Anusorn Cherdthong, PhD137748 Applied Biochemistry in Nutritional Science

Email: anusornc@kku.ac.thE-learning: http://ags.kku.ac.th/eLearning/137748

Metabolic Disorders in Animal Nutrition

Introduction

Mammary gland structure

Milk composition85% waterLactoseVitaminMineralsProtein: casein, whey proteinFat

Milk composition (%)

Animal Water Fat Protein LactoseCow 87.7 3.9 3.2 4.9Goat 86.6 4.1 3.3 4.7Swine 81.2 6.8 4.8 5.5Human 87.6 3.8 1.0 7.0

McDonald et al. (2011)

Milk

syn

thes

is a

nd

su

bst

rate

s

Milk synthesis

Lactose synthesisProtein synthesisFA synthesis

Lac

tose

syn

thes

is

McDonald et al. (2011)

Lac

tose

syn

thes

is

McDonald et al. (2011)

Protein synthesis

Milk---casein and few of -lactalbumin, -lactoglobulin

Occurred in endoplasmic reticulum and rough endoplasmic reticulum (RER)

Substrates are AA: diet and microbial protein

Protein product was storaged in golgiMechanism protein synthesis similar to other organs

FA synthesis

Occurred at smooth endoplasmic reticulum (SER)

triacylglyceride is major productStorage in alveolus FA received from:

Diet: intake, synthesis from C2, C4Mobilization from adipose tissue

Milk synthesis control

Brisken and O'Malley (2010)

Conclusion

1

2

Protein synthesis from diet and microbes

Lactose synthesis with 7 steps

3FA synthesis as triacylglycerol by use VFA, diet as substrate

Thank you!