metabolism power point

7/24/2019 Metabolism Power Point

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Chapter 5 Bacterial MetabolismQuestions for today

Whats the dierence betweenanabolism and catabolism?

What are the three processes bywhich AD is con!erted to A"?

What are some basics abouten#ymes?"erminolo$y% what in&uences theirfunction% 'inds of inhibition


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Metabolism( biochemical reactionswithin a cell Components of metabolism

A"

)*idation+reduction reactions

,lectron carriers

,n#ymes


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Metabolic reactions areeitherAnabolic -

,nder$onic .ener$y

re/uired0Catabolic -

,*er$onic .ener$y released0


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1i$ 523


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1i$2 524

)*idation and eductioneactions

)67 68rotons often accompany electrons( proton+electron pair 9 hydro$eatom

http(::www2youtube2com:watch?!9lQ;1BA3


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,lectron carriers

>AD? 4e+4


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A"


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32 @ubstrate le!elphosphorylation(

http(::www2nature2com:scitable:cont:$lycolysis+34E

"he transfer ofphosphate to ADfrom anotherphosphorylatedor$anic compound

$lycolysis


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42)*idati!e phosphorylation ,ner$y from proton moti!e force created by

redo* reactions used to attach inor$anicphosphate to AD

)ccurs at the cell membrane of pro'aryotes inelectron transport chain

=2hotophosphorylation ,ner$y form the sun used to phosphorylate AD


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,n#ymes

@imple en#ymes rotein only

ConFu$ated en#ymes rotein and some other non+protein cofactor

6f inor$anic% called cofactor

@uch as Cu4

6f or$anic% then called coen#yme @uch as >AD

Apoen#yme .protein0

cofactor9holoen#yme

@ubstrate ++++++++++products

,n#yme


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,n#yme Acti!ity

1i$2 52


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6nhibitors

Competiti!e 6nhibition Bloc's an en#ymes acti!e site

1i$2 521i$2 52


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6nhibitors

>on+competiti!e 6nhibition

Allosteric inhibitor or acti!ator 1eedbac' inhibition

1i$2 523E


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G 4E3 earson,ducation% 6nc2

Figure 5.11: Feedback inhibition.Substrate

Pathwayshuts down

Bound

end-product(allostericinhibitor)

Enzye 1

!llostericsite

Pathwayoperates

Feedbackinhibition "nterediate !

Enzye #

"nterediate B

End-product

Enzye $


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Heep in mindI

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