocatalysts in all the intermediary reactions necessary for proper respiratory metabolism and cell nutrition.


13 Essential Vitamins• Retinol (Vitamin A),

• Pyridoxine (Vitamin B-6),

• Thiamine Nitrate (Vitamin B-1),

• Biotin (Vitamin B-6),

• Tocopherol (Vitamin E),

• Riboflavin (Vitamin B-2),

• Amino Benzoic acid (Vitamin B-10),

• Inositol (Vitamin I),

• Niacinamide (Vitamin B-3),

• Cyanocobalamine (Vitamin B-12),

• Menadione (Vitamin K),

• Pantothenic Acid (Vitamin B-5), Folic Acid (Vitamin M ).


24 Amino Acids

• They are essential components of proteins (key construction

material for hair).

• Keratin is the most important protein in the formation of nails

and hair.

• They help create new hair follicles and promote hair growth,

its strength and volume.


24 Amino Acids

• Aminobutyric Acid AsparticAcid

• Glutamic Acid Alanine

• Arginine Asparagines

• Glycine Cysteine

• Glutamine Isoleucine

• Hydroxyproline Histidine

• Methionine Leucine

• Lysine Proline

• Ornithine Phenylalanine

• Threonine Serine

• Valine Taurine

• Tryptophan Tyrosine.


4 Coenzyme

• Catalysts that speed up metabolic reactions.

• They restore the quality of both the hair and its roots.

• Coenzyme A

• Nicotinamide Adenine Dinucleotide (NAD)

• Thiamine Diphosphate

• Flavin Adenine (FAD)


• 4 Minerals

• Calcium Chloride, Magnesium Sulfate, Potassium Chloride,

Sodium Phosphate.

• Cofactors that guarantee to absorb nutrients properly.

• 4 Nucleic Acid

• Cyclic Adenosine Phosphate, Guanosine, Cytosine, Thymine.

• Contains all the information that is needed to encode the

synthesis of structural proteins that make up hair and nails.

• 2 Antioxidants

• Glutathione, Ascorbic Acid (Vitamin C).

• Protects against external aggressive factors


• Hyaluronic acid (1.5%)

• Supports optimal hydration levels in the tissues,

protects against loss of elasticity and stimulates

collagen and elastin.

• Rutine reduces the production of histamine, which

helps prevent inflammation.

• Supports supply of hair follicles with oxygen and

nutrients. Increases fibrillar collagen synthesis, acts

against free radicals and has lipoperoxidation effects.


• Extract of Ginkgo Biloba

• It reduces capillary permeability and has significant

effects antiedematic.

• It eutrophic effects, increased collagen synthesis.

• Protects cells from hypoxia and promotes the growth of

new hair.

• Effectively reduces oxidative stress in cells induced by

UV radiation.


PROTOCOL for XTRA Hair Restorer

• 4 sessions IN A MONTH

• With gaps of 7 days

• Each session 2 ml

• For 3 months….


Protocols

• We can combine with US FDA approved PRP kit, monthly one session for 3months & weekly once mesotherapy of Xtra Hair Restorer.

• Using URTO Lotion everyday ,night application will give good results.


Before After

mesotherapeutic solution with biomimetic peptides, growth hormones for hair loss ...geosmatic.com...

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