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MOHD NABIL ABDUL HADI AL-AMA, M.D.
Hospital Address : King Abdulaziz University HospitalC/O Cardiology UnitP.O.Box 80215, Jeddah 21589Kingdom of Saudi ArabiaTelephone no.: +966 2 6408272 ext. 18285Fax no.: +966 2 6408315
Home Address : P.O.Box 17277, Jeddah 21484Kingdom of Saudi ArabiaTelephone no.: +966 2 6400996
Date of Birth : September 20, 1958
Place of Birth : Damascus, Syria
Citizenship : Saudi Arabian
Email Address : [email protected][email protected]
PRESENT ACADEMIC RANK AND POSITION CCU DIRECTOR & CONSULTANT ADULT
INTERVENTIONAL CARDIOLOGIST Former Chief of Cardiology Unit, King Abdulaziz University Hospital
Assistant Professor of Internal Medicine and Cardiology, King Abdulaziz University Medical School
Consultant Internist and Consultant Interventional Cardiologist, King Abdulaziz University Hospital
Consultant Interventional Cardiologist at Soliman Fakeeh Hospital.
Member of Morbidity and Mortality Committee at King Abdulaziz University Hospital, Jeddah, KSA.
Member of Cardio Pulmonary Resuscitation Committee at King Abdulaziz University Hospital, Jeddah, KSA.
EDUCATION
Graduated in King Abdulaziz University, Jeddah, K.S.A. on June 1982, MB & ChB with very good and honor degree.
Internship Completion: Medicine (3 months) Surgery (3 months) Paediatrics (2 months) Obstetrics and Gynaecology (2 months) Elective Haematology (2 months)
Senior House Officer (Medical Resident) – Medical Department of King Abdulaziz University Hospital on July 1983, attending clinics and in-patients, included in the on-call rota and carried out ward procedures such as bone marrow aspiration and biopsy, liver biopsy, pleural aspiration and biopsy, peritoneal tap central catheter, venous cut down, etc.
Passed the Canadian Evaluation Examination on March 1985. Completed The Medical Residency in McGill University, Canada
from July 1986 to June 1989. Worked in Montreal General Hospital, Royal Victoria Hospital,
Jewish General Hospital, Chest Hospital and Saint Mary’s Hospital in Canada.
American Board of Internal Medicine Certified on September 1989. Royal College of Physicians and Surgeons in Internal Medicine
Certified in 1990 in Internal Medicine. Completed The Cardiology Residency in McGill University,
Montreal General Hospital, Royal Victoria Hospital and Jewish General Hospital from July 1989 and June 1991.
Completed the Fellowship Training in Invasive and Interventional Cardiology at McGill University and Jewish General Hospital from July 1991 to November 1992 and did more than 1000 procedures of left, right heart catheterizations and PTCA.
BOARD CERTIFICATION
American Board Of Internal Medicine, 1989 American Board Of Cardiology, 1995
MEDICAL LICENSURE
Medical license in Saudi Arabia, 1992
HONORS / AWARDS
Graduated an Honor Degree at King Abdulaziz University Medical School in 1982.
Awarded as an Excellent Teacher (from Vice Dean for Clinical Department in 1996).
PREVIOUS PROFESSIONAL POSITIONS & APPOINTMENTS
Locum Consultant Interventional Cardiologist at Military Hospital in Riyadh.
Locum Consultant Interventional Cardiologist at Military Hospital in Jeddah.
Locum Consultant Cardiologist at Military Hospital in Jeddah (many times).
Locum Consultant Intensivist at Military Hospital in Jeddah.
Locum Consultant Interventional Cardiologist at King Faisal Specialist Hospital in Jeddah (many times)
Locum Consultant Cardiologist at National Guard Hospital in Jeddah (several times)
Locum Consultant Cardiologist at Al Salama (Private Hospital). Locum Consultant Cardiologist at King Faisal Specialist Hospital,
Jeddah (3 times). Locum Consultant Cardiologist at National Guard Hospital in
Jeddah (3 times). Chairman in International Cardiovascular Conference 2002 (30
April – May). HEPG. Chairman in HEPG (International Cardiovascular Conference)
June 2 – 4, 2003 Chairman (Symposium on Eprosartan – 2 times) in Jeddah.
EDUCATIONAL ACTIVITIES
From 1992 to present
Assistant Professor and Lecturer of Cardiology Curriculum (4th, 5th and 6th year in Medical School (lectures, curriculum of Cardiology under Medicine (Hypertension, Ischemic Heart Disease, Valvular Heart Disease, Congestive Heart Disease, Myocardial Disease, Introduction to Cardiovascular Exam, Infective Endocarditis, Pulmonary Embolism and teaching 4th year Dental School (Cardiology Lectures).
Medical Rounds to Interns and post graduates residents and teaching in clinics (medicine and cardiology) for 6th year students and senior doctors.
Teaching Clinical sessions and Seminars for 4th, 5th, 6th year, dental 4th year, house officer and residents and gave Grand Rounds at University Hospital and in Community hospitals.
Post Graduate Teaching (monthly basis).
Responsible for mortality and morbidity for last 3 years.
Teaching and active member of Jeddah Cardiology Club (monthly).
INSTITUTIONAL/DEPARTMENTAL & DIVISION ADMINISTRATIVE RESPONSIBILITIES
Acting Chairman of Cardiology Unit under the Department of Medicine at King Abdulaziz University Hospital, Jeddah, KSA.
Chief of Cardiology Division at United Doctors Hospital (private sector in evening) previously.
Consultant Interventional Cardiologist at Soliman Fakeeh Hospital (private sector).
Member of Cardio Pulmonary Resuscitation Committee.
Member of Morbidity and Mortality Committee.
Reviewer of King Abdulaziz Science Centre in Riyadh.
Active Member of Jeddah Cardiology Club.
PROFESSIONAL MEMBERSHIP AND SOCIETIES
Member, American College of Physician, June 1990.
Fellow, Royal College of Physicians and Surgeons in Canada, 1990.
Member, American Heart Association
Member, Clinical Cardiology Society
Associate Fellow, American College of Cardiology
Member, Society of Cardiac Angiography and Interventions
Member, Saudi Heart Association
Member, Cardiology and Hypertension Club, Jeddah
Member of Morbidity and Mortality Committee at King Abdulaziz University Hospital, Jeddah, KSA.
Member of Cardio Pulmonary Resuscitation Committee at King Abdulaziz University Hospital, Jeddah, KSA.
CONTINUING MEDICAL EDUCATION
December 2004 Update of IBS from Dubai
December 2, 2004 Latest Thinking in Acid Reflux Disease(Prof. David Armstrong, Mc Master University, Canada)
May 10, 2004 Myocardial Perfusion Using Definity (Dr. Roxy, UK)
April 27, 2004 Hypertension: New TrendsLe Meridian Hotel, Jeddah
March 16-18, 2004 The International Conference on Advances in Internal MedicineIntercon Hotel, Jeddah
March 7-10, 2004 American Colleges of Cardiology53rd Annual Scientific Session
March 6, 2004 Burning Question in the Management of Hypotension and Dyslipidemia New Orleans MarriottNew Orleans, LA
March 2004 American Heart Association and American Stroke Association
January 6-8, 2004 The 15th Scientific Session of Saudi Heart Association Hotel Intercontinental, Jeddah, KSA
Aug.30-Sept.3, 2003 European Society of Cardiology Congress 2003Vienna, Austria
April 14-17, 2003 2nd Conference for Advanced Medicine King Abdulaziz University HospitalJeddah, KSA
February 24-28,2003 The 30th Annual Meeting of Egyptian Society of Cardiology
June 2-4, 2003 International Cardiovascular ConferenceKing Faisal Specialist Hospital & Research Center Jeddah, KSA
Aug. 31-Sept. 4, 2002 European Society of Cardiology
Congress 2002Berlin, Germany
Reaching BP Target in Management of Hypertension by Prof. Bernard Weaber.
April 11, 2002 Emerging Data in Hypertensive Patients with Type II DM by Gerard Frangin.
March 17-20, 2002 51st Annual Scientific SessionAmerican College of CardiologyAtlanta, Georgia
March 16, 2002 New Approaches to Treating Dyslipidemia: Total Lipid ModificationAtlanta, Georgia
March 16, 2002 Futuristic Issues in the Treatment of ACSAtlanta, Georgia
March 16, 2002 Redefining ACS Care in the Era of Aggressive RevascularizationDuke University School of Medicine
March 5-7, 2002 11th Saudi Neurosciences Symposium & 3rd Annual Meeting of Saudi Chapter of Epilepsy.King Abdulaziz University HospitalJeddah, KSA
October 4-5, 2002 Valvular Heart Diseases in the 21st CenturyKing Faisal Specialist Hospital & Research Center Riyadh, KSA
September 1-5, 2001 XXIII Congress of the European
Society of CardiologyStockholm, Sweden
Jan. 23-25, 2001 3rd Cardiac SymposiumKing Fahd Armed Forces Hospital, Jeddah, KSA
Oct 17-22, 2000 Transcatheter Cardiovascular Therapeutics 2000Washington, DC
Jan. 16-17, 2000 2nd International Cardiac SymposiumIntercontinental Hotel, Jeddah, KSA
March 12-15, 2000 The American College of Cardiology Anaheim, California
March 07-10, 1999 48th Annual Scientific SessionThe American College of CardiologyNew Orleans, Louisiana, USA
March 05, 1999 Best Practices for Optimally Treating Advanced Heart FailureNew Orleans, Louisiana, USA
March 06, 1999 GPIIb-IIIa Inhibitors in Acute Coronary Syndrome:Applying Evidence from Clinical Trials to Medical PracticeNew Orleans, Louisiana, USA
March 06, 1999 Contemporary Strategies for Achieving BP GoalsUniversity of Miami School of MedicineMiami, USA
March 06, 1999 Acute Coronary Syndrome: Quarterbacking and Management Plan New Orleans, LA
March 28, 1998 Advanced Heart Failure: Defining, Debating and DecidingAtlanta, Georgia
March 28, 1998 Critical Clinical trials in Arrhythmia ManagementIndiana University School of Medicine
March 28, 1998 Myocardial Reperfusion XI: Concepts & ControversiesAtlanta, Georgia
April 26-29, 1998 The 1st Gulf and Mediterranean Advanced ECG and Pacemaker CourseCoral Beach Hotel, Beirut, Lebanon
November 08, 1998 American Heart Associations 71st Scientific SessionDallas, Texas
March 29-April 01, 1998 47th Annual Scientific SessionAtlanta, Georgia
March 29, 1998 Angiotensin Receptor Blockers:New Approaches to Cardiovascular Disease
March 15, 1997 Stents: Current Clinical IssuesFullerton, California
March 16-19,1997 46th Annual Scientific SessionThe American College of CardiologyAnaheim, California
March 23, 1996 Stents: A Framework for the Future in Interventional CardiologyTexas Heart Institute, Houston, Texas
March 21-23, 1996 Interventional CardiologyAtlanta, Georgia
September 12, 1996 SYNCOPE: Grand Round ProgrammeKing Fahd Armed Forces HospitalJeddah, KSA
January 15, 1996 Modern Therapeutic Aspects in the Treatment of HypertensionOstra University HospitalGoteborg, Sweden
March 24-27, 1996 45th Annual Scientific SessionAmerican College of CardiologyOrlando, Florida
September 6-10, 1995 Update in Cardiology: Cardiovascular Board Review American College of CardiologyBethesda, Maryland
November 13-16, 1995 American Heart Associations 68th Scientific SessionAnaheim, California
November 14, 1995 How Will We Manage Acute Coronary Syndrome?Duke University Medical CenterDurham, North Carolina
April 11, 1992 Improving Survival and Morbidity in Heart Failure and Ventricular DysfunctionHyatt Regency, Dallas, Texas
October 19-23, 1992 Review of CardiologyHarvard Medical SchoolBoston, Massachusetts
September 9-11, 1992 Complex Coronary Angioplasty and New Interventional DevicesSaint Luke’s Hospital of Kansas City, Missouri.
April 12-16, 1992 41st Annual Scientific SessionDallas, Texas
March 02, 1991 Managing the Patient with Hyperlipidemia: Current IssuesUniversity of Washington School of Medicine Seattle, Washington
October 3-6, 1991 Cardiovascular Board ReviewIndianapolis, Indiana
March 3-7, 1991 40th Annual Scientific SessionAtlanta, Georgia
March 02, 1991 Managing the Patient with Hyperlipidemia: Current IssuesUniversity of Washington School of Medicine Seattle, Washington
November 13-16, 1989 American Heart Associations 62nd Scientific SessionNew Orleans, Louisiana
April 13-16, 1989 70th Annual SessionSan Francisco, California
April 14, 1989 Chronic Valvular Regurgitation Management
April 11, 1989 Critical Care Medicine
April 16, 1989 Dealing with Patients After Serious Ventricular Arrhythmia
October 28, 1988 A 72 Year Old Woman With Onset of ConfusionStanford University School of MedicineStanford, California
SEMINARS/WORKSHOPS ATTENDED
March 3-5, 2009 11th KFAFH International Cardiac Conference 2009Jeddah, KSA
Nov 16-17, 2008 CT Angio & Cardiac MRI Course7th International Cardiovascular Conference 2008King Faisal Specialist Hospital, Jeddah
May 13-26, 2008 Euro PCR 2008Barcelona, Spain
Feb 25-29, 2008 35th International Congress of the Egyptian Society of CardiologyCairo, Egypt
Feb 14-26, 2008 Joint Interventional Meeting 2008
Rome, Italy
European Society of Cardiology 2008Munich
September 1-5, 2007 European Society of Cardiology Congress 2007Vienna, Austria
May 22-25, 2007 Euro PCR 2007Barcelona, Spain
March 24-27, 2007 56th Annual Scientific SessionInnovation in InterventionNew Orleans, USA
Feb 15-17, 2007 Joint Interventional Meeting 2007Rome, Italy
Feb 6-8, 2007 18th Scientific Session of Saudi Heart Association
TCT 2007
September 2-5, 2006 World Congress of Cardiology 2006Barcelona, Spain
May 16-19, 2006 Euro PCR 2006Paris
April 12-13, 2006 8th International Cardiac SymposiumKing Fahad AFH, Jeddah
Jan 31-Feb 2, 2006 17th Scientific Session of the Saudi Heart AssociationAl Khobar, KSA
Innovation in Intervention 2006American College of Cardiology
1st Conference of Saudi Society of Internal MedicineKing Abdulaziz Univ. Hospital, Jeddah
3rd Interventional Cardiology SummitTunisia
Summit TCT Asia Pacific 2006
Nov 28-Dec 1, 2005 3rd Conference on Advanced MedicineKing Abdulaziz Univ. Hospital, Jeddah
November 22-24, 2005 4th International Cardiovascular ConferenceKing Faisal Specialist Hospital, Jeddah
March 6-9, 2005 54th Annual Scientific SessionAmerican College Of CardiologyOrlando, USA
December 4-6, 2004 Jeddah Cardiovascular Interventional Symposium
September 5-9, 2004 European Association of the Study of Diabetes (Munich).
August 31-Sept. 3, 2004 European Society of Cardiology(Munich).
May 13-16, 2004 Reducing the Burden of Cardiovascular & Metabolic Disease along the Cardiovascular ContinuumIstanbul, Turkey
April 29-30, 2004 Advances in Managing Cardiology and Gastroenterology DisordersDurrah Beach Resort, Jeddah, KSA
March 16-18, 2004 The International Conference on Advances in Internal MedicineHotel Intercontinental Jeddah, KSA
March 7-10, 2004 53rd Annual Scientific SessionAmerican College of Cardiology
March 6, 2004 Burning Questions in the Management of Hypertension and DyslipidemiaNew Orleans, LA
January 6-8, 2004 The 15th Scientific Session of Saudi Heart AssociationHotel Intercontinental, Jeddah, KSA
Dec. 2003 How to read ECG
June 23, 2003 The Value of Early Diagnosis & Treatment Initiationof GP II b/III a Antagonist Prior PCI for Acute Coronary Syndrome Patients.Le Meridien Hotel, Jeddah, KSA
June 2-4, 2003 International Cardiovascular ConferenceKing Faisal Specialist Hospital & Research Centre Jeddah, KSA
April 27, 2003 Hypertension: New TrendsLe Meridien Hotel, Jeddah, KSA
April 14-17, 2003 2nd Conference for Advanced MedicineKing Abdulaziz University HospitalJeddah, KSA
February 24-28, 2003 The 30th Annual Meeting of the Egyptian Society Of Cardiology
Feb. 24-28, 2003 30th Annual Meeting of the Egyptian Society Of Cardiology
Jan. 7-9, 2003 5th International Cardiac SymposiumKing Fahd Armed Forces HospitalJeddah, KSA
October 26-28, 2002 3rd Jeddah Cardiovascular InterventionsHotel Intercontinental, Jeddah, KSA
October 1, 2002 Update of Thromboembolic Disease Treatment & ProphylaxisLe Meridien Hotel, Jeddah, KSA
Aug. 31, 2002 Total Risk Assessment: Advancing the Management of Cardiovascular Disease
Aug.-Sept. 2002 ESC Congress 2002Cardiac Electrophysiology, Detection, Evaluation and Treatment of High Blood Cholesterol in Adults
Aug. 31, 2002 Anticoagulation Therapy in Cardiac Disorder: Scientific Session 2002 Cardiac Imaging
June 23-27, 2002 Practical Implication and Implementation Of Progress
June 23-27, 2002 Joint ISH/ESH MeetingPrague, Czech Republic
TCT (Transcatheter Cardiovascular Therapeutics)
April 30-May 1, 2002 International Cardiovascular ConferenceKing Faisal Specialist Hospital & Research Centre Jeddah, KSA
The 29th Annual International Conference of the Egyptian Society of Cardiology
April 2002 Taif 10th Annual Cardiovascular Conference.
April 11, 2002 Reaching BP Targets in the Management of Hypertension
Emerging Data in Hypertensive Patients with Type II DiabetesHyatt Regency Hotel, Jeddah, KSA
March 27, 2002 4th King Fahd Armed Forces Hospital Cardiac Symposium
March 21-24, 2002 The Paris Course on Revascularization
March 17-20, 2002 51st Annual Scientific SessionAmerican College of Cardiology
March 9, 2002 New Advances in the Management of AtherothrombosisLe Meridien Hotel, Jeddah, KSA
January 2, 2002 Hypertension Risk, Systolic or Diastolic by Prof. Ahmed Zaki of Cairo UniversityHotel Intercontinental, Jeddah, KSA
Nov 10-15, 2001 Basic Life Support & Advanced Cardiac Life Support Saudi Heart Association
TCT (Transcatheter Cardiovascular Therapeutics)
Sept. 1-5, 2001 The Role of Statin in Managing Patients with Acute Coronary Syndrome.
June 15, 2001 Endothelial Dysfunction and Hypertension:Nebivolol, an Innovative Therapeutic Approach
June 15-19, 2001 Novel Calcium Antagonist Evidence on Blood Pressure Control and Target Organ Protection.
May 22-25, 2001 The Paris Course on Revascularization
May 1-4, 2001 An Integrated Approach to OptimizeCardiovascular CareLe Meridien Hotel, Jeddah, KSA
April 11, 2001 Taif 9th Annual Cardiovascular Conference
April 23-26, 2001 International Conference on Advanced MedicineKing Abdulaziz University Hospital, Jeddah, KSA
Transcatheter Cardiovascular Therapeutics 2001
January 23-25, 2001 The Joint Meeting of the 12th Scientific Session of the Saudi Heart Association and the 3rd Cardiac Symposium of King Fahd Armed Forces Hospital Jeddah, KSA
January 28, 2001 New Trends in the Management of Hyperlipidemia& Cardiovascular RisksCrowne Plaza Hotel, Jeddah, KSA
November 11, 2000 The Diagnosis and Treatment of Pulmonary EmbolismMarriott Hotel, Jeddah
October 4-5, 2000 Valvular Heart Diseases in the 21st CenturyKing Faisal Specialist Hospital & Research Centre Riyadh, KSA
Oct. 18, 2000 Harmonizing Mechanical and Pharmacological Approaches in Acute Ischemic Syndrome.
October 4-5, 2000 Valvular Heart Diseases in the 21st Century
September 26, 2000 Anti-leukotrienes & Current Trends in Asthma TherapyHotel Intercontinental, Jeddah, KSA
September 19, 2000 Angiotensin II Antagonism: Benefits Beyond Blood Pressure Control Holiday Inn Crowne Plaza, Jeddah, KSA
May 29-June 3, 2000 10th European Meeting on HypertensionGoteborg, Sweden
April 18, 2000 Gastro-Oesophageal Reflux DiseaseMarriott Hotel, Jeddah
March 12-15, 2000 49th Annual Scientific SessionAmerican College of Cardiology
February 4-6, 2000 Winning The Race Against Cardiovascular Disease Progression: The Contribution of Adrenergic Blockade
Feb. 4-6, 2000 Winning the Race against Cardiovascular Disease Progression: The Contribution of Adrenergic Blockade.
January 16-17, 2000 2nd International Cardiac Symposium(ECHOCARDIOGRAPHY)King Fahd Armed Forces Hospital Jeddah, KSA
November 16, 1999 Symposium on CardiologyJohns Hopkins University Hospital
November 16, 1999 4th Scientific Symposium on CardiologyHotel Intercontinental, Jeddah, KSA
October 20-22, 1999 The Role and Potential of StatinSharm El-Sheikh, Egypt
October 3, 1999 Hypertension and Elevated Heart Rate between Theory & Practice by Prof Halzgneze of GermanyHoliday Inn Crowne Plaza Hotel, Jeddah, KSA
October 6, 1999 The Role of Angiotension II Receptor Blockers In the Management of the Cardiovascular Disease In the 21st Century by Prof. Tomas Vagen & Prof. Louis RimlopeHoliday Inn, Jeddah, KSA
October 12-13, 1999 1st Live International Symposium onCardiovascular Catheter InterventionDr. Erfan & Bagedo HospitalJeddah, KSA
September 26, 1999 Treatment Approach for Coronary Heart Disease Patients by Dr. Ole Feergman of USA & Dr. Mogens Larsen of DenmarkLailaty Ballroom, Jeddah
September 14, 1999 Role of Angiotensin II Antagonists in Control of Hypertension & Vital Organ ProtectionLailaty Hall, Jeddah, KSA
December 2, 1998 Valvular Heart DiseaseKing Fahd Armed Forces Hospital, Jeddah, KSA
Jeddah Cardiovascular InterventionJeddah Heart InstituteJeddah, KSA
An Integrated Approach to OptimizeCardiovascular Care
October 21-24, 1998 9th International Congress of Cardiology and Cardiac SurgeryPortemilio, Kaslik, Lebanon
April 26-29, 1998 The 1st Gulf & Mediterranean Advanced ECG and Pacemaker CourseCoral Beach Hotel, Beirut, Lebanon
February 22-27, 1998 The 25th Anniversary of the Egyptian Society of CardiologyCairo, Egypt
June 17, 1997 Novel Approaches in Treating Hypertension and Renal Disease Via Blockade of the Renin-Angiotensin System.
February 18-20, 1997 8th Scientific SessionSaudi Heart AssociationJeddah, KSA
June 25-July 6, 1995 5th & 6th year Final Clinical ExaminationKing Abdulaziz University HospitalJeddah, KSA
January 24-26, 1995 6th Scientific SessionJeddah, KSA
January 25-27, 1994 5th Scientific SessionSaudi Heart AssociationJeddah, KSA
November 8-11, 1993 66th Scientific SessionAmerican Heart AssociationAtlanta, Georgia
October 5-6, 1993 Update on Endocrinology & Metabolic DiseasesKing Khalid National Guard HospitalJeddah, KSA
May 12-13, 1993 International Symposium on Current Concepts & Controversies in CardiologyKing Khalid National Guard HospitalJeddah, KSA
April 20-21, 1993 International Symposium on Renal Disease And Hypertension King Khalid National Guard HospitalJeddah, KSA
April 11-12, 1993 Current Trends in the Management of Coronary Artery DiseaseArmed Forces Cardiac Center, Riyadh, KSA
March 1989 W Mandell: Cardiac Arrhythmias
November 17, 1985 The Role of Beta Blockers in Myocardial InfarctionJeddah, KSA
Sept. 6-10, 1995 Update in CardiologyCardiovascular Board Review
Percutaneous Coronary Intervention after Subcutaneous Enoxaparin Pretreatment in Patients with Unstable Angina Pectoris.
Cardiac Electrophysiology:Detection, Evaluation and Treatment of Increase Blood Cholesterol in Adults.
Prevention of Disease Progression Throughout the Cardiovascular Continuum.Controlling Cardiac Arrhythmias Evolving Perspective in Atrial Fibrillation.
Board Review Course in Cardiovascular Disease
Electrical Therapy for Cardiac Arrhythmias.
PUBLICATIONS
Heart Rate Variability in Patients with Mitral Stenosis: A Study of 20 Cases from King Abdulaziz University Hospital
Time-Domain Analysis of Heart Rate Variability in Diabetic Patients with and without Autonomic Neuropathy.
Homocysteine Level and other Biochemical Parameters in Cardiovascular Disease Patients with Diabetes Mellitus.
Using Hemoglobine spectra as an Indicator for some diseases.
Multivalvular Infective Endocardistis in a Tetrology of Fallot.
Dietary Vitamin A may be a Cardiovascular Risk Factor in a Saudi Population.
The Impact of the Genetic Polymorphism of Paraoxosonase Gene (PON 1) on the Incidence of Coronary Vascular Disease in Saudi Population.
High Cardiovascular Risk in Young Saudi Males: Cardiovascular Risk Factor, Diet and Inflammatory Markers.
Relationship between Indices of Iron status and Coronary Risk Factors including Diabetes and the Metabolic Syndrome in Saudi Subjects without overt Coronary Disease.
Trace Elements status in Saudi patients with Established Atherosclerosis.
At present, I am involved in Monthly Research Projects like left carotid artery thickness, CAD, LAD, Hypertension, Pregnancy, Anticoagulation & Hypertension, Atrial Fibrillation and CHF.
Journal of King Abdulaziz UniversityVolume, 21, No. 1,
pp, March 2009-12-22
"USING HEMOGLOBINE SPECTRA AS AN INDICATOR FOR SOME DISEASES
Dear Dr. Mohammed Nabil Al Ama
I am very pleased to inform you that your manuscripts entitle:
"Using Hemoglobin Spectra as an Indicator for Some Diseases"
Which has been submitted to the King Abdul Aziz Bulletin "Science" has been accepted for publication in the journal and will appear in (Vol.21, No. 1, pp, March 2009)
Prof. Abdullah M. Asiri
Editor – in – chief SignatureChemistry of ScienceKing Abdul-Aziz UniversityP.O.Box 80203Saudi ArabiaTel. +02-695 2293Fax. +02-695 2292E – mail: [email protected]/aasiri2
Willy InterScience: JOURNALS: EchocardiographyVolume 25 Issue 1, Pages 88-90
MULTIVALVULAR INFECTIVE ENDOCARDITIS IN A TETRALOGY OF FALLOT
Ashraf M. Anwar, M.D., Youssef F, M.Nosir, Ph.D., M.D., Aref Ajam, M.R.C.P., Maimoona Mushtaq, F.R.C.P., Mohammed N. Alama, F.R.C.P.c, Hassan Chamsi-Pasha, F.R.C.P., (Lond) F.R.C.P. (Glasg), F.R.C.P.I., F.A.C.C.
ABSTRACTInfective endocarditis (IE) is still a problem in patients with adult congenital heart disease. Tetrology of Fallot (TOF) is one of the most important manifestations of congenital heart disease, which carries a high risk for the development of IE. We present an 18 year – old male with TOF complicated by an aggressive from of IE involving all cardiac valves.
Med Sci Monit,Volume 2003; 9(12) CR 523-527
HOMOCYSTEINE LEVEL AND OTHER BIOCHEMICAL PARAMETERS IN CARDIOVASCULAR DISEASES PATIENTS
WITH DIABETES MELLITUS
Mohammed Ajabnoor, Mohammed Al Ama, Zainy Banjar, Adel Abdul Rafee, Salah Sheweita
Abstract Summary:
Back ground:Atherosclerosis is the main cause of cardiovascular morbidity and mortality in may countries. It is believed that hyperhomocysteinemia is a risk factor for premature atherosclerosis and other cardiovascular diseases (CVD) in both men and women.
Material/Methods:Plasma samples from 31 non-CVD and 51 CVD patients with diabetes were studied. Informed consent was obtained from all subject. Blood samples were collected after overnight fasting. Total homocysteine (H [e]), the levels of high and low density lipoproteins (HDL, LDL), total cholesterol, urea and creatinine were determined with commercial kits.
Results:The levels of homocysteine, vitamin B12` creatinine and urea in CVD patients were significantly higher than those found in the normal subjects. On the other hand, the levels of folic acid, HDL and LDL were lower in CVD patients than in normal subjects. Interestingly, a linear relationship was found between the levels of homocysteine and total cholesterol in CVD samples, whereas no such linear relationship was present in normal subject.
Conclusions:The level of homocysteine in plasma is known to be mainly dependent on the levels of folic acid and vitamin B12. However, in the present study the level of homocysteine in the plasma of CVD patients is dependent on the level of folic acid and not on the level of vitamin B12. Subjects with high homocysteine levels should b advised to consume a folic acid-fortified diet in order to reduce the homocysteine level in patients at high risk for cardiovascular disease.
Key words: atherosclerosis. Homocysteine. Cholesterol. Diabetes
Annals of Saudi Medicine,
Vol.22, Nos. 5-6 2002
THE TIME DOMAIN ANALYSIS OF HEART RATE VARIABILITY IN DIABETIC PATIENTS WITH AND WITHOUT AUTONOMIC NEUROPATHY
Awdah Al-Hazimi, PhD; Nabil Al-Ama, MRCP; Ahmad Syiamic, PhD; Reem Qosti, BSc, Khidir Abdel-Galil,PhD
Abstract;The normal heart rate is determined by dynamic interaction between the spontaneous cardiac impulse generated by the sinoatrial (SA) node and conflicting influences of the sympathetic and parasympathetic nervous systems on the conducting tissue of the heart. The rate of spontaneous depolarization of the SA node is itself affected by its metabolic milieu and in the longer term, by hormonal influences. Normal resting heart rate is maintained by the tonic influence of the parasympathetic vagus nerve, and acceleration of the heart rate is affected both by the inhibition of vagal influence and the stimulation of the sympathetic nervous system. The activity of the autonomic is also governed by moment-to-moment changes in blood pressure and respiration, which alter heart rate continuously. The resultant heart rate is the summation of all these influences and thus inherently unpredictable on a beat-to-beat basis.
Recently advances in technology have enabled accurate recordings and the automated analysis of 24-hour ECG to detect beat-to-beat variability, providing not only more detailed, but much more accurate and precise information than the earlier tests.1Heart rate variability (HRV) decreases with age,2 and shows a circadian variation, being maximum during sleep.3 It is also rate dependent, the heart rate showing more variability at lower heart rates. The loss of this beat-to-beat variability is a sign of disease.
It has long been known that cardiovascular autonomic diabetic neuropathy (CADN) is associated with a loss of heart rate variability.4,5. These Patients have a poor cardiovascular prognosis,6,7 with a 5 year mortality greater than 50%.8 Some of this may be attributed to micro- or macrovascular disease,9 however, a recent study has shown the relatively poor prognosis of patients with CADN in the absence of clinically detectable micro- or macrovascular donditions.10 Clinically detectable autonomic failure is usually evident many years or decades after the onset of diabetes. It is likely that these patients develop subtle deficit in HRV much earlier, and these may include diminution in time-domain analysis. Detection of such changes may be used a markers of pathology, particularly to study the benefits of therapeutic interventions. Thus, the aim of this work was to study HRV in diabetic patients with clinical and sub-clinical autonomic neuropathy (AN), and to determine whether HRV in patients with sub-clinical AN is abnormal in comparison to normal control.
Subject and Method
Following Local Ethical Committee approval, we studied 10 consecutive, newly diagnosed non-insulin dependent diabetics mellitus (NIDDM), 10 NIDDM with autonomic diabetic neuropathy (AND), and 10 age-matched normal control (Table 1). Informed consent was obtained from each subject. The patients were selected from King Abdulaziz University Hospital in Jeddah, Saudi Arabia, under supervision of a medical consultant. The analysis of HRV was done in the Department Physiology. We found no gender differences in any measure of HRV (data not shown), which is consistent with previous published work.10 All subjects had no evidence of pre-existing cardiovascular disease, were normotensive, had no previous history of ill health, and were taking no regular medication except standard diabetic therapy.24-Hour ECG Recording
The 24-hour electrocardiogram (ECG) recordings were carried out using a two-channel tracker (DEL MAR Holter System). One channel records the ECG signal and the second channel records a time signal generated by the recorder. The time signal is used to make correction for vitiations in tape speed. Individuals went about normal daily activities. A new cassette tape and battery were used or each recording.
The electrodes were positioned in standard positions over the precordium. Reply, QRS detention and measurement of the RR interval was performed using DEL MAR ECG Analyzer. After analogue to digital conversion, a digital computer stored the time intervals (ms) between successive R waves as the interval tachogram (time series).
Asia Pacific J Clin Nutr
DIETARY VITAMIN A MAY BE A CARDIOVASCULAR RISK FACTOR IN A SAUDI POPULATION
Eman M Alissa BSc1,2, Suhad M Bahjri BSc, PhD1, Nabeel Al –ama, MD,FRCP(c)1,4
Waqar H Ahmed MD, MS1,3, Bryan Starkey BSc, PhD2 and Gordon A A Ferns MD. FRCP Path.2
Traditional risk factors do not appear to explain fully the variation in the incidence of the cardiovascular diseases (CVD). Epidemiological studies have not been entirely consistent with regard to the relationship between antioxidant vitamin intake and CVD and there appears to be little data on this relationship in non-Caucasian populations. This study aimed to investigate the dietary intake of vitamin A, C, and vitamin E, and carotenoids, serum concentrations of vitamin E and A and indices of lipid peroxidation were measured in male Saudi patients with established CVD and age-matched controls. We assessed the dietary intakes of vitamins A, C, and E and carotenoids, by a food frequency questionnaire. Serum vitamins A and E concentrations were measured by HPLC, in 130 Saudi male subjects with established CVD, and 130 age-matched controls. We also determined serum lipid profiles (total cholesterol, triglycerides, HDL-c, LDL-c), lipoprotein (a), oxidized LDL, and serum lipid peroxide concentrations. Diabetes mellitus (p<0.0001), a positive smoking habit (p<0.0001) and hypertension (p<0.05) were more prevent among CVD patients. Levels of dietary vitamin E and A were also significantly higher among cases. In conditional logistic regression analysis, the most significant characteristics differentiating CVD patients from controls were diabetes mellitus )Odds ratio 2.49 DI I.42-4.37, p<0.001), total fat intake (Odds ratio 1.02,CI 1.01-1.03,p<0.01), serum vitamin A (Odds ratio 0.72, CI 0.53-0.99, p<0.05), and the vitamin A/total fat intake ratio (Odds ratio 1.04, DI 1.01-1.06, p<0.01). in a Saudi population, smoking habit and hypertension were significantly more common among patients with CVD. Multivariate analysis showed that dietary total fat and vitamin A and the presence of diabetes mellitus were independent coronary risk factors. This is the first report of a potentially deleterious effect of dietary vitamin A in a non-Caucasian population. However it is possible that unidentified residual confounding factors may account for this finding.
Key words: vitamin A, C, and E, coronary disease, risk factors, lipid peroxides, dietary antioxidant vitamin intake, oxidative stress, coronary atherosclerosis, Saudi Arabia, Jeddah.
Tanta Medical Science Journal Vol.(32),No.(1),January 2008:pp 113-123
THE IMPACT OF THE GENETIC POLYMORPHISM OF RAOXOSONASE GENE (PON1) ON THE INCIDENCE OF
CORONARY VASCULAR DISEASE IN SAUDI POPULATION
Zeiny. M. Banjr(1), Adil. A. Abdulrafee(1), Nabil Alamaa(2) & Osama. A. Gaber(1)
Department of Clinical Biochemistry (1) and Internal Medicine(2) , Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
ABSTRACT:___________________________________________________________________________________
Background/Aim: Cardiovascular diseases as being one of the major causes of morbidity and mortality drags attention for the study of their pathogenesis which seems multifactorial including habitual, environmental and genetic causes. The major cause for atherosclerosis is deposition of oxidized lipoproteins in the blood vessel. Paraoxonase (PON1), an enzyme tightly linked to HDL plays an important role in decreasing the susceptibility of LDL-cholesterol for oxidation, thus minimizing atherosclerotic changes in the blood vessels. Paraoxonase activity in the serum alone is not a determining factor for this role. This function is also controlled and affected by many polymorphisms occurring in the PONI1 gene. The aim of this study was to evaluate the effect of one of this genetic polymorphism (at position 192) on cardiovascular disease in Saudi population.
Subjects & Methods: This study included 169 subjects (100 cases and 69 controls). For all participants in the study Paraoxonase activity, lipid profile, Apo A-1 and genetic polymorphism was done.
Results: The percentage distribution of this genetic polymorphism differs in Saudi population than those observed in previous studies as in Mexican population and is more similar to those in Japanese population. There was no significant difference in the genetic distribution between control and CVD groups. The activity of Paraoxonase was lower in the CVD group compared to the control; also there was no significant correlation between this genetic polymorphism and the lipid composition of the blood.
Conclusion: PON1 activities toward paraoxon are lower in subject with CVD than in control subjects regardless of the PON1 genotype although the PON1 activity is much lower in RR genotype than QQ genotype.
Key word: Paraoxonase, Polymorphism, HDL, Atherosclerosis, Coronary._____________________________________________________________________
ELSEVIER SCIENCE @ DIRECT Clinica Chimica Acta 365 (2006) 288-296
HIGH CARDIOVASCULAR RISK IN YOUNG SAUDI MALES: CARDIOVACULAR RISK FACTOR, DIET AND INFLAMMATORY
MARKERS
Eman M. Alissa a,b*, Suhad M. Bahjri a, Nabeel Al-ama a,d,Waqar H. Ahmed a,c , Gordon A.A. Ferns b
Abstract
Background: The relationship between coronary risk score (CRS), individual coronary risk factors and the serum inflammatory markers, high sensitivity C-reactive protein (hsCRP), ceruloplasmin (Cp), and soluble intercellular adhesion molecule-1 (sICAM-1) was studied in 140 Saudi males without clinically evident coronary heart disease (CHD).
Methods: One hundred forty subjects without clinically evident CHD were categorized into age tertiles. Demographic data together with an estimate of CRS using Framingham and PROCAM algorithms were obtained, and serum lipid profile, glucose, hsCRP, sICAM-1, and Cp were measured. Macronutrient intake was assessed by a questionnaire, the relationship between CRS, biochemical markers and diet was assessed by univariate and multivariate analysis.
Results: There was no significant difference in median hsCRP, sICAM-1 or Cp between the age groups. Serum Cp was positively associated with age (r=0.224,p<0.01) and FRS score (r=0.174, p<0.05). Serum sICAM-1 was negatively associated with PROCAM score (r=-0.183,p<0.05). sICAM-1 was positively associated with HDL cholesterol (r=-0.36,p<0.0001) among non diabetic and negatively associated (r=-0.397,p<0.05) among diabetic subjects. Age and dietary intake of saturated fatty acids together explained 7.9% of the variation in serum Cp levels in a stepwise multiple regression model. Similarly 6.5% of the variation in serum sICAM-1 level was explained by the total cholesterol/HDL-C ratio. The youngest tertile of the group (<30y) had the highest dietary intake of energy, fat and saturated fatty acids (p<0.05), and also had a high prevalence of obesity, smoking and sedentary lifestyle.
Conclusion: We have demonstrated that there is a high prevalence of coronary risk factors and poor dietary intake within a Saudi male population and that dietary factors are associated with serum sICAM-1 and ceruloplasmin but not hsCRP concentrations in this group.© 2005 Elsevier B.V. All rights reserved.
Keywords: Inflammatory markers; C-reactive protein; Soluble adhesion molecules; Ceruloplasmin; Coronary risk factors; Saudi males; Dietary fatty acids.
ELSEVIER Journal of Trace Elements in Medicine and Biology 21 (2007) 242-254
REALTIONSHIP BETWEEN INDICES OF IRON STATUS AND CORONARY RISK FACTORS INCLUDING DIABETES AND THE METABOLIC
SYNDROME IN SAUDI SUBJECTS WITHOUT OVERT CORONARY DISEASE
Eman M. Alissaa, Waqar H. Ahmeda,c , Nabeel Al-amaa,d, Gordon A.A. Fernsb
_____________________________________________________________________
Abstract
There have been inconsistent reports o the relationship between iron status and coronary artery diseases (CAD), and little data on this relationship in non-Caucasian populations. We assessed dietary iron by questionnaire and measured serum iron and ferritin levels in 270 Saudi male subjects without established CAD, 130 of whom were angiogram negative. Serum lipid profile, glucose, high sensitivity-C reactive protein (hs-CRP), serum soluble intercellular adhesion molecules-1 (sICAM-1), and ceruloplasmin were measured in all subjects. The angiogram negative patients, had lower serum ferritin (p<0.05) and iron (p<0.0001) levels than the 140 subjects without reported cardiovascular diseases (CVD). Serum iron correlated with serum triglycerides (p<0.0001) and total cholesterol (p<0.05) levels for this latter group and the groups combined. Serum ferritin correlated with serum total cholesterol and low-density lipoprotein (LDL)-cholesterol in the combined group (p<0.05), and was correlated with blood glucose and serum LDL-cholesterol (p<0.05) in the subjects without reported CVD. After adjustment for confounding variables, serum iron levels remained a correlated significantly with cholesterol intake and fasting serum total cholesterol. Dietary iron was significantly related to dietary cholesterol fiber, age, smoking habits, and total cholesterol level. Hence, indices of iron status were related to several coronary risk factors in the Saudi population.© 2007 Elsevier GmbH. All rights reserved.
Keywords: Ferritin; Saudi Arabia; Coronary risk factors; Metabolic syndrome; Diabetic mellitus
ELSEVIER Journal of Trace Elements in Medicine and Biology EPIDEMIOLOGY20 (2006) 105-114
TRACE ELEMENT STATUS IN SAUDI PATIENTS WITH ESTABLISHED ATHEROSCLEROSIS
Eman M. Alissaa,b, Suhad M. Bahjria , Waqar H. Ahmeda,c , Nabeel Al-amaa,d, Gordon A.A. Fernsb
Abstract
Background: Traditional coronary risk factors do not fully explain variation in the incidence of cardiovascular disease (CVD). Epidemiological studies have implicated perturbations in selenium, copper and zinc metabolism in the etiology of CVD. However, these studies have been principally undertaken in Caucasian populations, in whom trace element intake is generally sufficient. Method: Diabetes mellitus, positive serum and urine selenium, copper, and zinc; and superoxide dismutase, glutathione peroxidase, and dismutase, glutathione peroxidase, and lipid peroxide concentrations in 130 Saudi male subject with established CVD, and 130 age-matched control. Results: Diabetes mellitus, positive smoking habit (p<0.0001 for both), and hypertension (p<0.05) were more prevalent among CVD patients. Urinary copper (p<0.0001) and zinc (p<0.05) were higher among controls. Serum selenium concentration were lower among CVD patients (p<0.0001), and a high proportion (52%) had selenium levels below 79ug/L compared to controls (22%) (p<0.0001). Conditional logistic regression analysis, showed the characteristics differentiating CVD patients from controls were serum zinc (odds ratio (OR) 0.92, confidence interval (CI) 0.85-0.99, p<0.05) , serum copper/zinc ratio (OR 0.31, CI 0.10-0.96), serum selenium (OR 0.07, CI 0.02-0.031, p<0.0001), and urine selenium (OR 3.34, CI 1.40-7.99, p<0.01).
Conclusion: Measures of trace metals status appear to be associated with the risk of atherosclerosis in a Saudi male population.
Keywords: Copper; Zinc; Selenium; Atherosclerosis; Saudi Arabia
Tanta Medical Science Journal Vol. (32), No. (1), January 2006, pp 113-123
HEART RATE VARIABILITY IN PATIENTS WITH MITRAL STENOSIS. 20 CASES FROM KING ABDULAZIZ UNIVERSITY HOSPITAL
Name: Mohammed Nabil Al AmaCountry: Kingdom of Saudi ArabiaCity: JeddahP.O.Box: 17277Tel: 6408272Department: Cardiology (Medicine)College/Directorate: King Abdulaziz UniversityCountry of birth: SyriaDate of birth: 1958Nationality: SAUDILanguages: Arabic-EnglishDate of Graduation: 1991Highest Degree: AMERICAN BOARD OF INTERNAL MEDICINE (USA)Academic Title: Associate Professor
Abstract
1-Heart Rate Variability in patients with Mitral Stenosis. A study of 20 cases from King Abdulaziz University Hospital2- Time Domain Analysis of Heart Rate Variability in Diabetic Patients with and without autonomic Neuropathy3- Homocysteine Level and other Parameters in Cardiovascular Disease Patients With Diabetes Mellitus4- The impact of genetic polymorphism of Paraoxonase gene (PON1) on the incidence of coronary vascular diseases in Saudi population. Zeiny.M.Banjar, Adil. A. Abdulrafee, Nabil Alamaa and Osama A, Gaber.
Tanta Medical Science Journal , Vol. (32), No. (1), January 2006, pp 113-123
