Microplate Instrumentation - Fisher Scientific ?· Bio Tek Instruments ... and sale of microplate instrumentation…

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<ul><li><p>1www.biotek.com</p><p>CATALOG 2014</p><p>M i c ro p l a t e I n s t r u m e n t a t i o n</p><p>At BioTek, our philosophy transcends conventional thinking and challenges the old ways. We develop fresh, original solutions by unifying concepts that often appear to be opposed. It means to shape and reshape. To engineer, build, deliver and support products that best serve the marketplace by providing what you need, when you need it. </p><p>Think Possible. Its the difference between leading and following.</p><p>CATALOG 2014</p><p>BioTek Instruments, Inc.Tel: 802-655-4040 Toll-Free: 888-451-5171 Outside the USA: 802-655-4740 </p><p>www.biotek.com </p><p>Bio</p><p>Tek Instruments C</p><p>atalog</p><p> 2014</p><p>In the United States:For customer service, call 1-800-766-7000To fax an order, use 1-800-926-1166To order online: www.fishersci.com</p><p>In Canada:For customer service, call 1-800-234-7437To fax an order, use 1-800-463-2996To order online: www.fishersci.ca</p><p> 2013 Thermo Fisher Scientific Inc. All rights reserved. Trademarks used are owned as indicated at www.fishersci.com/trademarks.</p><p>Catalog 17/BN0813133www.biotek.com </p><p>AlphaScreen and AlphaLISA are registered trademarks of PerkinElmer, Inc.DLR and DLReady logo are trademarks of Promega Corporation.Dual-Luciferase is a trademark of Promega Corporation and is registered with the U.S. Patent and Trademark Office. FLIPR is a registered trademark of Molecular Devices, Inc.xMAP is a registered trademark of Luminex Corporation.Excel, Microsoft, Windows, Windows Vista are registered trademarks of Microsoft Corporation in the United States and other countries.Pentium is a registered trademark of Intel Corporation in the U.S. and/or other countries.All other trademarks are the property of BioTek Instruments, Inc. or their respective owners.</p><p>World Headquarters, United StatesBioTek U.S.Phone: (802) 655-4740Toll Free: (888) 451-5171Service Toll Free: (800) 242-4685Email: CustomerCare@biotek.comService Email: TAC@biotek.com www.biotek.com</p><p>ChinaBioTek China-BeijingPhone: +86 (10) 85865569Email: infochina@biotek.comwww.biotekchina.com.cn</p><p>BioTek China-ShanghaiPhone: +86 (021) 50435800Email: infochina@biotek.comwww.biotekchina.com.cn</p><p>FranceBioTek FrancePhone: +33 (3) 89206329Email: info@biotek.frwww.biotek.fr</p><p>GermanyBioTek GermanyEuropean Coordination CenterPhone: +49 (0) 71369680Email: info@biotek.dewww.biotek.de</p><p>IndiaBioTek IndiaPhone: +91 (22) 28789966Email: biotek@biotek.inwww.biotek.in</p><p>JapanBioTek JapanPhone: +81 (0)3 5812 8109Email: infojapan@biotek.com www.biotek.com/ja</p><p>SingaporeBioTek SingaporePhone: +65 65922100Email: singapore@biotek.com www.biotek.com</p><p>South KoreaBioTek South KoreaPhone: +82 (0) 25624740Email: korea@biotek.comwww.biotekinstruments.co.kr</p><p>SwitzerlandBioTek SwitzerlandPhone: +41 (41) 2504060Email: info@biotek.chwww.biotek.ch</p><p>TaiwanBioTek TaiwanPhone: +886 (2) 26277725Email: infotaiwan@biotek.comwww.biotek.com</p><p>United KingdomBioTek UKPhone: +44 (1767) 262000Email: info@biotek.uk.comwww.biotek.uk.com</p><p>For the rest of the world, contact your local distributor or BioTek U.S. at: Phone: +1 (802) 655-4740Email: CustomerCare@biotek.com</p><p>BioTek-Cat17-Fisher-version-081213.indd Letter V 8/14/13 3:38 PM</p></li><li><p>BioTek is headquartered in Vermont, USA with global sales, service and distribution support. BioTek is ISO9001/ISO13485 Certified, an FDA Registered Medical Device Manufacturer, and has appropriate products in compliance with the EU In Vitro Diagnostic Directive (IVD). Regulatory compliance is ensured with both validation (IQ/OQ/PQ) and FDA 21 CFR Part 11 tools.</p><p>BioTek Instruments, Inc., headquartered in Winooski, VT, USA, is a </p><p>worldwide leader in the design, manufacture, and sale of microplate </p><p>instrumentation and software. BioTek instrumentation is used to aid in </p><p>the advancement of life science research, facilitate the drug discovery </p><p>process, provide rapid and cost-effective industrial analysis and to enable </p><p>sensitive and accurate quantification of a wide range of molecules across </p><p>diverse applications.</p><p>Our company-wide commitment to quality and value is backed by superior </p><p>customer care, technical service centers, scientific application experts, </p><p>and a knowledgeable sales force. Our commitment and focus helps to </p><p>ensure your processes will be rapid, efficient and successful.</p><p>This catalog provides an overview of our complete line of microplate </p><p>instrumentation, and introduces Cytation3, the first instrument to </p><p>combine automated digital microscopy and conventional microplate </p><p>detection. For more detailed information visit our web site </p><p>at www.biotek.com.</p></li><li><p>u R E A D</p><p>NEW</p><p>Overview .................................................................. 10Synergy Neo ........................................................ 12</p><p>Synergy H4 .............................................................. 14</p><p>Synergy H1 .............................................................. 16</p><p>Synergy Mx ............................................................. 18</p><p>Synergy 2 ................................................................ 20</p><p>Synergy HT ............................................................. 22</p><p>Synergy Reader Comparison Chart ............... 24FLx800 ................................................................... 26</p><p>PowerWave ........................................................... 27</p><p>Eon ......................................................................... 28</p><p>Epoch .................................................................... 30</p><p>ELx808 ................................................................... 32</p><p>ELx800 ................................................................... 33</p><p>Absorbance Reader Comparison Chart ....... 34Gen5 Data Analysis Software .............................. 36</p><p>Take3 Micro-Volume Plate .................................. 38</p><p>Reader Accessories ................................................ 39</p><p>u W A S H</p><p>u D I S P E N S E</p><p>u A U T O M AT E</p><p>Compliance .......................................................................... 70</p><p>Applications Support ......................................................... 72Global Service and Support .............................................. 73</p><p>Decades of Innovation ....................................................... 74</p><p>Contact Information ........................................................... 76</p><p>NEW</p><p>Overview .................................................................. 40EL406 ..................................................................... 42</p><p>405 Touch ............................................................. 44</p><p>405 LS ...................................................................... 44</p><p>ELx405 Select Deep Well ................................... 44</p><p>ELx50 ...................................................................... 46</p><p>Washer Comparison Chart ............................. 48Liquid Handling Control Secure Software .......... 50</p><p>Washer Accessories ................................................ 51</p><p>Overview .................................................................. 52MultiFlo FX ............................................................ 54</p><p>MicroFill ................................................................. 56</p><p>Dispenser Comparison Chart ........................ 58Liquid Handling Control Software ...................... 60</p><p>Dispenser Accessories ........................................... 61</p><p>u P I P E T T E</p><p>Overview .................................................................. 62Precision ................................................................ 64</p><p>NEW</p><p>Overview .................................................................. 66BioStack ................................................................ 68</p><p>u I M A G EOverview .................................................................. 4</p><p>Cytation3 .............................................................. 6</p></li><li><p>4 BioTek Imaging Readers n Overview</p></li><li><p>5www.biotek.com</p><p>Image</p><p>The fusion of automated digital widefield fluorescent </p><p>microscopy and multi-mode microplate detection in </p><p>the new Cytation3 Cell Imaging Multi-Mode Reader </p><p>provides life science researchers many unique </p><p>and powerful capabilities. The use of Cytation3s </p><p>automated fluorescence microscopy and a wide </p><p>array of fluorescent probes for the study of fixed </p><p>or live cells, tissues, or whole organisms, provide </p><p>quantitative phenotypic data from images. These </p><p>cellular images provide rich cellular visualization </p><p>and multi-parametric information concerning many </p><p>biological processes.</p><p>This unique, patent pending design results in </p><p>workflow efficiency and a reduction in data analysis </p><p>and storage requirements, making Cytation3 the </p><p>ideal instrument as a standalone automated imager </p><p>or in combination with microplate reading as a </p><p>total system. </p></li><li><p>6</p><p>Cytation3 Cell Imaging Multi-Mode Reader</p><p>Cytation3 is a cell imaging multi-mode microplate reader that combines automated digital microscopy and conventional microplate detection. This unique patent pending design provides rich phenotypic cellular information with well-based quantitative data. The automated microscopy module provides researchers rich cellular visualization analysis without the complexity and expense of automated digital microscopy. Automated Widefield Fluorescence Microscopy</p><p>Cytation3 offers affordable high quality fluorescence and brightfield microscopy, with auto XY stage, auto focus, auto exposure and auto LED intensity. Cytation3 automates routine </p><p>microscopy and image analysis for all user experience levels. Hybrid Technology </p><p>BioTek brings the patented Hybrid Technology to the Cytation3 multi-mode detection system. The unique design incorporates monochromator-based and filter-based optics in one platform, providing great flexibility and optimal sensitivity for a variety of applications in HTS, research and drug discovery laboratories. When combined with the powerful automated microscopy capability, Cytation3 offers unsurpassed versatility for many important cell-based applications.</p><p>Workflow Efficiency</p><p>With a system like Cytation3, workflow steps can be combined </p><p>for efficiency and fast results. Use the multi-mode detection system to quickly scan the plate and hit-pick those wells for imaging that meet a defined threshold intensity. This saves valuable time, reduces data collection, analysis and storage requirements ultimately reducing costs.</p><p>Live Cell Assays</p><p>To create the ideal environment for live cell assays, a Gas Controller is available to monitor and control CO2 and O2 levels in the system. Along with the temperature control to 45 C and user programmable orbital, double orbital or linear shaking, Cytation3 provides the ideal platform for a variety of assays using live cells.</p><p>Typical Applications:</p><p> u Cell imaging and analysis</p><p> u Cell proliferation</p><p> u Cytotoxicity</p><p> u Biomarker quantification</p><p> u Drug discovery</p><p> u Genetic analysis</p><p> u Drug absorption and metabolism</p><p> u Biologics drug discovery </p><p>and development</p><p> u Environmental testing</p><p> u Food safety</p><p> u Nucleic acid quantification</p><p> u Protein quantification</p><p>BioTek Imaging Readers n Cytation3 Imaging Reader</p></li><li><p>7www.biotek.com</p><p>Cytation3 Cell Imaging Multi-Mode Reader</p><p>Specifications </p><p>General</p><p>Imaging mode Fluorescence and brightfield</p><p>Detection mode Monochromators: FL, Lum, UV-Vis Abs Filters: FL, TRF, FP, Lum</p><p>Read method Endpoint, time-lapse, kinetic, well mode, montage</p><p>Labware type 6- to 384- well microplates, microscope slides, cell culture flasks (T25), Compatible with Take3 Micro-Volume Plates with 2 L microspots</p><p>Temperature control</p><p>To 45 C +0.5 C at 37 C</p><p>Shaking Linear, orbital, double orbital</p><p>Automation BioStack and 3rd party automation compatible</p><p>CO2 and O2 control</p><p>Range: 0 - 20% (CO2); 1 - 19% (O2) Control Resolution: 0.1% (CO2 and O2) Stability: 0.2% at 5% CO2; 0.2% at 1% O2 Models for both CO2 and O2 or CO2 only are available</p><p>Software Gen5 Data Analysis Software included</p><p>Imaging System</p><p>Camera 16-bit gray scale, Sony CCD, 1.1 megapixel</p><p>Imaging filter cube capacity</p><p>4 onboard, user-replaceable filter cubes</p><p>Imaging filter cubes available</p><p>DAPI, CFP, GFP, YFP, RFP, Texas Red, CY5 and CY7</p><p>Imaging LED cubes available</p><p>365 nm, 465 nm, 590 nm, 523 nm, 505 nm, 623 nm, 740 nm</p><p>Objective capacity 2 onboard user-replaceable objectives</p><p>Available objectives</p><p>2x, 2.5x, 4x, 10x, 20x, 40x, 60x</p><p>Image collection rate</p><p>96 wells, 1 color (DAPI), 4x, 6 minutes 96 wells, 3 colors, 4x, 12 minutes</p><p>Fluorescence Intensity</p><p>Sensitivity Monochromators:Top: fluorescein 2.5 pM typical (0.25 fmol/well 384-well plate)Bottom: fluorescein 5 pM typical (0.5 fmol/well 384-well plate)</p><p>Filters/mirrors:Fluorescein 1 pM typical (0.1 fmol/well 384-well plate)</p><p>Light source Xenon flash lamp</p><p>Wavelength selection</p><p>Double grating monochromators (top/bottom) and, Deep blocking bandpass filters/dichroic mirrors (top)</p><p>Wavelength range Monochromators: 250 - 700 nm Filters: 200 - 700 nm (850 option)</p><p>Dynamic range 5 decades</p><p>Detection system Two PMT detectors: one for monochromator system, one for filter system</p><p>Specifications are subject to change.</p><p>Luminescence</p><p>Sensitivity Monochromator system: 20 amol ATP typical (flash)Filter system: 10 amol ATP typical (flash)</p><p>Wavelength range 300 - 700 nm</p><p>Dynamic range 6 decades</p><p>Fluorescence Polarization</p><p>Sensitivity 5 mP at 1 nM fluorescein typical</p><p>Wavelength range 320 - 700 nm (850 nm option)</p><p>Time-Resolved Fluorescence</p><p>Sensitivity Europium 100 fM typical with filters (10 amol/well in 384-well plate)Europium 1200 fM typical with monos (120 amol/well in 384-well plate)</p><p>Light source Xenon flash lamp</p><p>Wavelength range Monochromators: 250 - 700 nm Filters: 200 - 700 nm (850 option)</p><p>Absorbance</p><p>Light source Xenon flash lamp</p><p>Wavelength selection</p><p>Monochromator</p><p>Wavelength range 230 - 999 nm, 1 nm increment</p><p>Bandpass 4 nm (230-285 nm), 8 nm (&gt;285 nm)</p><p>Dynamic range 0 - 4.0 OD</p><p>Resolution 0.0001 OD</p><p>Reagent Dispensers</p><p>Number 2 syringe pumps</p><p>Dispense volume 5 - 1000 L in 1 L increment</p><p>Dead volume 1.1 mL, 100 L with back flush</p><p>Plate geometry 6- to 384-well microplates</p><p>Dispense precision </p></li><li><p>8 BioTek Imaging Readers n Cytation3 Imaging Reader</p><p>Gen5 Data Analysis Software for Cytation3</p><p>Gen5 can automate the entire imaging process: all the steps of image acquisition are fully automated including X and Y movements, focus, LED intensity and camera exposure. Image analyses like cell counting and subpopulation analysis happen on the fly as images are acquired; Gen5s data analysis tools: kinetic analysis, curve fitting, EC50, potency calculation and others can then be applied to image analysis results. With Gen5 you can go from samples to final results in one click.</p><p> Imaging Made Easy </p><p>Gen5 was designed for users with no previous experience with automated microscopy. Image capture and acquisition is done through a simple interface that includes auto focus and auto exposure algorithms. Image </p><p>analysis can be as simple as a one click process with visual feedback to fine-tune analysis parameters. </p><p>Automatic Cell Counting</p><p>Gen5 can automatically count cell nuclei in samples. In a 96- or 3...</p></li></ul>

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