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Microtubule/Tubulin 

Microtubules are a component of the cytoskeleton, found throughoutthe cytoplasm. These tubular polymers of tubulin can grow as long as50 micrometres, with an average length of 25 µm, and are highlydynamic. The outer diameter of a microtubule is about 24 nm whilethe inner diameter is about 12 nm. Microtubules are found ineukaryotic cells and are formed by the polymerization of a dimer oftwo globular proteins, alpha and beta tubulin. Tubulin is one ofseveral members of a small family of globular proteins. The tubulinsuperfamily includes five distinct families, the alpha-, beta-, gamma-,delta-, and epsilon-tubulins and a sixth family which is present only inkinetoplastid protozoa. The most common members of the tubulin

family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in anumber of cellular processes. They are involved in maintaining the structure of the cell.

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg

Purity: 99.87%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg

Purity: 99.75%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 10 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg

Purity: 99.20%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

50 mg, 100 mg

Purity: 99.82%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg

Purity: >98%Clinical Data: No Development ReportedSize: 10 mg, 50 mg

Microtubule/Tubulin Inhibitors & Modulators

Bioactivity: 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivativewith improved pharmacological features and higher watersolubility. IC50 value: Target: Microtubule inhibitor10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cyclearrest and apoptosis as measured by flow cytometry, DNA…

Bioactivity: 10-Oxo Docetaxel (Docetaxel Impurity) is a novel taxoid havingremarkable anti-tumor properties and a Docetaxel intermediate.

Bioactivity: 2-Methoxyestradiol is an inhibitor and angiogenesis apoptosisinducer with potent antineoplastic activity.2-Methoxyestradiol also destablize .microtubules

Bioactivity: 4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediatecompound for the preparation of podophyllotoxin-typeanti-cancer drugs; a potent inhibitor of microtubule assembly.

Bioactivity: 7-Epi-10-oxo-docetaxel (Docetaxel Impurity D) is a impurity ofdocetaxel detected by high performance liquid chromatography(HPLC).

Bioactivity: 7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere)is a impurity of docetaxel.

Bioactivity: 7-epi-Taxol is an active metabolite of taxol, with activitycomparable to that of taxol against cell replication,promoting bundle formation and againstmicrotubulemicrotubule depolymerization.

Bioactivity: 7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel)derivative; Paclitaxel binds to tubulin and inhibits thedisassembly of microtubules.

Bioactivity: ABT-751(E 7010) is a novel bioavailable tubulin-binding andantimitotic sulfonamide agent with IC50 of about 1.5 and 3.4μM in neuroblastoma and non-neuroblastoma cell lines,respectively. IC50 Value: 1.5 μM(neuroblastoma); 3.4μM(non-neuroblastoma) Target: Microtubule/Tubulin in vitro:…

Bioactivity: Amphethinile is an agent. The affinity constantanti-tubulinfor the association ( ) of Amphethinile with tubulin isKa1.3 μM.

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10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol;

10-Deacetylpaclitaxel 7-Xyloside; …) Cat. No.: HY-20584

10-Oxo Docetaxel (Docetaxel Impurity 1) Cat. No.: HY-16674

2-Methoxyestradiol (2-ME2; NSC-659853) Cat. No.: HY-12033

4'-Demethylepipodophyllotoxin (4'-O-demethylepipodophyllotoxin; 4'-DMEP) Cat. No.: HY-17435

7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) Cat. No.: HY-16675

7-Epi-docetaxel (4-epi-Docetaxel; 7-Epidocetaxel; 7-Epitaxotere) Cat. No.: HY-16676

7-epi-Taxol (7-epi-Paclitaxel) Cat. No.: HY-N0227

7-xylosyltaxol (7-Xylosylpaclitaxel; Taxol-7-xyloside) Cat. No.: HY-77574

ABT-751 (E7010) Cat. No.: HY-13270

Amphethinile (Amphetinile; CRC 82-07) Cat. No.: HY-100190

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Purity: 99.08%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.03%Clinical Data: Phase 1Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.29%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg

Purity: >98%Clinical Data: No Development ReportedSize: 500 mg, 250 mg

Purity: 99.96%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.62%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.49%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 97.51%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: 99.36%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: 98.0%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

 

Bioactivity: Ansamitocin P-3 is a inhibitor. Ansamitocin P-3microtubuleis a macrocyclic antitumor antibiotic.

Bioactivity: Auristatin E is a cytotoxic tubulin modifier with potent andselective antitumor activity; MMAE analog and cytotoxin inAntibody-drug conjugates.

Bioactivity: Auristatin F is a cytotoxic tubulin modifier with potent andselective antitumor activity; MMAF analog and cytotoxin inAntibody-drug conjugates.

Bioactivity: BNC105 is a tubulin polymerization inhibitor with potentantiproliferative and tumor vascular disrupting properties.

Bioactivity: BTB-1 is a potent, selective and reversible mitotic motorprotein inhibitor with an of 1.69 μM.Kif18A IC50

Bioactivity: Cabazitaxel is a semi-synthetic derivative of the naturaltaxoid 10-deacetylbaccatin III with potential antineoplasticactivity.

Bioactivity: CCB02 is a selective inhibitor, bindingCPAP-tubulin interactionto tubulin and competing for the CPAP binding site ofβ-tubulin, with an of 689 nM, and shows potent anti-tumorIC50activity. CCB02 shows no inhibition on the cell cycle- andcentrosome-related kinases, or the phosphorylation status of…

Bioactivity: Cephalomannine is a taxol derivative with antitumor,antiproliferative properties.

Bioactivity: Cevipabulin (TTI-237) is an oral, microtubule-active antitumorcompound and inhibits the binding of [ H] vinblastine to3

tubulin, with an of 18-40 nM for cytotoxicity in humanIC50

tumor cell line .[1] [2]

Bioactivity: Cevipabulin fumarate (TTI-237 fumarate) is an oral,microtubule-active, antitumor compound and inhibits thebinding of [ H] vinblastine to tubulin, with an of3 IC50

18-40 nM for cytotoxicity in human tumor cell line .[1] [2]

Ansamitocin P-3 (Antibiotic C 15003P3; Maytansinol isobutyrate) Cat. No.: HY-15739

Auristatin E  Cat. No.: HY-15582

Auristatin F  Cat. No.: HY-15583

BNC105  Cat. No.: HY-16114

BTB-1  Cat. No.: HY-101770

Cabazitaxel (XRP6258; RPR-116258A; taxoid XRP6258) Cat. No.: HY-15459

CCB02  Cat. No.: HY-114302

Cephalomannine  Cat. No.: HY-77554

Cevipabulin (TTI-237) Cat. No.: HY-14949

Cevipabulin fumarate (TTI-237 fumarate) Cat. No.: HY-14949C

Purity: 98.28%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.56%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg

Purity: 98.31%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg

Purity: 98.0%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: 99.42%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg

Purity: 98.04%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.41%Clinical Data: Phase 1Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 25 mg

Purity: 99.98%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

200 mg, 500 mg

 

Bioactivity: Colchicine is a inhibitor and a tubulin microtubuledisrupting agent. Colchicine inhibits microtubulepolymerization with an of 3 nM.IC50

Bioactivity: Combretastatin A4 is a -targeting agent thatmicrotubulebinds with of 0.4 μM.β-tubulin Kd

Bioactivity: Crolibulin is a small molecule tubulin polymerizationinhibitor.

Bioactivity: Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, isa toxin payload in antibody drug conjugate. IC50 Value: N/ATarget: tubulin; ADCs For comparison purposes, the ADC A1-mc-MMAD and/or A1 -vc-MMAD were used. The linker payload,mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was…

Bioactivity: D-64131 is a novel inhibitor of Tubulin polymerization thatcompetitively binds with [(3)H]colchicine to αβ-Tubulin.

Bioactivity: D8-MMAD is a deuterated form of MMAD, which is a disrupting agent.microtubule

Bioactivity: D8-MMAE is a deuterated labeled MMAE, a potent mitoticinhibitor.

Bioactivity: D8-MMAF is a deuterated form of MMAF, which is a disrupting agent.microtubule

Bioactivity: D8-MMAF hydrochloride is a deuterated form of MMAFhydrochloride, which is a disrupting agent.microtubule

Bioactivity: DM4 is is an agent that inhibit cell division. DM4antitubulincan be used in the preparation of antibody drug conjugate.

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Colchicine  Cat. No.: HY-16569

Combretastatin A4 (CRC 87-09) Cat. No.: HY-N2146

Crolibulin (EPC2407) Cat. No.: HY-13603

Cys-mcMMAD  Cat. No.: HY-15750

D-64131  Cat. No.: HY-15482

D8-MMAD (Demethyldolastatin 10 D8; Monomethylauristatin D D8;

Monomethyl Dolastatin 10 D8) Cat. No.: HY-15581S

D8-MMAE (D8-Monomethyl auristatin E) Cat. No.: HY-15162A

D8-MMAF (Monomethylauristatin F D8) Cat. No.: HY-15579S

D8-MMAF hydrochloride  Cat. No.: HY-15579AS

DM4  Cat. No.: HY-12454

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Purity: 98.97%Clinical Data: LaunchedSize: 500u g, 1 mg

Purity: >98%Clinical Data: LaunchedSize: 1 mg

Purity: 99.93%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

2 mg, 5 mg, 10 mg, 25 mg

Purity: 99.88%Clinical Data: Phase 3Size: 10mM x 1mL in DMSO,

2 mg, 5 mg, 10 mg, 50 mg

Purity: 99.05%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg, 25 mg

Purity: 98.04%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg, 20 mg

Purity: 95.55%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.83%Clinical Data: Phase 2Size: 1 mg, 5 mg

Purity: >98%Clinical Data: LaunchedSize: 100 mg, 200 mg

Purity: 99.93%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

100 mg, 200 mg

 

Bioactivity: Docetaxel is an antineoplastic drug by inhibiting depolymerization, and attenuating of themicrotubule

effects of and gene expression.bcl-2 bcl-xL

Bioactivity: Docetaxel Trihydrate is a semi-synthetic taxane analogue, actsas a stabilizer.microtubule

Bioactivity: Angiotensin II human is a vasoconstrictor that acts on the and the receptor.AT1 AT2

Bioactivity: ELR510444 is a novel microtubule disruptor; inhibitsMDA-MB-231 cell proliferation with IC50 of 30.9 nM; not asubstrate for the P-glycoprotein drug transporter and retainsactivity in βIII-tubulin-overexpressing cell lines.

Bioactivity: Entasobulin is a polymerization inhibitor withβ-tubulinpotential anticancer activity.

Bioactivity: Epothilone A is a competitive inhibitor of the binding of [H] paclitaxel to polymers, with a of 0.6-1.4 μM.3 tubulin Ki

Bioactivity: Epothilone B is a stabilizer with a ofmicrotubule Ki0.71μM. It acts by binding to the αβ-tubulin heterodimersubunit which causes decreasing of αβ-tubulin dissociation.

Bioactivity: Epothilone D (KOS 862) is a potent stabilizer.microtubule

Bioactivity: Eribulin (E7389) is a targeting agent that ismicrotubuleused in the treatment of metastatic breast cancer. Eribulin(E7389) inhibits the proliferation of cancer cells by bindingmicrotubule proteins and microtubules.

Bioactivity: Eribulin mesylate (E7389 mesylate) is a microtubuletargeting agent that is used in the treatment of metastaticbreast cancer. Eribulin mesylate (E7389 mesylate) inhibits theproliferation of cancer cells by binding microtubule proteinsand microtubules.

Docetaxel (RP-56976) Cat. No.: HY-B0011

Docetaxel Trihydrate (RP-56976 (Trihydrate)) Cat. No.: HY-B0011A

Dolastatin 10 (DLS 10; NSC 376128) Cat. No.: HY-15580

ELR510444  Cat. No.: HY-16191

Entasobulin  Cat. No.: HY-16777

Epothilone A (Epo A) Cat. No.: HY-13503

Epothilone B (EPO 906; Patupilone) Cat. No.: HY-17029

Epothilone D (KOS 862) Cat. No.: HY-15278

Eribulin (B1939; E7389; ER-086526) Cat. No.: HY-13442

Eribulin mesylate (B1939 mesylate; E7389 mesylate; ER-086526 mesylate) Cat. No.: HY-13442A

Purity: 98.74%Clinical Data: Phase 2Size: 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: 99.58%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: 97.23%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: >98%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: 99.03%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

Purity: >98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 50 mg

Purity: 99.46%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

Purity: 99.93%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

Purity: 99.47%Clinical Data: Phase 3Size: 10mM x 1mL in Water,

5 mg, 10 mg, 50 mg

Purity: 98.01%Clinical Data: LaunchedSize: 10mM x 1mL in Water,

10 mg, 50 mg, 100 mg

 

Bioactivity: Estramustine phosphate sodium is an antimicrotubulechemotherapy agent; arrests prostate cancer cells in the G2/Mphase of the cell cycle.

Bioactivity: Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubuledestabilizing drug, a type of vascular-targeting agent, a drugdesigned to damage the vasculature (blood vessels) of cancertumors causing central necrosis. IC50 Value: 4 nM [1] Target:microtubule in vitro: Cytotoxic IC(50) values of CA-4 in human…

Bioactivity: Ixabepilone is an orally bioavailable  inhibitor, which binds to tubulin andmicrotubule

promotes tubulin polymerization and microtubule stabilization,thereby arrests cells in the G2-M phase of the cell cycle andinduces tumor cell apoptosis.

Bioactivity: Lexibulin(CYT-997) is a potent tubulin polymerisationinhibitor with IC50 of 10-100 nM in cancer cell lines; withpotent cytotoxic and vascular disrupting activity in vitro andin vivo.

Bioactivity: Lexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulinpolymerisation inhibitor with IC50 of 10-100 nM in cancer celllines; with potent cytotoxic and vascular disrupting activityin vitro and in vivo.

Bioactivity: Maytansinol inhibits microtubule assembly and inducesmicrotubule disassembly in vitro. Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle andprevents mitotic exit in Drosophila. Maytansinol reduces thegrowth and/or survival of HCT116 cells in a dose-dependent…

Bioactivity: Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, isa toxin payload in antibody drug conjugate; Mc-MMAD is aprotective group (maleimidocaproyl) -conjugated MMAD. IC50Value: Target: tubulin; ADCs For comparison purposes, the ADCA1 -mc-MMAD and/or A1 -vc-MMAD were used. The linkerpayload,…

Bioactivity: Mc-MMAE is a protective group (maleimidocaproyl)-conjugatedmonomethyl auristatin E (MMAE), which is a potent tubulininhibitor, is a toxin payload in antibody drug conjugate (

).ADC

Bioactivity: Mc-MMAF is a protective group-conjugated MMAF. MMAF is a morepotent drug than Monomethyl auristatin E (MMAE), but ischarged and relatively membrane-impermeable, is a potenttubulin inhibitor, is a toxin payload in antibody drugconjugate. Target: MMAF is a new auristatin derivative with a…

Bioactivity: Mertansine (DM1) is a inhibitor and is anmicrotubulinantibody-conjugatable maytansinoid that is developed toovercome systemic toxicity associated with maytansine and toenhance tumor-specific delivery. Mertansine can be attached toa monoclonal antibody with a linker to create an antibody-drug…

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Estramustine phosphate sodium  Cat. No.: HY-13627

Fosbretabulin disodium (CA 4DP; CA 4P; Combretastatin A4 disodium phosphate) Cat. No.: HY-17449

Ixabepilone (Azaepothilone B; BMS 247550; BMS 247550-1) Cat. No.: HY-10222

Lexibulin (CYT-997) Cat. No.: HY-10498

Lexibulin dihydrochloride (CYT-997 dihydrochloride) Cat. No.: HY-10498A

Maytansinol (Ansamitocin P-0) Cat. No.: HY-19474

Mc-MMAD  Cat. No.: HY-15740

Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) Cat. No.: HY-15741

McMMAF (Maleimidocaproyl monomethylauristatin F) Cat. No.: HY-15578

Mertansine (DM1; Maytansinoid DM1) Cat. No.: HY-19792

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Purity: 99.97%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

50 mg, 100 mg, 500 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 20 mg

Purity: 99.57%Clinical Data: Phase 3Size: 10mM x 1mL in Water,

1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: Phase 3Size: 1 mg, 5 mg, 10 mg, 20 mg

Purity: 98.68%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: 99.94%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg, 1 g

Purity: 99.89%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

2 mg, 5 mg, 10 mg

Purity: >98%Clinical Data: No Development ReportedSize: 2 mg, 5 mg, 10 mg

Purity: 99.92%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 100 mg, 250 mg, 500 mg

 

Bioactivity: Microtubule inhibitor 1 is an antitumor agent with inhibitory activity, with anmicrotubule polymerization

value of 9-16 nM in cancer cells .IC50[1]

Bioactivity: MMAD is a potent inhibitor, is a toxin payload intubulinantibody drug conjugates ( ).ADCs

Bioactivity: MMAF (Monomethylauristatin F) is an antitubulin agent thatinhibit cell division; inhibits H3397 cell growth with an IC50of 105 nM.

Bioactivity: MMAF hydrochloride is an antitubulin agent that inhibit celldivision; inhibits H3397 cell growth with an of 105 nM.IC50

Bioactivity: Monomethyl auristatin E (MMAE; SGD-1010) is a syntheticderivative of dolastatin 10 and functions as a potent

inhibitor by inhibiting tubulin polymerization.mitoticMMAE is widely used as a cytotoxic component of antibody-drug

to treat several different cancer types.conjugates (ADCs)

Bioactivity: Nocodazole is a rapidly-reversible inhibitor of. Nocodazole binds to β-tubulin and disruptsmicrotubule

microtubule assembly/disassembly dynamics, which preventsmitosis and induces apoptosis in tumor cells. Nocodazoleinhibits , activates .Bcr-Abl CRISPR/Cas9

Bioactivity: Ombrabulin (AVE8062) is a derivative of CA-4 phosphate, whichis known to exhibit antivascular effects through selectivedisruption of the cytoskeleton of endothelial cells.tubulin

Bioactivity: Ombrabulin hydrochloride is a derivative of CA-4 phosphate,which is known to exhibit antivascular effects throughselective disruption of the cytoskeleton of endothelialtubulincells.

Bioactivity: OSIP-486823 is a novel -interfering agent withmicrotubuledistinct biological effects on both protein kinase G (PKG) andmicrotubules.

Bioactivity: Paclitaxel (Taxol), a naturally occurring antineoplasticagent, stabilizes , resulting intubulin polymerizationarrest at the G2/M phase of the cell cycle and apoptotic celldeath .[1] [2]

Microtubule inhibitor 1  Cat. No.: HY-114313

MMAD (Demethyldolastatin 10; Monomethylauristatin D;

Monomethyl Dolastatin 10) Cat. No.: HY-15581

MMAF (Monomethylauristatin F) Cat. No.: HY-15579

MMAF Hydrochloride (Monomethylauristatin F Hydrochloride) Cat. No.: HY-15579A

Monomethyl auristatin E (MMAE; SGD-1010) Cat. No.: HY-15162

Nocodazole (Oncodazole; R17934) Cat. No.: HY-13520

Ombrabulin (AVE8062; AC7700) Cat. No.: HY-14797

Ombrabulin hydrochloride (AVE8062 (hydrochloride); AC7700 (hydrochloride)) Cat. No.: HY-18256

OSIP-486823 (OSIP 486823; OSIP486823; CP248) Cat. No.: HY-U00004

Paclitaxel (Taxol) Cat. No.: HY-B0015

Purity: 99.90%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

Purity: 99.74%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: 99.76%Clinical Data: Phase 2Size: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 20 mg

Purity: 99.79%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: 93.44%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.68%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

Purity: 98.01%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Purity: 98.0%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg

Purity: 98.0%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

10 mg, 25 mg, 50 mg, 100 mg

 

Bioactivity: Parbendazole is a potent inhibitor of assembly,microtubuledestabilizes tubulin, with an of 8.79nM, and exhibitsEC50a broad-spectrum anthelmintic activity.

Bioactivity: PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts asa -depolymerizing agent and an apoptotic agent.microtubule

Bioactivity: PE859 is a potent inhibitor of both and aggregationtau Aβwith values of 0.66 and 1.2 μM, respectively.IC50

Bioactivity: PF-06380101 is a novel cytotoxic Dolastatin 10 analogue; withexcellent potencies in tumor cell proliferation assays anddifferential ADME properties when compared to other syntheticauristatin analogues that are used in the preparation of ADCs.IC50 value: ~0.2 nM(GI50 in BT474, MDA-MB-361-DYT2 and N87…

Bioactivity: Plinabulin (NPI-2358) is a vascular disrupting agents (VDA)against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumorcells. IC50 Value: 9.8~18 nM Target: Microtubule/Tubulin invitro: NPI-2358 binds to the colchicine-binding site oftubulin and has potent inhibitory to human tumor cell lines…

Bioactivity: Podofilox (Podophyllotoxin) is a potent inhibitor ofmicrotubule assembly and DNA topoisomerase II.

Bioactivity: Rosabulin is a potent inhibitor, withmicrotubuleanti-cancer activities.

Bioactivity: Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10derivative and inhibitor of polymerization.tubulin

Bioactivity: SSE15206 is a polymerization inhibitor (GI microtubule 50= 197 nM in HCT116 cells) that overcomes multidrug resistance.Causes aberrant mitosis resulting in G2/M arrest due toincomplete spindle formation in cancer cells .[1]

Bioactivity: Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin;potent tubulin inhibitor; ADCs cytotoxin. IC50 value: Target:tubulin in vitro: HTI-286 significantly inhibitedproliferation of all three hepatic tumor cell lines (mean IC50= 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease…

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Parbendazole (SKF 29044) Cat. No.: HY-115364

PBOX 6  Cat. No.: HY-U00446

PE859  Cat. No.: HY-12662

PF-06380101  Cat. No.: HY-12522

Plinabulin (NPI-2358) Cat. No.: HY-14444

Podofilox (Podophyllotoxin) Cat. No.: HY-15552

Rosabulin (STA 5312) Cat. No.: HY-14934

Soblidotin (Auristatin PE; TZT-1027) Cat. No.: HY-14672

SSE15206  Cat. No.: HY-111425

Taltobulin (HTI-286; SPA-110) Cat. No.: HY-15584

www.MedChemExpress.com 9

Purity: >98%Clinical Data: No Development ReportedSize: 250 mg, 500 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg

Purity: >98%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 98.38%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: 99.97%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 96.24%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: Phase 2Size: 5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 20 mg

Purity: 99.96%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 50 mg

Purity: 99.05%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

 

Bioactivity: Taltobulin hydrochloride is an analogue of Hemiasterlin;potent tubulin inhibitor; ADCs cytotoxin. IC50 value: Target:tubulin in vitro: HTI-286 significantly inhibits proliferationof all three hepatic tumor cell lines (mean IC50 = 2 nmol/L+/- 1 nmol/L). Interestingly, no decrease in viable primary…

Bioactivity: Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogueof Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.IC50 value: Target: tubulin in vitro: HTI-286 significantlyinhibited proliferation of all three hepatic tumor cell lines(mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly,…

Bioactivity: Tasidotin hydrochloride is a peptide analog of the antimitoticdepsipeptide dolastatin 15, as an inhibitor of microtubuleassembly and microtubule dynamics.

Bioactivity: Tirbanibulin (KX2-391) is an inhibitor of that targetsSrcthe peptide substrate site of Src, with of 9-60 nM inGI50cancer cell lines.

Bioactivity: Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) isan inhibitor of that targets the peptide substrate siteSrcof Src, with of 9-60 nM in cancer cell lines.GI50

Bioactivity: Tirbanibulin (Mesylate) (KX2-391 (Mesylate)) is an inhibitorof that targets the peptide substrate site of Src, withSrc

of 9-60 nM in cancer cell lines.GI50

Bioactivity: Triclabendazole(CGA89317) is a benzimidazole, it binds totubulin impairing intracellular transport mechanisms andinterferes with protein synthesis. Target: Microtubule/TubulinTriclabendazole treatment produces percentage decreases of thefluke egg output by 15.3%, 4.3% and 36.6%, respectively, in…

Bioactivity: Tubulin inhibitor 1 is a inhibitor, occupying thetubulincolchicine binding site, inhibits tubulin polymerization.Tubulin inhibitor 1 shows potent anti-tumor activity, casuescellular mitotic arrest in the G2/M phase, and inducescellular apoptosis .[1]

Bioactivity: Tubulysin A(TubA) is a myxobacterial product that can functionas an antiangiogenic agent in many in vitro assays;anti-microtubule, anti-mitotic, an apoptosis inducer,anticancer, anti-angiogenic, and antiproliferative. IC50value: Target: microtubule Tubulysin A is a novel antibiotic,…

Bioactivity: Valecobulin (CKD516), a valine prodrug of (S516) and avascular disrupting agent (VDA), is a potent beta-tubulin

inhibitor with marked antitumor activitypolymerizationagainst murine and human solid tumors .[1] [2]

Taltobulin hydrochloride (HTI-286 hydrochloride; SPA-110 hydrochloride) Cat. No.: HY-15584B

Taltobulin trifluoroacetate (HTI-286 trifluoroacetate; SPA-110 trifluoroacetate) Cat. No.: HY-15584A

Tasidotin hydrochloride (ILX651) Cat. No.: HY-13760

Tirbanibulin (KX2-391; KX-01) Cat. No.: HY-10340

Tirbanibulin dihydrochloride (KX2-391 (dihydrochloride); KX-01 (dihydrochloride)) Cat. No.: HY-10340A

Tirbanibulin Mesylate (KX2-391 (Mesylate); KX01 (Mesylate)) Cat. No.: HY-10340B

Triclabendazole (CGA89317) Cat. No.: HY-B0621

Tubulin inhibitor 1  Cat. No.: HY-112607

Tubulysin A (TubA) Cat. No.: HY-15995

Valecobulin (CKD-516) Cat. No.: HY-13598

Purity: 99.58%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: >98%Clinical Data: LaunchedSize: 10 mg, 50 mg

Purity: 99.14%Clinical Data: LaunchedSize: 5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: LaunchedSize: 5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.66%Clinical Data: LaunchedSize: 10 mg, 50 mg, 100 mg, 200 mg

Purity: 99.87%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.89%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

1 mg, 5 mg, 10 mg

 

Bioactivity: Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulininhibitor (MMAD), Vc-MMAD is an antibody drug conjugate. IC50Valu: N/A Target: tubulin; ADCs Monomethyl auristatin D(MMAD), a potent tubulin inhibitor, is a toxin payload andantibody drug conjugate. For comparison purposes, the ADC A1…

Bioactivity: VcMMAE is a with potentdrug-linker conjugate for ADCantitumor activity by using the anti-mitotic agent, monomethylauristatin E (MMAE), linked via the lysosomally cleavabledipeptide, valine-citrulline (vc).

Bioactivity: Vinblastine sulfate is a cytotoxic alkaloid used againstvarious cancer types. Vinblastine sulfate inhibits theformation of microtubule and suppresses nAChR with an ofIC508.9 μM.

Bioactivity: Vincristine sulfate is an antitumor vinca alkaloid whichinhibits formation in mitotic spindle,microtubuleresulting in an arrest of dividing cells at the metaphasestage. It binds to with a of 85 nM.microtubule Ki

Bioactivity: Vinflunine is a new vinca alkaloid uniquely fluorinated withthe properties of mitotic-arresting and tubulin-interactingactivity.

Bioactivity: Vinflunine Tartrat is a new vinca alkaloid uniquelyfluorinated with the properties of mitotic-arresting andtubulin-interacting activity. Target: Microtubule/Tubulin Themajor effects of Vinflunine on dynamic instability are aslowing of the microtubule growth rate, an increase in growth…

Bioactivity: Vinorelbine is an anti-mitotic agent which inhibits theproliferation of Hela cells with IC of 1.25 nM.50

Bioactivity: Vinorelbine (ditartrate) is an anti-mitotic agent whichinhibits the proliferation of Hela cells with IC of 1.2550nM.

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: sales@MedChemExpress.com

Vc-MMAD  Cat. No.: HY-15742

VcMMAE (mc-vc-PAB-MMAE) Cat. No.: HY-15575

Vinblastine sulfate (Vincaleukoblastine sulfate salt) Cat. No.: HY-13780

Vincristine sulfate (Leurocristine sulfate; 22-Oxovincaleukoblastine sulfate) Cat. No.: HY-N0488

Vinflunine  Cat. No.: HY-B0628

Vinflunine Tartrate  Cat. No.: HY-B0628A

Vinorelbine (KW-2307 base) Cat. No.: HY-12053

Vinorelbine ditartrate (KW-2307; Nor-5'-anhydrovinblastine ditartrate) Cat. No.: HY-12053A