mien dich bam sinh
TRANSCRIPT
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MIN DCH BM SINH
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Thut ngMin dch bm sinh (innateimmunity) ng ngha vi:- Min dch t nhin (nativeimmunity hay natural immunity)-
Min dch khng c hiu (non-specific immunity) ti liu c
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c im ca min dch bm
sinh Xut hin t nhin Lun lun tn ti, truyn t i ny
sang i sau theo di truyn Ngay t khi mi sinh ra lun
trong trng thi sn sng nhndin v loi b cc vi sinh vt c gi l min dch bm sinh
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c im ca min dch bm
sinh Nhn din v p ng li cc VSV
m khng phn ng chng li cc
cht khng phi ca VSV C th c chm ngi bi cc t
bo ca c th b tn thng dotc ng ca cc VSV
C tc dng ngay khi VSV xmnhp vo cc m ca c th
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c im ca min dch bm
sinh Cc c ch ny c hiu vi cc
cu trc chung c trn cc loi vi
sinh vt khc nhau Cc c ch ny c thc hin
thng qua cc th th c mho bi cc gene dng gc
p ng khng mnh hn sau miln tip xc vi vi sinh vt
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Cc thnh phn chnh ca
min dch bm sinh Cc biu m Cc t bo lm nhim v thc bo,
cc t bo git t nhin (t boNK)
Cc protein trong huyt tng baogm cc protein ca h thng bth
Cc cytokine
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Cc c ch khng C hc v ho hc: hng ro da v
nim mc C ch t bo: thc bo, hin
tng git bi t bo NK C ch dch th: tiu tan bi b
th, cc cytokine
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Cc c ch c v ho hc Biu m cung cp cc hng ro vt
l ngn cn s xm nhp ca vi
sinh vt Biu m sn xut ra cc cht
khng sinh Trong biu m cn c cc t bo
lympho c kh nng ngn nganhim trng
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Cc chc nng ca biu m trong min dch bm sinh
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C ch thc bo Cc t bo chnh lm nhim v
thc bo l bch cu trung tnh,
cc t bo mono/i thc bo y l cc t bo mu c
iu ng t mu n cc v tr xy
ra nhim trng
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Cc giai on chn ca cct bo n nhn lm nhim v thc bo
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Cc th th m cc t bo lm nhim v thc bo sdng bt gi VSV v cc p ng ca chng
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Din bin qu trnh thc
bo TBLNVTB nhn din cc vi sinh vt nh
cc th th c hiu trn b mt ca
chng TBLNVTB nut cc vi sinh vt sau
ph hu chng bn trong cc t bo
ny Cc t bo ny cn ch tit cc cytokine
v p ng bng nhng cch khc nhau loi b vi sinh vt v sa cha li ccm tn thng do nhim trng
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Din bin qu trnh thcbo
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Din bin qu trnhthc bo v git cc visinh vt bn trong tbo
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T bo NK
Cc t bo NK gitcc t bo ca tc
ch b nhim cc visinh vt ni bo
T bo NK ch titra IFN- c tc dng
hot ho cc ithc bo git mnhhn cc vi sinh vt b chng nutvo
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T bo mn trong mu ngoi vi
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Bch cu trung tnh mi trong mu ngoi vi
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B TH H thng b th bao gm mt h cc
protein c hot ho theo trnh t nitip nhau khi chng gp cc vi sinh vthoc khi chng c cc khng th hotho chng (trong p ng min dchdch th)
Cc protein ca b th ph ln cc visinh vt (opsonin ho) to thun chocc qu trnh tip cn v nut cc visinh vt bi cc t bo lm nhim vthc bo, kch thch phn ng vim, vlm ta r cc vi sinh vt
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Tng quan v 3con ng hotho v tc dng
ca b th
Con ng khng cin v con nglectin l thnh phnca min dch bm
sinh
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Cc
bc
g
iaion
u
(khc
nhau
ba
con
ng)
Con ng khng c in vcon ng lectin l thnh
phn ca min dch bm sinh
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th trong min dch bmsinh Osponin ho to thun cho hot ng
thc bo
Gy tan t bo ch: to ra phc hp tncng mng ph hu t bo ch (t bol, vi khun) do thm thu
Hot tnh ha hng ng: cc mnhpeptid ca C5,C6,C7 c tc dng hpdn bch cu, kch thch to phn ngvim
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Cc cytokine ca mindch bm sinh Kch thch phn ng vim (TNF, IL-
1, cc chemokine) Hot ho cc t bo NK (IL-2) Hot ho cc i thc bo (IFN-) Ngn nga nhim virus (IFN type I)
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Min dch t nhin kch thchmin dch thch ng
Min dch bm sinh cnh bo v bo ng choh thng min dch thch ng rng cn phi cmt p ng min dch hiu qu hn
Min dch bm sinh to ra cc phn t ngvai tr nh tn hiu th hai (khng nguyn ltn hiu th nht) hot ho cc t bolympho T v B
S cn thit phi c cc tn hiu th hai ny bo m cho cc p ng min dch thch ngc to ra l do chnh cc vi sinh vt (tcnhn t nhin sinh ra cc phn ng min dchbm sinh) ch khng phi do cc cht khng
c bn cht l vi sinh vt
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Xin cm n