ANNUAL REPORT 2016 -2017

MONELL HAS ADVANCED SCIENTIFIC DISCOVERY FOR 50 YEARS, LEADING THE WAY TO A HEALTHIER AND SAFER WORLD. TO LEARN MORE:

MONELL.ORG

TWITTER: @MONELLSC

FACEBOOK: MONELLCENTER

LINKEDIN: MONELL CHEMICAL SENSES CENTER

3500 MARKET STREETPHILADELPHIA, PA 19104267.519.4700

Test your knowledge on this question and those throughout this report. Find the answers at monell.org.

What public health challenge(s) does Monell’s research address?

© 2017 MONELL CHEMICAL SENSES CENTER

MONELLCHANGINGTHE WORLD

MONELL CENTER ANNUAL REPORT | 01

The Monell Chemical Senses Center is an unrivaled multi-disciplinary nonprofit research institution leading the world to a better understanding of taste and smell.

Every day, Monell scientists make discoveries about how our bodies detect and respond to chemical molecules in the worlds within and around us. Our work guides policies and inspires products that enable healthier diets, safer environments, and more powerful ways to meet pressing health challenges — from obesity to infectious diseases to Alzheimer’s dementia.

At Monell, we create and share knowledge to guide real-world advances in policy, practice, and behavior.

If I have seen further than others it is by standing on the shoulders of giants.”S I R I S A A C N E W T O N‘‘On the eve of Monell’s 50th anniversary, Newton’s words

resonate. For half a century, Monell researchers have defined a legacy of discovery and world leadership in the chemical senses, building on the knowledge of our predecessors and advancing scientific discovery to expand our understanding of how the primal senses of taste and smell are intricately interwoven with human health.

Today, Monell scientists continue on this mission, asking new questions and bringing diverse disciplinary perspectives and approaches to address significant global public health issues. As you’ll see in the following pages, this was an exciting year of advances with the potential to touch millions of lives, worldwide. We explored how and why a child might find certain medicines bitter or otherwise unpalatable with the goal of developing new approaches to help oral medications go down a little more easily, whether to save a child in sub-Saharan Africa from the ravages of HIV infection or malaria, or to reduce the fever of a young neighbor here in Philadelphia. Expanding our foundational work in the odor signatures of disease, we took great steps toward developing a method to detect ovarian cancer in its earliest stages, when it is most treatable. We ignited the spark of discovery in the next generation of researchers through our Postdoctoral Training and Science Apprenticeship Programs. These promising young scientists will stand on our shoulders and look farther into Monell’s next 50 years of discovery. We shared our expertise with artists associated with the Pew Center for Arts and Heritage who are interested in building taste and smell into their public engagement projects, and we also hosted smell training workshops for individuals recovering from anosmia.

Multi-disciplinary collaboration – bringing the right partners and approaches together to ask new questions – is a hallmark of Monell’s success. Partnerships enable progress. Monell scientists value our strong, productive alliances with academic researchers across the United States, the United Kingdom, France, Sweden, China, Japan, and the Middle East and actively partner with more than 40 leading corporations in the U.S. and

abroad. These collaborations translate new knowledge about the chemical senses into better clinical practice and consumer products, and help strengthen global public health policy.

Our progress toward a safer, healthier future is only possible because of you and your strong support of Monell. We achieved great successes over the past year in the face of a challenging decline in federal funding for research, and are developing new partnerships to ensure our strong future. Now, more than ever, your support is vital to our mission. We are deeply grateful to have all of our partners – our donors, sponsors and collabora-tors – with us on our journey of discovery.

As we celebrate 50 years of biomedical breakthroughs, we look ahead with new perspective and ask tomorrow’s questions. How can we harness odor and taste receptors throughout the body to fight obesity, diabetes and hypertension? What will it take to restore smell through transplanting nasal stem cells? Can we develop sensory strategies that will lead people to choose a healthier diet?

From atop the shoulders of giants – our predecessors and our partners, old and new – Monell is sensing the future and accelerating the pace of discovery. We value your participation and invite you to join us in supporting our pioneering endeavor.

Thank you for being part of our enterprise. As partners, we are Changing the World.

R O B E R T F . M A R G O L S K E E , M D , P h DPresident and Director

Monell Chemical Senses Center

D W I G H T R . R I S K E Y , P h DChairman of the Board

Monell Chemical Senses Center

Potential Causes for a Rare Odor-Producing DisorderGenetic research provided new insight into the causes of the rare disease trimethylaminura (TMAU), characterized by the accumulation of a chemical that smells like rotting fish. “We now know that multiple genes may contribute to TMAU. These new genes may help us better understand the underlying biology of the disorder and perhaps even identify treatments,” said Danielle Reed, PhD. M

Now halfway through an 18-month project funded by the Bill & Melinda Gates Foundation, Monell researchers think the answer is, “Yes!”

All three conditions are treatable with life-saving, cost-effective medicines, but children often reject them due to their bad taste. Seeking to translate Monell’s broad, multi-disciplinary taste expertise, the Gates Foundation reached out to ask for potential solutions.

“Even the best drugs are not effective if children won’t take them,” notes Monell Director Robert Margolskee, MD, PhD, a molecular neurobiologist who leads the research team. “This important project leverages Monell’s collective strengths in sensory science and taste cell technology to reduce the awful tastes of life-saving oral medications.”

Focusing on four commonly-used medications, Monell’s initial proof-of-principle approach combines human sensory testing and cell-based taste screening assays.

Thus far, the sensory testing has revealed that the medicines produce the expected bitterness — and also sensations of astringency, sourness, and nausea. These findings indicate the need to go beyond blocking bitter receptors to effectively counteract all the undesirable sensory properties.

Supporting the sensory findings, research using Monell’s human taste cell cultures has identified multiple types of sensory receptors that appear to be stimulated by the medications. Still other studies have identified specific human bitter receptors that may be activated by the medicines, providing potential targets for the development of bitter-blocking compounds.

Moving forward, the research team will continue its work to identify effective solutions to the problem of bad-tasting medicines impeding pediatric compliance, with the broader goal of using taste biology to improve the palatability and effectiveness of oral medications worldwide.

A MATTER of TASTE

Cold and Bubbly: The Sensory Qualities that Best Quench ThirstOral perceptions of coldness and carbonation help to reduce thirst, the uncomfortable sensation caused by the need to drink fluids. “We have a decent understanding of what turns thirst on, but need to better understand what turns it off so we can motivate the elderly and other at-risk populations to keep drinking their fluids,” said Paul A.S. Breslin, PhD. M

Identifying Practical Solutions to a Deadly Problem

Can four Philadelphia taste scientists help save the lives of millions of children in sub-Saharan Africa and other developing regions who die each year from malaria, parasitic infections, and diarrhea? And can that knowledge be used to help children, everywhere?

Why do children reject certain life-saving liquid medications?

(L to R) Paul Breslin, PhD; Robert Margolskee, MD, PhD; Hakan Ozdener, MD, PhD, MPH; (inset) Peihua Jiang, PhD

MONELL CENTER ANNUAL REPORT | 02 • 03

MORE FROM MONELL . . .

MONELL: CHANGING THE WORLD R E S E A R C H

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The SCENT of DISEASE

Imagine if humankind had an accurate and reliable screening test for early stage ovarian cancer. This is Preti’s objective, and it is within reach, as he seeks to identify the distinctive odor signature of early stage ovarian cancer.

Informed by reports of dogs that have detected cancer in their owners and in the laboratory, Preti teamed with scientists from the University of Pennsylvania’s Nano/Bio Interface Center, Ovarian Cancer Research Center, and Penn Vet Working Dog Center to identify the unique smells produced by ovarian cancer — smells that are undetectable to the human nose.

In early studies, funded entirely by private donations, the team collected blood plasma samples from small groups of ovarian cancer patients, most of whom had advanced disease. Preti, a world-recognized expert on

the chemistry of human body odors, isolated the unique chemical mixture associated with the cancer-related odor.

Now, with a grant awarded this past year from the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation, Preti and colleagues are extending their focus to identify the chemical composition of odor signatures from patients with early stage ovarian cancer.

Associated studies will determine which chemical odorants provide the most specific and sensitive biomarker information for the different stages and subtypes of ovarian cancer. The ultimate goal, within reach in the next five years, is to use the odor information to customize a portable screening device capable of diagnosing the deadly disease at early, treatable stages.

The Social Costs of Smell Loss in Older WomenA study of older U.S. adults found that a woman’s social life is associated with how well her olfactory system functions. “Our findings confirm that the sense of smell is a key aspect of overall health in the aging population,” said Johan Lundström, PhD. “Over 20 percent of the U.S. population over 50 years old has a reduced sense of smell. We need to better understand how olfaction is linked to social behavior in order to improve quality of life as we age.” M

Taming an Unruly SenseNo one knows precisely how the brain interprets olfactory information. Using advanced data analysis, Monell scientists worked with researchers from around the globe to better understand how the brain transforms information from chemical molecules into the perception of a smell. “The models we created were not perfect, but we now know that there are some broad themes that we can use to understand olfactory perception,” said Joel Mainland, PhD. M

What is the next step in Monell’s research on ovarian cancer?

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Monell chemist George Preti, PhD, is on a quest to save women’s lives. Ovarian cancer – known as a silent killer – has the lowest survival rate of all female reproductive cancers, primarily because its early symptoms are difficult to detect. Most patients are identified in later stages of the disease, when treatment options are limited. Each year, approximately 250,000 women worldwide are diagnosed with ovarian cancer and 140,000 die of the disease.

George Preti, PhD

MORE FROM MONELL . . .

R E S E A R C H

Stopping a Silent Killer

MONELL CENTER ANNUAL REPORT | 04 • 05

MONELL: CHANGING THE WORLD

Starting even before birth, good nutrition underlies a child’s health, promoting growth and cognitive development and protecting against diet-related disease. But why does one child demand nothing but sweetened cereal while her next door neighbor loves to chomp down on spinach salad? And, once we know, can we apply this knowledge to influence healthy choices for a nutritious lifetime?

For the past three decades, Julie Mennella, PhD, has explored the question of why kids eat the foods they do. Her research focuses on the basic biology of taste in children and how they learn to like foods, with an eye toward understanding how individual preferences impact a child’s risk for disease. With over 175 scientific publications to date and hundreds of speaking engagements worldwide, Mennella is widely regarded as a go-to expert on the topic, often called upon to bring her knowledge to national and international organizations involved in formulating public health policy recommendations. This year, she served as a Nutrition Thought Leader on the National Institutes of Health Nutrition Research Task Force, which is charged with developing a strategic plan to guide NIH funding for research on nutrition-related diseases, and also on a similar panel for the Canadian government.

A sampling of Mennella’s recent publications demonstrates how she and her busy lab tease out the diverse determi-nants of early nutritional programming – biology, learning, and genes – in developing children. Some of her findings:

• Building on earlier studies showing that infants begin learning to like the taste of foods their mothers eat

during breastfeeding, a randomized clinical trial found that learning to like vegetables starts as early as two weeks after birth.

• By analyzing how infants communicate hunger and fullness during bottle-feeding sessions, Mennella’s group established an experimental approach to help identify bottle-fed babies most at risk for overfeeding and excess weight gain.

• Several studies examined liking for sweet taste in school-aged children, who not only like higher levels of the natural sugars sucrose (table sugar) and fructose (in fruits) than their parents, but also have a heightened liking for non-nutritive sweeteners, in part modulated by their taste genes. “While non-nutritive sweeteners reduce added sugars and the associated calories, they still teach children to expect high levels of sweetness in their foods and beverages,” commented Mennella. The combined findings reveal why children are particularly vulnerable to overconsuming sweet-tasting foods and beverages.

MONELL: CHANGING THE WORLD R E S E A R C H

Revealing How Early Nutritional Programming Shapes Lifelong Dietary Health

More than CHILD’S PLAY

Does Good-Tasting Food Cause Weight Gain?Most people think that good-tasting food causes obesity, but that is not necessarily so. “Good taste determines what we choose to eat, but not how much we eat over the long term,” said Michael Tordoff, PhD. M

Flavor is More Than the Sum of Its PartsFlavor results when the brain combines sensory information from taste, smell, and other qualities, but exactly how those qualities interact remains unclear. A study looking at taste-odor interactions found that sweet aromas can suppress bitterness. “This information may be of help in the formulation of more palatable medicines, particularly bitter-tasting liquid oral formulations used by young children, who have difficulty swallowing pills,” said Paul Wise, PhD. M

Julie Mennella, PhD

How can breastfeeding mothers encourage their infants to like vegetables?

MORE FROM MONELL . . .

Find the answer at M

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MONELL CENTER ANNUAL REPORT | 06 • 07

ASPIRATION AND ACTIVISM IN AFRICAArmed with determination and fortitude, Shadrack Frimpong is personally changing the world.

Born in the impoverished village of Tarkwa Breman in Ghana, he made his way to the University of Pennsylvania, where he found himself overwhelmed and soon began to doubt himself.

Frimpong found his answer in the summer of 2012, working with Hakan Ozdener, MD, PhD, MPH, as a participant in Monell’s long-standing Monell Science Apprenticeship Program (MSAP). In Ozdener’s lab, Frimpong found himself challenged not only to become a productive scientist, but also someone who could make a difference.

“WOW, for the first time in life someone believed that I could take on anything on my own! This seed of faith and belief you sowed in me has been the springboard of where I am today,” Frimpong wrote to Ozdener in March 2015, the day after it was announced that he was one of five recipients of Penn’s $150,000 Presidential Engagement Prize.

After Penn, Frimpong returned to Ghana, founding Cocoa360 (initially known as the Tarkwa Breman Community Partnership), and using his prize money to establish a school for girls, who historically lack educational options, and open a medical clinic.

Recognizing that women scientists were critical to Africa’s ability to contribute to emerging technologies and medical innovation in the developing world, he went on to found the African Research Academy for Women, an organization devoted to encouraging STEM careers in African women.

Not yet 25 years old, this remarkable young man continues to aspire to make the world a better place for those in need. Recognizing the importance of staying connected to his mentors, he recently returned to Monell to share his story at a MSAP fund-raiser. With the career goal of becoming a physician-scientist who can tackle problems of infectious disease in underserved commu-nities, Frimpong next plans to attend medical school in the U.S.

One can only imagine what he will do after that.

DEVELOPING SCIENTIFIC LEADERSHIP

Advancing discovery means training the next generation of scientific leaders. Immersing the world’s best and brightest scientists in Monell’s trans-disciplinary approach to chemosensory science, thus preparing them for leadership, has been a core principle since the Center’s inception. This past year, over 30 scientists at all levels of professional development benefitted from training at Monell. These leaders will move on to positions in academia, industry and government across the globe, bringing their Monell training and perspectives to touch many worlds and countless lives.

Sensory neuroscientist Sanne Boesveldt, PhD, exemplifies how Monell’s postdoctoral fellows integrate disciplines to forge the future of chemosensory research.

Now Assistant Professor of Sensory Science and Eating Behavior at the Wageningen University Division of Human Nutrition in the Netherlands, Boesveldt spent two years at Monell as a postdoctoral fellow in the lab of Johan Lundström, PhD. During that time, she co-authored nine papers, seven as first author, integrating her interests in olfactory perception, brain neurobiology, and human food choice.

Boesveldt’s research interests led her to a focus on anosmia, loss of the sense of smell, a condition that until recently has received little attention from the scientific community. In 2015, she co-founded the Netherlands’ first center for taste and smell disorders, which combines scientific research with health care. She then convened a symposium on anosmia at the 2016 AChemS taste and smell research conference, integrating presentations from a patient, a clinician, and two research scientists to present a rounded snapshot of what currently is known about anosmia. This year, she published a comprehensive review paper that identified knowledge gaps to guide future anosmia research, and co-authored with Lundström a study on the social consequences of smell loss.

Boesveldt credits her time at Monell as an influential step in her career. “Through Monell, I gained impressive credentials that add strength and value to my grant applications and professional interactions,” she said.

Looking to pay it forward and inspire the next generation of scientists, Boesveldt co-founded WIOS, Women in Olfactory Science, an international organization that seeks to advance women as scientific leaders. The organization’s first research conference takes place in October 2017 in Trieste, Italy.

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Shadrack Frimpong takes a spin with children at the Tarkwa Breman School in Ghana

How is Monell helping to build a healthier and more knowledgeable world?

MONELL CENTER ANNUAL REPORT | 08 • 09

Sanne Boesveldt, PhD

MONELL: CHANGING THE WORLD T R A I N I N G G L O B A L L E A D E R S

MONELL: CHANGING THE WORLD

GLOBAL REACHThis past year, Monell scientists engaged with sponsors around the globe, leading the way to a healthier future for all of us.

NORTH AMERICA

56 MIDDLE EAST

2 ASIA20

AFRICA1

SOUTH AMERICA

2

ENGAGEMENTSponsors benefit from first opportunity to license Monell intellectual property, as demonstrated by a high rate of successful commercialization.

2016 – 2017 MONELL IP ACTIVE DISCLOSURES

C O R P O R A T E S P O N S O R S H I PFor 50 years, Monell has been at the vanguard of academic-industry partnerships, leveraging basic scientific discovery into real-world solutions.

CORPORATE SPONSORS 2016-2017

GlaxoSmithKline Heng Yuan Xiang China (Group) Co., Ltd.Intelligent Sensor Technology, Inc. (INSENT)International Flavors & Fragrances Inc.Japan Tobacco Inc.Johnson & JohnsonKao CorporationKellogg CompanyKerryMarsMcCormick & Company, Inc.Mead Johnson NutritionalsMondelēz InternationalOgawa & Co. Ltd.

Panasonic IncPepsiCo, Inc.Pfizer, Inc. Procter & GambleProduce Marketing AssociationSuntory Holdings Ltd.SymriseTate & LyleTakasago International CorporationUnilever Research & DevelopmentWm. Wrigley Jr. CompanyYoung Living Essential OilsZensho Holdings Co. Ltd.

AFB International Inc.Air LiquideAjinomoto Co., Inc.Altria Group Asahi Group Holdings Lmtd.Campbell Soup CompanyThe Coca-Cola CompanyCoty Inc.Diageo, plcDiana IngredientsEstée Lauder Companies, Inc.Firmenich IncorporatedGeneral MillsGivaudan SA

LICENSED OR OPTIONED BY SPONSORS FOR COMMERCIALIZATION

IN COMMERCIALIZATION DISCUSSIONS WITH SPONSORS

F I N A N C I A L SRevenue for the Monell Center comes principally from three sources: competitive federal grants to our scientists; corporate sponsorships and sponsored basic research; and philanthropic gifts and grants from individuals and foundations. Federal grants have traditionally been the largest source of funding for Monell. However during this fiscal year and last, each of the three major sources of funding were critically important. Total revenues fell by 13 percent this fiscal year compared to last, while total expenses were 6 percent lower. Monell reserve funds were used to cover the shortfall. We expect federal grant revenue to rebound during the next fiscal year and anticipate a return to a balanced budget. The Center is grateful for the continued generosity of the Monell Foundation, the Center’s founding funder and largest private donor.

TOTAL REVENUES: $12, 333,561

TOTAL EXPENDITURES: $13,837,187

25%

11%

29.7%

10.8%

32.7%

26.8%

PHILANTHROPY

OTHER

CORPORATE SPONSORS

FEDERAL GRANTS

73.9%RESEARCH PROGRAMS19.5% ADMINISTRATION

6.6% FUNDRAISING

★ MONELL PHILADELPHIA, PA, U.S.

MONELL CENTER ANNUAL REPORT | 10 • 11

EUROPE18

Osama Ahmed David Allison Wilbur Amand Gerald and Sandra Ambrozy Anonymous Donna AntonucciAnahi Baca Jessey Baker Linda Ballrick Doug L. BayleyAnne M. Belcher Nuala Bobowski Nataliya P. Bosak Holly Bowers Rachel Brown Lyn M. Buchheit Helen Butler Jin and Dani Cao Ken CarlstenJodie Carr Gurbuz Celebi Philip and Mary Ann ChristensonWalter and Kathi Clayton Anthony Commesso Ed and Geralyn CovingtonBeverly Cowart Sheri-Ann Cowie Elizabeth CumminsPamela Dalton Edward DandridgeConan de Vries Philip Devitte Di Bruno Bros. Charles Dilks Dieuwke Dillo Wiguensly DorelusJason Eades Robert Elias Richard Elliott Bard Ermentrout William Fidler Adarrel Fisher Mimi Fisher Corbett Foster

Michelle Gallagher-Frail and Paul Frail Donna FrancoDavid E. Gabl Alan Gelperin Stephanie GervasiMarilyn Getchell Ann Giampietro Brian Gilbert Alfred E. GoossensNicole Greenbaum Ellen GreeneNeil HammerstromGiovanna C. Hansen

Bonita Hay Dorothy Hayes Linda Hayes HollidayTracey A. Hewitt Tersia Hibbard Cliff Holmes Joy Horwitz Liquan Huang Samantha Huge Carmelina Ignelzi John Ivers Shusuke Iwata William W. Jacobs, Jr.

Cristina Jaen Gail Jaffe Julapa Jagtiani Mary Beth JamesPeihua Jiang A.T. Charlie JohnsonPaule Joseph Masafumi Jotaki Adrienne Junek Susan KareJohn Kauer Christine Kelly Don Kimelman Frazierita Klasen

Daniel and Deborah KnoxSusan Knox Donna M. KupniewskiHarry T. LawlessWeiwei Lei Harriet Lembeck Brian LewandowskiLil Pop Shop Charisse LillieLittle Baby’s Ice CreamMary MacArthur Kathleen MadiganJoel Mainland

Daniel Malamud Charles H. ManleyTeresa Maone Talia D. Martin Ichiro MatsumotoRichard Mattes Daneil Mazone Robert McGorrin Erin Mierzwa Takenori MiyamotoModern Strategic Branding + CommunicationsMaxwell M. MozellYuko Murata

Claire Murphy Michael Naim James Narron Huong Lan NguyenMarek Niklas Lisa Norris-Downing and Arnold DowningMatt O’Keefe Maureen O’LearyHilary O’Neil Linda Oraha Vera Orthlieb Kazumi Osada

James J. AlbrechtAlcresta Therapeutics Altria GroupArthur and Carolyn Asbury Mary E. Bak Margaret Bath Gary and Fay BeauchampRobert Bedoukian, Bedoukian ResearchRaymond and Barbara Bendure Berje, Inc. Richard L. BerkmanMary Bertino Paul Breslin Robert H. CaganSusan W. Catherwood Carol ChristensenDarlene ClarkHilda & Preston Davis Foundation Dolf DeRovira Jeannette DesorGrant DuBois Robert EilermanThe Charles E. Ellis TrustEugene E. Garfield*

Bill & Melinda Gates FoundationRobert Goldstein Robert W. Harkins Deborah L. Hayes Jane E. Henney John and Teresa HickeyJade YogaPhilip S. Johnson Kaleidoscope of Hope FoundationKerry Takeshi Kimura Christina Kind Kenneth Kind Andrew Kindfuller Valerie Kind-Rubin Robert J. Kleberg Jr. and Helen C. Kleberg FoundationJohn N. Labows Alan I. Leshner Dale Lowry William J. Ludlum The Christopher Ludwick Foundation Stephen R. Manheimer Robert F. Margolskee Laura Kind McKenna David Jason Mela The Ambrose Monell Foundation Ambrose K. Monell

Maurizio J. Morello Kumiko Ninomiya Yuzo Ninomiya Sam Rao Dwight R. RiskeyGail E. Seygal John Shapiro, Shapiro-Silverberg FoundationLouise Slade The Society of Flavor Chemists Lewis S. Somers, 4th Andrew SpielmanMonica Taylor Lotty Jeng-chyi Tsai The Wawa Foundation Judith Wellington Hiroko YamazakiTomoko Yamazaki William N. Zeiger

Susan Knox | PREPARING ME TO BE A SCIENTIST

I am a PhD student in Chemistry at Yale University with a focus on chemical biology, and can firmly state that the Monell Science Apprenticeship Program prepared me to be here today. Learning to read scientific literature, even without a high-level science background, during the MSAP journal club taught

me how to interpret tough material. Through poster presentations, I gained public speaking skills that increased my confidence

in explaining science to others. I want to support other young people who want to be a part of the Apprenticeship Program and am proud that my parents have matched my contribution. M

M A N Y T H A N K SOne of our greatest pleasures is to

thank you – the friends, alumni, employees, foundations, and businesses – who support Monell’s research mission

through philanthropic gifts and grants. Below, we gratefully recognize your

donations received between July 1, 2016 and June 30, 2017.

MONELL CIRCLE ($1,000+)

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MONELL: CHANGING THE WORLD D O N O R S 2 0 1 6 • 2 0 1 7

*Deceased

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M. Hakan OzdenerMary K. Parker Charles PetersonPew Center for Arts & Heritage Philadelphia Activities FundBennett G. Picker and Terry RogalRachel Poole Michael D. Pratt George Preti Edmund A. PribitkinRoslyn Price Matthew B. Price Beth Probinsky Jim and Shirley Puhl Yumei Qin R2L, Daniel SternKhannan RajappanKrystyna M. RankinFrederick RansierNancy E. RawsonPaul Rawson Tara Redmond Jeanne RentezelasLauren Rogers

Peter Jon Rogers Jeanne Rose Louis and Clara Ruvolo Joseph Salkowitz Maurice Savard Savoury Systems Elizabeth K. Secor-WoyGreg Shaffer Bassam ShakhashiriAlan Shelton Gordon M. ShepherdRachel Shorey

Theresa SingletonSlidemakers Rachel Smart Sharon Smith-JonesLindsey Snyder Leslie Stein Lenore SteinmetzCharles N. StewartElizabeth Somers StutzmanSunil Sukumaran Annalee SwitekAnthony Tann

Hideki Tateba Elisabeth TeelucksinghSarah TentlerNicholas M. TerminiChristopher and Anilet Tharp Elisabetta Tonelli-SippelJenifer TrachtmanMr. and Mrs. John K.T. TranAlyssa Treff Jill TreffCasey Trimmer

To view a full list of consistent, long-term support of the Monell Center, consecutive year donors, and donors by affinity group, please visit www.monell.org/thankyou.

Kerry | COMBINING TASTE, SMELL AND NUTRITION

Kerry is a global leader in taste and nutrition serving the food, beverage and pharmaceutical industries. Thirteen years ago we acquired J. Manheimer Inc

and brought on board not only a thriving business but also the expertise of Stephen Manheimer, now an executive VP at Kerry. In 2014, Steve,

a long-time Monell friend and advisor, brought us an opportunity to support Monell’s anosmia research. We were eager to invest and participate given smell and aroma are a large part of the taste experience. Millions of individuals worldwide experience loss of smell and many, including the elderly, do not eat a healthful and varied diet as a result of their anosmia. Monell is bringing the world closer to solutions each

day through its anosmia research and Kerry is proud to support their efforts. M

Deborah Hayes | COMBINING PASSIONS

When Susan Catherwood first suggested that I consider joining the Monell Board of Directors, I remember thinking, “What in the world do these people want a

communications professional to do, at an organization about smelling?” But I was able to provide advice and soon became enthralled with how Monell’s

scientists and their research impact health.

I began to support Monell’s summer apprenticeship program because I have always been an active mentor to young people. Recently, I hosted a fundraiser to introduce my friends and colleagues to the program. Who knew that together we could raise enough money to support two students this summer? Then, when I had the opportunity to have a roundtable discussion

with this year’s apprentices, I jumped at it! What better way to combine my dedication to mentorship and my passion for Monell? M

Catherine Tyree-DavisHong WangIra Warder, Jr. Stephen WarrenburgHoward Wilk Catherine WilliamsDon C. Williams Mr. and Mrs. Herbert WilsonVerner and Patricia Wilson

Monica P. Winter Paul Wise Colin Wolfe Jiang Xu Ronald Yarger Toskiaki Yasuo Karen Kalun Yee Young Living Essential OilsDebra A. Zellner

*Adrienne Junek | GIVING AND PERSONAL CONNECTION

I’m a family doctor pursuing a fellowship in integrative medicine, which incorporates complementary health approaches with Western medicine. I came across Monell’s research through one of our teaching modules and it struck me as a perfect match

between my interests and professional goals. As a dog owner, I was interested to hear about Monell’s work with dogs detecting cancer

using scent a few years ago – I wanted to support your cause, so went online and made a contribution. M

TO DISCUSS A GIFT TO MONELL, please contact Jenifer Trachtman, Director of Development, at 267-519-4715 or jtrachtman@monell.org.

Visit www.monell.org/giving to make a secure online contribution.

Every effort has been made to ensure the accuracy of these lists. If we have inadvertently misspelled or omitted your name, please accept our apologies and notify Jenifer Trachtman.

MATCHING GIFT COMPANIESAmazon Smile FoundationColgate-Palmolive CompanyGE FoundationInternational Flavors & FragrancesThe Kresge FoundationJohnson & JohnsonThe William Penn FoundationThe Pew Charitable Trusts

MONELL CENTER ANNUAL REPORT | 14 • 15

FACULTYGary Beauchamp, PhDPaul Breslin, PhDBeverly Cowart, PhDPamela Dalton, PhD, MPHLiquan Huang, PhDPeihua Jiang, PhDBruce Kimball, PhDGraeme Lowe, PhDJohan Lundström, PhDJoel Mainland, PhDRobert Margolskee, MD, PhDIchiro Matsumoto, PhDJulie Mennella, PhDGeorge Preti, PhDNancy Rawson, PhDDanielle Reed, PhDJohannes Reisert, PhDAmos B. Smith, III, PhDMarco Tizzano, PhDMichael Tordoff, PhDHong Wang, PhDPaul Wise, PhDYali Zhang, PhD

ADJUNCT FACULTYNoam Cohen, MD, PhDYuzo Ninomiya, PhD, MDSciLuis Saraiva, PhD

EMERITUS FACULTYJoseph Brand, PhDBruce Bryant, PhD Mark Friedman, PhD Alan Gelperin, PhDMarcia Pelchat, PhD Charles J. Wysocki, PhD

RESEARCH ASSOCIATESCristina Jaén, PhDWeiwei Lei, PhDCailu Lin, PhDMakoto Ohmoto, PhDM. Hakan Ozdener, MD, PhD, MPHCatherine Peyrot des Gachons, PhDSunil Kumar Sukumaran, PhDJiang Xu, MDKaren Yee, PhD

POSTDOCTORAL FELLOWSFederica Genovese, PhDStephanie Gervasi, PhDAkihito Kuboki, MDBrian Lewandowski, PhD Gary K. Beauchamp Director’s Fellow

Young Eun Lee, PhDPatrick Millet, PhDAlissa Nolden, PhDCarolyn Novaleski, PhDCasey Trimmer, PhD Morley R. Kare Fellow

ADMINISTRATIONRobert Margolskee, MD, PhD Director & President

Carol M. Christensen, PhD Director, Institutional Advancement

David Gabl, MST, CPA Controller

Nicole Greenbaum Research Grants and Contracts Specialist – Pre-Award

Donna Kupniewski Director, Facilities Management

Maureen O’Leary, PhD Director, Technology Transfer

Rachel Poole, PhD Research Grants and Contracts Specialist

Nancy Rawson, PhD Associate Director

Tara Redmond, MBA Human Resources & Employee Benefits Manager

Danielle Reed, PhD Associate Director

Greg Shaffer Director, Information Technology

Leslie J. Stein, PhD Director, Science Communications

Jenifer Trachtman, MBA, CFRE Director, Development

John K.T. Tran, MS, CRA Director for Finance & Administrative Services

S C I E N T I S T S A N D A D M I N I S T R A T I O N

B O A R D A N D A D V I S O R SMONELL: CHANGING THE WORLD

BOARD OF DIRECTORS

Dwight R. Riskey, PhD (Chair) Principal, Riskey Business Solutions LLC

Robert F. Margolskee, MD, PhD Director & President, Monell Chemical Senses Center

Richard L. Berkman, EsqOf Counsel, Dechert LLP

Susan W. Catherwood Board Member, The Glenmede Trust, N.A. Board Member, The Pew Charitable Trusts

Garret S. FitzGerald, MD, FRSProfessor of Medicine & Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania

Deborah L. HayesSenior Vice President of Corporate Affairs, Federal Reserve Bank of Philadelphia

Philip J. Johnson, EsqSenior Vice President, Intellectual Property, Policy & Strategy (retired), Johnson & Johnson

Alan I. Leshner, PhDChief Executive Officer Emeritus, American Association for the Advancement of Science

David Macnair, PhDVice President, Global Petcare Research & Development (retired), Mars Petcare

Ambrose K. MonellPresident and Director, The Ambrose Monell Foundation & The G. Unger Vetlesen Foundation

Maurizio Morello, EsqDirector, The Ambrose Monell Foundation & The G. Unger Vetlesen Foundation Partner, Fulton Vittoria LLP

Louise Slade, PhDPrincipal, Food Polymer Science Consultancy

BOARD OF DIRECTORS EMERITUS

Arthur K. Asbury, MD Van Meter Professor of Neurology Emeritus, University of Pennsylvania

INTERNATIONAL ADVISORY COUNCIL

Todd Abraham, PhD (Chair)Senior Vice President, Research, Development & Quality (retired), Mondelez International

James J. Albrecht, PhDConsultant to Food Industry and Agribusiness

Margaret Bath, PhDSenior Vice President (retired), Kellogg Company

Ahmet Baydar, PhDExecutive Vice President (retired), Flavor & Fragrance R&D, International Flavors & Fragrances

Robert Eilerman, PhDFormer Senior Vice President, Global Flavor Science & Technology, Givaudan Corporation

John D. Fernstrom, PhDProfessor of Psychiatry, Pharmacology & Behavioral Neuroscience, University of Pittsburgh School of Medicine

Takeshi Kimura, PhDMember of the Board, Corporate Vice President for Research & Development, Ajinomoto Co., Inc.

Stephen ManheimerVice President, Kerry

Shawn M. MarcellChairman & CEO, ReadCoor, Inc.

Charles M. Peterson, MD, PhDSenior Advisor, U.S. Army Medical Research and Materiel CommandPresident, MarquiSci

Arthur H. Rubenstein, MBBChProfessor of Medicine, Division of Endocrinology, Diabetes and Metabolism, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania

Judith Wellington, PhDPresident & CEO (retired), Clay Center for the Arts and Sciences

MONELL HAS ADVANCED SCIENTIFIC DISCOVERY FOR 50 YEARS, LEADING THE WAY TO A HEALTHIER AND SAFER WORLD. TO LEARN MORE:

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