molecular testing in nsclc....pm->en egfr hist3h3 krt8 pld2 krt18 map2k1 mapku p nij map3k3 dnm...
TRANSCRIPT
Molecular testing in NSCLC.
P.Pauwels (UZA/UZG)
EGFR
• Exist as monomers
• Binds ligand, changes shape and homo/hetero-dimerize
• Autophosphorylation of tyrosine residues
• Recruitment of adaptor/signaling molecules
• Downstream signalingPao & Miller JCO 2005;23:2556-2568