The ARISER Conference 4th International Summer School

Minimally Invasive Technologies and Nanosystems for Diagnosis and Therapies

June 9th – 13th, 2008 Aragonese Castle of Otranto

Otranto (LE), Italy

SCIENTIFIC PROGRAM & EVENTS

ORGANIZED BY:

http://www.ifc.cnr.it http://www.ariser.info

PROGRAM DIRECTORS

Sergio Casciaro, PhD, Eng – School and Program Director Division of Biomedical Engineering Science and Technology National Research Council, Institute of Clinical Physiology, CNR-IFC Lecce, ItalyEuro Mediterranean Scientific Biomedical Institute, ISBEM, Brindisi, Italy

Eigil Samset, Prof, PhD – Program Co-Director The Interventional Centre, Rikshospitalet University Hospital, Norway Centre of Mathematics for Applications, University of Oslo, Norway

Alessandro Distante, Prof, MD – Program Co-Director National Research Council, Institute of Clinical Physiology, CNR-IFC Lecce, ItalyEuro Mediterranean Scientific Biomedical Institute, ISBEM, Brindisi, Italy Cardiothoracic Department, Pisa University Medical School, Pisa, Italy

SCIENTIFIC BOARD – ARISER CONSORTIUM

Eigil Samset University of Oslo, The Interventional Centre Norway

Dieter Schmalstieg Graz University of Technology Austria

Jos Vander Sloten The Catholic University of Leuven Belgium

Adinda Freudenthal Delft University of Technology The Netherlands

Jerome Declerck Siemens Molecular Imaging, Oxford United Kingdom

Sergio Casciaro CNR-IFC - National Research Council, Lecce Italy

Øyvind Rideng Kongsberg SIM AS, Oslo Norway

Borut Gersak University Medical Center, Ljubljana Slovenia

SCIENTIFIC SECRETARIAT

For more information on registration to the event please contact:

Juliette Dubois dubois@ifc.cnr.it Tel. +39 0832 422 313

or

Sergio Casciaro casciaro@ifc.cnr.it - casciaro@isbem.it Tel. +39 0832 422 310 Mob. +39 349 25 35 183

KEYNOTE LECTURERS

Dr. Fernando BELLO Fernando Bello received a PhD in Biomedical Systems from Imperial College London in 1996. After finishing his PhD he worked as a post-doctoral research fellow at Guy's Hospital and at the University of Kent where he was appointed as a lecturer in the Electronic Engineering Department in 1998. In September 2000 he joined the Department of Biosurgery and Surgical Technology at Imperial College

London, where he is currently a Senior Lecturer in Surgical Graphics & Computing. His main research interests are in medical visualisation and analysis, medical virtual environments and haptic interaction. A significant proportion of his work is devoted to investigating and promoting the use of new technologies in medical education and clinical practice.

Dr. Paolo FIORINI Paolo Fiorini, received the Laurea degree in Electronic Engineering from the University of Padova, (Italy), the MSEE from the University of California at Irvine (USA), and the Ph.D. in ME from UCLA (USA). From 1985 to 2000, he was with NASA Jet Propulsion Laboratory, California Institute of Technology, where he worked on telerobotic and teleoperated systems for space exploration. Since 2000

he is an Associate Professor of Control Systems at the School of Science of the University of Verona (Italy) where he founded the ALTAIR robotics laboratory. His research focuses on teleoperation for surgical applications, service and exploration robotics.

Dr. Joerg RACZKOWSKY Jörg Raczkowsky studied Mechanical and Electrical Engineering and obtained his Diploma Degree in 1981. He received his Doctoral Degree in Informatics in 1989. Since 1990, he holds a tenure position at the Institute for Process Control and Robotics (IPR), University of Karlsruhe (TH). Currently, he is head of the Medical Robotics Group of IPR (MeGI). His field of research covers the complete process

chain from imaging over image processing, surgical planning, simulation, surgical robot systems and augmented reality.

SCHEDULE AT A GLANCE

JUNE ‘08 Monday 9th Tuesday 10th Wednesday 11th Thursday 12th Friday 13th 8:00 – 9:00 Registration

9:00 – 9:30 Welcome and Introduction to the International School

M. Sette Elastotouch: In Vitro

Experiments

S. Pujol Image-Guided

Neurointerventional Surgery

T. Stüdeli Surgical Navigation during

Minimally Invasive Procedures

9:30 – 10:00 S. Milko

Analysis of Ultrasound Images of the Liver: Dynamic Texture

Approach

L. Massoptier Ultrasound Liver Imaging in Minimally Invasive Surgical

Interventions

M. Maffia “Omic” Platforms for the

Diagnosis, Prognosis and Therapy of Tumors

Surgical Augmentation Based on Shading Information

P. Lamata The Reconstruction Step

T. Morvan The Alignment Step

H. Furtado Aortic Endoclamp Visualization and Automatic Positioning: First

Results 10:00 – 10:15 Coffee Break Coffee Break Coffee Break Coffee Break Coffee Break

10:15 – 11:00 R. McLaughlin

Advances in Optical Coherence Tomography

B. Gersak Minimally Invasive Mitral Valve

Surgery - Port Access Technique

P. Makowski Review of Vessel Segmentation

Methods

C. Le Terrien Current Minimal Invasive

Techniques Associated with IGS and Intra Operative

Imaging

J. Muehl Constructing Verifiable Models

for Radiofrequency Ablation Simulation

11:00 – 12:00 Speaker to be confirmed P. Fiorini

Haptic Perception in Teleoperated Surgery

S. Casciaro Non Invasive Therapies of the

Future

J. Raczkowsky Overview on Surgical Robotics with Focus on High Precision

F. Bello The Use of Simulation to Teach

and Assess Surgical Skills

12:00 – 13:30 Lunch Lunch Lunch Lunch Best Paper Award Announcement & Lunch

13:30 – 14:15 H. de Ridder

Human Information Interaction, Ambient Intelligence and

Minimally Invasive Therapies

D. Mishaly Esthetical Consideration in Pediatric Cardiac Surgery

U. Pasquali Minimally Invasive Heart Valve

Replacement: an Industry Perspective

T. Clijmans Pre-operative Planning,

Templating and Implant Design for Reconstructive Cranio-

maxillofacial Surgery

14:15 – 14:30

A. Malvasi Use of Minimally Invasive Technologies to Reduce

Endoscopic Complications in Gynecology

L. Cucurachi Bioethical Issues in

Nanomedical Applications

M. Stark Simplifying Surgery - Back to

the Fingertips

G. Nicolardi Classical and Non Invasive

Electromyography in the Diagnosis and Follow-up of

Motor Neuron Diseases

14:30 – 14:45 Coffee Break Coffee Break Coffee Break Coffee Break

14:45 – 15:15 F. Conversano

Ultrasound Realtime Positioning and Guidance for

Endovascular Systems - Demo

T. Morita Endoscopic Cardiac Surgery

Overview Study: from Invasive to Minimally Invasive Therapy -

Aortic Clamping

15:15 – 15:45

Workflow Driven Visualization in Surgical Information System:

A Case of RFA

A. Jalote Parmar Human Factors

W. Ali Tools and Techniques

The Resection Map for Hepatectomy Guidance

A. Jalote Parmar Requirements Analysis

P. Lamata First Prototype

J. Cornellà Tools for Improving Telesurgical Robots

Performance

M. Solinas How to Rethink Cardiac

Surgery

DEMO 20:30 Social Event DEMO

INVITED SPEAKERS

Eng. Tim CLIJMANS After receiving a Master of Engineering in 2004, Tim Clijmans has been a PhD-researcher at the division ofBiomechanics and Engineering Designof the University of Leuven (Belgium). His current research interests include

computer aided pre-operative planning and simulation ofcraniosynostosis and mandibular reconstruction surgery.Simultaneously, he obtained a specialization in CAD/CAM(Univ. of Twente), a post-graduate of Business Studies(Leuven School of Business and Economics) and a Masterof Medical Imaging (Univ. of Leuven). He is (co-) author of 14 scientific papers and received several prizes for his PhD-research.

Prof. Borut GERSAK Borut Gersak, medical doctor, is head of the Department of Cardiovascular Surgery at the University Medical Center Ljubljana (Slovenia). With hisgroup, he doing all types of classic and modern operations, including beating

heart valve surgery, beating heart coronary surgery, endoscopic cardiac surgery, measurements of electrical signals during cardiac surgery, enzymatic studies, cardiac transplantation programme and pediatric cardiac surgery. Within the ARISER project, he is leader of the clinical focus group workpackage.

Dr. Francesco CONVERSANO After receiving his MSc degree inmaterials engineering in 2003, FrancescoConversano has been working at ISBEMand IFC-CNR Lecce in the developmentof new ultrasound-based diagnostictechniques. He has got the PhD in

Bioengineering at the University of Pisa, with a thesis onacoustic characterization of ultrasound contrast agentsfor advanced biomedical imaging. His current researchinterests include non-invasive tissue characterization andinnovative strategies for ultrasound molecular imaging. He is Research Scientist at IFC-CNR Lecce.

Mr. Cyrille LE TERRIEN Cyrille Le Terrien graduated in biomedical engineering from the university Paul Sabatier in Toulouse in 1996. After a Military Service in the neurosurgery department at Val de Grace Hospital in Paris, he joined Carl Zeiss GmbH as an

application engineer in Image Guided Surgery (1997). Cyrille took a new position at Medtronic as a Sales and Technical representative 2002 in Switzerland and has been working as an European product manager in Cranial neurosurgery, ENT and intra operative imaging fields since 2003. His principal activities today are concentrating on Upstream (market trends feedback) & downstream marketing (strategies) and Commercialization.

Dr. Luca CUCURACHI Luca Cucurachi is Professor of History ofModern and Contemporary Philosophy at the High Institute of Religious Sciences-Theological Faculty of Puglia-Lecce. After his degree in Philosophy, he obtained a Ph.D. in Bioethical-Juridical Sciencesat the University of Lecce. Actually, he’s

attending his second Ph.D. in Ethics and Anthropology, at the same University. After a Master in Bioethics at theUniversity of Rome “La Sapienza”, he participated also ininternational events and courses, such as the European Academy of Bioethics (Germany). His fields of interest are:bioethics of genetics and biomedical research, andrelationships among science, philosophy and ethic.

Prof. Michele MAFFIA Michele Maffia is graduated in Biological Sciences (1984) and holds a PhD degree in Physiology (1989). He has been associated professor of Physiology since 2001 at the department of Biological and Environmental Science and Technology, University of Salento (Italy). His

research interests are gastroenterology and transport systems for nutrients and ions of teleosts, as well as functional and structural analysis of proteins transporters. He has been participating in the National Research Program in the Antarctic since 1989.

Prof. Dr Huib DE RIDDER Huib de Ridder is full professor ofInformational Ergonomics in the Facultyof Industrial Design Engineering (IDE) at Delft University of Technology, The Netherlands. He holds a MSc degree in Psychology and a PhD degree. In 1998he initiated the research program on

Product Intelligence in particular the subprogramTransparent Interfaces. He is vice-director of the Delft ICTResearch Center and involved in research on ambientintelligence and wireless communication. Current researchtopics include trust in Peer-to-Peer networks. Within the IDE Medisign program his current contribution to theresearch project called “Surgeon’s cockpit” is thesupervision of three PhD students.

Judith MUEHL Judith Muehl was born in 1971 in Mainz, Germany. She currently works as senior researcher at Graz University of Technology, Austria since January 2006. Her research interests include visualization and interaction techniques in

virtual and augmented reality, physically based simulation, as well as medical computer science. She studied at the Darmstadt University of Technology, Germany and at the University of Illinois at Urbana-Champaign, USA. She holds two Master's Degrees, one in Physics and one in Computer Science (Dipl.-Phys. and Dipl.-Inform.), both from TU Darmstadt.

Dr. Antonio MALVASI Antonio Malvasi is graduated in Medicineat the University of Bari and got hisspecialization in Obstetrics andGynaecology in 1987. He has been employed as assistant surgeon and thenas Director of Reproductive Center,

Santa Maria Hospital, Bari, Italy. Recently he has beenappointed Director of anatomic drawing at the Faculty ofMedicine of the University La Sapienza in Rome. He has published more than 128 research papers, 2 text-books and has been invited speaker in several meetings. He has been a NESA member since the year 2005.

Eng. Umberto PASQUALI Umberto Pasquali holds a degree in engineering from Politectico di Milano and a Master in Business Administration from INSEAD. He worked as a Geotechnical Engineer and then joined McKinsey & Co, a Management

Consulting firm, where he spent 6 years advising companies on strategy, organization and marketing issues. In 2004 Umberto joined Sorin Group, the largest European Cardiovascular Medical Device company as Director of Strategic Planning and Business Development. In 2007 Umberto was appointed Director, Innovation Portfolio Planning and R&D funding. Within this last assignment he is also responsible for Sorin’s minimally invasive program in the Heart Valve space.

Dr. Robert McLAUGHLIN Robert McLaughlin leads research inimage processing of Optical CoherenceTomography at the Optical+BiomedicalEngineering Laboratory at the University of Western Australia. His currentresearch is focused on imaging of

cancerous cells in breast surgery applications and imagingof the upper airway for obstructive sleep apnoea.Previously, he has been both a research scientist with Siemens Molecular Imaging, and held various commercialpositions in industry. From 1999-2002, he was a post-doctoral researcher at the University of Oxford.

Dr. Sonia PUJOL Sonia Pujol is an Instructor of Radiology at Harvard Medical School. Her research focuses on computer-assisted surgical navigation for endovascular therapy. She holds a Ph.D. in Biomedical Engineering from the Université Joseph

Fourier, Grenoble, France. Sonia Pujol joined the Surgical Planning Laboratory in the Department of Radiology, at Brigham and Women’s Hospital, Boston, Massachusetts, in 2004. She teaches neuroimaging analysis within the National Alliance for Medical Image Computing, and she is a lecturer in computer-assisted surgery at Harvard Medical School.

Dr. David MISHALY David Mishaly graduated from the Hebrewuniversity medical school in JerusalemIsrael 1989. Became specialized incardiothoracic surgeon in 1996. Hespent his fellowship in pediatric cardiacsurgery in the Cleveland clinic (Dr. RBB

Mee) and in UCSF San-Francisco (Dr. Frank Hanley). On1999 he became the head of pediatric and congenitalcardiac surgery in the largest hospital in Israel (ShebaMedical Center). In the last year he renew the congenitalcardiac surgery service in Ljubljana University Medical Center in Slovenia. He has become worldwide pioneers inusing minimally invasive techniques in congenital cardiacsurgery, as well as other innovative technique in the fronttechnology.

Dr. Marco SOLINAS Marco Solinas graduated magna cum laude in 1994 at the Faculty of Medicine -University of Bologna. In 1999 he specialized magna cum laude in Cardiac Surgery at the University of Bologna. He spent part of his training at the St

Antonius Ziekenhuis in Netherlands and at the Columbia University (USA). Since 2000 he has been working at the Heart Hospital, Fondazione G. Monasterio, Massa (Italy). His principal interest is developing new minimally invasive cardiac surgery techniques and strategies.

Prof. Giuseppe NICOLARDI Giuseppe Nicolardi got a Medical degree with honours in 1982 and obtained theSpecialization in Neurology with honoursfrom University of Bari Medical School in1986. He became associate professor ofHuman Anatomy at University of Lecce

in 1992 and took the position of Chief of the Laboratory of Human Anatomy at the Department of Biological andEnvironmental Sciences and Technologies. His mainresearch topics are in the physiopathology ofneurodegenerative disorders and sleep respiratorydisturbances.

Prof. Michael STARK Michael Stark was for many years medical director at the Misgav Ladach hospital in Jerusalem, where he initiated and developed the “Misgav Ladach” caesarean section method and the so called Ten Step Vaginal Hysterectomy.

He is now the president of the New European Surgical Academy. NESA deals with the analysis and evaluation of existing surgical procedures and their ways of performance and created the first European based working group on Natural Orifice Surgery. Michael Stark is also the chairman of the gynaecological departments of the HELIOS hospital group. With 55 hospitals in Germany and the Czech Republic with a capacity of 15,700 beds, this is one of the most important hospital groups in Europe.

ARISER NETWORK SPEAKERS Wajid Ali, Pakistani The Interventional Center, Rikshospitalet, University of Oslo, Norway

Jordi Cornella, Spanish The Interventional Center, Rikshospitalet, University of Oslo, Norway

Hugo Furtado, Portuguese University Medical Center, Ljubljana, Slovenia

Ashis Jalote Parmar, Indian Department of Industrial Design, Delft University of Technology, The Netherlands

Pablo Lamata, Spanish Siemens Molecular Imaging, Oxford, United Kingdom

Piotr Makowski, Polish National Research Council, Institute of Clinical Physiology, CNR-IFC Lecce, Italy

Laurent Massoptier, French National Research Council, Institute of Clinical Physiology, CNR-IFC Lecce, Italy

Sergiy Milko, Ukrainian Kongsberg SIM AS, Oslo, Norway

Terumasa Morita, Japanese University Medical Center, Ljubljana, Slovenia

Tangui Morvan, French The Interventional Center, Rikshospitalet, University of Oslo, Norway

Mauro Sette, Italian The Catholic University of Leuven, Belgium

Thomas Stüdeli, Swiss Department of Industrial Design, Delft University of Technology, The Netherlands

Minimally Invasive Technologies and Nanosystems for Diagnosis and Therapies

City of Lecce

The ARISER Conference 4th International Summer School

June 9th - 13th, 2008

Aragonese Castle of Otranto Otranto (LE), Italy

Acknowledgements for supporting this event to:

Italian Ministry of University and Research Apulia Region Province of Lecce City of Otranto

Salento University

Special thanks to: