monthly prostaglandin bibliography prepared by the university of sheffield biomedical information...

TWICE MONTHLY BlBLIOGRAPHY ON PROSTAGLANDINS BIOLOGY- EARLY FEBRUAtRY PREPARED BY SHEFFIELD UNIVERSITY BIOMEDICAL INFORMATION SERVICE

SHEFFIELD 5310 2TN

1. BOORS, ~RWS, SYMPOSIA Honn KV, Mamett LJ, Nigam S, Walden T (eds) Kluwer Academic Pub&hers 1991. pp 512. ISBN O-7923-1303-8. UsSI2%OO. Eicoaanoids and other bioactive lipids in cancer and radiation injury.

2. GENERAL Bikbaxi AB, Lakkis NM, Abu~hebade KD// Amer U&Beirut, flept Physiol, 850 3rd Ave. New York. NY 10022. USA J PI&RM sCI’1991,&J (ri) 111a ~ium~e~nden~ retention of prostaglan- dims in rat ileum.

PREcURSoRs 4. Arachidonie Acid Marin P, Delumeau JC, Tence M, Cordier 3, Glow&&i J. Premont J// Lab Neuropharma- col, INS, U114, Cellcge de F&=x, 11 PI Marcelin Berlhelot, F-75231 Paris Cedex 05, France PRGC NAT ACAD SCI USA 1991,88 (20) 9016-9020 Somatostatin potentiates the alphal-adrener- gie activation of ph~h~i~ C in striataf astrcqtes through a mechanism involving arachidonic acid and glutamate,

Cooke BA, Dirami G, Chaudry L, Choi MSK, Abayasekara DRE, Phiip I& Rq%l Free Hasp, Sch Med, Dept Biochem, Row- land Hill St, London NW3 ‘ZPF, England .I STEROID BIGCHEM MOL BIOL 1991, 40 (2.3) 465 Release of arachiionic acid and the effects of cortieosteroids on steroidogenesis in rat Ces- tis Leydig cells.

Alam SQ, Bergens BM, Alam I&‘/ Louisiana State Univ, Med Ctr, Dept B&hem & Molec Biol, 1100 Florida Ave, New Orleans, La 70119, USA LIPIDS 1991,26 (11) 895 Arachidonic acid, prostaglandin I%? and leukotriene C-4 levels in gingiva and subman- dibular salivary glands of rats fed diets eon- taining N-3 fatty acids.

Rice GE, Baker MS// Monash Univ, Dept Physiol, Clayton, Vie 3168, Australia GEN P~~ACO~ 1991,22 (6) 1109 The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes.

Kato K, Urono K, Saito K, ffito H//Wash- ington Univ, Seb Med, Dept Psychiat, 4940 Audobon Ave, St Louis, MO 63110, USA BRAIN RES 1991,563 (l-2) 94 Both arachidonic acid and I-oleoyl-2-acetyl glycerol in low magnesium solution induced long-term ~~entiation in hippocampal CAT neurons in vitro.

Breton M, &lard Of/ CHU St Antoine, CNRS, Unite Biochim, URA 1283,27 rue Chaligny, F-75571 Paris, France ~IOCH~ J 1991,280 (Nat) Pt I, 93 Protein kinase-C promotes aracbidonate mo- bilization through enhancement of CoA-independent transacylase activity in platelets.

Buckley BJ, Barcbmky A, Dolor RJ, Whor- tan AR& Duke Univ, Med Ctr, Dept Med,

Durham, NC 27714 USA BIO~IEM J 1991,280 @EC) P&281 Regulation of arachidonic acid release in vas- culat endothelium - Ca2 +-dependent and Ca2 + -independent pathways.

Mimouni V, Cbristiansen EN’, Blond JP, Ul- mann I., Poisson JP, Bezard J// l Univ Oslo, Inst Nutr Res, POB 1046, N-0316 Oslo 3, Norway BIOCHIM BIOPIIYS ACI-A 1991,1086 (3) 349 Elongation and desaturation of arachidonic and eicosapentaenoic acids in rat liver - Ef- feet of ciofibrate feeding.

Pivovarov AS, Droxdova El, Kotlyar BI/I MV Lomonosov State Univ, Fat Biol, Dept Higher Nervous Act, Moscow 117234, USSR ZH VYSS NERV DEYAT PAVL SSSR 1991,41(d) 796 Arachidonic acid and its acyclic derivatives regulate short-term plasticity of Helix neur- ones cholinoreceptors (Russian)

5, PROSTAG~D~NS E AND F Wolf R, Rommel W, Richter A, Bier H, Tschauschev P// Karl Mant Univ, Wiinsch Bereich Fortpflanzung Landwirtsch Nutztiere, W-7010 Leipzig, FRG ARCH EXP VEI’ERINARMED 1991,4S (1) 67 Studies into ~ch~n~tion of oestrus and ovulation in mutton Merino sheep - 1st com- munication - effect on mutton Merino sheep of Gonavet Berlin-Cbemie, following pmstaglandin IQ-alpha oestrus synchronisation (German)

Nagata T, Kido J, Hamasaki A, Ishida H, Wa- kano Y/i Univ Tokushima, Sch Dent, Dent Periodonto % Endodontoi, 3 &ran&o bo, Tokushima 770, Japan J ENDODGNI’ 1991,17 (12) 594 Regulation of glycosaminoglycan synthesis by parathyroid hormone and prostaglandin-I?2 in cultured dental pulp cells.

F$eren MWJA, Vandenbe~ GJCM, Bene- fraim S, Bonta II.& Erasmus Univ, Hasp Dijkzigt, Dept Internal Med 1, Dr Molewater- plein 40,3015 GD Rotte~arn, Netherlan~ IMMUNOL LEZIT 1992,31(l) 85 P~~agfandin-~ inhibits the release of tumor necrosis factor-alpha, rather than interleukin-1 beta, from human macrophages.

Candela M, Barker SC, Ballou LR’N ‘Univ Tennessee Ctr With Sci, Dept Med, Div Con- nect Tissue Dis, 956 Court Ave, Memphis Tn 38163, USA J EXP MED 1991,174 (6) 1363 Sphingosine synergistically stimulates tumor necrosis factor-slpha-induct prostaglandin- U production in human fibmblasts.

Fyda DM, Cooper KE, Veate WI.# Dept Med Physiol, Fat Med, Univ Calgary, Cal- gary, Alberta, Canada T2N 4Nl J PHYSIOL (LGND) 1991,442 337 Nueleus traftus solitarii lesions alter tbe metabolic and bypertbermic response to central prostaglandin El in the rat.

Aizu E, Yamamoto S, Nibikawa K, Kate R /l *Keio U&v, SEh Med, Dept Pbarmacol, 35

~inan~~~ Shinjuku ku, Tokyo 260, Japan JPN J Pan 199& 57 (3) 361 Synergistic dirndl of ~~-~ release by epidem1 grow% factor and a tumor piwnoter antbralin from primary cul- tures of mouse epidermal cells.

Ruf A, Patscheke H, Morgenstcm EL// *Univ Saarland. W&!Kl Hornburp. PaG THROMB IQ&I&m 1991,&i 6) 308 Role of ~~~~ti~ in p&let activation induced by collagen fibem - DiKere&al effects of aspirin, cytocbalasin-D, and prostaglandin-El.

Raper RF* S%baId WJ’, I-k&on J, R&edge FS// *Victoria Hoq Richard Ivey Crit Care Trauma Ct r, 375 South St, London, Ontario, Canada N6A 4GS CHEST 1991,100 (6) 1703 Effect of PGEl on altered distribtuion of re- gional blood flows in ~~a~i~ sepsis.

Iwamoto H, Sakamoto S*, Nawata Ii!/ ‘Kyushu Univ, Fat h&d, Dept ;ntarnal Med 3,3-l-l Maidashi, Fukuoka 812, Japan ~~A~O~Y 1991,X4 (6) 1123 Serum factor from patients witb cirrhosis and hepatocelhdar carcinoma enhancea production of prostaglandinZ2 hy U937-ceIls.

Mikawa K, Maekawa N, Goto R, Yaku H, Takao Y. N~hina K Ohara HN Kohe Univ. Sch Med; Dept Anaksthesiol, &sunoki chd 7, Chuo ku, Kobe 650, Japan J INT MED RE!S 1991,19 (6) 457 Prostaglandin-El and tracheal intubation - relationship between the csrdiovaseuiar responses and piasma Patecholamine concentra- tions.

Okada S, Mii Y, Sato K, Higuchi T, Icbiki K, Tanokuchi S, kbii R, Hamada &I, Ota z(f Okayama Univ. Sch Med, Dept Med 3, Okayama 700, Japan J INT MED RES 1991,19 (6) 493 Decreased creatinine clearance which may be observed during pmstaglandin-El therapy - is it reversible with d~ntin~tion of tber-

aw’

Okada S, Ogino Y, I&&i K, Tanokucbi S, Ishii K, Hamada H, Ota Z, Hiraki Y// Okayama Univ, Sch Ned, Dept Med 5 Okaysma 700, Japan J INT MED RES 1991,19 (6) 497 Effect of prostaglandin-El on renal baemody- namics in a patient with diabetic nephro- parhy (Case Report)

Whittier JM, Oconnor CX// Univ Queen- sland, Dept Anat, St Lucia, Qld m72, Austra- lia COMP BIOCHEM PHYSIOL IT A 1991, loo (4) 881 P~~~andin F-2alpha, sexual behavior and ovarian estrogen synthesis in garter snakes (Thamnophis sirtalis parietalis)

Bennegard B, Hablii M, Weaaberg I$ Noren H// Gotbenbu~ Univ, Sablgrens Hasp, Dept Obstet & Gynecol, S-41345 Go- tbcnburg, Sweden mRT SI-ERIL 1991,!% (6) 10M Local luteolytic effect of prostaglandia F2alpba in the human corpus b&cum,

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Michael AE, Webley GE# Royal Free Hasp, Sch Med, Dept Biochem, Rowland Hill St, London NW3 2PF, England MOL CELL ENDOCRINOL 1991,82 (2-3) 207 Prostaglandin-FJalpha stimulates CAMP phosphodiesterase via protein kinase-C in cultured human granulosa cells.

Koxawa 0, Tokuda H, Miwa M, Kotoyori J, Oiso Y// Aichi Prefectural Colony, Inst Dev Res, Dept B&hem, Kasugai, Aichi 48003, Japan EXP CELL RES 1992,198 (1) 130 Cross-talk reeulation between cvclic AMP production aid phosphoinositide hydrolysis induced by pmstaglandinE2 in osteoblast- like cells.

Whittier JC, Caldwell RW, Anthony RV, Smith MF, Motrow RE// Univ Missouri, Dept Anim sci, Columbia, MO 65211, USA J ANIM SCI 1991,69 (12) 4678 Effect of a prostaglandin F-2alpha injection % hours after introduction of intact bulls on estrus and calving distribution of beef cows.

Slama H, Vaillancourt D, Gaff AK// Univ Montreal, Fat Med Vet, Ctr Rech Reprod Anim, St Hyacinthe, Quebec, Canada J2S 2C6 THERIOGENOLOGY 1991,36 (6) 1071 Pathophysiology of the puerperal period - Re- lationship between prostaglandinE2 (PGE2) and uterine involution in the cow.

Cavallini G, Franc0 L, Brocco G, Orlandi PG, Riela A, Manara P, Pavesi V, Velo G // Policlin Borg0 Roma, Med Clin, 1371?4 Verona, Italy ITAL J GASIROENTEROL 1991,23 (8) 487 Measuring gastric PGE2 release in healthy and alcoholic subjects after ethanol stimulation.

6. PROSTACYCLIN Vergote IB, Vandam PA, Laekeman GM, Keersmaeckers GH, Uyttenbroeck FL, Her- man AG// Norwegian Radium Hosp, Dept Gvnecol Oncol. N-0310 Oslo 3. Norway TUMOR sroi ml,12 (5) 261 _ Prostacyelin/thromboxane ratio in human breast cancer.

Danon A, Prajgrod G// Ben Gurion Univ Negev, Carob-Ctr Hlth Sci, Dept Clin Phar- macol. POB 653. IL-84105 Beer Sheva, Israel AGEI;JT ACI-IdN 1991,34 (34) 416 Glucocorticoids regulate prostacyclin syn thesis and response to lipopolysaccharide in the rat aorta.

Halldorsson II, Magnusson MK, Thorgeirs- son GO// l Univ Iceland, Dept Pharmacol, POB 8216, IS-128 Reykjavik, Iceland EUR J PHARMACOL-MOLEC PHARM 1991,208 (3) 193 Different mechanisms of homologous and he- terologous desensitization of thrombin-induced endothelial prostacyclin production.

Katoh K, Mizuno K, Sanada H, Haga H, Fu- kuchi S// Fukushima Med Sch, Dept Internal Med, Fukushima 96912, Japan RES COMMUN CHEM PATHOL PHARM 1991,74 (2) 185 Effect of aging on endothelin-induced prostaglandin- release in isolated hind legs of the spontaneously hypertensive rat.

Hayashi T, Kaji T, Hayakawa y, Niiya K, Sa-

kamoto M, Sakuragawa N// Toyama Med & Pharmaceut Univ, Fat Med, Dept Clin Lab Med, 2638 Sugitani, Sugitani, Toyama 93001, Japan THROMB RES 1991,64 (3) 321 Inhibitory effect of heparin cofactor-II on thrombin-stimulated prostacyclin production by cultured vascular smooth muscle cells.

Force T, Milani R, Hibberd P, Lorenz R, Ue- delhoven W, Leaf A, Weber P// Massachu- setts Gen Hasp, Med Serv, Bigelow 840, Bos- ton, Ma 02114, USA CIRCULA’IION 1991.84 (6) 2286 Aspirin-induced decline in’p&tacyclin production in patients with coronary artery disease is due to decreased endoperoxide shift - Analysis of the effects of a combination of aspirin and n-3 fatty acids on the eicosanoid profile.

Pluta R// Polish Acad Sci, Med Rea Ctr, Dept Neuropathol, 3 Dworkowa Str, PI_.- 00784 Warsaw. Poland J HIRNFORSCH 1991,32 (2) 175 The effects of prostacyclin on early ultrastruc- tural changes in the cytoplasm and nuclei of neuroglial cells following complete cerebral ischemia.

Emori T, Hirata Y*, Marumo F// *Tokyo Med & Dent Univ, Dept Internal Med 2,1-5- 45 Yushima, Bunkyo ku, Tokyo 113, Japan J CARDIOVASC PHARMA COL 1991,17 (S7) s140 Endothelin-3 stimulates prostacyclin production in cultured bovine endothelial cells.

Nakaki T, Ohta M, Kato Rf/ Keio Univ, Sch Med, Dept Pharmacol, 35 Shinanomachi, Shinjuku ku, Tokyo 160, Japan J CARDIOVASC PHARMACOL 1991,17 (S7) s177 Inhibition of endothelin-1 induced DNA synthesis by prostacyclin and its stable analogues in vascular smooth muscle cells.

Filep JG, Herman F, Battistini B, Chabrier PE, Braquet P, Sirois P// Univ Sherbrooke, Fat Med, Dept Pharmacol, Sherbrooke, Que- bec, Canada JlH SN4 J CARDIOVASC PHARMACOL 1991,17 (S7) S216 Antiaggregatoly and hypotensive effects of endothelin-1 in beagle dogs - role for ptosta- cyclin.

Dorleansjuste P, Lidbury PS, Telemaque S, Warner TD, Vane JW/ Univ Sherbrooke, Fat Med, Dept Pharmacol, Sherbrooke, Que- bec, Canada JlH SN4 J CARDIOVASC PHARMACOL 1991,17 (S7) s251 Human big endothelin releases prostacyclin in vivo and in vitro through a phosphorami- don-sensitive conversion to endothelin-1.

Klosterhalfen B, Horstmannjungemann K, Vogel P, Dulbues G, Simon B, Kalff G, Kirk- patrick Cl, Mittermayer C, Heinrich PC// Tech Inst Aachen, Dept Pathol, Pauwelsstr 30, W-5100 Aachen, FRG CIRC SHOCK 1991,35 (4) 237 Hemodynamic variables and plasma levels of PG12, TKA2 and IL-6 in a porcine model of recurrent endotoxemia.

Pettersson K, Hansson G, Bjorkman JA, Ablad B// Astra Hassle AB, Dept Cardiovasc Pharmacol, S-43183 Molndal, Sweden CIRCULATION 1991,84 (6) S, 38 Pmstacyclin synthesis in relation to sympath-

oadrenal activation - effects of beta-blockade.

Mulvin DW, Jones DK, Howard RB, Gmsso MA. Reuine JE. Johnston MR*N l Univ Co- lorado, Hlth Sci’ Ctr, Box C-310; Denver, Co 88262, USA J HEART LUNG TRANSPLANT 1991,lO (6) 986 Extracellular flush solution that contains blood, mannitol, albumin, and prostacyelin protects rat lungs from six hours of ischemia.

7. THROMBOXANES Furuhashi N, Tsujiei M, Kimura H, Okamura K Yaiima A// Tohoku Univ. Sch Med. Deut Obstit & Gynecol, Aobaku &yo Machi i-1, Sendai, Miyagi 980, Japan GYNECOL OBSI’ET INVEST 1991,32 (3) 164 Antithromboxane drug in the treatment of preeclampsia.

Brune B, Ullrich V// Univ Konstans, Fat Biol, Universitatsstr S-10, Postfach 5560, W- 7750 Konstanz, FRG J BIOL CHEM 1991,266 (29) 19232 Different calcium pools in human platelets and their role in thromboxane A2 formation.

Jancar S, Teixeira CFP, Delima WT, Fujimu- ra AYH, Sirois P// Univ Sao Paulo, Inst Cien- cias Biomed, Dept Immunol, CP 4365, BR- 01051 Sao Paulo, Braxil AGENT ACI-ION 1991,34 (34) 387 Inhibitory effect of econazole on the release of thromboxanes.

Mais DE, Mohamadi F, Dube GP, Kurtz WI.., Brune KA, Utterback BG, Specs MM, Jakubowski JA// Eli Lilly & Co, Lilly Rea Lab, Lilly Corp Ctr, Dept Cardiovasc, India- napolis, In 46285, USA EUR J MED CHEM 1991,26 (8) 821 Thromboxane-A2 receptor antagonists - synthesis and activities of phenylsulfonamido derivatives.

Ninomiya H, Fujiwara M*// l Mukogawa Wo- mens Univ. Fat Pharmaceut Sci, Dent Phar- macol, Nishinomiya, Hyogo 663; Japan JPN J PHARMACOL 1991.57 (3) 349 Epithio-l&12-methano-thromb&ine-A2 stimulates inositol phosphates accumulation in isolated canine mesenteric artery strips.

Lau CS, Khan F, McLaren M, Bancroft A, Walker M, Belch JJF// Univ Dundee, Nine- wells Hosp & Med Sch, Dept Med, Dundee DD19SY, Scotland RHEUMATOL INT 1991,11(4-S) 163 The effecta of thromboxane receptor blockade on platelet aggregation and digital skin blood flow in patients with secondary Ray- naud’s syndrome.

Kushiku K, Ohjimi H, Yamada H, Tokunaga R, Fu~ltawa T// Fukuoka Univ, Sch Med, Dept Pharmacol, Fukuoka 81401, Japan J CARDIOVASC P HARMACOL 1991.17 (S7) s197 Endothelin3 inhibits ganglionic transmission at preganglionic sites through activation of endogenous thromboxane-A2 production in dog cardiac sympathetic ganglia.

Watanabe F, Matsuura T, Shirahase K, Ohta- ni M*// l Shionogi & Co Ltd, Shionogi Rea Labs, Fukushima ku, Osaka 553, Japan CHEM PHARM BULL TOKYO 1991,39 (11) 2842 Synthesis of metabolites of S-1452, an orally

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active thromboxaneA2 receptor antagonist.

Backon J// Mt Pleasant Hosp, Addict Studies Fdn, POB 16336, Jerusalem, Israel EUR J OB!TTET GYN REPROD BIOL 1991,42 (2) 163 Ginger in preventing nausea and vomiting of pregnancy - A caveat due to its thromboxane synthetase activity and effect on testosterone binding (Letter)

Fischerrasmussen W// Univ Copenhagen, Hvidovre Hosp, Dept Obstet & Gynecol537, DK-2650 Hvidovre, Denmark EUR J OBSIET GYN REPROD BIOL 1991,42 (2) 164 Ginger in preventing nausea and vomiting of pregnancy - a caveat due to its thromboxane synthetase activity and effect on testosterone binding - Reply (Letter)

8. LEUKOTRIENES Homma Y, Ohshima K, Yamaguchi H, Naka- mura H, Araki G, Goto Y// Tokai Univ, Sch Med. Dept Internal Med, Isehara, Kanagawa 25911, Japan ATHEROSCLEROSIS 1991,91 (l-2) 145 Effects of eicosapentaenoic acid on plasma Ii- poprotein subfractions and activities of leci- thin-cholesterol acyltmnsferase and lipid transfer protein.

Eriksson AS, Thomsen P*// l Gothenburg Univ, Dept Anat, POB 33031, S-40033 Go- thenburg, Sweden BIOMATERIALS 1991,12 (9) 827 LeukotrieneB4, interleukin-land leucocyte accumulation in titanium and PTFE cham- bers after implantation in the rat abdominal wall.

Pivovarov AS, Drozdova EI, Belosludtsev YY, Demin PM, Myagkova GI// MV Lomon- osov State Univ, Dept Higher Nervous Act, Moscow 117234, USSR BULL EXP BIOL MED-ENGL TR 1991, 112 (7) 893 Short-latency and long-latency effects of 15 hydroxyeicosatetraenoic acid on extinction of the acetylcholine-induced inward current in Helix lucorum neurons.

Spangelo BL, Jarvis WD, Judd AM, Macleod I&I/iMed Univ S Carolina, Dept Physiol, 171 Ashlev Ave. Charleston. SC 29425. USA ENDOCRINOLOGY 1991; 129 (6) 2886 Induction of interleukin-6 release by inter- let&in-l in rat anterior pituitary cells in vitro - Evidence for an eicosanoiddependent mechanism.

Hosni R, Chabannes B*, Pacheco Y, Moliere P, Grosclaude M, Fayolle MP, Lagarde M/l *HOP St Eugenic, INSERM, U205, Immu- noaliergol I&p Lab, Bat SF, 1 Ave Georges Clemenceau. F-69230 St Genis Laval. France EUR J CLIN INVEST 1991,21(6) 631 LeukotrieneB4 levels from stimulated neutrophils from healthy and allergic subjects - Effect of platelets and exogenous arachidonic acid.

Debravo MG, Deantueno RI*, Toledo J, Detomas ME, Mercuri OF, Quintans U/ *Efamol Res Inst, POB 818, Kentville, NS, Canada B4N 4H8 LIPIDS 1991,26 (11) 866 Effects of an eicosapentaenoic and docosahexaenoic acid concentrate on a human lung carcinoma grown in nude mice.

Mourente G, Tocher DR*, Sargent JR// l Univ Stirline Sch Nat Sci. Dent Molec Br Biol Sci, NE&Z Univ Aq& B&hem, Stir- ling FK9 4LA, Scotland LIPIDS 1991,26 (11) 871 Specific accumulation of docosahexaenoic acid (22:6n-3) in brain lipids during development of juvenile turbot Scophthalmus maxi- mus.

Detomas ME, Mercuri 0, Serres C// Fat Ciencias Med La Plata, Inst Invest Bioquim La Plata, Calle 60 & 120, RA-1900 La Plata, Argentina LIPIDS 1991,26 (11) 891 Metabolic transformation of intracraneally in- jected [1-C-14]linoleic and [1-C-14]alpha-linolenic acids in malnourished developing rats.

Yamamoto K, Shibahara A*, Nakayama T, Kajimoto G// *Kobe Gakuin Univ, Dept Nutr, Ikawadani cho, Nishi ku, Kobe 65121, Japan LIPIDS 1991,26 (11) 948 Double-bond localization in heneicosapen- taenoic acid by a gas chromatography ma= spectrometry (GC/MS) method.

Wallingford JC, Yetley EA// US FDA, Div Nutr, Clin Nutr Branch, 200 C St, Washing- ton, DC 20204, USA NUTR REV 1991,49 (11) 323 Development of the health claims regula- tions - the case of omega-3 fatty acids and heart disease.

Conroy DM, Samhoun MN, Piper PJ// Royal Cob Surg England, Hunterian Inst, Dept Pharmacol, Lincolns Inn Fields, London WC2A 3PN, England BRITJPHARMA COL 1991,104 (4) 1012 Effects of vasoactive intestinal peptide, he- lodermin and galanin on responses of guinea- pig lung parenchyma to histamine, ace- @choline and leukotrieneD4.

Hughes GS, Ringer TV, Francom SF, Ca- swell KC, Deloof MJ, Spillers CR// Upjohn Co, Upjohn Res Clin, BCIU Jasper 7216- BRN-S, 7000 Portage Rd, Kalamazoo, Mi 49001, USA CLIN PHARMACOL THER 1991, SO (5) Pl, 538 Effects of fish oil and endorphins on the cold pressor test in hypertension.

Maddox JF, Cao YZ, Mastro AM, Scholx RW, Hildenbrandt G, Reddy CC*// *Penn State Univ, Dept Vet !ki, Univ Pk Pa 16802, USA BIOCHEM BIOPHYS RES COMMUN 1991,181(l) 389 Increased 12-HETE pmduetion in bovine lymphocytea during selenium deficiency.

Hadjiagapiou C, Travers J, Fertel R, Sprecher H*// ‘Ohio State Univ, Dept Med Biochem, 337 Hamilton Hall, 1645 Neil Ave, Columbus, Oh 43210, USA ARCH BIOCHEM BIOPHYS 1992,292 (1) 112 Beta-oxidation of 12(S)-hydroxy-S,8,10,14-ei- cosatetraenoi c acid by MOLT-4 lymphocytes.

Smith CM, Christie PE, Hawksworth RJ, Thien F, Lee TH*// l Guvs Hasp, Dept Al- leqzy & Allied Resp Dis&dem, 4th Floor, Hunts House. London SE1 9RT. Enxland AMER REV’RESP DIS 1991,144 (6’> 1411 Urinary leukotrieneE4 levels after allergen and exercise challenge in bronchial asthma.

Bajpai P, Bajpai PK Ward OP.// l Univ Waterloo, Waterloo, Ontario, Canada N2L 3Gl MYCOL RES 1991,9S (NOV) 1294 Eicosapentaenoic acid (EPA) formation - Comparative studies with Mortierella strains and production by Mortierellaelongata.

Yun KL, Michie SA, Fann JI, Billingham ME, Miller DC*// *Stanford Univ, Med Ctr, Cardiovasc Res Ctr, Dept Cardiovasc Surg, Stanford, Ca 94305, USA J HEART LUNG TRANSPLANT 1991,lO (6) 1004 Effects of fish oil on graft arteriosclerosis and MHC class-11 antigen expression in rat heterotropic cardiac allografts.

9. PLATELET-ACTIVATING FACTOR Kohler E, Vamai G, Knospe S, Forster W, Michaelis D, Wanka I-I// Inst Diabet Ger- hardt Katsch, W-2201 Karlsburg, FRG INT ARCH ALLERGY APPL IMMUNOL 1991,9s (4) 352 Effects of the platelet-activating factor antagonist BN32021 on anti-islet cytotoxicity of mononuclear cells and serum from type-l (insulin-dependent) diabetic patients.

Formukong EA, Evans AT, Evans FJ*, Gar- land LG// ‘Univ London, Dept Pharmacog- nosy, Sch Pharm, 29-39 Brunswick Sq, Lon- don WClN IAX, England PHYTOTHER RES 1991, S (6) 258 Inhibition of A23187-induced release of leu- kotrieneB4 in mouse whole blood ex viva and human wlvmombonuclear cells in vitro by the cannabiioid inalgesic cannabidiol.

Tomeo AC, Duran WN// Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Physiol, Div Microcirculatory Res, Newark, NJ 07103, USA AMER J PHYSIOL 1991,261(5, Pt 2) H1648 Resistance and exchange microvessels are modulated by different PAF receptors.

Dharma S, Baxan HEP*. Pevman GA. Atef

Vane JR Botting RM// St Bartholomews MSE// *Louisiana State ‘U&, Med Ctr, Sch

Hosp, William Harvey Res Inst, Charter- Med, Ctr Eye, 2020 Gravier St, Suite B, New

house Sq, London EClM 6BQ England Orleans, La 70112, USA

CIRCULATION 1991,84 (6) 2588 CURR EYE RES 1991,lO (11) 1031

Heart disease, aspirin, and fish oil (Editorial) Production of platelet-activating factor in photocoagulated retinas.

Sakurai T, Ichimiya H, Miyaxaki H, Na- kayama F*// l Kyushu Univ, Fat Med, Dept Surg 1,3-l-l Maidashi, Higashi ku, Fukuoka 812, Japan J CHROMATOGR-BIOMED APPL 1991, 571 (l-2) 1 Profiling of eicosanoids in inflamed gall blad- der wall by gas chromatography with selected- ion monitoring.

Li KM, Sagawa N*, Ihara Y, Okagaki A, Hasegawa M, Inamori K, Itoh H, Mori T, Ban c// l Kyoto Univ, Fat Med, Dept Gyne- col & Obstet, 54 Shogo In Kawahara Cho, Sakyo ku, Kyoto 606, japan ENDOCRINOLOGY 1991,129 (6) 3132 The involvement of platelet-activating factor in thrombocytopenia and follicle rupture during gonadotropin-induced superovulation in

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immature rates.

Nakamura M, Honda W, Izumi T, Sakanaka C, Mutoh H, Minami M, Bito H, Seyama Y, Matsumoto T, Noma M, Shimixu TO// l Dept Biochem, Fat Med. Univ Tokyo, 7-3-l Hongo, Bunkyo ku; Tokyo 113, Japan J BIOL CHEM 1991.266 (30) 28480 Molecular cloning and exp.&ion of platelet- activating factor receptor from human leuko- rytes.

HU WM, Man RYK*// l Univ Manitoba, Fat Med. Deot Pharmacol & Theraneut, Winni- peg, Maitoba, Canada R3E OV?3 BRIT J PHARMACOL 1991,104 (4) 773 Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodi- lator and vasoconstrictor effects of PAF in the rat perfused heart.

Filep JG, Sirois MG, Rousseau A, Foumier A, Sirois P// Univ Sherbrooke, Fat Med, Dept Pharmacol, Sherbrooke, Quebec, Cana- da JlH 5N4 BRIT J PHARMACOL 1991,104 (4) 797 Effects of endothelin-1 on vascular permeability in the conscious rat - interactions with platelet-activating factor.

Hu WM. Man RYK*// l Univ Manitoba, Fat Med. Deot Pharmacol & Therapeut, Winni- peg, Ma&oba, Canada R3E Ow3 BRlT J PHARMACOL 1991.104 (4) 933 Interaction of vasoactive substances released by platelet-activating factor in the rat perfused heart.

Merlos M, Gomez LA, Girai M, Vericat ML, Garciarafanell J, Fom J’// l J Uriach & CIA, Res Ctr, Dega Bahi 59-67, E-08026 Barcelo- na, Spain BRIT J PHARMACOL 1991,104 (4) 990 Effects of PAF-antagonists in mouse ear oedema induced by several inflammatory agents.

Miller LG, Baxan NG, Roy RB, Clostre F, Gaver A, Braquet P/I Tufts Univ, Srh Med, Dept Pharmacol, 36 Harrison Ave, Boston, Ma 02111, USA RES COMMUN CHEM PATHOL PHARM 1991,74 (2) 253 Platelet activating factor antagonists interact with GABAA receptors.

Torr SR, Haskel El, Vonvoigtlander PF, Bergmann SR, Abendschein DR.// l Wash- ington Univ, Sch Med, Div Cardiovasc, 660 S Euclid Ave, Box 8086, St Louis, MO 63110, USA J AMER COLL CARDIOL 1991,18 (7) 1804 Inhibition of cyclic flow variations and reoc- cl&on after thrombolysis in dogs by a novel antagonist of platelet-activating factor.

Dossantos OFP, Boim MA, Barros EJG, !Ichor N*// l Escola Paulista Med Sch. Deut Med, DivNephrol, Rija Botucatu 746, BR- 04023 Sao Paula, Brazil KIDNEY INT 1991,48 (4) 742 Role of platelet activating factor in gen- tamicin and cisplatin nephrotoxicity.

Rabovsky J, Pailes WH, Judy DJ, Castranova V*// *NIOSH, Div Resp Dis Studies, Biochem Sect, 944 Chestnut Ridge Rd, MS 211, Morgantown, WV 26505, USA BIOCHIM BIOPHYS ACTA 1991,1095 (3) 223 Cytochrome-P45Odependent metabolism in alveolar type-11 epithelial cells - Modulation

by platelet*ctivating factor.

Evans RD, Ilic V, Williamson DH// Radcliffe Infirm, Nuflield Dept Anaesthet, Woodstock Rd, Oxford OK2 6HE, England BIOCHEM J 1991,280 (DEC) P2,541 Effects of platelet-activating factor on lipid metabolism in rats in vivo - Origin of the hypertriglyceridaemia.

Pique JM, Ayuso RMP, Bilbao J, Teres J// Univ Barcelona, Hasp Clin, Dept Gastroente- rol, Villarroel 170, E-08036 Barcelona, Spain DIGEST DIS SC1 1991,36 (12) 1715 Effects of stimulation and inhibition of acid secretion on gastric damage induced by platelet-actimting factor.

Kurose I, Miura S, Suematsu M, Fukumura D, Nagata H, Sekizuka E, Tsuchii M*// l Keio Univ, Sch Med, Dept Internal Med, Shinanomachi 35, Shinjuku ku, Tokyo 160, Japan J CARDIOVASC PHARMA COL 1991,17 (S7) s279 Involvement of platelet-activating factor in endothelin-induced vascular smooth muscle cell contraction.

Pugskey MK, Salari H, Walker MJA*// l Univ British Columbia, Dept Pharmacol & Thera- peut, Vancouver, BC, Canada V6T 1WS CIRC SHOCK 1991,35 (4) 287 Actions of platelet-activating factor on isolated rat hearts.

Massey CV, Kohout TA, Gaa ST, Lederer WJ, Rogers TB*// l Univ Maryland, Sch Med, Dept Biol Chem, 660 W Redwood St, Baltimore. Md 21281. USA J CLIN INVEST 199i, 88 (6) 2106 Molecular and cellular actions of platelet-activating factor in rat heart cells.

Horvath CJ, Kaplan JII, Malik AB*// *Union Univ, Dept Physiol, A66, Albany, NY 12288, USA AMER REV RESP DIS 1991,144 (6) 1337 Role of platelet-activating factor in mediat- ing tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport.

Teng CM, Yu SM, Ko FN, Chen CC, Wang WC, Chen KY, Huang YL, Huang TF// Natl Taiwan Univ, Coll Med, Inst Pharmacol, 1 Jen AI Rd, Sect 1, Taipei, Taiwan EUR J PHARMACOL 1991,205 (2) 151 Comparison of the actions of some platelet- activating factor antagonists on platelets and aortic smooth muscles.

10. METABOLITES Liu B, Timar J, Howlett J, Diglio CA, Honn KV// Wayne State Univ, Dept Radiat Oncol, Detroit, Mi 48282, USA CELL REGUL 1991,2 (12) 1045 Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase-C.

Morii H, Watanabe Y*// *Osaka Biosci Inst, Dept Neurosci, 6-24 Furuedai, Suita, Osaka 565, Japan ARCH BIOCHEM BIOPHYS 1992,292 (1) 121 A possible role of carbohydrate moieties in prostaglandin-D2 and prostaglandinE2 receptor proteins from the porcine temporal cortex.

Velex JS, Randel RD., Neuendorff DA// ;;I$as Agr Exptl Stn, Overton, Tx 75684,

THERIOGENOLOGY 1991,36 (6) 987 Effect of uterine manipulation on postpar- tum fertility and plasma 13,14dihydro-IS- keto-pmstaglandin F2alpha in brahman cows and lst-calf heifers.

11. RELATED ENZYMES Tamai K, Dohi T, Yoshino H, Shirakawa M, Okamoto H, Tsujimoto A// Hiroshima UnIv, Sch Dent, Dept Endodont & Periodontal, l- 2-3 Kasumi, Minami ku, Hiroshima 734, Japan ARCH ORAL BIOL 1991.36 (12) 913 Stimulation by carrageenan of acharidonate 12-lipoxygenase activity in dog gingival tissue.

Libe ML, Brusovanik VI, Erin AN// Acad Me-d Sci USSR, Mental Hlth Res Ctr, Mos- cow 109801, USSR BULL EKP BIOL MED-ENGL TR 1991, 112 (7) 980 Alpha-tocopherol protects rat brain alpha- adrenoceptors against damage by phospholipase-A2.

Lassmann G, Odenwaller R, Curtis JF, De- Gray JA, Mason RP, Mamett I_.& Eling TB*// *Lab Molec Biophys, Nat Inst Envi- ronm Hlth Sci, Nat Inst Hlth, Res Triangle Pk, NC 27789, USA J BIOL CHEM 1991,266 (30) 28045 Electron spin resonance investigation of tyro- syl radicals of prostaglandin H synthase. Rela- tion to enzyme catalysis.

Arita H, Hanasaki K, Nakano T, Oh S, Ter- aoka H, Matsumoto K// Shionogi Res Lab, Shionogi & Co Ltd, Fulcushima-ku, Osaka 553, Japan J BIOL CHEM 1991,266 (29) 19139 Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells via specific binding site.

Yu L, Dennis EA’// *Dent Chem, Univ Calif San Diego, La Jolla, Ca 9‘2093, USA PROC NAT ACAD SCI USA 1991.88 (28) . \, 9325-9329 Critical role of a hydrogen bond in the interaction of phospholipase A2 with transition- state and substrate analogues.

Fujii S, Inoue T, Inoue S, Ikeda K*// *Osaka Univ Phannaceut Sci, Dept Biochem, Mat- subara, Osaka 580, Japan J BIOCHEM TOKYO 1991,110 (6) 1008 Kinetics of the hydrolysis of monodispemed dihexanoylphosphatidylcholine catalyxed by bovine pancreatic phospholipase A2 - roles of Ca2 + binding and ionizations of amino acid residues in the active site.

Zhang H, Gaginella TS. Chen K. Comwell DG*fi *Ohio-State Univ, Coil Med, Dept Med B&hem. Columbus. Oh 43210. USA AGENT ~Cri0N 1991,34 (34 j397 Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic acid cascade.

Ogawa M, Yamashita S, Sakamoto K, Ikei S // Kumamoto Univ, Sch Med, Dept Surg 2, Kumamoto 868, Japan RES COMMUN CHEM PATHOL PHARM 1991,74 (2) 241 Elevation of serum group-11 phospholipase A2 in patients with cancers of digestive organs.

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Petmni A Bksevich M, Viioli F, ZanCoC- chia B, Caruso D, Galli U/ Uaiv Milan, lnst Pharmacol !Ici, Via Balraretti 9.1~20133 Milan, Italy DEVELOP BRAIN RES 1991,63 (l-2) 221 Arachidonic acid @xrtygeaase and lipoox- ygeaase pathways are differently activated by platelet activating factor and the calcium-io- nophore A23187 in a primary culture of as- troglial cells.

Liu W, Hildebrand DF, Graybum WS, Phil- lips GC, Collins GB*// l Univ Kentucky, Dept Agron, Lexington, Ky 40546, USA PLANT PHYSIOL 1991,97 (3) 969 Effects of exogenous auxins on expression of lipoxygenase in cultured soybean embryos.

Watanabe K, Fuiii Y, Ohkubo H, Kuramitsu S, Kagamiyama H, Nakanishi S, Hay-&hi 0 // Gifu Univ. !Ich Med. Deot Phvsiol. 40 Tsuka- sa Machi, Gifu 500, Papa> ’ BIOCHEM BIOPHYS RES COMMUN 1991,181(l) 272 Expression of bovine lung prostaglandin-P synthase in Escherichia coli.

Femandez MS, Mejia R, Zavala El, Pacheco F// Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Bioquim, AP 14-740, Mexi- co Citv o7ooo. DF. Mexico BIOCHEM CELL BIOL 1991,69 (10-11) 715 Dependence on neutral salt concentration of the latency phase in the time course of hydrolysis of dimyristoylphosphatidylcholine lips somes by phcspholipase-A2.

Femandez MS, Mejia R, Zavala E4/ Inst Pol- itecn, Ctr Invest & Estudios Avanzados, Drpt Bioquim, AP 14-740, Mexico City 07fMJ0, DF, Mexico BIOCHBM CELL BIOL 1991,69 (10-11) 722 The interfacial calcium ion concentration as modulator of the latency phase in the hydra- lysis of dimyristoylphosphatidylcholine lipo- somes by phospholipaseA2.

Yen CH, Tzeng MC*// Acad Sinica, Inst Biol Chem, POB U-106, Taipei 115, Taiwan BIOCHEMISTRY-USA 1991,30 (48) 11473 Identification of a new binding protein for crotoxin and other neurotoxic phospholipase- A.& on brain synaptic membranes.

Lambeau G, Barhanin J, Lazdunski M*// l Inst Pharmacol Mokc & Cellulaire, 660 Route Lucioles, Sophia Antipolii, F-06560 Valbonne, France FEBS LEIT 1991,293 (l-2) 29 Identification of different receptor types for toxic phospholipasesA2 in rabbit skeletal muscle.

Trave G, Lees D, Liautard JP, Widada JS // Univ Montpellier 2, INSERM, U65, Dept Biol Sante, PI Eugene Bataillon, F-34995 Montpellier 5, France FEBS LEIT 1991,293 (l-2) 34 Mutational analvsii of the outative PLA2-inhibiting sequence of annein-1.

Waszkowycz B, Hillier IH*, Gensmantel N, Pavling DW// l Univ Manchester, Dent ChemrManchester Ml3 9PL, L&s, *England J CHEM SOC PERKIN TRANS II 199lG2) . , 2025 Combined quantum mechanical-molecular mechanical study of catalysis by the enzyme phosoholipase-A2 - An investigation of the potential energy surface for amide hydrolysii. Jarabak J// Univ Chicano, Deot Med. Box 435,5841 S Maryland Ave, Chicago, II 68637,

USA ARCH BIOCHEM BIOPHYS 1992,292 (1) 239 Polycyclic aromatic hydrocarbon quinones may be either substrates for or irreversibk in- hibitoa of the human placental NAD-linked l.5.hydroxypmstaglandin dehydmgenase.

Hsuanyu YC, Dunford HB*// *Univ Alberta, Dent Chem, EdmOntOII, Alberta, hUIda

T6G 2G2 ARCH BIOCHEM BIOPHYS 1992,292 (1) 213 Reduction of prostaglandiiN synthase com- pound-11 by phenol and hydtuquinone, and the effect of indomethacin.

Murakami M, Kudo I, Fujimori Y, Suga H, Inoue K*// l Univ Tokyo, Fat Pharmaceut Sci, Dept Hlth Chem, Bunkyo ku, Tokyo 113, Japan BIOCHEM BIOPHYS RES COMMUN 1991,181(2) 714 Group-II phospholipase&Z inhibitors sup pressed lysophosphatidylserinedependent de- granulation of rat peritoneal mast cells.

McDonald PP, McCall SR, Naccache PH, Borgeat P*// l CHU Laval, Ctr Rech Inllam- mat Immunol & Rhumatol, 2705 Blvd Lau- tier, Quebec City, Quebec, Canada GlV 4G2 BIOCHEM J 1991,280 (DEC) P2,379 Studies on the activation of human neutrophil S-lipoxygenase induced by natural agon- ists and Ca2 + ionophoreA23187.

Bouchier C, Boyot P, Tesson F, Ttemeau 0, Bouet F, Hodgson D, Boulain JC*, Menez A// l CENS, Ingn Prot Lab, Serv Biochem Prot, BAT 152, F-91191 Gif Sur Yvette, France EUR J BIOCHEM 1991,202 (2) 493 Notechis-11’2, a non-toxic phospholipaseA2 from the venom of Notechis scutatus scutatus.

Kulkami AP, Cai Y, Richards IS// Univ S Florida, Coil Publ Hlth, Dept Environm & Occupat Hlth, Florida Toxicol Res Ctr, MIIH-lD4, Tampa, Fl33612, USA INT J BIOCHEM 1992.24 (2) 255 Rat pulmonary lipoxygenase’-‘dioxygenase activity and role in xenobiotic metabolism.

Chiou SH, Lee BS, Chang CC, Yu NT// Inst Biochem Sci, Nat Taiwan Univ, Inst Biol Chem, PO Box 23-106, Academia Sinica, Tai- pei, Taiwan BIOCHEM RUT 1991,25 (2) 387 Structural analysii of phospholpase A2 by near-IR Fourier transform raman spectros-

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Sanduja SK, Mehta K, Xu XM, Hsu SM, San- duja R, Wu KK// Univ Texas, Seh Med, Dept Internal Med, Div Hematol Oncol, 6431 Fan- nin, Houston, TX 77030, USA BLOOD 1991,78 (12) 3178 Differentiation-associated expression of prostaglandin-H and thromboxane-A synthases in monocytoid leukemia cell lines.

12. PRODUCTION AND RELEASE Almazov VA, Gurevich VS, Eliiv W, Ktv- lova IB, Skhollengberts AD, Poltavchenko _ GM// Minist Publ Hlth USSR Leninerad Res Inst Cardiol, Leningrad, USSR ” BULL EXP BIOL MED-ENGL TR 1991, 112 (7) 943 Effect of adenosine on blood prostaglandin levels and platelet aggregation in experimen- tal myocardial infarction.

TtybulecM,DudekRR,Gty@waklRJ//N CopernicusMedAerd,DcptPh==4 Gmegorreeka 16, Krakow, I’oland J CARDIOVASC PHARMACOL 1991,17

(S7.)=9 E&et of endotbehn-1 and eodothelm-3 on the release of pmatanoids from isolated perfused rat kidney.

Mccauley J, Studer R, Craven P, Murray S // Univ Pittsbunzh. Sch Med. Div Renal Ekctro- lyte, 11431 S&ife Hall, Pittsburgh, Pa 15213, USA TRANSPLANT PROC 1991,23 (6) 3141 The effects of @ksporine-A, cycloaporine- G, and FK-506 upon pmataglandin pmduc- tion in renal mesa&al cells in culture.

Massey WA, Hubbard WC, Liu MC, Kagey- sobotka A, Cooper P, Lichtenstein LM*// *Johns Hopkins Asthma & Allergy Ctr, Div Clin Immunol, 301 Bayview Blvd, Baltimore, Md 21224, USA BRIT J DERMATOL 1991,125 (6) 529 Profile of prostanoid release following antigen challenge in vivo in the skin of man.

Rudko IA, Pokrovsky YA, Ermolenko VM, Kubatiev AA// Cent Physicians Continuing Educ Inst, Chair Gen Pathol & Pathophysiol, Moscow, USSR TERAPEVT ARKH 1991,63 (10) 128 The influence of recombiint human erythro- poietin on platelet aggregation and the level of some prostanoids in the blood of hemodia- lyzed patients with chronic renal failure.

13. EFFECTS Peachey JA, Kitchen I*// l Univ Surrey, Dept B&hem, Receptors & Cellular Regulat Res Grp, Guildford GU2 SXH, Surrey, England J CARDIOVASC PHARMA COL 1991,17 (S7) s190 The importance of tachyphylaxis and release of cyclooxygenase products in the modulation of endothelin-1 induced responses in rat and guinea pig tracheal chains.

Arnold WP, Lintsen AME, Vandekerkhof PCM, Mier PD// Univ Nijmegen, Dept Der- matol, Philips Van Leydenlaan 25,6525 EX Nijmegen, Netherlands BRIT J DERMATOL 1991,123 (6) 577 Cyclo-oxygenase products do not participate in the induction of omithine decarboxylase in human epidermis.

Narizzano OC, Karara A, Reynoso R// CIMER, Fontana 685, RA-3600 Formosa, Ar- gentina PRENSA MED ARGENT 1991,78 (8) 386 Effect of ethanol on the thyroid-hypophyseal- hypothalamic axis - Role of prostaglandins and leukotrienes (Spanish)

14. PROSTAGLANDINS IN MEDICINE Hauptman HW, Ruddy S, Roberts WN*// *Virginia Commonwealth Univ, Med Coil Virginia, Div Rheumatol Allergy & Immu- nol, Box 647, MCV Stn, Richmond, Va 23298, USA J RHEUMATOL 1991,18 (11) 1747 Reversal of the vasopastic component of lupus vasculopathy by infusion of prostaglandin-El (Case Report)

Edwards RJ, Fulde GWO, McGrath MA// St Vincents Hosp, Ctr Accid & Emergency, Vic- toria St, Darlinghurst, NSW 2010, Australia

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MED J AUSTRALIA 1991,155 (11.12) 825 Successful limb saIvage with prostagiandin infusion - a review of crgotaminc toxicity.

Lappas CA, Giannakodimos GG// Elena Venixelou Obstet & Gynecol Hasp, Dept Ob- stet & Gynecol, 2 Elena Venixelou Sq, GR- 11521 Athens, Greece FERT STERIL 1991,56 (6) 11% Treatment of unruptured tubal pregnancy by local injection of methotrexate and prostagiandin F2aIpha in 52 patients.

Lyndrup J, Nickelsen C, Guldbaek E, Weber T// Gammel Hareskowej 329, DK-3500 Vaer- loese, Denmark EUR J OBSIET GYN REPROD BIOL 1991,42 (2) 101 Induction of labor by prostaglandin E2 - In- tracervical gel or vaginal pessaries.

Rath W, Gerland W, Osmers R// Univ Got- tingen, Frauenkhn, Robert Koch Str 40, W- 3400 Gottingen, FRG ZBL GYNAKOL 1991,113 (9) 519 Termination of pregnancy in the second and third trimester by application of prostagiandins in dependence on the cervical state.

Diet1 J, Korte K, Lippert TH// Univ Tubing- en. Deot Obstet & Gvnecol. W-7400 Tubine- en’& &G

. ,

AMER J PERINATOL 1991,8 (6) 423 Risks in the treatment of tubal pregnancy by prostagiandin (Letter)

15. PROSTAGIANDINS AS DRUGS Wolf R, Rommel W, Conradi J, Richter A// Karl Marx Univ, Wiinsch Bereich Fortp- fianzung Landwirtsch Nutxiere, W-7610 Leip- zig, FRG ARCH EXP VEIERINARMED 1991,45 (1) 75 Studies into synchronisation of oestrus and ovulation in mutton Merino sheep-2nd com- munication-fertility performance resulting from synchronisation of oestrus and ovulation, using Cioprostenol Jenapharm and Go- navent Berlin-Chemie as well as term- oriented artificial insemination (German)

Guilmot JL, Diot E// CHU Tours, Med CIin B, F-37944 Tours, France DRUG INVEST 1991,3 (5) 3.51 Treatment or lower limb ischaemia due to atherosclerosis in diabetic and nondiabetic patients with iloprost, a stable analogue to prostacyclin - results of a French multicentre trial.

Tanonaka K, Maruyama Y, Takeo !?/I *Tokyo Coil Pharm, Dept Pharmacoi, Ha- chioji, Tokyo 19203, Japan BRIT J PHARMACOL 1991,104 (4) 779 Beneficial effect of beraptost, a prostacyclin- mimetic agent, on post-hypoxic recovery of cardiac function and metabolism in rabbit isolated hearts.

Takanashi H, Itoh 2// Chugai Pharmaceut Co Ltd, Exploratoty Res Labs, Dept Pharma- col, Gotemba, Shixuoka 412, Japan JPN J PHARMACOL 1991,57 (3) 447 Gastric antisecretory activity of 15(R)-15- methyIprostagiandinE2, arbaprostil, in dogs.

Muller MK, Wojcik M, Coone H, Philipp T, Singer MV// Univ Heidelberg, Dept Med, Med CIin Mannheim 4, Theodor Kutxer Ufer, W-6800 Mannheim, FRG TRANSPLANT PROC 1991,23 (6) 2812 Inhibition of insulin release by FK-SO6 and its prevention by rioprostil, a stable prostagiandin-El analogue.

Gomezsanchez MA, Delacaldxada CS, Pajue- IO CG, Tascon JC, AIonso M, Andreu J, Aranzana M, Delafuente A// Univ Madrid Hosp, 12 O&b+ Dept Cardiol, Crtra Anda- lucia KM 54. E2gO41 Madrid. Soain AMER REV RESP DIS 1991; l&l (6) 1404 Different hemodynamic responses between acute and chronic infusion of iloprost (prostacyclin-stable analogue) in severe pulmonary hypertension.

16. INHIBITORS OF SYNTHESIS . Williams WR, PawIowicx A, Davies BH//

Sully Hosp, Asthma de Allergy Unit, Catdiff CF6 2YA, Wales INT ARCH ALLERGY APPL IMMUNOL 1991,95 (4) 303 Aspirin-sensitive asthma - Significance of the cyclooxygenase-inhibiting and ptotein-binding properties of analgesic drugs.

Churchill L, Pongracic JA, Reynolds CJ, Na- clerio RM. Proud D*// *Johns Hookins As- thma & Ahergy Ctr, CIin Immunoi Unit Off 2,301 Bayview Blvd, Baltimore, Md 21224, USA INT ARCH ALLERGY APPL IMMUNOL 1991,95 (4) 322 Pharmacology of nasal provocation with bradykinin - Studies of tachyphybtxis, cyclooxygenase inhibition, alpha-adrenergic stimulation and receptor subtype.

Matsumura H, Takahata R, Hayaishi O// Osaka Biosci Inst. FuNedai 6-2-4. Suita. Osaka 565, Japan’ PROC NAT ACAD SCI USA 1991,88 (20) 9046~9oso Inhibition of sleep in rata by inorganic selenium compounds, inhibitors of prostagiandin D synthase.

Tanxer H, Braun C, Seidel M, Wiegrebe W // Univ Regensburg, Inst Pharm, POB 397, W- It400 Regensburg, FRG ARCH PHARM 1991,324 (11) 841 Anthralin derivatives - inhibition of S-Iipox- ygenase - antipsoriatic efficacy.

Prasit P, Belley M, Evans JF, Gauthier JY, Leville C, McFarIane CS, MacIntyre I!!, Peter- son L, Piechuta H, Therien M et aI// Merck Frosst Canada Inc, Ctr Therapeut Res, POB 1005, Pointe Claire, Quebec, Canada H9R 4ps BIOORG MEDICINAL CHEM LEITER 1991,1(11) 645 A new class of leukotriene biosynthesis inhibitors -The development of ((4-(4_chIoro- phenyi)-1-(4-(2quinolinyI methoxy)phenyi)butyi)thio) acetic acid, L-674636.

Sugimoto M, Kojima T, Asami M, Iixuka Y, Matsuda K*// l Sankyo Co Ltd, New Lead Res Labs, l-2-58 Hiromachi, Shinagawa ku, Tokyo 140, Japan BIOCHEM PHARMA COL 1991,42 (12) 2363 Inhibition of prcetaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory pmdrug.

18. CHEMICAL SYNTHESIS Fujisawa T, Mobele BI, Shimixu M// Mie Univ, Dept Cbem & Mat, Tsu, Mie 514, Japan TETRAHEDRON LEFT 1991,32 (48) 7055 Enantioselective reduction of 4-oxo&tetrahy- drothiopyranyi-acetates with bakers yeast and application to the synthesis of a prostagIan- din intermediate in optically pure form.

20. FORTHCOMING EVENTS Omega-3 fatty acids metabolism and biologi- cal effects. Omega 3 symposium Sept. 15-19 1992, Oslo, Norway. Details from: Omega-3 symposium, c/o Congress conference, PO Box 7609 Skillebekk, N-0295 Oslo, Norway. Tel: + 47-2-56 19 30, Telefax: + 47-2-56 OS 41.

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TWICE MONTHLY B~BLI~~~ ON FR~TAG~B~NS BIOLOGY- LATE FEBRUARY P~F~D BY REWELD ~~~~ BIO~DIC~ I~O~~ON SERVICE

SHEFFIELD SlQ 2TN

1. BOORS, REVIEWS, mPosIA Knight KR, Lepore DA, Obrien BM// St Vin- cents Hasp, Microsurg Res Ctr, Melbourne, Vie 3065, Australii PROSTAGLAND LEUK ESSEm FATTY 1991,44 ( 4) 195 Interrelationships between prostanoids and skin flap survival - a review (Review)

Das UN// Nizams Inst Med sci, Dept Med, Hyderabad 500682, India PROSTAGLAND LEUK EssEm FATIY 1991,44 ( 4) 201 Interaction(s) between essential fatty acids, eicosanoids, cytokines, growth factors and free radicals - relevance to new therapeutic strategies in rheumatoid arthritis and other collagen vascular diseasea (Review)

2. GENERAL Femandes AI, C&o IFL, Defalco V, Daro- cha FA, Sirois P, Jancar S// Univ Sao Paulo, Fat Med. Dent Rheumatol. Sao Paulo. Brazil PRoSTAGL;~NDINS i99i, 42 (6) 49j Mechanisms of thromboqtopenia in the acute phase of antigen-induced arthritis in rabbits.

3. PRECURSORS Vanderschouw Y’I’, Al MDM, Hornstra G*, Bulstraramakers MTEW, Huisjes HJ// *Univ Limburg, Dept Human Biol, POB 616,620O MD Maastricht, Netherlands PRO~AG~ LEUK ESSEMT FATTY 1991,44 (4) 247 Fatty acid composition of serum lipids of mo- thers and their babies after normal and hypertensive pregnancies.

4. Arachidonic Acid Zaleska MM, Wilson DF// Univ Penn&- nia, Sch Med; Dept B&hem & BiophG, Phii- adelohia. Pa 19104. USA J &UROCHEM i992,58 (I) I07 Effect of hydroperov fatty acids on acylation and deacylation of arachidonoyl groups in synaptic phospholipids.

Naccache PH, Leblanc Y, Rokach J, Patrigna- ni P, Delaclos BP, Borgeat P’// *CHU La&, Ctr Rech, Ctr Rech Inflammat Immunol & Rhumatol, 2705 Blvd Laurier, Quebec City, Quebec, Canada GlV 4G2 BIOCHIM BIOPHYS ACI-A 1991,1133 (1) 102 Calcium mobiliition and right-angle light scatter reaponsea to 12-oxo-derivatives of arachidonic acid in neutrophils - evidence for the involvement of the leukotriene B4 receptor.

Jyothirmayi N, Ramadoss CS, Divakar S’N ‘Cent Fo&i Technol, Res Inst, Dept Food Chem. Mvsore 570013. Kamataka. India J AGk F&D CHEti 1991,39 (i2) 2123 Nuclear magnetic resonance stud& of cyclo- dextrin complexes of linoleic acid and arachidonic acid.

Shimizu N, Kita T, Aoe M, Nakata M, Miyai Y, Teramoto S// Okavama Univ. Sch Med. D&t Surg 2,Okaya&a 700, Jap& ACI-A MED OKAYAMA 1991,45 (6) 417 Changes in levels of arachidonic acid metabo- litcs in blood and bronchalveolar lavage fluid after warm ischemia-reperfusion of lung.

5. PROSTAGLANDINS E AND F Hake& Y, Harada SI, Matsumoto T, Tezuka KI, Higashino K, Kodama H, Haahimoto- Goto T, Ogata E, Kumegawa M/i Dept Oral Anat, Meikai Univ Sch Dent, Sakado, Saita- ma 350-02, Japan J BIOL CHEM 1991,266 (31) 21044 Prostaglandin F2alpha stimulates prolifera- tion of clonal osteoblastic MC3T3-El cells by up-regulation of insulin-like growth factor I receptors.

Watanabe T, Morimoto A, Morimoto K, Na- kamori T, Murakami N// Dept Physiol, Yamaguchi Univ Sch Med, Ube, Yamaguchi 755, Japan J PHYSIOL (LOND) 1991,443 431 ACI’H release induced in rats by noradre- naline is mediated by p~~~andin E2.

Mori S, Jee WSS, Li XJ// *Univ Utah, Sch Med, Dept Radiobiol, Bldg 586, Salt Lake City, Ut 84112, USA CALCIFIED TISSUE INT 1992,SO (1) 80 Production of new trabecular bone in oste- openic ovariectomized rats by prostaglandin- E2.

Vandelft JL, Vanhaeringen NJ, Bodelier VM, Elarthen ER, Oosterhuis JA// Univ Hasp Leiden, Dept Qphthalmol, POB 9600, 2300 RC Leiden, Netherlands OPHTHALMIC RES 1991,23 (S) 240 Prostaglandin-E2 in the vitreous body of the normal rabbit eye and after ocular trauma.

Peplow PV// Univ Otago, Dept Anat, POB 913, Dunedin, New Zealand PROSI’AGLAND LEUK ESSENT FATTY 1991,44 ( 4) 217 Uterine production of pmstaglandin-F2- alpha and 6-keto-F&alpha by ovariectomized pregnant rats receiving antip~te~ne steroid or in which progesterone has been with- drawn.

Vassar MJ, Fletcher MP, Perry CA, Holcroft JW*// ‘Univ Calif Davis, Sac&mento Med Ctr. Dent Sure 4301 X St. Room 2310. Sa- erakenio, Ca%Sl7, USA’ PROSTAGLAND LEUK IZSSENT FATTY 1991,44 ( 4) 223 Evaluation of prostaglandin-El for prevention of respiratory failure in high risk trauma patients - a prqective clinical trial and correlation with plasma suppressive factors for neutrophil activation.

Bry K, Hallman M/i Univ Calif Irvine, Dept Pediat. CCM Med Sure: 1. Rm 1WF Irvine. Itine,’ Ca 92727, USA- PROSTAGLAND LEUK ESSENT FATTY 1991,44 ( 4) 241 Synergistic stimulation of amnion cell prosta- glandinZ2 synthesis by interleu~n-1, tumor necrosis factor and products from activated human granuloqtes.

Dowling DD, RomeFo RI, Mitchell MD’, Lundinschiller S// l Univ Utah. Sch Med. Dept Obstet & Gynecol, Salt &ke City, ‘Ut 84132, USA PRO~AG~ LEUK BSSEW FATTY 1991,44 ( 4) 253 Isolation of multiple substances in amniotic fluid that regulate amnion prostaglandinZ2

production - the effects of gestational age and labor.

Conte G, Cianciaruso B, Denicola L, Sepe V, Roman0 G, Domenico R, Cagtiti A, Fuiano G, Dalcanton A// Naples Univ, Fat Med 1, Dept Nephrol, Via Luigi Caldiere IO, I-80128 Naples, Italy NEPHRON 1992,60 (1) 42 Inhibition of urea tubular reabsorption by PGEl infusion in man.

Chung SW, Kim PCW, Koh IHJ, Fung LS, Cole EH. Cohen 7.. Lew GA*// *Toronto Gen Ho&, 200 El&be& St, &I%3 538, To- ronto, Ontario, Canada MSG 2C4 IMMUNOLOGY 1991,74 (4) 670 The comparative effects of cyclosporin A and 16,16 dimethyl basin E.2 on the al- logeneie induction of rnon~~~a~ procoagulant activity and the cytokines mac- rophage procoagulant inducing factor and interleukin-2.

Mattarelli G, Leibundgut B// Kantonsspital, Ural Klin, CH-4031 Basel, Switzerland HELV CHIR ACTA 1991,58 (3) 3’35 Preliminav experiences with prostaglandin- El and injectable PG-El dosage forms (Ger- man)

Waymack JP, Flescher E, Venkatraman J, Fernandes G, Guzman RF, Yurt RW, Mason AD, Pruitt BA// US, Inst Surg Res, Lib Branch, Ft Sam Houston, TX 78234, USA J SURG ONCOL 1991,48 (4) 239 Effect of prostaglandin-E in multiple ex- perimental models. 8. Effect of host response to metastatic tumor.

Rowley RF, Lawson JP// St Peters Hosp, Dept Med Imaging, 315 S Manning Blvd, Al- bany, NY 12208, USA SKELETAL RADIOL 1991,20 (8) 617 Case report 701 - pmstaglandin E-l (PGE-1) periostitis.

Sismeydurrant HJ, Hopps R&i*// *Inst Dent Surg, Dept Maxillofacial Surg & Oral Med, 2.56 Grays Inn Rd, London WCIX SLD, Eng- land ORAL MICROBIOL IMMUNOL 1991,6 (6) 378 Effect of lipopolysaccharide from Porphyro- monas gingivalis on prostaglandinZ2 and interleukin-lbeta release from rat periwteal and human gingival fibroblasts in vitro.

Nakahata N// Fukushima Med Sch, Dept Phannacol, Fukushima 96012, Japan FOLIA PHARMA COL JPN 1992,99 (1) 1 Signal transduction of prostaglandin-E2 and thromboxane&Z (Award Lecture) (Japanese)

Lau TM, Gow CB, Fairclough RJ// Victorian Inst Anim Sci, Werribee, Vi; 3030, Australia BIOL REPROD 1992.46 (1117 Differential effects of &o&terone treatment on the oxytocin-induced pmstaglandin F-2alpha response and the levels of endome- trial oxytocin receptors in ovariectomized ewes.

Kjaeve J, Vaage J, Bjertnaea I& Univ Trom- so, Dept Anesthesiol, N-9012 Tromso, Nor- WaY INT J MICROCIRC-CLIN EXP 1992,11(l)

I338

8.5 Inhibition by prostacyclln and mrbaq&ns of ~t~-l~~rni~o~ l)~tb~i~ne]~,lldi- Toxic oxygen metabolites reduce inactivation endothelin-induced DNA synthesis in cut- hydrodibe ~b,e~c~ne-2~a~~a~ of prostaglandinE2 in isolated perfused rat tured vascular smooth muscle cells. monohydrate on smooth muscle preparations. lutigs.

Cochrane E, McCarthy ID// Univ Glasgow, Inst Physiol, Glasgow G12 8QQ, Scotland J ENDOCRINOL 1991,131(3) 359 Rapid effects of parathyroid hormone(l-34) and prostaglandinE2 on bone blood flow and strontium clearance in the rat in viva.

Long NC, Morimoto A, Nakamori T, Yama- shire 0, Murakami N// Dept Physiol, Yama- guchi Univ Med Sch, Ube, Yamaguchi 755, Japan J PHYSIOL (LOND) 1991,444 (Dee) 363- 373 Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by re- straint or interleukin-1 in rats.

Cardenas H, Padilla A, Alvarado F5, Vivanco W, Berardinelli JG// Univ Nacl Agr La Moli- na, Dept Prod Anim, Apdo 456, Lima, Peru ANIM REPROD SC1 1991,26 (3-4) 211 Natural and prostaglandin-F (PG)-syn- chronixed estrous cycle in brown Swiss and Simmental heifers in the highland of Peru.

Guillette W, Masson GR, Demareo V/l Univ Florida, Dept Zool, Vertebrate Reprod Lab, Gainesville, Fl32611, USA P~O~AG~INS 1991,42 (6) 533 Effects of ~ta~andin-alpha prostaglandin-E2 and arachidonic acid on the induction of oviposition in vivo and in vitro in ovipar- ous lixards.

Ishixawa M// Sapporo Med Coil, Sch Allied Hlth Profess, Physiol Lab, S-3, W-17, Sappo- ro, Hokkaido 060, Japan PROSTAGLANDINS 1991,42 (6) 579 Contractile effects of %-methyl analogues of PGE2 on the circular and lon~tudinal muscles of the guinea-pig isolated colon.

6. PROSTACYCLIN Suzuki S, Nakamura S, Koixumi ‘I’, Sakaguchi S, Baba S, Muro H, Fujise Y// Hamamatsu Univ, Sch Med, Dept S&g 2,360O Handa Cho, Hamamatsu, Shixuoka 431-31. Janan TRANSPLANTATION 1991,.52 (6) 9% The beneficial effect of a p~~~andin-12 analog on ischemic rat Ser.

Yamaga H, Hashiiume M*, Wada H, Kitano S, Sugimachi K/1 l Kyushu Univ, Fat Med, Dept Surg 2, 3-l-l Maidashi, Higashi ku, Fu- kuoka 812, Japan EUR SURG RES 1991,23 (3-4) 228 Platelet aggregability and prostaqclin/throm- boxaneA2 ratio after endoscopic injection scletotherapy with different sclerosants.

Wakasugi M, Noguchi T, Inoue M, Tawata M, Shindo H, Onaya T// Univ Yamanashi, Sch Med, Dept Internal Med 3, Tamaho, Yamanashi 48938, Japan PROSI’AGLAND LEUK ESSENT FATTY 1991,44 ( 4) 233 Effects of aldose reductase inhibitors on prostacyclin (PG12) synthesis by aortic rings from rats with streptoxotocin-induced diabetes.

Nakaki T, Ohta M, Kato Rf/ Keio Univ, Seh Med, Dept Pharmacol, 35 Shinanomachi, Shinjuku tat, Tokyo 160, Japan PROSTAGLAND LEUK FBSENT FATIY 1991,44 ( 4) 237

Tsai AL, Hsu MJ, Patsch W, Wu KKII Univ Texas, Hlth !Ici Ctr, Dept Internal Med, Div Hematol Oncol, POB 28708, Houston, TX 77225, USA BIOCHIM BIOPHYS ACTA 1991,1115 (2) 131 Regulation of PC12 activity by serum proteins - serum albumin but not high density li- poproteins is the PGI2 binding and stabilii- ing protein in human blood.

Ma XL, Porta R, Peacador R, Lefer AM*// *Thomas Jefferson Univ, Jefferson Med Cog, Dept Physiol, 1020 Locust St, Philadel- phia, Pa 19107, USA MEIH FIND EXP CLIN PHARMACOL 1991,13 ( 10) 667 Novel beneficial rn~han~~ of delibrotide, a prostacyclin enhancing agent in splanchnic artery occlusion and reperfusion in rats.

Mihai K et al ACTA PAEDIATR HUNG 1991,31 (1) 113. 8 Prostacyclin and thromboxane levels of children of parents suffering from early ischemic heart disease.

Iioka H et al NIPPON SANKA FUJINKA GAKKAI ZASSHI 1991,43 (6) 619-21 The study on the degradation of prostaqclin activity in tissue culture supematant of human placental villi (Jpn)

Fujimura M, Oxawa S, Matsuda T// Kansra- wa Univ, Sch Med, Dept Internal Med 3,13- 1 Takara Machi, Kanaxawa, Ishikawa 920, Japan 3 ASIHMA 1991,28 (6) 419 Effect of oral administmtion of a prostacyclin analog (OP-41483) on pulmonary function and bronchial responsiveness in stable asthmatic subjects.

7. THROMBOXANES Louden KA, Pipkin FB, Heptinstall S, Fox SC, Mitchell JRA, Symonds EM// Plymouth Gen Hasp, Obstet Br Gynaecol, Plymouth PL4 7JJ, England BRIT J OBSIEI GYNAECOL 1991,98 (12) 1239 Platelet reactivity and serum thromboxane- B2 production in whole blood in gestational hypertension and pre-eclampsia.

Karasawa A, Kawakage M, Shirakura S, Higo K Kubo K. Ohshima E Obase W/ Kvowa Hakko Kogyo Co Ltd, Dept Pharmacbl, Phar- maceut Res Labs, 1388 Shimotogari, Nagaizu- mi, Shixuoka 411, Japan MAIM-FO~CH-DRUG RES 1991,41- 2 (12) 1230 Antiplatelet effects of the novel thromboxane-A2 receptor antagonist sodium (E)-11-[2- (Sbdimethyl-l-benzimidaxoly l)ethylidene]- 6,lldihydmdibe nx[b,e]oxepine-2-catboxy- late monohydrate.

Karasawa A, Shirakura S, Higo K, Kubo K // Kyowa Hakko Kogyo Co Ltd, Dept Pharma- col, Pharmaceut Res Labs, 1188 Shimotogari, Nagaixumi, Shixuoka 411, Japan ~~-~~~-DRUG RES 1991,41- 2 (12) 1237 Actions of the novel thromboxaneA2 receptor antagonist sodium (E)-ll-[2-(5,6di-

Shirakura S, Karasawa A, Kubo K// Kyowa Hakko Kogyo Co Ltd, Dept Pharmacol, Phar- maceut Res Labs, 1188 Shimotogari, Nagaizu- mi, Shixuoka 411, Japan ARZNEIM-FORSCH-DRUG RES 1991,41- 2 (12) 1242 Protective effects of the novel thromboxane- A2 receptor antagonist sodium (E)-ll-f2-(5,6- dimety-l-be~irni~o~ l)~th~idene]~,ll- dihydrodibe m[b,e] oxepine-2-carboxylate monohydrate a-$&t 9,ildideoxy_9aipha, llalpha-epoxymethano-prostaglandinF2al pha-induced sudden death in guinea-pigs and rats.

Kawakage M, Shirakura S, Karasawa A, Takeda M. Miki I. Ishii A. Kubo K/I Kvowa Hakko Kogyo Co ‘Ltd, Dept Phar&&, 1188 Shimoto~~, Nagaixumi, Shiiuoka 411, Japan HIM-FOG-DRUG RES 199l,41- 2 (12) 1246 Beneficial effect of the novel thromboxane- A2 receptor antagonist sodium (E)-11-[2-(5,6- dimethyl-1-benximidaoly I)ethylidene]d,ll- dihydrodiben z[b,e]oxepine-2-carboxylate monohydrate on collagen-induced coronary ischemia in guinea-pigs.

Higo K, Karasawa A, Kubo K/ Kyowa Hakko Kogyo Co Ltd, Dept Pharmacol, Phar- maceut Res Labs, 1188 Shimotogari, Nagaixu- mi, Shizuoka 411, Japan ARZNEIM-FORSCH-DRUG RES 1991,41- 2 (12) 1251 Enhancement of tissue-type plasminogen acti- vator-induced thrombolysis and prevention of reocclusion by sodium (E)-11-[2-(5,6-dimethyl-l-benximidaxoly I)-ethylidene]-6,lldi- hydrodibe nz[b,e]oxepine-2-carboxylate monoh~~te in a canine model of femoral th~mb~is.

Fitzgerald GA, Lupinetti M, Charman SA, Charman WN// Univ Coil Dublin. Mater Hasp, Ctr Cardiovasc Sci, Dept Med & Exptl Therapeut, 41 ficles St, Dublin 6, Ireland J PHARMACOL EXP THER 1991,259 (3) 1043 Presystemic acetylation of platelets by aspirin - Reduction in rate of drug delivery to im- prove biochemical selectivity for thromboxane-A2.

Campbell IB, Collington EW, Finch H, Hayes R, Lumley P, Mills K, Robertson GM, Wharton K, Watts IS// Glaxo Grp Res Ltd, Dept Med Chem, Ware SG12 ODP, Herts, England BIOORG MEDICINAL CHEM LE’ITER 1991,1(12 ) 695 Synthesis and pha~a~lo~~l evaluation of combined thromboxane receptor antagonist/th~mb~ne synthase inhibitors - py- ridine-containing amino-prostanoids.

Campbell IB, CoIlington EW, Finch H, Hayes R, Lumley P,Mills K, Pike NB, Ro- bertson GM. Watts IS// Glaxo Grn Res Ltd. Dept Med &em, Wan SG12 ODP, Herts, ’ England BIOORG MEDICINAL CHEM LEGTER 1991,1(12 ) 699 Synthesis and pha~a~lo~~l evaluation of combined thromboxane receptor antagonist/synthase inhibitors - pyridinecontaining sulphonamido acids,

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Horton AA, Wood JM// Univ Birmingham, Sch Biochem, POB 363, Birmingham B15

%%!%PHYS ACTA 1991,1133 (1) 31 Prevention of Ca-2 +-induced or thrombox- ant B2-induced hepatoqte plasma mem- brane bleb formation by thromboxane recep tor antagonists.

Ritz MA, Luscher TF*// l Univ Hosp Base], Dent Med. Div Clin Pharmacol, CH-4031 E&l, Sw&erland CORONARY ARTERY DIS 1991.2 (9) 1001 Different potencies of endotheliumderived relaxing factors against thromboxane and endothelin-1 in coronary arteries - comparison with nitrovasodilator and calcium antagonists.

Squadrito F, Altavilla D, Zingarelli B, Iocula- no MP, Campo GM, Calapai G, Saitta A, Uma G, Sardella A, Spignoli G, et al // Univ Messina, Sch Med, Inst Pharmacol, Piazza XX Settembre 4, I-98122 Messina, Italy J CARDIOVASC PHARMA COL 1992,19 (1) 11s Protective effects of G-619, a dual thromboxane synthase inhibitor and thromboxaneA2 receptor antagonist, in splanchnic artery occlusion shock.

Vakhrushev LL et al PEDIATRIIA 1991(2) 18-22 The role of thromboxane A2 and prostacyclin in the pathogenesis of diabetes mellitus in children and adolescents (Rus)

Backon J// POB 16336, Jerusalem, Israel MED HYPOTHESES 1991,36 (3) 225 Increased bowel permeability in psychiatric disorder - relevance of thromboxane.

Torresduarte A, Amezcua JU/ Ctr Univ In- vest Biomed Apdo, Postal 199, Colima, Mexi-

%OSI-*G-INS 1991,42 (6) 571 Thromboxane and prostaqclin generation by human umbilical veins after thrombin.

Fomsgaard JS, Kim YD, Burke TA, Viswana- than T, Schaffer AV, Peppard J, Douglas FL, Danchak M, Myers AK*// *Georgetown Univ, Med Ctr, Dept Physiol & Biophys, 3900 Reservoir Rd NW, Washington, DC 20007, USA ANESIH ANALG 1992,74 (1) 38 Comparison of thromboxane synthetase inhibitor and methylprednisolone effects on protamine responses in dogs.

8. LEUKOTRIENES Wainwright SL, Powell WS*// l Meakins- Christie Laboratories, 3626 St Urbain St, Montreal, Quebec, Canada H2X 2P2 J BIOL CHEM 1991,266 (31) 20899 Mechanism for the formation of dihydro metabolites of 12-hydroxyeicosanoids. Conver- sion of leukotriene I?4 and 12-hydroxy- S,8,10,14cicosatetraenoic acid to 12-0~0 inter- mediates.

Ohuchida M, Sasaguri Y, Morimatsu M, Na- gase H, Yagi K*// l Int Applied Biochem, Yagi Memorial Pk, Mitake, Gifu SOS-01, Japan BIOCHEM IN-T 1991,25 (3) 447 Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human skin fibroblasts.

Takahashi M, Przetaki&cz M, Ong A, Borek C. Lowenstein JM// Bra&is Univ. Grad Dept B&hem, Waltham, Ma 022.54; USA CANCER RES 1992,52 (1) 154 Effect of omega3 and omega6 fatty acids on transformation of cultured cells by irradia- tion and transfection.

Morelli JG, Hake SS, Murphy RC, Norris DA// Univ Colorado, Sch Med, Dept Derma- tol, B-153,4280 E 9th Ave, Denver, Co 80262, USA J INVEST DERMATOL 1992,98 (1) SS Leukotriene-B4-induced human melanocyte pigmentation and Ieukotriene-Cl-induced human melanocyte growth are inhibited by different isoquinolinesulfonamides.

Mayer M// Palacky Univ, Fat Med, Dept Neurol, IP Pavlova 13, CS-77550 Olomouc, Czechoslovakia PROSTAGLAND LEUK ESSENT FATTY 1991,44 ( 4) 2.57 Linoleic acid - dependent slowing of erythro- cyte sedimentation in multiple sclerosis.

Pate1 PM, Drummond JC*, Mitchell MD, Yaksh TL, Cole DJ// ‘Univ Calif San Diego, Dept Anaesthesiol, Mailstop 0629, La Jolla, Ca 92893, USA J CEREBR BLOOD FLOW METAB 1992, 12 (1) 88 Eicosanoid production in the caudate nu- cleus and dorsal hippocampus after forebrain ischemia - a microdialysis study.

Giordano MJ, Mathur SN, Moore SA*// l Univ Iowa, Med Labs, Dept Pathol, Room 119, Iowa City, Ia 52242, USA J NEUROCHEM 1992,58 (1) 374 Differential metabolism of hydroxyeicosatetraenoic acid isomers by mouse cerebromicro- vascular endothelium.

Moghaddam MF, Gerwick WH’// *Oregon State Univ, Coil Pharm, Corvallis, Or 97331, USA J NAT PROD-LLOYDIA 1991,54 (6) 1619 Cell-free biosynthesis and source of hydroxyl groups in (12R,13S)dihydroxy- (SZ,8Z,lOE,14Z)eic osatetraenoic acid, a novel eicosanoid from the marine alga Graci- lariopsis lemaneiformis.

Debrumfemandes AJ, Guillemette G, Bor- geat P, Sirois P’// ‘Unlv Sherbrooke, Fat Med, Dept Pharmacol, Sherbrooke, Quebec, Canada JlH SN4 J PHARMACOL EXP THER 1991,259 (3) 103s Specific binding sites for leukotrieneB4 in guinea pig brain membranes.

Vaillier D, Daculsi R, Gualde N, Bezian JH// Univ Bordeaux 2, Immunol Lab, 146 Rue Leo Saignat, F-33876 Bordeaux, France CELL IMMUNOL 1992,139 (1) 248 Effect of LTB4 on the inhibition of natural cytotoxic activity by PGE2.

Hilger RA, Neuber K, Konig W*// l Ag In- fektabwehrmech, Inst Med Mikmbiol & Im- munol, Univ Str 150, W-4630 Bochum, FRG IMMUNOLOGY 1991.74 (4) 689 Conversion of leukotriene A4 by neutrophils and platelets from patients with atopic der- matitis.

Weber C, Aepfeibacher M, Lux I, Zimmer B, Weber PC*// l Univ Munich, Kreislaufkrank- heiten, Inst Prophylaxe & Epidemiol, Petten-

koferstr 9, WsooO Munich 2, FRG BIOCHIM BIOPHYS ACI’A 1991,1133 (1) 38 Docosahexaenoic acid inhibits PAF and LTD4 stimulated [Ca-2 +]i-increase in dif- ferentiated monocytic U937 cells.

Murakami M, Kudo I, Inoue K’// l Univ Tokyo, Fat Pharmaceut Sci, Dept Hlth Chem, 7-3-l Hongo, Bunkyo ku, Tokyo 113, Japan FEBS LEFT 1991,2w (3) 247 Eicosanoid generation from antigen-primed mast cells by extracellular mammalian 14- kDa group-11 phospholipaseA2.

Rouvinen KJ/ Nova Scotia Agr Coil, Dept Anim Sci, POB 550, TN~o, NS, Canada B2N SE3 ACI-A AGR SCAND 1991,41(4) 401 Dietary effects of omega-3 polyunsaturated fatty acids on body fat composition and health status of farm-raised blue and silver foxes.

Vilchez C, Touchbum SP*, Chavez ER, Chan CW// *McGill Univ, Macdonald Coil, Dept Anim Sci, St Anne Bellevue, Quebec, Canada H9X 1CO POULTRY SC1 1991, 70 (12) 2484 Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Cotumix cotur- nix japonica) .l. Reproductive performance and tissue fatty acids.

Pahl MV, Barbari A, Vaziri ND, Hollander D, Yazdani M, Tran J, Kan R// Univ Calif Ir- vine, Dept Med, Div Nephrol, Orange, Ca 92668, USA BRIT J NUTR 1991,66 (3) 467 Intestinal absorption of linoleic acid in ex- perimental renal failure.

Arai M, Fukuda H// Kanegafuchi Chem Ind Co Ltd, l-8 Miyamae, Takasago, Hyogo 676, Japan J FERMENT BIOENG 1991,72 (6) 473 An analytical study of adsorption and desorp- tion of gamma-linolenic acid ester using CsY- zeolite.

Young PR, Bell RL, Lanni C, Summers JB, Brooks DW, Carter GW// Abbott Labs, Dept 47K Immunosci Res Area, AP-9, Ab- bott Pk, II 60064, USA EUR J PHARMACOL 1991,205 (3) 2.59 Inhibition of leukotriene biosynthesis in the rat peritoneal cavity.

Kulkami PS// Univ Louisville, Sch Med, Ken- tucky Lions Eye Res Inst, Dept Ophthalmol & Visual Sci. Louisville. Kv 48292. USA J OCUL P HARMACGL i991,7 (3) 227 The role of endogenous eicosanoids in rabbit. intraocular inflammation.

Arenberger P, Ruzicka T, Kemeny U/ Univ Munich, Dept Dermatol, Frauenlobstr 9-11, W-8008 Munich 2, FRG SKIN PHARMACOL 1991,4 (4) 272 Effect of ciclosporin on epidermal 12(S)-hydroxyeicosatetraenoic acid binding sites.

Dejong EMGJ, Vanvlijmen IMMJ, Scholte JCM, Buntinx A, Friedman B, Tanaka W, Vanderkerkhof PCM// Univ Hosp Nijmegen, Dept Dermatol, Javastr 104,6524 MJ Nijmegen, Netherlands SKIN PHARMACOL 1991,4 (4) 278 Clinical and biochemical effects of an oral leukotriene biosynthesis inhibitor (MK886) in psoriasis.

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Pet M et al CESK FYSIOL 1991,40 (2) 147-57 Leukotrienes as mediators of respiratoty tract obstruction in bronchial asthma (Sio)

Kojima T et al NIPPON NIBIIKOKA GAKKAI KAHO 1991,94 (4 ) 587-93 A study of chemical mediators in patients with allergic rhinitis. 3. Release of histamine and leukotricnes from in vitro nasal mucosa (Jpn)

Maruyama T NIPPON IKA DAIGAKU ZASSHI 1991,58 (2) 219-35 The alteration of eicosanoid levels in arterial blood and its relation to the pathologic status of acute myocardial infarction (Jpn)

Bandyopadhyay I, Saha S, Dutta J*// *BE- 217. Salt Lake. Calcutta 700 064. India BIGCHEM Iti 1991,25 (5) 919 Effect of dietary fiih oil on platelet aggrega- bilityz Comparison between two oils with different eicosapentaenoic to arachidonic acid ratio.

Chung SW, Sinclair SB, Fung IS, Cole EH, Levy GA// Univ Toronto, Dept Med, 1 Kings Coil Circle, Med Sci Bldg, Lab 7392, Toton- to, Ontario, Canada MSS lA8 PROSI-AGLANDINS 1991,42 (6) 501 Effect of eicosanoids on induction of procoagulant activity by murine hepatitis virus strain-3 in vitro.

Peskar BM, Kluge S, Peskar BA, Soglowek SM, Brune K// Ruhr Univ Bochum, Dept Exptl Clin Med, W-4630 Bochum, FRG PROSTAGLANDINS 1991,42 (6) 515 Effects of pure enantiomets of flurbiprofen in comparison to racemic flurbiprofen on ei- ccsanoid release from various rat organs ex vivo.

9. PLATELET-ACTIVATING FACTOR Adam K, Oswald I// The Birches, 41 St Ronan’s Terrace, Innerleithen EH44 6RB, Scotland LANCEI 1992,339 (8786) 186 Triazolam and platelet-aggregating factor (Letter)

Ono S, Voelkel NF*// l Univ Colorado, Hlth Sci Ctr, Dept Med, Catdiovasc Pulm Res Lab, B-133,4200 E 9th Ave, Denver, Co 88262, USA J APPL PHYSIOL 1991,71(6) 2483 PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.

Denizot Y, Chaussade S*, Couturier D// ‘Hop Cochin, Serv Hepatogastroenterol, F- 75674 Paris 13, France GASTROEN CLIN BIOL 1991, I5 (11) 817 PAF-acether and digestive tract (French)

Sakuma Y, Shirato M, Nagaoka J, Obaishi H, Tsunoda H, Katayama S, Ono H, Ka- tayama K// Eisai & Co Ltd, Tsukuba Res Labs, 1-3 Tokodai 5 Chome, Tsukuba, Iba- raki 300026, Japan ARZNEIM-FORSCH-DRUG RES 1991,41- 2 (12) 1255 Pharmacological activities of a novel thieno- diaxepine derivative as a platelet-activating factor antagonist - Effects on microvascular permeability, hypotension and nephrosis.

Murphy CT, Elmore M, Kellie S, Westwick J// Ut& Bath, Sch Pharm & Pharmacol, Bath BA2 7AY, Avon, Eneland BIOCHIM BIOPHY3 ACI-A 1991,1133 (1) 46 Comparison of the role of protein kinase-C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and amchidonic acid.

Herbert JM, Lespy L, Maffrand JP// Sanofi Rech, Ligne Hemobiol, 195 Route Espagne, F-31936 Toulouse, France EUR J PHARMACOL 1991,285 (3) 271 Protective effect of SR-27417, a novel PAF antagonist, on lethal anaphylactic and endo- toxin-induced shock in mice.

Kulikov VI, Muxya GI// Minist Publ Hlth USSR Sci Ind Ctr Med Biotechnol, Inst Biochem & Cell Physiol, Moscow, USSR VESI-N AKAD MED NAUK SSSR 1991 (10) 13 Phospholipid platelet-activation factor, its analogs and antagonists - Prospects of the use in medicine (Russian)

Heller R, Bussolino F, Ghigo D, Garbarino G, Pescarmona G, Till U, Bosia A’// *Univ Turin, Dipartimento Genet Biol & Chim Med, Via-Santena S-Bis, I-10126 Turin, Italy J BIOL CHEM 1991.266 (32) 21358 Stimulation of platelet-acti&t&faftor synthesis in human endothelial cells by activation of the denovo pathway - Phorbol12-myr- istate 13-acetate activates I-alkyl-2-lyso-sn- glycero-3-phosphate:a cetyl-CoA acetyltrans- ferase and dithiothreitol-insensitive l-alkyl-2- acetyl-sn-glycerol:CDP-cholin e cholinephos- photransferase.

Sakuma Y, Muramoto K, Harada K, Ka- tayama S, Tsunoda H, Katay-ama K// Eisai & Co Ltd, Tsukuba Res Lab, 13 Tokodai 5 Chome, Tsukuba, Ibaraki 30026, Japan PROSIAGLANDINS 1991.42 (6) 541 Inhibitory effects of a novel’PAF z&ttagonist- E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice.

11. RELATED ENZYMES Stoner CR Reik LM, Donohue M, Levitt W, Crow1 RM’II ‘Hoffmann La Roche Inc, Roche Res Ctr, Dept Molec Genet, Nutley, NJ 07110, USA J IMMUNOL METHOD 1991,145 (l-2) 127 Human group-11 phospholipase-A2 - Charac- terization of monoclonal antibodies and im- munochemical quantitation of the protein in synovial fluid.

Boros M, Bako L, Nagy S/l Szent Gyorgyi Al- bert Med Univ, Inst Exptl Surg, POB 464, H- 6701 Szeged, Hungary EUR SURG RES 1991,23 (34) 141 Effect of antioxidant therapy on cyclooxyge- nasederived eicosanoid release during intestinal ischemia-reperfusion.

Gutierrez JM, Nunez J, Diax C, Cintra ACO, Homsibrandeburgo MI, Giglio JR// Univ Costa Rica, Fat Microbial, Inst Clodomiro Pi- cado, San Jose, Costa Rica EXP MOL PATHOL 1991,55 (3) 217 Skeletal muscle degeneration and regener- ation after injection of bothropstoxin-II, a phospholipase-A2 isolated from the venom of the snake Bothrops jararacussu.

Chaud MA, Franchi AM, Viggiano M, Gime- no AL, Gimeno MAF*// l MAFG, Serrano 665, RA-1414 Buenos Aires, Argentina PROSTAGLAND LEUK ESSENT FAT-I-Y 1991,44 ( 4) 211 Effect of exogenous phospholipaseA2 and triacylglycetol lipase on the synthesis and release of monoenoic and bisenoic prostaglandins from isolated rat uterus.

Bhat MK, Prasad BN, Gowda TV*// ‘Univ Mysore, Dept Studies B&hem, Mysore 570006. Kamataka. India TOXICON 1991,29 (11) 1345 Purification and characterization of a neuto- toxic phospholipase&? from Indian cobra (Naja naja naja) venom.

Delot E, Bon C*// *INSERM, U285, Inst Pas- teur. Unite Venins. 25 Rue Dr Roux. F-75724 Paris 15, France J NEUROCHEM 1992,58 (1) 311 Differential effects of presynaptic phospholi- paseA neurotoxins on torpedo synapto- somes.

Luthin DR, Cline WH*// ‘So Illinois Univ, Sch Med, Dept Pharmacol, POB 19239, Springfield, II 62794, USA J PHARMACOL EXP THER 1991,259 (3) 1174 Evidence for enhanced inhibitoty modulation by cyclooxygenase products of noradrenergic neurotransmission in the mesenteric vascula- ture of young spontaneously hypertensive rats.

Komatsu H, Yaju H, Chiba K, Okumoto T// Yoshitomi Pharmaceut Ind Ltd, Res Labs, 7- 2.5 Koyata 3 Chome, Iruma, Saitama 358, Japan INT J IMMUNOPHARMACOL 1991,13 (8) 1137 Inhibition by cyclo-oxygenase inhibitors of interleukin-6 production by human peripheral blood mononuclear cells.

Bell E, Mullet JW/ Texas A&M Univ Svst. Dept &hem & Biophys, College Stn,‘Tx 77843. USA MOL’GEN GENEI 1991,230 (3) 456 Lipoxygenase gene expression is modulated in plants by water deficit, wounding, and methyl jasmonate.

Stubbs CD, Kisielewski AE, Rubin E// Tho- mas Jefferson Univ, Dept Pathol & Cell Biol, Room 271 JAH. 1020 Locust St. Philad- elphia, Pa 19107, USA BIOCHIM BIOPHYS ACTA 1991,107O (2) 349 Chronic ethanol ingestion modifies liver microsomal phosphatidylserine inducing resistance to hydrolysis by exogenous phos- pholipaseA2.

Diax C, Gutierrez JM, Lomonte B, Gene JA // Univ Costa Rica, Fat Microbial, Inst Clo- domiro Picado, San Jose, Costa Rica BIOCHIM BIOPHYS ACI-A 1991,107O (2) 455 The effect of myotoxins isolated from bo- thtops snake venoms on multilamellar lipo- some6: - relationship to phospholipaseA2, anticoagulant and myotoxic activities.

Misaki A, Ide M, Kono M// Shionogi & Co Ltd, Shionogi Res Labs, Fukushima ku, Osaka 553, Japan J CLIN BIOCHEM NUTR 1991,11(2) 79 Production and characterization of monoclonal antibodies against human pancreatic

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phospholipaseA2.

Miiki A, Punakoahi A, Kono M// Shionogi & Co Ud. ShionoEi Res Labs. Fukushima ku, Osa)o;553, Ja$n J CLIN BIOCHEM NUT-R 1991,11(2) 91 Method for simultaneous determination of pancreatic phoapholipaseA2 and prophos- pholipaseA2 in human sera and its clinical significance.

Acton KS, Boermans HJ, Bray TM*// l Univ Gueloh. Deot Nutr Sci, Collaborat Program Toxi& G&ph, Ontario, Canada NldZWl COMP BIOCHEM PHYSIOL PT C 1992, 101 (1) 101 The mle of prostaglandin-H synthase in 3- methylindole-induced pneumotoxicity in goat.

Sugrue MF, Oneilldavis IJ/ Merck Sharp Jc Dohme Ltd, WP26-25, W Point, Pa 19486, USA J OCUL PHARMA COL 1991,7 (3) 201 The effect of qclooxygenase inhibition on the ocular hypotensive action of topical car- bonic anhydrase inhibitors in rabbits.

Kamata K, Arai Y, Kasuya Y, Aoiki Y, Same- jima Y// Hoshi Univ, Sch Pharm, Dept Phar- macol. 2441 Ebara, Shinagawa ku, Tokyo 142, Japan RES COMMUN CHEM PATHOL PHARM 1991,74 (3 ) 375 Pharmacological actions of chemically-modi- fied phospholipase A2 from the venom of Trimeresurus llavoviridis on the smooth muscle of the rat stomach fundus.

Bomalaski JS, Steiner MR, Simon PL, Clark MA*// l Scherine Ploueh Corp. 60 Orange St, Bloomfield, NJ ii7003,USA _ - J IMMUNOL 1992,148 (1) 155 IL-l increases phospholipase-A2 activity, expression of phospholipase-A2-activating protein and release of linoleic acid from the murine T-helper cell line EL4.

Kumar S et al INDIAN J EXP BIOL 1991,29 (4) 37984 Involvement of mono-oxygenases as a major mechanism of deltamethrin-resistance in lar- vae of three species of mosquitoes.

Watanabe H et al NIPPON SANKA FUJINKA GAKKAI ZASSHI 1991,43 (4) 443-50 A study on GTP-binding protein in the activation of phospholipase C and phospholipase A2 in cultured rat luteal cells (Jpn)

Yamamoto S et al SEIKAGAKU 1991,63 (3) 188-201 Recent studies on mammalian lipoxygenases

(Jan)

Izumi T SEIKAGAKU 1991,63 (3) 212-7 Arachidonate lipoxygenase family (Jpn)

Chang CC, Lin SN, Chen FS, Chang WC// Natl Cheng Kung Univ Hosp, Dept Uml, 138 Sheng Li Rd, Tainan 70428, Taiwan BRlT J UROL 1991,68 (6) 579 15-hydmxyprostaglandin dehydmgenase activity in the lower genitourinary tract - A pre- liminary report.

Nguyen T, Falgueyret JP, Abramovitz M, Riendeau D// Merck Fro& Ctr Therapeut Res, POB 1005, Pointe Claire, Quebec, Cana- da H9R 4P8 J BIOL CHEM 1991,266 (32) 22-57

Evaluation of the role of consed Hi and Met residues among lipoaygenases by sitedi- rected mutagenesis of recombinant human 5- lipoxygenase.

Klajn VM, Moreira MAJ/ Dept Quimica, Univ Fed Vicosa, 36570 Vicoaa/MG, Portugal ARQ BIOL TECNOL 1991,34 (2) 243 Detection of soybean lipoxygenases L-l and L-3 by the carotene bleaching reaction (Por- tuguese - Eng. Abstract)

Byczkowski JZ, Ramgoolie PJ, Kulkami AP*// l Toxicol Program, Coil Public Hlth, Univ South Florida, Tampa, Fl33612, USA BIOCHEM INT 1991,25 (4) 639 Pmline hydroxylation by soybean lipoxygenase.

12. PRODUCTION AND RELEASE Peplow PV// Univ Otago, Dept Anat, POB 913, Dunedin, New Zealand PROSLAGLAND LEUK ESSENI’ FATTY 1991,44 ( 4) 259 Effects of progesterone withdrawal on uterine prostaglandin levels in the ovariectomized pregnant rat.

Wittenberg JM, Wittenberg RH*// *St Josef Hosp, Dept Orthoped, Gudrunstr 56, W- 4630 Bochum, FRG ACTA ORTHOP SCAND 1991,62 (6) 577 Release of pmstaglandins from bone and muscle after femoral osteotomy in rats.

Wittenberg RH, Willburger RE, Kleemeyer KS, Schleberger R// Ruhr Univ Bochum, St Josef Hasp Bochum, Orthopad Klin, Gu- drunstr 56, W-4630 Bochum, FRG Z ORTHOP GRENZGEB 1991,129 (6) 531 Pmstaglandin (PG) and leukotriene (LT) release from synovial tissue in different joint diseases.

Hsu P, Zuckerman S, Mirro R, Armstead WM, Leffer CW// Univ Tennessee Ctr Hlth Sci, Dept Physiol Biophys, Res Neonatal Physiol Lab, Memphis, Tn 38163, USA PROSIAGLANDINS 1991,42 (6) 557 Effects of ischemia/reperfusion on brain tissue prostanoids and leukotrienes in new- born pigs.

Fukuda T, Arakawa T, Mach T, Durbin T, Tamawski A// Vet Adm Med Ctr, Gastroen- teml Sect, Long Beach, Ca 98822, USA PROSI’AGLANDINS 1991,42 (6) 587 Calcium channel blockers and prostaglandin generation by gastric surface epithelial cells.

Mine T, Kataoka A, Fujisaki J, Sate E, Yasu- da H, Akimoto K, Ogata E, Sekiguchi H, Ha- mada K// Univ Tokyo, Sch Med, Dept Inter- nal Med 4, Div Gastmenteml, 3-28-6 Mejim- dai, Bunkyo ku, Tokyo 112, Japan CURR THER RES 1991,50 (6) 878 Effects of cimetidine and tmxipide on gastric mucosal prostaglandin synthesis in patients with chronic gastric ulcer.

13. EFFECTS Morimoto A, Watanabe T, Morimoto K, Na- kamori T, Murakami N// Dept Physiol, Yamaguchi Univ Sch Med, Ube, Yamaguchi 755, Japan J PHYSIOL (LOND) 1991,443 421 Possible involvement of pmstaglandins in psy- chological stress-induced responses in rats.

Oneill P, Walton S, Foy PM, Shaw MDM// Mater Private Hosp, Dept Neurosurg, Eccles

St, Dublin 7, Ireland NEUROSURGERY W92,30 (1) 17 Role of pmataglandii in delayed cerebral &hernia after subarachnoid hemorrhage.

Nafeeza MI, Shahimi MM, Haahim S, Ishak MS, Isa MR// Univ Kebangaaan, Dept Phar- macol, Kuala Lumpur 50300, Malaysia AMER J GASI-ROENTEROL 1991,86 (12) 1852 Pmstaglandin and Helicobacter-pylori-related non-ulcer dyspepsia (Letter)

Chan WY, Chen DU/ Cornell Univ, Med Ctr, Coil Med, Dept Pharmacol, New York, NY 10021, USA BIOL REPROD 1992,46 (1) 58 Myometrial oxytocin receptors and prostaglandin in the parturition process in the tat.

Genda T MASUI 1991,40 (5) 754-62 Effects of pmstaglandins on pulmonary cinzu- lation (Jpn)

Nijs G, Dewitte P, Vanhoestenberghe A, Ge- boes K. Lemli J/1 Catholic Univ Lewen, Inst Pharmaceut Sci, Pharmaceut Biol & Phyto- pharmacol Lab, E Vanevenstr 4, B-3000 Lou- vain, Belgium ACTA GASTRO-ENTEROL BELG 1991, 54 (2) 184 Direct and indirect evidence for the involvement of prostaglandins in the secretagogue action of rhein anthmne in the small intes- tine.

14. PROSTAGLANDINS IN MEDICINE Fraser R// Univ Sheffield, No Gen Hasp, Deot Obstet & Gvnaecol. Sheffield S5 7AU. England ’ BRIT J OBSIET GYNAECOL 1991,98 (12) 1314 Intrauterine pressures in labours induced by amniotomy and oxytocin or vaginal prostaglandin gel, compared with spontaneous la- bour (Letter)

Lament RF// Northwick Pk Hosp & Clin Res Ctr, Harrow HA1 3UJ, Middx, England BRlT J OBSTEI GYNAECOL 1991,98 (12) 1315 Intrauterine pressures in labours induced by amniotomy and oxytocin or vaginal pmstaglandin gel, compared with spontaneous la- bour - reply (Letter)

Iakovlem AA et al REVMATOLOGIIA (MOSK) 1991(3) 3-7 Pmstanoids in children with joint diseases (Rus)

Skajaa K, Mamsen A, Secher NJ// Aarhus Univ, Dept Obstet & Gynecol, DK-8000 Aar- hus, Denmark EUR J OBSI’ET GYN REPROD BIOL 1991,42 (3 ) 177 Influence of vehicle form on efficiency of prostaglandinE2 gel for cervical ripening.

15. PROSTAGLANDINS AS DRUGS Weir MR. Li XW, Gomolka D, Peppler R, Obtyantear CG, Moran MA// UnivMatyland HOSD. Deut Med. Div Neuml. 22 S Greene St, I%ltimbre, Mb 21201, USA TRANSPLANTATION 1991,52 (6) 1053 The immunosuppressive properties of eniso- pmst and a 5-lipoxygenase inhibitor (SC- 45662)

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Sanchudazpal L, Gores GJ, Ferguson DM, Krom RAF*// *Mayo Qin & Mayo Fdn, Dept Surg, Rochester, Ma 55905, USA TRANSPLANTATION 1991,52 (6) 1105 Improved liver preservation with addition of iloprcst to Eurocollins and University of Wii- consin storage solutions.

Ohnishi ST, Oh&hi T// Philadelphia Biomed Res Inst, King of Prussia, Pa 19406, USA ARZNEIM-FGRSCH-DRUG RES 1991,41- 2 (12) 1201 Biologically significant physico-chemical properties of antioxidative prostaglandin deri- vat&es.

Perkins WE, Burton EG, Tsai BS, Collins PW, Casler JJ, Gasiecki AF, Bauer RF, Jones PH. Gaginelia TS// Searle Labs, Res 8~ Dev, G~~in~~inal Dis Res, 4901 Searle Pkwv. Skokie. 1160077. USA J PHARMACOL Exi, THER 1991,2!i9 (3) 1001 SC46275 - A potent, long-acting gastric antisecretory pmstaglandin with low oral bioavailability in the dog.

Campbell IB, Collington EW, Finch H, Hal- lett P, Hayes R, Lumley P, Mills K, Wallii Cl, White BP// Glaxo Grp Res Ltd, Dept Med Chem, Ware SGl2 ODP, Herts, England BIOORG MEDICINAL CHEM LETIER 1991,1(12 ) 689 Synthesis and pharmacological evaluation of novel amino-prostanoids - potent and orally effective thromboxane A2 receptor antagonists.

Lanza FL, Kochman RL, Geis GS, Rack EMF, Deysach LG// 6636 Demoss, Houston, TX 77974, USA AMER J GASI’ROENTEROL 1991,86 (12) 1743 A double-blind, placebo-controlled, six-day evaluation of two doses of misopmstol in ga- stroduodenal mucosal protection against damage from aspirin and effect on bowel ha- bits

Kikuehi Y, Kita T, Hirata J, Kuki E, Nagata 1, Fukushima M/l Minist Agr Forestry & Fisheries, Nat1 Food Res Inst, Div Food Engn, Instrumentat Res Lab, Tsukuba 365, Japan INT J IMMUNOPHARMACOL 1992,14 (1) 10s Modulation of human lymphocyte response to ph~ohema~utinin by antineoplastic pros- ~~andi~.

Rusterboltz T, Lqage JY*, Malinovsky JM, Dedieuleveult C, Cozian A, Bouyer L, Ga- nansia MF, Pinaud M, Souron W/ *CHR Nantes, Hotel Dieu, Dept Anesthesie Reani- mat Chirurg, F-44035 Nantes 01, France ANN FR ANE?SIH REANIM 1991,lO (6) 535 Comparative effects of p~medi~tion with diazepam, ranitidine, sodium citrate and en- pmstil on gastric juice pH and volume.

Belch JJF, Lau CS, Saniabadi A, McLaren M, Forbes CD// Univ Dundee, Carnegie Lab Phys, Dundee DD14HN, Scotland AMER J MED 1991,91 (6) 666 Iloprost and risk of thromboembolism (Let-

ter)

Kovacs IB// St Bartholomews Hasp, London EClA 7BE, England AMER J MED 1991,91(6) 667 Ilopmst and risk of thromboembolism - reply (Letter)

16. INHIBITOBS OF SYNTHESlS Spitz B, Vanbree R, Vanballaer P, Verbeke G, Hanssens M, Vanassche F// Univ Hosp Leuven, Dept Obstet & Gynecol, Herestr 49, B-3006 Lowain, Belgium CLIN EKP HYPERTENS B-HYPERTEN 1991.10 f 3) 371 Different‘alinhibition of vascular prostacyclin and platelet thtomboxane synthesis by different doses aspirin and by the thmmbox- ane inhibitor ridogrel (R-6gO7fJ)

18. CHEMIC~ ~~1s Caky El, Imai N, Pikul !I// Harvard Univ, Dept Chem, Cambridge, Ma 02138, USA TEXRAHEDRON LJXTI.’ 1991,32 (51) 7517 CataIytic enantioselective synthesis of a key intermediate for the synthesis of prostanoids.

The bibIiog~phy which appears in this journal is also available on subscription, on a fortnightly basis, from Sheffield University Biomedical Information Service. Sheffield SIO 2TN, UK. It is entitled ‘Prostaglandins - Biology’ (ISSN 0142-8284) and costs fl6.00 (also available on diskette at E60.00).

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monthly prostaglandin bibliography prepared by the university of sheffield biomedical information...

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