metabolism of magnesium and its clinical significance
TRANSCRIPT
MetabolismofMagnesiumanditsclinicalapplications
Dr.Rohini CSane
MagnesiumMetabolismvMagnesiuma) Intracellularcationb) 20g/humanbodyc) 75%complexeswithcalciumDaily dietary Requirement :Men:à 400mg/dayWomenà 300mg/dayDailyoralintake>600mgleadstodiarrheaIntravenousintake>600mgCNSdepression
MagnesiumMetabolismvMagnesium dietary sources :cereals,beans,leafvegetables,fishvAbsorption of dietary Magnesium :proximalrenaltubulesvNormalserumMagnesiumconcentration:1.8-2.2mg/dlIonizedMagnesium -60%proteinboundMagnesium -30%MagnesiumBoundtootherions-10%vMagnesiuminRBC - 5meu/ltvMagnesiuminmuscles- 20meu/ltvHomeostasisismaintainedbykidney.vAbsorption :throughcarrierprotein,PTHincreasesabsorptionofMg²⁺
MagnesiumMetabolism
FunctionsofMagnesiumvFunctionsofMagnesium:1. functionsasactivatorofenzymesà AlkalinePhosphatase,Hexokinase,
Fructokinase ,Phosphofructokinase,Adenylate cyclaseC- Ampdependentkinase
2. DecreasesNeuromuscularirritability3. playsroleininsulinsensitivity4. MagnesiumsupplementationincreasesGlucoseTolerance5. MagnesiumdeficiencydecreasesinsulindependentuptakeofGlucose
Functions of MagnesiumMetabolism
MagnesiumdeficiencyvHypomagnesaemia:serumconcentrationofMagnesium<1.7mg/dlvCauses :a) DiabetesMellitusb) Chronicalcoholismc) Livercirrhosisd) Proteincaloricmalnutritione) Diuretictherapyf) Hypocalcaemia/HypokalemiavDeficiencymanifestation1. Neuromuscular irritability2. Tremors
MagnesiumdeficiencyvDeficiencymanifestation1. Neuromuscular irritability2. TremorssimilartoHypocalcaemia3. Carpo pedalspasm4. Cardiacarrhythmia
HyperMagnecemia :kidneyfailure
NeurologicalManifestationsinMagnesiumdeficiency
CommonsymptomsofMagnesiumdeficiency
Hypomagnesemia
MagnesiumMetabolisminHypomagnesemia
MagnesiumMetabolisminHypomagnesemia
MagnesiumMetabolism