molecular biology of the cellbayanbox.ir/view/2921979997502904368/آپوپتوز.pdfmolecular...
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آپوپتوز
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مرگ سلولي ):نكروز(به علت صدمه•
صدمه مكانيكي صدمه شيميايي
):آپوپتوز(به علت خودكشي •مسير داخلي مسير خارجي
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ضرورت آپوپتوز ايجاد و توسعه اندام ها•
oبازجذب دم در نوزاد قورباغه oايجاد انگشتان دست و پا در جنين oايجاد حفره در مركز رحم oايجاد اتصاالت مناسب بين نرون هاي مغز
نابودي سلول هاي مضر•oسلول هاي آلوده به ويروس oسلول هاي ايمني غير الزم oسلولهاي داراي جهش در دي ان آ oسلول هاي سرطاني
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تصميم به خودكشي سلول حذف پيام هاي مثبت•
oعوامل محرك رشد در سلول هاي عصبي o 2اينترلوكين
دريافت پيام هاي منفي•oافزايش عوامل اكسيدانت oصدمه به دي ان آ oپيام رسانان مرگ:
TNFα TNFβ يا لنفوتوكسين ليگاندFas
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مقايسه آپوپتوز و نكروز
• Cellular swelling • Membranes are broken • ATP is depleted • Cell lyses, eliciting an
inflammatory reaction • DNA fragmentation is
random, or smeared • In vivo, whole areas of the
tissue are affected
• Cellular condensation • Membranes remain intact • Requires ATP • Cell is phagocytosed, no
tissue reaction • Ladder-like DNA
fragmentation • In vivo, individual cells
appear affected
آپوپتوز نكروز
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آپوپتوز و بيماريها :آپوپتوز بيش از حد•
زوال مغزي(بيماريهاي نورودژنراتيو(
:نقص در آپوپتوز•سرطان خود ايمني
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نكروز آپوپتوز آپوپتوز
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آپوپتوز در پنجه جنين موش
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آپوپتوز در طي متامورفوز قور باغه نقش هورمون تيروييد
حذف دم
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الگوي نردباني قطعه شدن دي ان آ در لنفوسيت هاي تيموس موش Fasاز آنتي بادي بر عليه گيرنده هاي استفاده
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در بررسي آپوپتوز TUNELتكنيك terminal deoxynucleotidyl transferaseاستفاده از
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فعال شدن پرو كاسپاز در فرايند آپوپتوز
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executionerبه initiatorتقويت پيام از
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فعال شدن مسير خارجي آپوپتوز Fasتحريك گيرنده هاي
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نقش كاسپازها در مسير خارجي آپوپتوز
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از ميتوكندي Cآزاد شدت سيتوكروم intrinsic pathwayمسير داخلي
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مسير داخلي در آپوپتوزIntrinsic Pathway
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Bcl2پروتئين هاي سه دسته مختلف از خانواده
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و نوع تداخل آنها با يكديگر Bcl2نقش اعضاي خانواده
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مسير داخلي آپوپتوز BH123از دسته Bcl2نقش پروتئين هاي
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تنظيم مسير داخلي آپوپتوز BH3و محرك آپوپتوز Bcl2نقش گروه ضد آپوپتوز خانواده
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تنظيم مسير داخلي آپوپتوز BH3و محرك آپوپتوز Bcl2نقش گروه ضد آپوپتوز خانواده
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IAPو مولكول هاي آنتي IAPنقش سلول هاي پستانداران
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IAPو مولكول هاي آنتي IAPنقش سلول هاي پستانداران
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survival Factorsعوامل بقا
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survival factorنقش عوامل بقا يا تنظيم تعداد سلول هاي عصبي نسبت به سلول هاي با فت هدف
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survival factorنقش عوامل بقا يا مكانيزم هاي سه گانه مهار آپوپتوز
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Apaf1=Apoptotic protease activating factor 1
ايجاد موش هاي ترانس ژن موتانت Caspase 9و Apaf1نقش دو ژن
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القاي آپوپتوز با اشعه ماوراء بنفش از ميتوكندري C –GFPآزاد شدن سيتوكروم
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مشاهده آپوپتوز درحال انجام