Microfluidics

Controlling and handling of liquids is in the blood of the Dutch. This is true when it comes to either huge infrastructural constructions like the Afsluitdijk or the Maeslant Storm Surge Barrier, or when it comes to the handling of very small quantities of liquid or gas. In either case, the Dutch excel in this domain.

The Dutch Association for Microsystems and Nanotechnology MinacNed (www.minacned.nl) and the business cluster MicrofluidicsNL bring together, in this brochure, eleven Dutch specialist organisations in the area of microfluidics. Together they cover the complete microfluidic business chain from components to complete systems.

The companies presented are:

Microfluidics R&D• KIT Biomedical Research• MESA + Institute• TNO Science & Industry

Microfluidics Equipment• Kryoz Technologies • MA3 Solutions

Planar Microfluidic Chips• Micronit Microfluidics• Technogation

Flow Chemistry• Flowid• FutureChemistry

Flow Measurement and Control• Bronkhorst High-Tech• Brooks Instrument

Holland’s High Tech Entrepreneurship in MicrotechnologiesDutch Design in Microtechnology, Competences of High Tech Companies from Holland

Microfluidics is a hotspot in microtechnology. The technology is developing fast, and continuously. Microfluidics specifically is enabling three application areas: research laboratory, life sciences and industrial processing. Analytical lab equipment is the most basic application area for microfluidics. The importance of microfluidics for life science is growing. The most important market segment is undoubtedly point of care diagnostics, but also younger applications like encapsulation of drugs and drug delivery through micro nozzles achieve a growing interest. Many new applications are also expected to arise in the chemical industry through microreactors, flow chemistry, process intensification and fabrication of nanoparticles. In the application area of process intensification, a major contribution from microfluidics may be expected in optimizing the yield from raw materials and reducing energy use in production processes. Dramatic wins in terrains of sustainability are ahead.

In the field of medical diagnostics, fast reaction times and the use of small sample sizes are both attractive features offered by microfluidics. The small size and low fabrication cost enables the transfer of diagnostics from the clinical labs closer to the patients, thereby minimising response times. In systems biology main breakthroughs are expected, enabled by microfluidics. The injection of biocells can only be adequately executed by microfluidics.

Typically, microfluidic products can be divided into products to be used in production, where efficient mixing, material and heat transfer and more precise control of process are of importance, and products for more accurate measurement. The more precise measurement is needed when extremely small amounts of fluid must be detected. Examples in this domain and in this brochure are:

Plug & Produce Skid by Flowid, FutureChemistry, Bronkhorst High-Tech and Micronit Microfluidics

Microdispensing by MA3 Solutions

DLI (Direct Liquid Injection) Vapouriser by Brooks Instrument

Kryoz CryoLab© by Kryoz Technologies

High-throughput experimentation in microreactor chips by MESA + Institute

Unique Room Temperature Bonding Process by Technogation

®

As you can notice, we in the Netherlands are very fortunate to have a group of innovative companies covering the whole range of technologies required as well as an active user community. This brochure presents the Dutch microfluidic supply chain, from component suppliers to system integrators.

MinacNed - mission and objectives

MinacNed is the association of companies and institutes creating economic added value in the Netherlands based on joint activities among members and with relevant stakeholders in the field of microsystem and nanotechnology.

The association’s ambition is to provide room for all new subsectors within the field of microsystem and nanotechnology within the association, including its scientific base and its areas of application.

In addition to this, MinacNed aspires to a representative circle of affiliated members regarding the scope of the association.

Business clusterMicrofluidicsNLThe branche cluster MicrofluidicsNL has been established the first of October 2010. Fifteen high-tech enterprises initiated to set up the cluster as part of the association MinacNed, with the mission to strengthen the development of the microfluidica market in the Netherlands. The activities of the cluster cover three domains: • Joint(inter)nationalmarkets• StimulatingR&DprojectsintheNetherlandsinthefield

of microfluidica and the participation of members in these projects

• Promotionofmembers’intereststostakeholdersinthemarket, research institutes and government

Concrete activities are:• XS2Hitekworkshopstoshareknowledgeandsupportcooperation,preferablyorganizedbya(potential)userofthetechnology and specified to one field of application

• Regularpublicationand(inter)nationaldistributionofthebrochure“Microfluidics:Holland’shigh-techentrepreneurshipin Microtechnologies”, containing business profiles, activities and contact information of cluster members.

• Collectiveparticipationinlargenationalandinternationalconferences and other events

• PreparingcollectiveR&Dprojects

Mission:“Strenghten Dutch Economic Activity

based on Micro- and Nanotechnology”

MinacNed – Target GroupsMinacNed is targeted at all links in the knowledge chain. The multi-disciplinary nature of Micro- and Nanotechnology, together with the high-quality technological solutions that they provide, requires intensive cooperation between all players involved.

Activities• membermeetingstoreinforcenetworks• workshopsfocussingonmarketdevelopmentwithspecificgroupsof

customers or potential customers of members / users of micro and nano technology.Suchworkshopscouldbewithintheframeworkofdevelopmentofjointroadmaps,aswasthecaseinthepastforFood&Nutrition.

• theannualNetherlands’MicroNanoConferenceinwhich,besidesbothobjectives specified, we also strive for broad reinforcement of the image of the micronano industry, nationally and internationally. During organisation of theNetherlands’MicroNanoConference,MinacNedcollaborateswithrelatedorganisations wherever possible.

• initiatingandorganisingspecificclusterswithintheassociationwhichneed their own network and identity in the market, within the framework ofMinacNed.Specificmarketingactivitiescanbesetupforandwithsuchclusters. When forming and running such clusters, collaboration with other industry organisations is possible, with the aim of preventing companies that fit in here having to join too many organisations at the same time.

• initiating,encouragingandtoacertainextentfacilitatingtheformationof consortia between members and groups of members with other stakeholders,focussedonjointR&Dand/ormarketing.

For more information on this activities, please go to: www.minacned.nl

Relationship with existing organisationsIn the dissemination of knowledge, MinacNed organises activities in accordance with NanoNextNL research programme. There are other Dutch organisationswhoseaimsaresimilartothoseofMinacNed,suchas:“SensorTechnology Club” or “Development Club”, both run by the Dutch Federation ofTechnologyBranches(FHI),theDutchAssociationforPrecisionTechnology(NVPT),and‘Sensorplatform,’runbytheDutchFoundationforTechnicalSciences(STW).MinacNedintendstoalignitselfwiththeseorganisationsandwork in partnership with them. In addition, further partnerships will be sought with other organisations working within other application areas and market sectors, including the field of genomics, biotechnology, food, fine chemistry, etc.

Business cluster MicrofluidicsNL members are: Beckman Coulter Nederland B.V.www.beckmancoulter.com

BIOS Lab-on-a-chip Group, University of Twentehttp://bios.ewi.utwente.nl Bronkhorst High-Tech B.V.www.bronkhorst.com

Brooks Instrument B.V.www.brooksinstrument.com CALIPER LifeSciences N.V.www.caliperls.com

Capilixwww.capilix.com

ChemtriXwww.chemtrix.com

Delft Institute of Microsystems and Nanoelectronicswww.dimes.tudelft.nl Distrilab B.V.www.distrilab.nl

Eindhoven University of Technologywww.tue.nl

enablingMNT Netherlandswww.enablingmnt.com Flowid www.flowid.nl

FutureChemistrywww.futurechemistry.com KIT Biomedical Researchwww.kit.nl

Kryoz Technologieswww.kryoz.com LioniX B.V.www.lionixbv.nl

MA3 Solutions B.V.www.ma3solutions.com MESA+ Institute for Nanotechnologywww.mesaplus.utwente.nl

Micronit Microfluidics B.V.www.micronit.com Nanomi B.V.www.nanomi.com

Philips Research Applied Chemical Technologywww.research.philips.com

TNOwww.tno.nl Technogationwww.technogation.com

University of Leiden http://abs.lacdr.gorlaeus.net

ObjectiveWithin its vision, MinacNed sets itself the aim of having the Netherlands participate at international level in all fields of enabling microsystem technology and nanotechnology and become and remain an international leader in a number of more precisely defined specialisms, such as microfluidics. MinacNed aims to effect an exponential increase in the applications of microsystem and nanotechnology in the Netherlands.

ContactKIT Biomedical ResearchMeibergdreef 391105 AZ AmsterdamThe NetherlandsTel.: +31(0)205665441Email: info@kit.nlInternet: www.kit.nl

KIT Biomedical Research

Mission: The aim of KIT Biomedical Research (KIT BR) is to improve the quality and effectiveness of health provision and services for people in low and medium income countries. We achieve this through interrelated laboratory and applied activities, including research, advice and capacity building. Our focus is on detection, management and control of infection and disease.

Objectives•Todevelop,manufactureandimplement,togetherwith

local public and private partners, diagnostics and diagnostic methods for sustainable use in resource limited situations.

•Togenerate,evaluateandtranslateknowledgeandevidencefor improved detection, diagnosis, management and control of infectious diseases.

•Tobuildsustainablelocalcapacitythroughtrainingandcollaboration in long-term partnerships.

•Toadviseonnationalandinternationalhealthrelatedpolicies.

KITBRhasbeenaccreditedaccordingtheISO15189standardformedicallaboratoriesandhasfullyequippedBSL3,BSL2andBSL1laboratoriesandhoststheWHO/FAO/OIEInternationalReferenceLaboratoryforLeptospirosis.

KITBRhasatrackrecordandinternationalreputationinthefieldofessential diagnostics; the department is active in different aspects of the diagnosticpipeline.KITBR’sdiagnosticandresearchlaboratoryhasspecificmicrobiological, molecular, immunological and epidemiological expertise. KIT BRcarriesoutbasicandoperationalresearchfocusedonthediagnosisofTB,andalsoonMDR-TB.KITBRisattheforefrontofdiagnosticdevelopment(e.g.LED-basedfluorescencemicroscopyforTBwasinventedbyKITBR;rapidtestsforseveralneglectedinfectiousdiseasesdevelopedbyKITBRhavebecomethegoldstandardforfielddiagnosis)andprovidesparticipatoryassistancetoimprove diagnostic test implementation in the form of workshops/trainings, monitoring and assessment visits.

Our interest in Microfluidics is based on the promise that this technology will allow sophisticated but cost-effective diagnostics to be developed suitable for use where they are most needed.

ContactMESA+ Institute for NanotechnologyHan GardeniersUniversity of TwenteMesocaleChemicalSystemsgroupP.O.Box2177500AEEnschedeThe NetherlandsTel.: +31(0)534894356Email: j.g.e.gardeniers@utwente.nlInternet: www.mesaplus.utwente.nl

Micro and nanofluidicsat MESA+ Institute for Nanotechnology

Fluidics at the nano to micro scale is a key research area of MESA+, in which the behaviour of single and two-phase fluids in a confined environment and on nanostructured surfaces is studied.

Physics of fluids at the nano scaleThe behavior and applications of droplets and bubbles on nanostructured surfaces(electrowetting,superhydro-phobicity)andofliquidflowpropertiesinmicroandnanochannel(mixing,electrokinetic liquid slip, bubble cavitationforsonochemistry)arestudied.

High-throughput experimentation in microreactor chipsSilicon-glassmicroreactorswithmicrofluidicnetworksandintegrated analysis optics and electronics are developed to generate more reaction kinetic data in less experimentation time. Performingchemicalsynthesisatthe scale of nanoliters to microliters allows the study of chemistry under extreme conditions like high pressure, high electric field, or supercritical conditions, or with toxic or explosive reactants.

Analytical microdevices for Life ScienceLiquid chromatography at high speed with ultimate resolution, in micro and nanostructured devices, with integrated injection and detection functionality, as well asthecouplingtospectrometricmethodslikeMSandNMR,aredevelopedandappliedtochemical,medicaland biological problems.

MESA+isoneofthelargest nanotechnology research institutes in the world, delivering competitive and successful high quality research. It uses a unique structure, which unites scientific disciplines, and builds fruitful international cooperation to excel in science andeducation.MESA+hascreateda perfect habitat for start-ups in the Micro- and Nanoindustry to establish and to mature.

Microfluidic technology

Microfluidic technology is an important ingredient for many new technological developments. The combination of microfluidics with engineering, physics, chemistry, micro-technology, manufacturing technology and biotechnology enables the creation of innovative miniaturized analytical systems and new production concepts. TNO has more than 10 years of experience in this field and is still growing stronger.

Main application areas

• Instruments for physical, chemical and biological analysis TNO develops analytical equipment for process, pharmaceutical, and semiconductor industries to improve and simplify process control. By using innovative microfluidic sensor-principles, instruments are designed for in-line determination of relevant parameters. Examples of our activities in this area include the development of microfluidic flow-meters and micro gas chromatography systems.

• Lab-on-a-chip for biological detectionThe trend in biological detection is in parallellization, miniaturization and integration of laboratory processes and development of on-site detection systems. We develop instruments for environmental, forensic, and medical industries to measure relevantbiologicalparameters(e.g.inDNA,RNA,proteins).One of our main activities in this area is in lab-on-a-chip technology for the integration of sample preparation and biological detection for on-site applications.

• Process intensificationProcessintensificationaimsatmaking industrial processes faster, more efficient, and environment-friendly. We play an important role in the development and implementation of process intensification technologies in the fine-chemical and pharmaceutical industry. This involves upscaling of existing technologies and development of new technologies. Examples of our efforts include the development and scale-up of the helix mini-reactor and the development of parallel microreactor systems.

• Printing equipmentPrintingisaversatiletechniquetoproducespraysanddepositthinlayersofmaterials. TNO explores the different high-end application areas of printing. Ourmainactivitiesareinprintinghighlyviscousmaterials(e.g.bio-compatiblematerialsorhighlyviscouspolymers),inpyrolyticmetalprinting,andinmicrostereolithography for 3D structures for custom manufacturing.

When your product or process involves small amounts of fluids or when small scale effects play an important role, please do not hesitate to contact us. We can help to find out where microfluidic technology might have a benefit, both technically and economically. When it does, we are a trustworthy partner in developing the technology for the specific application.

Parallellized micro-reactor

ContactTNOMarc van KleefProject Manager Industrial InnovationP.O.Box62355600HEEindhovenThe NetherlandsTel.: +31(0)888662415Mob.: +31(0)631757058Email: marc.vankleef@tno.nl

The role of TNOTNO is an independent contract research&developmentorganization. We work on projects ranging from basic research to the development of functional models and/or prototypes. We support a large variety of customers in their research and development, ranging from small to large international companies.

We offer various possibilities:- Contract R&D: TNO applies its

multitude of different technology competences in different phases: research, proof-of-principle, proof-of-concept, demo/pilot or combinations.

- Cooperative R&D: For this, the company and TNO will set the goal of the project together. This goal will have to fit with the long-term strategic vision of TNO.

- Feasibility studies: We assess the possibilities and risks of a certain technology development.

- Licensing: We offer the possibility to get a license on one of our inventions.

ContactKryoz Technologies BVColosseum 15d7521PVEnschedeThe NetherlandsTel.: +31(0)532030995Email: info@kryoz.comInternet: www.kryoz.com

Kryoz TechnologiesMicro cryogenic cooling systems

Kryoz Technologies is a specialised technological business in the field of cryogenics. We design, optimise and manufacture small, fully integrated cryocooler systems for specific applications. These stand-alone systems can be used to cryocool advanced electronics, such as low noise amplifiers, sensors (e.g. IR / X-ray), and superconducting circuits for various markets including:

• R&D and laboratory cryocooling• Telecom• Measurement and sensing devices• Space industry• Radio astronomy• Medical applications• Superconducting circuits

Plug-and-play micro cooling solutionsOur microcooling systems contain a micro cold tip, which is fully optimised for the specific application at hand. The devicetobecooled,whichissuppliedbyourcustomer(e.g.anALA,SQUIDorIR-sensor),isthermallyconnectedtothemicrocooler’scoldtip.Interfacingbetweencoldtipandthedevice to be cooled is easy and efficient.

The micro refrigerators can reach temperatures as low as 80K(-193Celsius).Withamulti-stagemicrocooleritispossibletoreachtemperaturesaslowas30K(-243Celsius).Cooling powers vary from a few mW to about 250 mW.

CryoLab©

By combining the micro cold tip with a base-station, which controls: cold tip temperature, gas supply, pressure safety and vacuum, we offer a plug-and-play cryocooling platformforR&Dandlaboratoryenvironment.

Kryoz CryoLab© system key advantages•Compactandeasytouse•Fastcool-down•Nocryogenicknow-howrequired•Controllablecool-downcurves•Easyexchangeablecoolerunits•Novibrations-nointerference•Cryogenfree

“High value at low temperatures”

CryoCube©

Using a downscaled sorption compressor and long-life vacuum chamber, we can offer an extremely small, fully integrated, stand-alone cryocooling system. A micro cryogenic refrigerator meant for in-field applications. Final system size depends on the required cooling power and temperature.

Kryoz CryoCube© system key advantages•Compactandeasytouse•Fullyintegratedandstand-alone•Nocryogenicknow-howrequired•Novibrations-nointerference•Lowinputpower-lowweight•Longlifetime•Cryogenfree•Highvolume-lowcost•Onecompressormultiplecoldtips

possibleCryoCube©

CryoLab©

ContactMA3 Solutions BVMartin van AchtSales DirectorSciencePark50805692EASon(Eindhoven)The NetherlandsTel.: +31(0)402969330Email: info@ma3solutions.comInternet: www.ma3solutions.com

MA3 SolutionsIn just a couple of years since it was founded in 2003, MA3 Solutions has carved a well-defined market position for itself. Still small, with about ten employees, the company operates within a network of knowledge and skills and has established both a well-defined customer service concept and cutting edge technology.

WiththemajorityshareholdingofTEGEMAGrouplate2008,MA3SolutionshasfoundastrongstrategicpartnerandTEGEMAcanexpanditsactivitiesintheareaofHighTechSystemsandspecial machines. MA3 will continue to operate independently as a process developer and system supplier, mainly at the front end of the market. The cooperation will in particular result in shared activities in, on the one side, process development and on the other side engineering and realization.

Thecompanyisdrivenbycustomerdemand.MA3Solutionsresponds to manufacturers of micro-system products for new typesofassemblyprocesses.MA3’sownin-houseR&Dspecialistsdo the development work required to achieve the target. This might involve devising new processes, machines or products. All work

is carried out in close co-operation with the customer. MA3 specializes in the multi-disciplinary approach to micro assembly and micro dispensing issues. When possible, use is made of ‘proventechnologies’,whichresultsinStateoftheArtproductionequipment,including among others the production of biosensors, micro arrays, print heads and miniature lenses for mobile telephones. In this respect, the company carries out its own product development.

Key productsMA3 offers tailored assembly and dispensing solutions for micro systems at a range of levels, fromthe‘ramp-up’ofproductionfor one customer to an automated turnkey assembly system for another.

By replacing traditional production

member of the TEGEMA Group

methods with an MA3 solution, a customer can shorten the production cycle by up to half. The solution comprises a number of keystages.AQuickScanisalwaysthe first step. This determines whether the requirements fall withinMA3’sfieldofworkandwhether room for improvement can be identified. Next comes a feasibility study that focuses on the risks involved. If those are found to be acceptable a pilot series follows. This could range from 2,000 to 3,000 units and gives the customer a clear idea of the developed assembly method. During this phase rapid prototyping and standard process devicesareusedandoncethe‘go’decisionistaken,anassemblycellwillbecreated for volume production that could output as much as ten million units a year.

MarketSincemicro-systemsareusedinavariety of industries, the company operates on many, diverse markets. LifeScience/MedicalandICT/Telecom are just two fields that springtomind.IntheLifeSciencemarket,MA3’sworktodatehasconcerned actuators. Well-placed intheSoutheastNetherlands,thecompany has been able to find international business abroad and closetohome;80%ofitsturnoveris earned in Europe. America and Japanaccountfortheremainder.

This is a relatively new market in which MA3 has surged ahead of its competition. While no industry standards exist, MA3 is already working with de-facto standardized processes that enables it to provide tailored solutions. It is also a member of more than one body seeking industry standards.

ContactMicronit MicrofluidicsRonny van ‘t OeverManaging DirectorColosseum 157521PVEnschedeThe NetherlandsTel: +31(0)538506850Email: info@micronit.comInternet: www.micronit.com

Micronit MicrofluidicsYour partner for microfluidic components

In many cases Micronit Microfluidics creative ideas and world-class capabilities have led to groundbreaking product innovations for our customers in analytical and diagnostic instrumentation. With this spirit Micronit Microfluidics has grown to become a leading supplier of microfluidic and lab-on-a-chip devices in life-science and chemistry.

With its own cleanrooms, production and quality department Micronit Microfluidics is able to provide its customers with consistent quality from the first prototype to full scale manufacturing. Micronit Microfluidics offers a unique combination of micro structuring capabilities, glass technology, microfluidics and customer application know-how. Micronit Microfluidics has the vision to operate as a market leader in the development and manufacturing of integrated microfluidic components, by investing in quality, innovation and capacity.

MicrofluidicsMicrofluidics opens up new possibilities previous impossible on the macro-scale. Two decades of research have yielded a gold-mine of microfluidic principles, techniques and applications, including:•ContinuesFlowSystems•(Digital)DropletMicrofluidics•DNAChips•SingleCellResearch•ChipElectrophoresis

Besides these unique features there are several trends which stimulated the ongoing adoption of microfluidic technology in modern day analytical instrumentation:•MiniaturizationofLab-equipmenttowardsDesktoporHandheld

•IntegrationandSimplificationofSampleHandlingandAnalysis

•AutomationtoIncreaseDataOutputandDecreaseHands-onTime

•DecreasecostsperAnalysisand/orIncreaseDataQuality

Volume manufacturingWhether you are looking for low-volume manufacturing of a precision product or high-volume manufacturing of a disposable microfluidic devices, Micronit Microfluidicsistheretodeliver.MicronitMicrofluidicsisISO9001:2008certified,workingtowardsISO13485andusesstatisticprocesscontroltoensureconstantquality.

Foundry Capabilities: •4”,5”,and6”substrateprocessing •plasmadeposition•glass-etching(HFandDRIE) •surfacemodifications•structuredMEMSwafers •metrology•bonding(glass-to-glass,glass-to-silicon) •dicing•thinglasshandling •packagingandlabelling•metalization(Pt,Au,Cu,etc)

Product developmentThanks to our micromaching and microfluidics know-how we can support instrument manufacturers with their product development. By working in close cooperation with our customers time to market can be drastically reduced and the product will be designed for manufacturing. Our experience enables us to optimize the chip not only in functionality, but also in manufacturing cost.

Research products The lab-on-a-chip platform Fluidic Connect offers a user-friendly way of creating your own lab-on-a-chip setup. They can easily be used with standard laboratory equipment such as syringe pumps and microscopes. The platform includes a user-friendly chip holder, connection material, a number of standard chips andthepossibilitytohaveyourowndesignsmanufacturedbytheFluidicProprototyping service.

MarketsMicrofluidics is an innovative growth driver in markets such as biotechnology, medical industry, chemistryandMEMS(micro-electro-mechanicalsystems).Customers range in size from ambitious start-up companies tosomeoftheworld’slargestanalytical and diagnostic instrumentation manufacturers. Main markets include:•MolecularDiagnostics•Point-of-Care•CellandMicrobialResearch•MicroreactorTechnology•AnalyticalInstrumentation

ContactTechnogationRichard BijlardManaging DirectorFangorn63 5661AJGeldropThe NetherlandsTel.: +31(0)647594741Email: info@technogation.comInternet: www.technogation.com

Advanced microfluidics and 3D MEMS in glassTechnogation is European distributor and manufacturing contractor for the Invenios group of companies, which includes Invenios (USA) and mikroglas - chemtech GmbH (Germany).

Invenios is a world leader in the manufacture of gene-sequencing bio chips, microfluidic devices, microfluidic mixing and -separation systems, nano-scale motion control platforms and high volume precision micromanufacturing. With a vertically integrated manufacturingfacilityintheUSandafastturnprototyping/small volume production facility in Europe, the Invenios group is able to maintain total process control of substrates from their raw form to a finished product, and can manage multiple high-volume production lines for glass based microfluidics products. Invenios’in-housedesign,productionandqualityengineeringstaffenable companies to expand and expedite their prototyping and productionrequirements.Photo-structuraldeepetchcapabilityprovidesstraightwall(3°fromthevertical)structuresonlypossiblewithahighercostDRIEorBoschprocessing.

Unique Room Temperature Bonding ProcessInvenios has developed a unique room temperaturebondingprocess(withoutusingpolymerbasedadhesives),whichprovidespermanent glass-to-glass bonding solutions (othermaterialsarepossibleaswell,patentspending).Thisuniquebondingprocessallowsour customers to functionalize the substrate prior to bonding and then attach the cover slip without damaging critical micro-structures or biological treatments. This unique advantage significantly expands packaging and microfluidic design capabilities over the current high temperature bonding process, such as diffusion bonding or anodic bonding.

“What can we do for you?”

Adhesive-free bonded 64 nozzle, 100 x 100µm Invenios patented print head with fully imbedded and centred nozzles

Bio chip in FOTURAN:• 2.7 mm wide channels, 0.100 mm deep, with 130µm channel wall• 350µm inlet/outlet holes in 1 mm thick glass

FOTURAN® Photo-Sensitive-Glass-Ceramics

ByapplyingUVlightatcertainfrequencies at areas of interest on the optically clear glass surface, the native amorphous glass phase ofFOTURANisconvertedtoacrystalline lithium silicate phase. When this phase is then oven-developed, the resulting substrate will etch up to 30 times faster than the surrounding substrate. This accelerated etch capability allows significantly steeper wall and port angles than other conventional wet etch methodologies. By varying the development oven profile, FOTURANcanalsobe‘ceramized’to produce various phase changes in the glass for light absorption, mechanical- or electronic purposes.

The Invenios group develops, designs and manufactures a complete range of glass products for microfluidics, microfluidic systems and sensors, from concept to production:•microreactorsforseparatingandmixing•sensors,sensorencapsulation•DNAresearch•genefracturingchipsand-systems•lab-on-a-chipsystems•channel-andnozzlesystems,suchas: inkjetprint-heads(chemicallyinert)titerplates

•3Dmicro-structures(MEMS)•customerspecificglasscomponents

FOTURAN PSGCFOTURAN® Photo-Sensitive-Glass-Ceramic(PSGC)isaveryimportanttoolinthe toolbox for the production of a wide variety of micro-biological, -mechanical and-electricalsystems.Highaspectratiomicrostructurescanbeproducedrelativelyquicklywithoutmasks,photo-resist,DRIEorsubstantialupfrontcosts.Forthepurposeofproduction,FOTURANcanbeprocessedinhighvolume using masks, however, without the use of photo resist making it a very “Green Material”.

®

Flowid solves mass and heat transfer limitations in the chemical industry, with process engineering solutions that go far beyond the standard. Stop wasting valuable resources by redesigning your process with Flowid’s experts.

Over the years Flowid has implemented dedicated solutions in the fine-chemical industry and pharma. Making unique products by processes that excel in terms of safety, yield and selectivity. Successivelysimplifyingthedownstreamprocessingaswell.

At Flowid we cooperate. With you as a client and your experts. With leading research groups in the field of micro flow chemistry and process technology. With the best manufactures of specialized components. And with advanced mechanical engineering firms.Securingapreciseandsmooth on site implementation and maintenance.

Although Flowid has been awarded severaltimesforit’sinnovativeandgroundbreaking work. We push ourselves to go beyond our own standards. New patented reactor technology enables us to reach production capacities that will make a difference.

YouarewelcomeatFlowid’sbrandnewfacilities to experience how we work, learn about our technologies and what it looks like.

Take back control over your whole process and go beyond your standards.

Flowid Go Beyond the Standard

From lab to production scale!

Plug & Produce Skid: Easy to operate, customize and transport

CashFlowid: Maximise value using continuous processing

ContactFlowid B.V.Wouter StamDirector Business DevelopmentDe Lismortel 315612AREindhovenTel: +31(0)624679774Email: wouter.stam@flowid.nlInternet: www.flowid.nl

ContactFutureChemistryKaspar KochManaging DirectorVisitingaddress:Toernooiveld1(Mercator3)6525EDNijmegenThe NetherlandsTel.: +31(0)247114029Email: k.koch@futurechemistry.com

FutureChemistry

Flow process developmentFutureChemistry uses its expertise, know-how and experience for converting commercial chemical processes to flow chemistry, as well as for creating new flowchemistryprocessesstartingfromanyR&Droutetoachemicalproduct.

FutureChemistry’sresearchfacilitiesincludeflowchemistryinstrumentsandanalysis equipment. In addition to standard analytical tools, the company has easy access to several leading research facilities in the Netherlands, enabling it to use specific equipment relevant to flow chemistry research.

The company has successfully conducted its contract research services for several international blue chip customers, having created demonstrable benefits of flow chemistry processes for a range of fine and specialty chemical products.

“Smart, safe and clean chemistry”

FutureChemistry is a worldwide technology leader in flow chemistry. With proven methodology for screening chemical reactions and synthetic routes the company develops, optimises and implements efficient flow chemistry processes.

Flow chemistry instrumentsFutureChemistry develops and provides equipment and instruments required for successfully validating and operating flow chemical processes. FutureChemistry offers, combined with its instruments, a flow chemistry practical course for the implementation of flow chemistry at universities, research institutesandcorporateR&D.Thispractical course, developed by world leading universities in collaboration with FutureChemistry, helps to understand the benefits of flow chemistry.

Custom manufacturing servicesFutureChemistry offers flow chemistry custom manufacturing services to those companies that choose not to invest in setting up their own flow chemistry facility.

FlowStart Evo Give your flow chemistry a head start!

Conventional mass flow and pressure meters and controllers have a footprint of 1.5”, for example as specifiedwithintheNeSSI™system.Now,andincloseco-operationwithLioniXandtheNetherlandsOrganisationforAppliedScientificResearchTNO,BronkhorstHigh-TechhasdevelopedtheIQ+FLOW mass flow sensor. Due to micro solid state technology (MEMS),Bronkhorsthasbeenabletohalvethefootprintdimensionto0.75”,therebyrealisingultracompactflow controllers for flow rates from 1 to 2000 mln/min

and pressure controllers for 0.3 to 100 psi. Thanks to these compact solutions the overalldimensionsoftheinstrumentationcanbedownsizedby50%.

ContactBronkhorst High-Tech B.V., Nijverheidsstraat 1A7261AKRuurloThe NetherlandsTel.: +31(0)573458800Email: info@bronkhorst.comInternet: www.bronkhorst.com

Microfluidic mass flow and pressure controllersEquipment manufacturers require compact solutions to monitor or control gas flow and pressure in their systems. Due to micro solid state technology (MEMS), the footprint dimensions compared to conventional mass flow and pressure controllers can be halved.

BronkhorstHigh-TechB.V.hasover25yearsofexperienceindesigning and manufacturing precise and reliable measurement and control devices for mass flow and pressure. With a wide range of instruments, the company offers innovative solutions for many different applications in many different markets. Theseinstrumentscanbemadetoacustomers’specification,in whichever style is suitable, for laboratory, industrial or even hazardous environments within such markets as semiconductor industry and analytical instrumentation.

Customer specific designsA core philosophy within Bronkhorst is to form close working links and collaborations with its customers and more specifically with Original Equipment Manufacturers thereby ensuring optimised integration of our instruments. Most often, this results in bespoke designs for which various functions are combined into onemicrofluidicsystem.TheIQ+FLOW range has so far offered, but is not limited to, the following functional modules: flow meter, pressure meter, control valve, shut-off valve, three-way valve and mixing chamber. A combination of these modules can be mounted on a compact manifold, in line with a customers requirement, and following open design discussions. The ”plug and play” assembly ensures space efficiency, cost reduction and minimization of potential leak points. Examples of a typical applications would include flow/pressure control in sample injection for Gas Chromatography systems and Nebulizer gasflowcontrolinMassSpectrometers.

“World’s smallest mass flow and pressure controllers”

Flow sensor principle of operationThe actual flow sensor chip consists of a thin square membrane with two heaters and two temperature sensors(T-sensors)onitssurface.The membrane is suspended by a frame around it and can withstand 200psi(15bar).Thetwoheatersare raised in temperature to a T over the medium temperature by providing them with constant power. From each T-sensor, the hot side is located on the membrane, and the cold side is on the frame around the membrane. The temperature difference between the hot sides of the upstream and downstream T-sensors is proportional to, and a measure of, the flow. The combination of the patented, thermally balanced chip-sensor with the digital electronics ensureshighaccuracy(0,8%RD+0,2%FS),fastresponse(<0.5sec)and a very stable zero.

ContactBrooks Instrument B.V.Neonstraat 3671WXEdeThe NetherlandsTel: +31(0)318549300Fax: +31(0)318549309Email: brookseu@brooksinstrument.comInternet: www.brooksinstrument.com

Brooks InstrumentA world-leading provider of advanced flow, pressure, vacuum and level solutions

Brooks Instrument is a company of highly trained specialists whose goal is to provide flow, pressure, vacuum and level solutions that exceed customer expectations. The company has a proven history of innovation including the first pressure transient insensitive (PTI) mass flow controller, the first watertight and explosion proof thermal mass flow controller (Mf Series), the first thermal mass flow controller with Foundation Fieldbus (SLA Series), the first variable area flow meter with Foundation Fieldbus (MT3809 & MT3750), and the first miniaturaized Coriolis mass flow controller (Quantim).

Product portfolioBrooksInstrument’sportfolioincludesglassandmetaltubevariableareaflowmeters(rotameters),thermalmassflowcontrollers and meters, Coriolis mass flow controllers and meters, pressure control products, vacuum capacitance manometers, magnetic level instruments, and a variety of flow accessories.

The company also owns Key Instruments which offers precision machined acrylic flow meters, molded plastic flow meters, glass tube flow meters, electronic flow meters, and flow control valves.

European Headquarter & Support CenterOur European headquarter is based in Ede - the Netherlands. We work closely with our customers to develop and deliver innovative solutions to their flow measurement needs. Our multi-lingual staff is involved in Sales,R&D,CustomerSupport,AfterSalesandService,including start up and helpdesk functions.

Another important activity of Brooks Instrument relates to the verification and calibration of all flow measurement and control equipment. Our calibration tools are certified andtraceabletoNationalStandards.BrooksInstrumenthas a specially classified clean room for assembling and calibratingtheirproductsandiscertifiedtoISO9001:2000.

For more information on flow solutions, products, or sales contacts please visit www.BrooksInstrument.com.

Global Market LeaderBrooks Instrument is a global market leader and has a large installed base in research centres, laboratories and process industries and additionally focuses in emerging markets.

Brooks Instrument has manufacturing locations, sales, and service offices in the Americas, Europe and Asia.

Brooks TMF Family

Brooks Pressure Family

Brooks Liquid Vaporizer Systems

Brooks VA Family

Brooks Vacuum Family

MinacNed SecretariatMinacNedisaffiliatedtoFHI,Federation of Technology Branches, within which a common secretariat, a common management, an administrative and a personnel unit are shared.

MinacNed Secretariat Dodeweg6bP.O.Box366NL3830AKLEUSDENTel.: +31(0)334657507Fax: +31(0)334616638Email: info@minacned.nlInternet: www.minacned.nl

Founding FathersIn order to provide the MinacNed launch with an extra boost, several organisations have been requested to join MinacNed as the “Founding Fathers”. The cost of participating in this scheme is € 5.000,- for which organisations will benefit from:•Anofficialrecognitionofthe

Founding Father status, with the respective company name and logo mentionedinallofMinacNed’spubliccommunications(folders,brochures,websiteetc.).

•EntitlementtoparticipateinMinacNed’smeetingsandactivitiesfree of charge or for a member fee with an unlimited number of employees to participate in these meetings/activities.

•Entitlementtoputforwardamaximum of 20 members as “contributors”.

•Permissiontoreference,intheir own corporate communications, that they are an official MinacNed “Founding Father”.

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