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Whereas I underomatic cell typeajor unmet meseases are a murvive with dialymmunosuppressenerated for thelated to kidneyuman iPSCs (hfferentiate patiesearch has exte

ome of the objeall of ERC Startieveloping new s

sumen del Cbecame interesostdoctoral felloospital of Santa

2008 I movedegenerative Meanking of new ime (Nature Pro

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d to the Centeredicine of Barcinduced pluripootocols, 2010).

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s been focusedrentiation and entical propertstrategies for n(iPS).

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results obtaineeve that providave chosen thisealth problem iantation, theseemployed on thmodel of kidnet and regeneratatients with gPSCs towards rence and resourc

current researc2014, revealinegenerative Me

Vitae: egeneration anhe Fundaçao pau in Barcelona.

r of Regeneratelona (CMRB), otent stem cellBased on my

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d in stem cellsorgan regenerties of human enuclear somatic

nt derived iPS ombined my badeveloped duration.

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ed during the coing this informs research topicin Europe and procedures arhe patient. Furey regenerationtion. Third, othenetic based denal cells (ureteces allowing me

h line have beeg the interest oedicine and Biom

d stem cells duara a Ciência e

ive Medicine oas research as(iPSC) lines. Inprevious know

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a.eu

s biology and iration. The discembryonic stemc reprogrammi

cells for the prackground in oring my pre‐do

omoting kidney

nd feeder‐free i

establishment

ourse of my resmation will openc for a number worldwide, an

re expensive, drthermore, then in mice, offerhers and I havedisorders. Foueric bud progene to tackle thes

en selected forof the scientificmedicine discip

uring my masteTecnología (Po

of Barcelona (Cssociate. Theren 2010 I first cowledge on stem

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n the identificacovery in 2006m cells, offered ng and disease

roduction of in rgan regeneratoctoral studies

y regeneration i

induced pluripo

of kidney disea

search line cannn new venues of reasons. Firsnd although paemanding and re is a shortagring an unprecee reported metrth, I have conitors). Fifth, thse major questio

r funding from c community foplines.

er and PhD traiortugal). In 2007

CMRB), as rese, I participatedo‐authored howm cells and tiss

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vitro platformstion in differenfor the genera

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not be generalifor the developst, the high incitients with Endcan be prone tge of organs foedented opporthodologies for‐authored for he institution wons.

the European or this type of m

ning that finish7 I was hired as

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molecular and cmatic cell type olast eight yearthe generation

s for compoundnt animal modeation of massiv

idney regenera

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ized to the genepment of theraidence and pood Stage Renal to life‐long sideor transplantatrtunity to addrer the generatiothe first time

where I am curre

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In 2008 I move strategies for cord blood stent I reasoned

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GENERAL HUMANOS TIGACIÓN

cellular mechanof our body cas an unpreceden of patient sp

d screening andels (teleost fishve strategies fo

tion in mamma

patients with ki

eration of any oapeutics targetor prognosis of Disease (ESRDe effects due toion. Second, I ess major queson of transgenee, the possibilitently conductin

ncil (ERC) withinry approaches w

he same year I ral researcher a

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btained by meast whether derso found, for teplaced by GATollaborated in oerm cells, neuraethods 2012, Nthe generationature Communf kidney organurposes [Nature

aking advantagerder to understeen selected foudies have ideeart can be reastitute for Bioe

MINISTERIO


ans of safe stratrmal fibroblast he first time, tTA3. The work other projects aal cells, endothNature Commun of platforms fication 2014). Moids, suitable e Cell Biology (2

e of my experttand how to actor funding fromntified, for theactivated and eengineering of C

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tegies using specould be reproghat OCT4, the resulted in a

aimed to characelial cells, retinnications 2013,for the study ofMoreover, my for the study 2013)].

tise in the fieldtivate endogen

m the Europeane first time, howelicit heart regeCatalonia (IBEC)

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ecific transcriptgrammed to plonly transcripthigh‐impact pucterize the genonal cells or bloo, Protein and Cef disease progreinterest on orgof iPSCs differ

ds of somatic reous programs Research Counw the reactivateneration [Cell ).

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de acceso g

tion factors deturipotency. Notion factor belieublication in Comic integrity ood cells. These sell 2013, Naturession and comgan regeneratiorentiation tow

eprogramming in order to regncil (ERC) withition of endogeStem Cell, in p

Y CAJAL A 2014

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erminant for linot only I succeedeved to be indell Stem Cell (of human iPSCsstudies were pue Communicatmpound screenion provide newards renal line

and organ regenerate the adin the call of ERenous regenerapress 2014]. Fro

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generation I amult mammalianRC Starting Grative programs om January 201





ation. With this trating that thissomatic reprogre I am the firhe differentiatim Cells 2011, Ne same mannery by means of hr the generatiompound screen

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ENERAL CNOLOGÍA

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in mind, I set os was the case,gramming, courst co‐author. Ion of iPSCs towNature 2012, Nar I have participiPSCs (Nature 2n, for the first ing for therap

massive strateed this approachWithin this linant in adult mgroup leader a

out to but I ld be I also wards ature pated 2012, time, peutic

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Embryoell types. The fiells are more simem cells cannond 1 in Cell.

Inducedource of cells foNature Commu

Direct fferentiation prsing a specific ce reprogrammbroblasts into iansplantation. ublished in this

Spermaonditions withoestore spermatones have not beenewal in vitroeatments compuman SSC lines permatogenesisublications have

verall, my reseNSCs) or male fe

sumen del CURRENT POSITOne 2014,

DUCATION: 999, Degree in

005, Ph.D. in Im

ESEARCH EXPERune 2014, Indeunded by the N

ep 2009‐May 2

MINISTERIO


TAPIA , NRYC‐2014

a: Biomedicnico: nata

egenerative me

a Memoria: ars, I have been

onic and epiblainal goal was tomilar to mouseot be fully extra

d pluripotent sor patient‐speciunications.

reprogrammingrotocols for all combination ofming efficiency induced neuralMy group is ntopic, including

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arch is focusedertility disorder

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n working on 4

st stem cells. I o ascertain thee epiblast stem apolated to the

stem cells (iPS)fic cell‐replacem

g into somatic cell types are sf transcription fis very low andl stem cells (iNow trying to reg 2 Cell Stem Ce

cell (SSC) linesc manipulationtesticular transyet. One of mya human SSC lertility of pre‐pved prior to thehuman SSC linesed in this topic,

d on stem cell s (e.g. SSCs), th

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main topics rela

have assessed teir similarity to cells than to mhuman model

). I have investment therapy. 7

cells. iPS needstill not availablfactors. Howevd neurons do nNSCs) that can eprogram iNSCell and 1 Nature

s can be stablyn, thus represesplantation intoy main researchine will have mubertal patiente anticancer tres will be the pe, including 1 in

topics that canhus it fits into th

r, Heinrich‐Hein

de + Master) w

noma de Barcel

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eader, Max Plan

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de acceso g

ated to stem ce

the mechanismhuman embry

mouse embryon. 4 publications

tigated the me7 reports have

d to be differenle. In 2010, thever, the amounnot proliferateself‐renew. ThC in vivo in orde Protocols.

y derived in vitrenting a new so infertile miceh lines is focusemany implicatits in which speeatment and trerfect tool to stCell Stem Cell a

n improve the he Biomedicine

ne University (D

with Special Hon

lona (Barcelona

ersity (Düsseldon, Science and

nck Institute for

Y CAJAL A 2014

general

ells and their po

ms underlying thyonic stem cellsnic stem cells. Hs have been pu

chanisms undebeen published

ntiated into thee direct converst of generated. To avoid thiserefore an unlder to eliminat

ro and can be ource of cells e. Unfortunatelyed on decipherons in the treerm cannot beransplanted afttudy the mechaand 1 in Nature

medical treatm ANEP area.

Düsseldorf, Ger

nors, Universita

a, Spain).

orf, Germany).Research.

r Molecular Bio

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e required cell ion of fibroblasneurons is notlimitation, I himited numbere the transplan

converted to pfor transplantay, the culture cing the conditiatment of infecryopreserved

ter tumor elimianism underlyin.

ment of disease

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regenerative m

f pluripotency ishow that humdata obtained ftopic, including

amming to pluincluding 1 Nat

types prior to sts into neuront enough for trhave been abler of neurons cantation step. 5

pluripotency unation. Furthermconditions to eons required toertility. For instd. In this scenaination, a proceng some types

es such as neur

Valencia, Spain


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


medicine:

in these two mman embryonic rom mouse epig 1 in Cell Stem

ripotency as aure Cell Biology

transplantations was accompliransplantation to directly coan be produce5 reports have

nder specific cumore, SSC linesestablish humano maintain SSCtance, some caario, patient‐spess that will reof male infertil

rodegenerative

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urine stem iblast m Cell

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(MEm ‐S(MFu ‐NFu ‐MFu ‐OFu TE‐M ‐Ju ‐O TH‐M ‐M ‐O IN‐D ‐Ju ‐NDe IN AW‐T‐F‐A‐D‐R CO RE‐ 3‐ 9‐ 3‐ 925Na

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Münster, Germamployed as a sc

ep 2005‐Aug 20Münster, Germaunded by a Max

Nov 2004‐Feb 20unded by a rese

May 2000‐June unded by a rese

Oct 1998‐June 1unded by a rese

EACHING: May 2014

uly 2012, 3rd Ro

Oct 2011‐July 20

HESIS SUPERVISMay 2014, Doct

March 2014, Do

October 2013, M

NVITED EXTERNADec 2014, ANR 2

une 2014, CE11

Nov 2013, Call evelopment).

NVITED REVIEW

WARDED GRANitle: Dissecting unding organizAmount: 1.250.0Duration: 5 yearRole: Principal In

ONFERENCES: 2

ESEARCH ARTIC30 articles acce9 first authorsh3 corresponding9 papers have 5,4), 1 in Naturature Commun

MINISTERIO


any). cientist accordin

009, Poany). x Planck Society

005, Guearch fellowship

2005, Predoctoearch fellowship

1999, Pregraduaearch fellowship

Habilitation

oyan Internatio

013, 3 h

SION: oral thesis: Ulf

octoral thesis: A

Master thesis: H

AL REVIEWER F2015 Program (

1 2014 Program

for Internatio

ER FOR PEER‐R

NTS AS PRINCIPAthe molecular ation: North‐Rh000 euros rs nvestigator

25 conferences

CLES: pted plus 2 repips g authorships pbeen publishedre (IF:38,5), 1 iications (IF:10)

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ng to the Germ

ostdoctoral fello

y postdoctoral f

uest scientist, Jop from the Span

oral fellow, Funp from the Span

ate researcher,p from the Span

for Privat Doze

onal Summer Sc

hours/week pe

Tiemann (Mag

Adele Marthaler

Hannah Flaßkam

FOR GRANT PRO(French Nationa

m (French Natio

nal Stem Cell

REVIEWED JOUR

AL INVESTIGATmechanisms thhine Westphali

including oral a

ports that are u

plus the 2 repord in journals wn Cell (IF:31,9).

AYUDASCONVO

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an Public Secto

ow, Max Planck

fellowship to pr

ohns Hopkins Unish Ministry of

dacio Irsicaixa (nish Ministry of

Universitat de nish Ministry of

entin, German a

chool: Stem Ce

r semester (4 se

na Cum Laude)

r (Magna Cum L

mp (Excellent).

OPOSALS: al Research Age

nal Research Ag

Research, Bre

RNALS: Stem Ce

OR: hat regulate hua Ministry of In

and poster pres

nder revision.

rts that are undith an impact f, 1 in Nature C

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de acceso g

or Labor Agreem

k Institute for M

romote scientif

University (Baltif Health (BEFI).

(Barcelona, Spaf Health (BEFI).

Valencia (Valef Education and

accreditation re

lls and Develop

emesters), Wes

).

Laude).

ency).

gency).

eakthrough Pro

ells, Nature Cel

man spermatognnovation, Scien

sentations.

der revision. factor higher thCell Biology (IF:

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general

ment (TVöD).

Molecular Biome

fic cooperation

imore, USA).

ain).

ncia, Spain). d Culture.

equired for app

pmental Biology

stfälische Wilhe

oject (The Neth

l Biology, EMBO

gonial stem celnce and Resear

han 10, from w:20,7), 1 in Jou

SDD

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edicine

with foreign co

plying to Profess

y, (Tehran, Iran

elms‐Universitä

herlands Organ

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l fate decisionsrch (Germany)

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ountries.

sorship position

n). Organizer an

ät (Münster, Ge

nization for He

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ENERAL CNOLOGÍA

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ÉCNICA


ns in Germany.

nd Lecturer.

ermany).

ealth Research

Scientific Repo

n Cell Stem Cene (IF:13,2) and

h and

orts.

ell (IF: d 1 in

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tulo: olecular mecha

sumen de laeing a moleculagh affinity antctivation Inducndergraduate RNA repair and tudent (MEC‐Covestigate the aeukemia, Clin Dellowship (MECnnual Rev Immf distinct mismndonuclease aceleterious impand lymphomas;epair/DNA deamellowship (MINEading scientist:eld of B cells anemin Immunols co‐author: to alfunction in Cnctional link bey long‐term goroviding new taMINECO‐Retos, o this goal.

sumen del CRAINING: BSc haracterization y Postdoctoral

MMR) proteins edical Researcudies on the imecently awardedy current Euroostdoc, I receivbert Einstein CP7‐PEOPLE‐201fferent SpanishPU Research Feublished a totaorresponding auomed & Pharm

mmunol, 2009; 011; PNAS, 201o‐authored revi

MINISTERIO


ROA GORYC‐2014

a: Biomedicnico: sroa

anisms of DNA e

a Memoria: ar immunologistibodies. Such ced DNA DeamResearch Studethe mutagenic olaboración) anberrant expres

Dev Immunol. O). During the founol, Mol Medmatch DNA rectivity; PCNA‐ubact of aberrant ; and (iii) the pmination‐AID/lyECO) first, and to discern the nd allergy (JACI); (ii) as first authe characterizLL cells (Blood)etween autophal of uncoverinargets and theGobNavarra‐Sa

Currículum Vin Biology (20of activation‐in training continin the generath (CIMA, Univempact of DNA d two grants fropean FP7‐mobved 2 competitiCollege of Medi2 Internationalh programmes:ellowship (2002l of 24 articlesuthor articles (Jmacother, 2011;Med Clin, 200

10; PNAS, 2009;iew (Annu Rev

A VIDAD

MEZ, SERG4‐16399 cina [email protected]

editing and gen

st, I have alwaydiversification

minase (AID) pent at the U. ofenzyme AID, bnd PhD (MEC‐Fssion of Bcl2 in Once I got my Pollowing 6 yeard, Trends Genetpair (MMR) pbiquitylation roAID activity an

potential impacymphomagenea FP7‐Marie Crole of MLH1‐AI); and write a uthor: to elucidazation of cis‐ele; the identificathagy and BCL6 ng specific druggrapeutical stratalud), and my i

Vitae: 001) and PhD nduced cytidinenued at the Albtion of antibodersity of Navarrdeaminases in om MINECO‐Rebility‐IIF grant ive intramural icine, NY, USA l Incoming Fell Inncorpora‐To‐2006), and Un, which have aJACI, 2014; J Ex; Discov Med, 21); 10 co‐autho; DNA Repair, 2Immunol, 2008

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nomic instability

ys been intrigueprocess in theromoting genof Salamanca. Sinboth in the phyFPU) Fellowshipmalignant B cePhD, I moved tors, my work wat*, Disc Med*, proteins in theole in recruitmed MMR in the t of AID in epigsis in Europe urie InternationATPase signalinbook about epate the role of ements that aretion of the Exo(British J Haemgable moleculategies for patiencorporation t

in Molecular e deaminase (Abert Einstein Cody diversity andra) as a Researthe molecular etos (145K, SAF(20K, PIIF‐2012Pilot Project gr(2010, 2011). Rowship (IIF) foorres Quevedo ndergraduate Rccumulated 46xp Med, 2012; 2011); 6 first‐auor papers (PNA2009; Leukemia8), all of them

S RAMÓN YOCATORIA

de acceso g

y through DNA

ed by the plaste germinal cenomic instabilitynce then, my rysiological funcps, allowed meells, and identifyo the lab of Proas published in Biomed Pharme mutagenic aent of error‐prpromotion of ggenetics. In latat CIMA in thnal Incoming Feng downstream igenetics of B cthe TF FOXP1 de critical for AID1‐exonuclease matol). In the fuar mechanisms ent care. I am to the recently

Medicine by AID) gene]. For ollege of Medicd prevention orch Associate inr mechanisms oF2013‐45787‐R2‐328177) to srants (10K & 1RESEARCH FELLr career reinteProgram (2012

Research Fellow61 cites, so far Trends Genet. uthor papers (PAS, 2013; Britisa, 2004; J Allergin prestigious

Y CAJAL A 2014

general

A deamination

ticity of B cells nters (GC) of sy and error‐proesearch interesction and malige to study the y 5 alternative of. Matthew D numerous artic

macother*, *as activity of AID one polymerasgenomic instabe 2011, I decidhe U. of Navaellowship laterof AID‐initiatedcells in allergy (during the engaD accessibility trole resecting Auture, the awaof DNA deaminconfident thatcreated Europ

the Universitythis work I reccine, NY, USA (f lymphoid man the Oncohemof B‐cell lymphR) and Gobiernostudy molecula5K) from the CLOWSHIPS: Curegration in Euro2) [by MINECO]wship (2000‐200scoring an h‐in2010); 3 correPNAS, 2010; PLsh J Haematol, gy Clin Immunojournals. More

SDD

SDE

DDC

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to produce a trsecondary lymone DNA repast has centeredgnant transformclinical relevansplicing variantScharff (USA), cles and reviewcorresponding(i.e. MSH2/M

ses; RNF8/168 ility, and intracded to continuearra, funded by. During this timd lesions (J Exp (Ed. Springer), aagement of B co the Ig locus (AID lesions (PNrd of a RyC Felnases and errort the recent awean DeamiNET

y of Salamancceived the Extra(2006‐2011) onalignancies. Thematology Divisioomagenesis. PAo de Navarra (5ar mechanisms Cancer Center arently, I am abope. Previously]; Postdoctoral 01) [all three byndex of 10 (ISI sponding authooS ONE, 2010; 2013; Blood, 2ol, 2003); 1 editover, my publi





remendously dmphoid organs air. I learned td on the role omation of GC B nce of AID SNPts of AID; with funded by a S

ws (5 PNAS, DNg author) charaMSH6‐mediatedmediation to rclonal evolutione my primary rby an Inncorpome, I was able Med); initiate and a review acells in the GC r(J Immunol); thNAS); and reveallowship wouldr‐prone DNA reward of my firsT Consortium w

ca, Spain (200aordinary Gradn the role of DNen I joined theon (2011‐preseARTICIPATION 56K, GNS‐106/2s of lymphomaand Center for bout to finish a y, I was awardeResearch Felloy MEC]. KEY PUWeb of Sciencor reviews (SemPNAS, 2008; P2012; J Immuntorial (Genet Rication as corre


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


diverse repertoiis triggered bythis as a Volunf DNA deaminacells. The awa

Ps in atopic astpublications in panish PostdocA repair, PLoS cterizing (i) thed sensoring; Prepair DSBs); (iin of leukemias research about ora‐Torres Queto contribute: new projects oabout AID and Mreaction (Bloode description oaling in B cells a tremendouslypair in oncogenst 2 research gwill highly contr

1‐2006) [Molede Award in BioNA mismatch r Center for Apent), to continuIN PROJECTS: 2014), in additiogenesis. DuringEpigenomics atwo‐year Euroed fellowships owship (2006‐2UBLICATIONS: I ce). These inclumin Immunol, 2NAS, 2008; Clinol, 2012; Mol Res Int, 2011); aesponding auth

ire of y the nteer ation, ard of thma, JACI, ctoral ONE, e role MS2‐i) the (CLL) DNA

evedo (i) as n the MMR ); (iii) of AID a new y help nesis, rants ibute

ecular ology. repair pplied e my I was on to g my at the opean from 008), have ude 3 2012; n Dev Med, and 1 hor in

TrimascamSum

MDY

rends in Genetmmunology ands delivered lectuareer with stayentorship expeupervisor in theembers of the

MINISTERIO


tics (2010) wad allergy. INVITEures in nationays (CNIO, CIC);erience in Spaine Research TraiDeamiNET Euro

A VIDAD

s front cover, ED LECTURES &l and internatio; technology tn and USA (teacning Program, opean Consorti

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and I have se& MEETINGS: I honal research inransfer activitiching courses anand a Professoum, including 1

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de acceso g

everal manuschave participatnstitutions and ies (SHMTool nd supervising or in the Biome17 partners acr

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ripts in prepared in 8 internaassociated hosalgorithm, Hybstudents and tedicine Master doss 7 EU count

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ration. BOOKS:tional and 10 nspitals. OTHERSbridoma Facilitechnicians). Cudegree. Internaries.





: 1 SpringerBrinational researcS: I have strengtty at AECOM‐Uurrently at the Uationally, I am o


ENERAL CNOLOGÍA

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iefs on epigench meetings, asthened my scieUSA); teachingU. of Navarra, I one of the foun

etics, s well ntific g and am a nding

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a Memoria: of my research cof Chemistry anperior Council in and in the wcterize immun

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in February 200ntal InvestigatioResearch (CSIC)wo years (2002‐s, produce spe

y. Immediatelyg in the laboratmical immunos was working phoresis technials Research (Aernational Reseorts, Science ace in material sssor. In this pos. In this area oNano Lett., amoosensor technos was expectedtion of fully fu

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aceutical assaysmaceutical induesponses to extar requirementors, and immuno

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the group of PrVila (IIQAB) (noreference in immed a M.S. in Bs, modify prote

ster�s degreer Marco at thesticides residueection of profe. After my postoku University Initiative (WPy (MEXT). Thed the group of orking in the intave recently p2011, I started technology withn understandines with microsc

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ted my Ph.D. sncil of Scientificimmunoassaysat Hyogo Uni

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ENERAL CNOLOGÍA

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cisco Sanchez Bmistry of Catalogical and artd how to synthee an enzyme‐li

studies in the sc Research (CSs technology (2versity in Japaversity (2011) Ihe AIMR at Tothe support othird most releystems group aology with stem in journals of as become my ue engineeringtheir functionslowed us to o

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a particular tasts. My primary, surface chemn presented inkewise it has gtent.

A VIDAD

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roduce scientifedicine, biosench the results oons and 15 pnal patents and

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F CELL SIGNALIN

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Currículum V

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il.com

CHONDRIAL M

increasing burapeutic strateglay a central roetabolites to schinery, thus conce has shownthrough mecha are coordinates on mitochondd characterizinegration of sig

Parkinson�s sis as well as noo carry out thisogression of thin real time wilmeasurement

rial dynamics amongst others. d the regulatioe are proposinrobiology and bioenergetics h

may pave the wa

utonóma de Maas. Universidad

el Instituto Karoen Dana‐Farber

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n CBMSO‐UAMst Centre for Hude carrera en CBrera en Instituto

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rden in develogies. A commonole in neurons bserve as precurontributing to n that the metanisms that are ed through a cdrial activity ang new mechannaling and me

disease and ovel molecular s proposal is dhe selected neull be employedts of mitochondas well as otheAdditionally, thon of mitochondng to study ancell signaling has endowed uay to develop n

adrid. Autónoma de

olinska (Estocolr Cancer Institu

Biología Mole

M uman GeneticsBMSO‐UAM o Cajal (Consejo

Y CAJAL A 2014

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oped countriesn feature to mby supplying enrsors of neurotcell death duritabolic programnot yet fully unomplex netword its subsequenisms of regultabolism in the

Friedreich�s atargets for theevised. It encourodegenerativ, including extrdrial respirationr parameters, he use of cell bdrial metabolisd target neuropathways in neus with the expnew therapeutic

Madrid

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, University of O

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ataxia. Ultimatrapeutic purpoompasses the uve disorders unacellular flux ann and substratesuch as mitochbiology, biochem in the brain ogenerative diseurodegeneratpertise and thec strategies to t

edical School (B

o Ochoa�, Un

Oxford, Oxford

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ng the molecunerative diseasg intracellular cnd other intracnt or in the evmitochondria

pathways. Howeuronal functiochondrial metaeurodegenerat

tely, we may oses. use of mouse ander investigatinalysis that offee utilisation; anhondrial membemistry, proteoand its role in sorders from ation combined e tools to carrytarget neurode

Boston, EEUU)

niversidad Au

(Reino Unido)

Científicas, CSI


ENERAL CNOLOGÍA

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ular mechanismses is mitochoncalcium, maintacellular messenvent of accumumay contribut

wever little is knon and survivalbolism by signtive diseases w

uncover meta

and cellular moion. State‐of‐thers the possibilnd confocal imabrane potentiamics and molethe pathogenen innovative awith the extey out the propgeneration.

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an J, Blanco J, G

ez‐Cassina A, M

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ez‐Cassina A, [.

D, Benitez MJ,

Palomo GM, Ma

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Cassina A, Lim F

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m F, Diaz‐Nido

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sor Contratado

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ugusta Hedlund

� ara la Diabetes)

ial NN. Method

Cell Metabolism

sina A, Norberg

do J , Neuroscie

a A, Danial NN,

ois JR [...], Dania

Gene Therapy,

ecular Cell, 2010

era D, Advance

Anderson P, Bio

, Diaz‐Nido J. Jo

Journal of Biol

na A, Garrido J

nez‐Cassina A, I

a A, Diaz‐Nido J

J. Neurochemi

J. Journal of Ne

Ormö M, NilssoAvila J. Journal o

Doctor

esos nacionaless centros intern

S RAMÓN YOCATORIA

de acceso g

eurociencia)

ds�

)

ds in Mol Biolog

m, 2014, 19(2):

g E, Danial NN,

ence Letters, 20

, Watkins SM, H

al NN, Neuron,

2011, 18(10):1

0, 40(5):687‐68

es in Experimen

ochemical and

ournal of Neuro

ogical Chemist

JJ, Bhat RV, Dia

llana B, Wando

J, Lim F, Wade‐

istry Internation

euroscience Re

on Y, Radesäteof Biological Ch

s e internacionanacionales

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general

gy, 2015, 1241:5

272‐284

En prensa en T

012, 531(2):182

Hotamisligil GS,

2012, 74(4):71

1015‐1019

88

ntal Medicine a

Biophysical Res

oscience Resea

ry, 2009, 284(5

az‐Nido J, Wand

osell F, Diaz‐Nid

‐Martins R. Mo

nal, 2007, 50(1

esearch, 2006, 8

er AC, Jerning Ehemistry, 2003,

ales

SDD

SDE

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59‐69

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‐187 (*: AGC &

PLoS Genetics

9‐730

nd Biology, 201

search Commu

rch, 2010, 88(9

5):3001‐3011

dosell F. Journa

o J. Molecular T

lecular Therapy

):181‐188

84(4):755‐767

E, Markgren PO 278(46):45937





ology,

& JDN co‐corres

s, 2012, 8(8):e10

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unications, 2010

9):1943‐1950.

al of Neuroscien

Therapy, 2007,

y, 2007, 15(2):2

O, Borgegård T,7‐45945


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sponding autho

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These fstance, how is ediate the actiey regulate th

Boulahbel, DuráKG that leads tof HIF expressiondependently ofmino acids, and

sumen del CURRENT POSITInce June 2013,

ESEARCH EXPER010 ‐ 2013, Sennd Developmen006 ‐ 2009, Posnd Tumour Met001 ‐ 2005, PhDiguel A. de la R

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DURAN RYC‐2014

a: Biomedicnico: raul

en cell growth s

a Memoria: career to 3 maism, and the invstablished a coer regulator of

mine, the most ketoglutarate (further undersrough glutamin(GDH. GLS is rand Gottlieb, N. On the other that glutamine012). Inhibitionrsely, enhance, cell growth anby glutamine anfindings positioaKG sensed bvation of mTOe stability of Hán and Gottliebo PHD inactivatn. In agreemenf HIF. Therefored forming a link

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D CERTIFICATES14, Université d

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DIAZ, RAUL4‐15698 cina .duran@inse

signaling and m

n relevant projvestigation of tnnection betwecell growth (Duabundant amin(aKG) of the tricscored by the nolysis, which regulated at thNat. Rev. Cancehand, the esse

e in combination of glutaminod glutaminolysnd autophagy, tnd leucine via goned aKG as any the cell? On RC1 by glutamHIF, the cellular, Biochem. Soction. Importantnt with this rese, PHD proteinsbetween gluta

Vitae:

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etabolism in ca

jects, comprisinthe response oeen the increasurán and Hall, Eno acid in the carboxylic acid observation thconsists of twhe expression er 2010). Inhibitential amino acon with leucine olysis prevents sis or a cell petwo processes glutaminolysis an intracellular mthis lead, my sinolysis (Duránr coordinator oc. Trans. 2009). ly, loss of PHD sult, PHD inhibs act as generalminolysis and t

Européen de Ch

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son Institute fo

Bioquímica Vel Proteomics G

ordeaux. Franc

ad de Sevilla, Sevilla, Seville, Splla, Seville, Spai

urán RV. Glutam

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de acceso g

ancer cells

ng the study ofof cell signalingsed consumptioEMBO Rep 2012blood, plays a cycle, for nuclehat cancer cellswo deaminatiolevel by sevetion of GLS precid leucine direactivates mTO the Rag‐depeermeable aKG controlled by mand aKG producmessenger for nstudies also sun et al., Oncogeof the responseImportantly, oactivity during ition blocks th metabolic senthe mTORC1 pa

himie et Biolog

(University of B

or Cancer Resea

egetal y Fotosínroup)

ce, Autorisation

eville, Spain, Phain, Diploma ofin, BSc in Biolog

minolysis and a

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f fundamental to nutrients aon of glutamine2). particularly imeotides and fors are particulaon steps catalral oncogenes,vents malignanectly binds and ORC1 by enhancendent lysosomanalogue stimumTORC1, are rection upstreamnutrients availauggest that proene 2013). PHDe to hypoxia. Pour work showeamino acid stae response of sors in the cell,athway.

ie (Pessac, Fran

Basel, Switzerla

arch (Glasgow,

ntesis (CSIC / U

n à Diriger une T

hD in Biochemisf Advances Studgy

autophagy in ca

SDD

SDE

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bioenergetics ovailability in cae in cancer cells

portant role in other amino arly dependent ysed by gluta and its activint transformatioactivates GDH cing glutaminolymal translocatioulates lysosomegulated by glut of Rag (Durán ability and sugglyl hydroxylaseDs are considerPHDs also requed that amino aarvation does nmTORC1 to am detecting scar

nce), affiliated t

nd) in the grou

UK) in the grou

University of Se

Thèse.

stry dies in Molecul

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of redox procesancer cells. As as and the over‐

n cell growth aacids. The impoon this amino

aminase (GLS) ity correlates won and slows ce to stimulate aysis and aKG pon and subseqal translocatiotaminolysis. Thet al., Cell Cyclgest new interees (PHD) are thred the oxygenuire aKG for thacid starvation not activate HIFmino acids andrcity not only of

to the U916 Un

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eville, Spain), in

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sses, the analya main result o‐activation of m

nd metabolismortance of glutao acid. Glutamiand by glutawith tumor grell growth in ceKG productionroduction (Durquent activation and activatiohus, mTORC1 see 2012). esting questionhe aKG sensors sensors of celeir catalytic accauses depletio, likely due to ainduces autopf oxygen, but al

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NIVERSITY TEAC014 ‐ 2015, Mas010 ‐ 2013, Lab 002 ‐ 2005, Labprox.), Departm

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Kenzie EM, Boe of prolyl hydrall MN (2012) Gger W, Robitaill9‐58. all MN (2012) Rán RV and Gott

CHING RESPONster Course LecPractice Coordb Practice Coorment of Plant B

ED TALKS OR and glutam

king metabolicFrance king metabolic tgulation of mTOstalk between cutamine metabute, Cambridge,

A VIDAD

ulahbel H, Freoxylases in the

Glutaminolysis fe AM, Heiseric

egulation of TOtlieb E (2010) T

NSIBILITIES cture, Cancer mdinator, Biochemrdinator, Experiochemistry an

ine metabolism

c transformatio

transformationOR signaling by gcell growth signolism and mTO, UK

AYUDASCONVO

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ezza C, Tarditocellular responeeds mTORC1. h L, Skendaj R,

OR by small GTPargeting metab

metabolism, 4 h,mistry, 90 h (apimental Technid Molecular Bio

m in cancer cells

on and cell sig

n and cell signalglutamine metanaling and metaOR signaling in

S RAMÓN YOCATORIA

de acceso g

o S, Heiserich nse to amino acCell Cycle 11: 4Gottlieb E and

Pases. EMBO Rebolic transform

, Master Courseprox.), Departmiques on Biochology (Universi

s, Prof. Sergio M

gnaling deregu

ling deregulatioabolism, Prof. Labolism in cancn cell growth r

Y CAJAL A 2014

general

L, Bussolati O,cids. Oncogene 4107‐8. Hall MN (2012

ep. 13, 121‐8.ation for cance

e, Université dement of Biochemhemistry, Structty of Seville, Sp

Moreno, Institu

lation in cance

on in cancer, PrLluis Fajas Coll, cer cells, Prof. Eregulation, Prof

SDD

SDE

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Rocha S, Hal32, 4549‐56.

) Glutaminolysi

r therapy. Nat.

e Bordeaux mistry (Universitture of Macrompain)

to de Biología

er, Prof. Mario

of. Maria Jose SUniversité de Lric Solary, Institf. Ashok Venki





l MN and Got

is activates Rag

Rev. Cancer 10

ty of Basel, Swimolecules, and

Funcional y Ge

o Pende, Instit

Sanchez Sanz, CLausanne, Lausatute Gustave Ritaraman, MRC


ENERAL CNOLOGÍA

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ÉCNICA


ttlieb E (2013)

g‐mTORC1 signa

0, 267‐77.

itzerland) Biochemistry,

nómica, Salam

tut Necker Enf

CABD, Seville, Sanne, SwitzerlaRoussy, Paris, FrC Cancer Cell U

HIF‐

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90 h

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ext, I moved tovestigate the rell biology, elecortical circuits. ontrols the esthibitory synapsverall, this land010; 123 cit.).

o continue, I beee Pedrique & the field of gae processing oromotes excitatazzari et al., eLtogether, my wn the etiologica

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a Memoria: REST r neurobiologisd pathological cresearch that c

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midal neurons; ovided a novel

ed in the pooro, 2010). Hencee biology. Hereover, I showedransmission, sy

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lab of Prof. Luirst KO mice foy in different c

UK) and in theion of PlexinB1nal regeneratioem and it had a

Beatriz Rico, wnd ERBB4 in coshowed that d by basket anes in two waysErbB4 promoten the involveme

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uca Tamagnoneor Plexins, specountries such

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where I was awortical wiring. UNrg1/ErbB4 sigd chandelier ins: on one sidees the formatioent of inhibitor

ular signalling wo the VIB in Leuc Aph1b‐gammion experimenmation in pyra

ward signallinglogy.

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al regenerationin different tiscord injury. Thmpact on the S

warded a MarieUsing a multidisgnalling contronterneurons ane, it is requiredon of excitatory circuits in Sch

which is regulatuven to the lab a‐secretase comts that Aph1b‐midal neurons.

in cortical wiri

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ered Plexins asB1. Already fromDr. Flavio Main

n lead by Prof. Fssues, ii) relevahis study was Semaphorin/Ple

e Curie Postdocsciplinary approols the developnd I showed Nrd for perisomary input receivehizophrenia (Fa

ted by gammaof Prof. Bart Dmplexes are se‐gamma‐secret. This study was

ing and provide

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ring and functiohes by performalysis.

s the receptorm the PhD, I gaa (IBDM, Mars

Ferdinando Rosance in Semapamong the firsexin field (Fazza

ctoral fellowshoach that combpment of inhibrg1/ErbB4 signaatic and axo‐aed by interneuazzari et al., Na

‐secretase prote Strooper, a lelectively involvtase/Nrg1 signas recently publi

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mouse developdicine, Universit

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LOPEZ SARYC‐2014

a: Biomedicnico: bert

mechanisms of

a Memoria: eer has been foscade is a knowre protein kinasy stages, melanat these cases aitiation, metastniversity of Mun aberrant intra

Richard Maraisester, UK), I usequencing or mrtial protectionutant p53 and oary for melanoon in Cancer DS mutant and Bcombination in ng the phosph

to the �Instital models and I of finding new

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work in several

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melanoma initi

ocused on cancwn driver of meses activated dnoma can be care still inefficietasis, resistancurcia (Spain) byacellular traffick

s� laboratory sed BRAF and Rmass spectromn from the effeconcogenic BRAma growth andDiscovery); (3) BRAF inhibitor‐the clinic (first‐odiesterase PD

uto de Neurocam currently intargets for ant

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mh.es

iation, metasta

cer research, paelanoma. RAS isdownstream of cured by surgerent. I have usede to targeted ty characterizingking and dimeri

at The InstitutRAS‐driven mouetry to show tcts of UVR. I ideAF cooperate tod that melanomParadoxical acresistant melan‐author publicaDE5A, which in

iencias CSIC‐UMnvestigating theimetastatic the

y and BiochemiGarcia‐Borron. D1R) and its funUK) and NationaEuropean Doctoand 1 paper fros and participat

ara Profesor Ay

ancer Research�ise in the unde

ester Institute�ding melanomat‐author in Natticles in Cance

conferences (o

eto, a renowneonment metast‐Esteban Cobo

doctoral Fellowsary and projectd capabilities to

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articularly on ms a small G protf RAS. BRAF is ry, but the advd different strattherapies and ng the melanocization of natur

e of Cancer Reuse models of mthat (1) UVR aentified p53 as o drive melanoma immuno‐enctivation of ERKnoma cells whication in Scienceturn, promote

MH� to enlare role of the tuerapies.

istry, I did my PDuring my PhD nctional characal Institutes of or mention andom a collaborated in Biochem

yudante Docto

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� (Manchesteragenesis, metature, Cancer Dir Cell, Nature

oral and poster

ed expert in celasis. In additionos Short‐Term Fship and a grant costs‐. In addio lead my resea

Y CAJAL A 2014

general

nce to targeted

melanoma, the ein activated dmutated in 45%vanced metastategies to gain innew therapeutortin 1 receptoral variants of t

esearch (Londomelanoma, patiaccelerates BRAa bona fide targoma (cofirst‐aunvironment proK by the BRAF ch can be blocke Signaling) andes cell contract

ge my expertismour microenv

PhD in Biochemmy research wcterization. I alHealth, Bethesd the Extraordition that was s

mistry teaching

r� (2009). Aft

London (UK) Inf melanoma. In

r, UK). During mstasis mechaniscovery and ScCommunicatio

r presentations

ll movements in, I have designFellowship, Postnt from Cancer ition, I have march career.

SDD

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therapies

deadliest form ownstream of % of melanomatic disease is insight into the mic approaches. or (MC1R), I shthe MC1R (4 fir

n, UK) and theient samples, aAF‐driven melaget of UVR in mthor publicatioomotes resistaninhibitors usedked by MEK inh(4) Oncogenic ility (second‐au

se in the mechvironment in ca

mistry and Molewas focused on tso performed da, (Maryland, nary PhD Awarsupervisor‐indecourses for Me

ter my PhD, att

October 2008 October 2012,

my postdoc in tsms, and resisience Signalingons, and Cance

s). I am curren

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of skin cancer.receptor tyrosias, and RAS is invariably fatalmechanisms un During my Phhowed that merst‐author publ

e Cancer Reseaand cutting‐edganomagenesis melanoma in mon in Nature). nce to targetedd in clinic promhibitors, in this BRAF drives muthor publicatio

hanisms underlyarcinoma meta

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ttracted by the

to join Prof Ric, together with

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ntly working at

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. The RAS‐RAF‐ne kinases andmutated in 25 and unfortunanderlying melanD with Prof Gaelanoma risk caications). Durin

arch UK Manchge tecniques suand that sunscice and human(2) Myeloid‐ded therapies (comotes invasionway supportinelanoma metason in Cancer C

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at the Universunction relationstays to learn ) for 3 months etime I publisheddition, I preseursery students

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urrently, I'm plaor the last two e structural vaacial Tumour (D

sumen del CCurrent positio013‐2015: Mari

University deg2001: First degr2009: PhD degr

Scholarships aong my career redoctoral: 2003‐2005: Pre2003‐2005: Moostdoctoral: 2010‐2012: ANG2010‐2012: Two2012: JOSE CAS2013: SARA BOR

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on) in genome focused on the avered 60 new r‐39). After this s were publish.1258522). moved to the fil Cancer Genomural variation bythe genes that sed the hypothreds of clustereto the Wellcom

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eld of cancer gme Consortium y next‐generatidrive the diseahesis of 'aborteed chromosomame Trust Sangened the osteosan acquired soma (Nat Genet 45Curie grant (FPcancer genomeovery in the fiela common evenpresent anotheesearch article

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ong my scients role in diseaseetrotransposonn families and vited to collabopapers in high‐i

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e �Retrotransd to the undersrotranspositionminary results o

t Wellcome Tru

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sease

tific career hase. ns in the genomcharacterized rate in several impact journals

, in 2010, I jointre for Genomi data analysis u5:101‐105; Natuo explain 'chronts (Tubio & EsCambridge (UKcancers, breascancer develop

ATF7IP in acute 2‐IEF) to analyzobtained withinnomics: a new umours. Becausby which tumohe journal Scien

position Subgrostanding of the n) of the canineof this research

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d European SocSF

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Ministry of Econalth Carlos III.

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me of the Malartheir evolutioninternational ins (Science 316:

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oup� of the �biology of trane transmissible h in Science 343

tute (Cambridge

ty of Santiago d

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mic structural v

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er genes and reons that help tthor (Tubio et a

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variation (espe

iae. In the Mosce, Tubio et al. ojects funded b88; Science 347

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act journals (5 S1 Nature). I wou

tre Dame (IndiUK). Until the d

tre for Genomicllcome Trust Sa

ssful grants fro

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ym: �CANCER

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research with sse; all projects

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ana, USA) anddeadline of this

c Regulation anger Institute

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e published 5 pa

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ses and 4 Natio

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ud Carlos III. Hy

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docrinology, JCEuropean Journ

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journals Publisabetes, Internamedicine, FAS

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dical Research. Tovar S, Vázque

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of Cologne,Germ

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nt from the A

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virus (HCV) andnate immune echanism of reecrete HCV RNAontrol of HCV inechanism invoKR). The resulticrobe and Jou

s part of my trriting of two NIs an Assistant epatitis B virus BV. We are curfection using bompounds that rology, I am a mrology Journal,

sumen del CERSONAL INFORame: Urtzi Garamail: ugaraig@s

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GARAIGORYC‐2014

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nity fields, whescape from itsnfected cells byosomes that acifferent projection of translat projects led toy.

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ere I�ve been antiviral activy plasmacytoid ctivate pDCs, wht I discovered ation, including o several public

rof. Chisari in po him that had sdependent Prindentifying new Pharmaceuticald in vivo HBV md will hopefullyd of Virus ReseaAntimicrobial A

oma de Madridrsidad de Navar

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de acceso g

pathogen interV)).

d the functionsvirus morphoghance to superogether with ot

a very competiDuring this time

focused on unvity. In collabodendritic cellshich produce tya new mechanithat of antiviracations in high

peer‐reviewing since then suppncipal Investiga molecular targls in the pre‐clinmouse model y move forwardarch and I serveAgents.

d. Qualification:rra. Qualificatio

La Jolla, USA. Ju

007 � June 201

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actions that re

s of influenza vienesis, leading rvise 3 undergrther experimen

tive and preste my scientific i

nderstanding thoration with ot (pDCs). We shype 1 interferonism by which Hal IFN‐stimulateimpact journal

manuscripts aported my reseator my researcgets that could nical testing of systems. In thd Phase II trials e as reviewer fo

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nd I�ve activearch till I obtainch is now focube exploited tonew antisense is regard, we by the end of 2or 4 internation

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ENERAL CNOLOGÍA

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virus infections

tion of (i) viral c Acid Researchversity‐end prored me for my

ip from the Caza towards hep

ploys to activate discovered a HCV‐replicatingbute this way tal action of IFNof protein kinas, PNAS, Cell Ho

d in the designnding from NIHng basic aspec

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articles. J. Virol.

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. Cell Host & Met al. Hepatitis D: 22855484. Asabe S, Wienhibit infectionand Chisari FV. 9. PMID: 200068and Ortín J. Mumic transport ofet al. Genetic . 2005. PMID: 1

VITIES: Editorial Board ous Research, Vir

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AND POSTER COal Symposium oal Symposium ol Symposium onrus Entry, Replal Symposium oal Symposium oal Conference of Virology. Microngress of Virol

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PMID: 23084922s the formation

orta U, et al. PMID: 2023145us blocks interf

s of a recombinmRNA. Nucleic Afluenza virus NS

rch. and Internation

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tute (01/2008�7).

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de acceso g

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nant NS repliconAcids ResearchS1 gene: a tem

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. NIH (04/2014‐

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nules whose pro

dendritic cells

function by indu

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gents.

10 USA (oral).





e late steps in t

tis C virus‐infe

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he virus life cyc

cted cells, pro

horylation. Cell

ocks the splicing

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cle. J.

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sumen del Cducation 8/2003 to 12/200/2003 to 06/200/1995 to 06/20

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MINISTERIO


AGIS BARYC‐2014

a: Biomedicnico: robe

genetic link bet

a Memoria: : I obtained a pursued my Phd the epigenetscience Institutcognitive impa

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m part of the �media. I have tw

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cs (Ph.D.), UIC, .Sc.), USC, Spaiy (B.Sc.), USC, S

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S RAMÓN YOCATORIA

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at the Instituteassociated to parkers and thersor at the PhD

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ve fear and cershowed in a marly, I showed us. In additionmer¿s disease (A

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ain oettingen, Germ ENI‐Goettinge

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al Research of urodegeneratives for diagnosis,euroscience and

edicamentos (R

cia� and �El

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PTSD, depressinetic mechanisd be a potentiato treat such br

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ch as PTSD. Herates fear extinIGF2/IGFBP7 py that IGFBP7

biomarkers in oession are also depression withAD as shown byssion with the genetic) mecha

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ago de Compong the neurostas a postdoc aie, epigenome)eases.

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re, fear extinctiction, while IGpromotes survivregulates me

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thens, Greece.

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ect (FP7‐316265

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and presented

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HY, Agis‐Balboa

C* and Fischer A

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or my postdoctver disease (ALUFAs) such as ae found out thaUrtasun, 2009; U

y second postdCasp8) and its roat death recep012; Hatting, 20f JNK during acund then providever disease (Scheatment for acu

or my independecent results suompound functcrease in a signillions of peopl

sumen del Coon after I finis

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CUBERORYC‐2014

a: Biomedicnico: cube

ion of Jnk1 and

a Memoria: compasses a wiM) or chronic livd‐stage hepatoc

and later my Polate hepatocyt1). Next, we ar transplantatioration of transp

oral investigatiLD) (Cubero, 20arachidonic aciat reactive oxygUrtasun, 2012).

doctoral has focole in death recptors in hepatoc015) and its theute and chroniced evidence thahaefer, 2015; Cute liver failure

dent career, I aggest that (1) ttion of Jnk1 annificant mannee around the w

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ions I first focu006; Cubero, 2d (AA) to the mgen (ROS) and n.

cused on the stceptor‐mediatecytes and immuerapeutic potenc liver injury (Cuat JNK1 in hemaCubero, 2015).e might have be

im to unmask the oxidative stnd Jnk2 in hepr our understaworld could be b

Vitae: in the Univers

ab, granted wir. Paloma Magaof bilirubin UDPpanish FISS (ISCmetabolism, s

ation of hepatolasses at UCM. began at Trinity

hysiology undeMount Sinai Scnistry of Sciencn (both fetal an

AYUDASCONVO

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mail.com

cute and chroni

f injury includinh as alcoholic livma (HCC).

became strongew of transplay hepatocyte sbilirubinemic raubero, 2005; Cu

used on the con2009). Our resumechanism whenitrogen specie

tudy of molecued apoptosis (Lune cells have dntial (Malato, 20ubero, 2010; Cuatopoietic cells Furthermore, een misinterpre

the compoundress response ipatocytes deternding of key mbenefited from

idad Complute

th a Fellowshianto, at the SerP‐glucuronosyl CIII), we focuseduch as the Crig

ocytes in an exp

y College Dubli

r the Supervisihool of Medicce and Educationd adult), I exp

S RAMÓN YOCATORIA

de acceso g

JAVIER

ic liver disease

ng acute liver faver disease (AL

gly interested innting them in suspensions (Aats (Cubero, 20ubero, 2007).

ntext of Kupffeults unveiled aereby KC mediaes (RNS) can ind

ular mechanismLiedtke, 2011) adifferent roles 012; Kaldenbacubero 2011). Wis crucial not owe have very

eted (Cubero, 2

and distinct fuis essential for rmines the fat

molecular mechtherapies that

nse Madrid (UC

p from the Regrvice of Experimtransferase thd on hepatocytgler‐Najjar synd

perimental mo

in where I cou

ion of Prof. Gaine as a postdon (Beca MEC),perimentally ap

Y CAJAL A 2014

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ailure such as dLD), non‐alcoho

n fetal hepatocorder to resto

Arza, 2001) and001; Bustaman

er (KC) and hepa synergism beate ECM remodduce a protectiv

ms of cell death.and later in NASin chronic liverch, 2014). My mWe first identifieonly for liver regrecently found015; Gastroent

unctions of Jnkthe modulatione of cancer ceanisms involvemodulate the f

CM), I started m

gional Governmmental Surgeryhroughout fetae transplantatidrome type I.

del of type I Cr

uld finish my P

abrielle McKeedoctoral fellow under the auspproached the

SDD

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drug‐induced livolic steatohepat

cyte isolation. Tore liver functiod used them ate, 2006). Fina

atic stellate ceetween ethanoeling (Cubero, ve mechanism i

We first investSH (Hatting, 20injury and tum

main focus durined Jnk1 in HSC ageneration but d that the currterology, In Rev

1 and Jnk2 in dn of JNK during ells. These viabd in essential afunction of the

my predoctoral

ment of Madrid in Puerta de Hl developmenton as an alternMy doctoral th

rigler‐Najjar syn

hD papers and

. Later, I joinefirst and thenpices of Prof. Sstudy of the pa





ver injury (DILI)titis (NASH) wh

Thus we workeon impaired byat the most aally, we formul

ells (KC), and thol and polyunsa2008; Cubero, in HSC in early s

tigated the act013). Furthermomorigenesis (Cung the past yeaas a profibrotic also for the prorent dogma of vision).

different forms g different formble projects haaspects of liver JNK genes.

l stage as a stud

d. During this Hierro Hospital.t. With the finative to orthothesis, outstand

ndrome�. Dur

d simultaneous

d Dr. Natalia Nn as a recipienScott Friedman.athophysiology


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) or inborn‐erroich may progre

d on optimiziny IEM (Sierra, 2appropiate staglated a strateg

heir role in alcoaturated fatty 2012). Futhermstages of liver i

ivation of caspaore, we have shbero, 2013; Arsrs has been thekinase (Zhao, 2ogression of chJNK inhibition

of liver injury. ms of DILI and (2ve the potentidisease. There

dent‐collaborat

period, we beg. We focused mancial support opic liver transing cum laude,

ing this stage,

sly acquire teac

Nieto�s lab, int of a postdoc Using my expey of alcohol‐ind

ors of ess to

g the 2000; ge of gy for

oholic acids more, njury

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ow (2012‐2014)rincipal Investigabio), and took s Secretary twoongresses, manapers indexed ieviewer for sev

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a result of me New York Cend the research gnaling pathwaycurrently superRWTH, giving a) to attend thegator. In additiopart of the Theo times (2013 any of them awn Pubmed inclueral Scientific J

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awarded the pSB) in 2008. wein who has binjury. During 5 people. Moreek. In addition he Study of thvited Speaker tthesis (CNIO, Moreover, I havestinctions and a and corresponearch Foundatio

Y CAJAL A 2014

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prestigious Live

been several yethis time I haeover, I have cI have receivedhe Liver (EASL) to CNIC (Madriadrid). Furthere submitted ovas Oral Presennding author. Aon (DFG). I am a

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rd (AASLD), an

ng the functionllaborated in tith the Teachin

mithkline Travelnd received 3 der the auspiceeen part of theings to nationaal I have up‐toten 2 book chahe EASL.


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nd the postdoc

al relevance ofwo MD thesesng in the Facull Award 3 yearsResearch granes of Dr. Guada Thesis Examinal and internato‐date 31 publipters and acted

ctoral

f cell‐s and lty of s in a nts as alupe ation tional ished d as a

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echanisms or �echanisms in hells integrate mells lack this reodriguez‐Bravo

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W Hetzer. Cell. echanism to prstability openiotentially proteuring the last yes taxanes, comodels and patirogram controll. Cancer Cell, in

y research goavision, analyzeesponses. To acancer biology, onsequences of

sumen del Cstudied Biologyolecular procesf Barcelona. SupDr. Neus Agelvolving redund

ombining DNA r

octorate Awardene Medema lterested in the

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RODRIGRYC‐2014

a: Biomedicnico: rodr

Genome Instabi

a Memoria: ions such as chnd contribution

�checkpoints�human cells. Mymultiple pathwaedundancy giviV, et al. Cance

tdoctoral reseagregation in huV, et al. PLoS Bsegregation to 2014; Kirsty Mrevent structurng new avenuects against canears I have alsomonly used inient tumor samled by the mastn press, Februar

al as an indepe the contributihieve this, I wilto elucidate

f deregulation i

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her study errorgenome editinrk, USA) as a po009) and focusemon in humanan anaphase i

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lity in Human C

hromosomal insn to cancer are

� that safeguay work revealeays involving acing a rational r Res. 2007).

arch I have auman cells. I haBiol. 2009) and protect genom

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endent investigion of their fail take a multi‐dhow nuclear n cancer.

Vitae: rsity of Barcelog cancer I did medoctoral fellowowed that non‐by several kina

replication che

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O, VERONIC

c.org

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stability (CIN) ae not complete

rd genome inted different resctivation of Chkfor specific ca

pplied genomave participatedI have shown t

me integrity (Rov Mol Cell Biolcal chromosomh to understan

n the study of hese studies hgo‐Domenech JATA2 that driveng me to gain e

gator is to studlure to genomdisciplinary apppores and th

ona (Spain) supmy PhD studyingwships from thetumor cells actases that cance

eckpoint inhibit

lona in 2007. TMedical Centeity of mitosis du

ome segregatiocreate conditioearcher in 200h on the cell div as aneuploidyal in interphas

S RAMÓN YOCATORIA

de acceso g

CA

equences in Can

and aneuploidyely understood.

egrity. During mponses of tumk1 and p38 kinancer treatmen

e‐editing methd in the study that nuclear poodriguez‐Bravo l. 2014). My we alterations annd the intricate

how cancer celhave uncoveredJ, Vidal S, Rodes aggressiveneexpertise in can

dy the molecume instability anproach building he mitotic che

pported by theg cell cycle chee Catalan Govetivate robust cer cells lack. T

tors (Cancer Re

To gain expertiser of Utrecht (uring human ce

on in human ceonal knock out 8. During the lavision control my and CIN. Use that ensures

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general

ncer

y are a hallmark. I have focuse

my PhD I studieor and non‐tumnases to ensurent combination

hods to precisof Plk1 kinase re complexes (V, et al. Cell. 20

work uncoverednd revealed NPe NPC‐checkpo

lls acquire chemd new mechanriguez‐Bravo Vess and survivancer biology and

lar and celluland the consequon my expertiseckpoint monit

e "Extraordinaryckpoint mecharnment (FI, 200heckpoint mechis work gave

es. 2006 and 20

se on cell cycle UMC, The Netell division (J. C

ells, chromosomhuman cells (cast years I havemechanisms thsing genome‐eds proper speed

SDD

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k of cancer, howd my research

ed ATR/ATM‐inmor cells to repe robustness ofs (Rodriguez‐B

sely dissect mroles in cytokiNPCs) ensure p014) (Highlightd mitotic timingPCs deregulatiooint network th

motherapy resisisms of chemo

V et al. Cancer l to chemotherd translational o

r mechanisms uences for canse in cell, molector faithful ch

y College Awarnisms in the Sc02‐2005) and frhanisms in resa rational for

07) and was re

control mechantherlands) as aell Biol. 2009).

me instability (CKO), I joined Dre worked on Plat ensure mitoditing I discoved of the next m





wever their mo on the study

ndependent repplication stallinf the checkpoiBravo V, et al.

mechanisms conesis (Burkard proper speed ofted by: Abigail Bg fine‐tuning bon as a new mehat guards ge

stance to anti‐motherapy resist Cell. 2012) anrapy (Vidal S, Roncology.

controlling errncer pathogenecular biology (ghromosome se

rd". Motivatedchool of Medicirom the Schoolsponse to DNA selective targe

ecognized with

nisms of DNA da postdoctoral

CIN) impact in cr. Prasad V. Jalk1 kinase reguosis fidelity and ered that nuclemitosis, high‐fi


ENERAL CNOLOGÍA

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olecular and ceof cell cycle co

plication checkg. While non‐tunt response, caCancer Res. 2

ontrolling errorME, Maciejowf mitosis and fidButchwalter, Mby NPCs as a schanism of gennome integrity

mitotic agents, tance in cancend a transcriptodriguez‐Bravo

ror‐free humanesis and therapgenome‐editingegregation and

d to understandne of the Unive of Medicine (2synthesis inhibeting of tumor

the �Extraord

damage, I visitefellow where

cancer and eaglepalli laboratolation of cytokiavoid chromosear pore compdelity chromos

ellular ontrol

point umor ancer 2006;

r‐free wski J, delity

Martin safety nome y and

such r cell tional o V et

n cell peutic g) and d the

d the ersity 2006) bition cells

inary

ed Dr. I got

ger to ory at nesis some plexes some

setofrose Mmpure Inowin fu

MDY

eparation and go CIN cancers. ontiers in Oncoelected for oral

oreover, to intechanisms of cublished in Canesponses that w

summary, my wn laboratory. cancer biologndamental me

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genome integritMy work was ology where it wpresentations

egrate my molchemotherapy ncer Cell (2012,will be instrume

research trainImportantly, thgy. These prodchanisms unde

A VIDAD

ty. Failure of thpublished in Cwas listed as a in internationa

ecular and cell resistance to a and Feb. 2015ntal in my own

ing has allowedhe interaction wductive researcerlying chromos

AYUDASCONVO

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his pathway accell (Feb. 2014) new mechanisl conferences.

biology backgranti‐mitotic age5 in press) and laboratory.

d me to gain thwith multi‐discich activities hasome instability

S RAMÓN YOCATORIA

de acceso g

celerates mitos and highlightesm of chromoso

round with canents (taxanes) allowed me to

he expertise inplinary collaboave empowerey in cancer.

Y CAJAL A 2014

general

sis inducing theed by Nat. Revome instability

cer biology appcommonly useo obtain extens

n cell and molerators made md me to deve

SDD

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proaches I haved in cancer treive experience

cular biology (ge grow as a scilop my own r





of chromosomol., Cell previewmplications. In a

e collaborated ieatment. Thesein cancer biolo

genome‐editingientist and broaresearch progr


ENERAL CNOLOGÍA

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me errors assocw, Faculty 1000addition it has

in studies dissee studies have ogy and therap

g) I will apply iaden my knowlram to address

ciated 0 and been

ecting been peutic

n my ledge s the

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uring the cours

olla, CA, USA) asf genetically en012). ubsequently in ount Sinai Schohis laboratoryctation. By genegulator of posoreover, analyterestingly, thee adipose tissuaddition, I havf new tumor suhRNA pooled sc014 Nature‐und

sumen del Cavid Llobet Navavid.llobet@ms

NSTITUTIONS: The Mount SinInstitute for CaThe Sanford‐BuIRB‐LLEIDA: Pre

ELLOWSHIPS Pre‐doctoral: ISCIII‐Instituto Spanish AssocPifarré FoundaPost‐doctoral: Beatriu de Pinó Spanish Minist

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LLOBET NRYC‐2014

a: Biomedicnico: davi

metrio, mama y

a Memoria: enetics and Ce

degree in Dr. Xa

uiu�s laboratocer and their imk during my PhDmetrial cancer c11). In parallel Iurnal of Pathoan Pathology 2hibitor Sorafen

se of my PhD I

s a visitor scienngineered mous

2010 I joined ool of Mediciney I identified terating a miR‐4stlactational inysis of the genoe miR‐424‐/‐/50ue which I will cve also participauppressors andcreenings. As ader review; Rod

Currículum Vvàs, Ph.D. ssm.edu

ai Hospital‐Icahancer Genetics urnham Institute‐doctoral Stud

de Salud Carloiation Against Cation Fellowship

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ll biology in the

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joined Dr. Joh

ntist to continuese models of A

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Vitae:

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e Autonomous

uiu�s molecul

ed in the studypoptosis resistaon the study oy Investigation ted in the analyernational Jouored in vitro theiological Chem

n C. Reed�s la

e studying the Autoimmunity a

at the Herbert‐er genes in thend miR‐503 to nockout mouseated by TGF&#R‐424/503 revemouse model dy in the near fign and developy of new breastl manuscripts co R et al 2014 C

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ch) y

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de acceso g

a regulación de

University of B

ar pathology g

y of molecular nce. of the molecula2005; Oncogenysis of additionrnal of Gynecoe potential theristry 2006; Ant

aboratory in Th

role of TNF ligaand Chronic Lym

‐Irving Compree mammary glabe differentiae model I repor#946; (Genes ealed that this develop tumo

future. pment of side‐pt cancer vulnerare under prepCancer Discove

ctoral Fellow r Columbia Univor Scientist

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general

la tumorogéne

Barcelona (Spa

roup in the Bio

alterations inv

ar mechanisms ne 2008; Amerinal prosurvival fological Patholorapeutic effectsi‐Cancer Drugs

he Sanford‐Bur

ands. In Dr. Reemphocytic Leuk

ehensive Cancend developmenlly expressed drted the charac& Developmencluster is delers in the mamm

projects in the rabilities by usparation or in ery‐under review

versity: Post‐do

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in). After finish

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volved in devel

underpinning acan Journal of factors such as ogy 2005), in ts of NF‐KappaB2008; Europea

nham Institute

ed�s laboratorkemia (CLL) (Bl

r Center in Colnt with relevantduring remodeterization of thnt 2014; Moleted in a significmary gland and

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opment and p

apoptosis resisPathology 200expression of the identificatiB inhibitors as wan Journal of Ca

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ENERAL CNOLOGÍA

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or degree in 20

n Lleida (IRB‐LL

rogression of t

tance to TNF‐fa9; American JoNF‐kappaB subion of PIK3CA well as the receancer 2010).

esearch in 200

the characterizrnal of Immuno

sity (NY) and atrigenesis. ammary gland 3 cluster as a mular Biology 2n of breast tumplastic phenoty

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WARDS IEC_Premio SanUdL (University

RTICLES Hua‐Sheng ChiFélix Sanchez‐GDavid Llobet‐NHerranz D, et aLlobet‐Navas DEritja N et al. APérez‐Chacón GEritja N et al. JoMontserrat N e0‐Sumazin P et #65532;11‐Yera2‐Llobet D et al3‐Eritja N, Llobe4‐Llobet D et al5‐Tarragona J et6‐Zapata JM, Llo7‐Pallarés J*, Llo8‐Llobet D et al9‐Pallares J et a0‐Llobet D et al1‐Llobet D et al2‐Gallel P et al. 3‐Sorolla A et a4‐Ortega E et al5‐Dolcet X*, Llo6‐Velasco A et a7‐Dolcet X, Llob8‐Pallarés J et a9‐Pallarés J et a0‐Dolcet X, Llob1‐Pallarés J et a

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nt Jordi Award:y of Lleida) Best

u*, David LlobeGarcia, et al. Ceavas et al. Molal. Nature MediD, et al. Genes &American JournaG, Llobet D et aournal of Cell Set al. Human Paal. Cell. 147:37amian A et al. L. American Jouet D et al. Amer. European Jout al. Archiv Vircobet D et al. Bloobet D* et al. A. Journal of Clinl. Analytical an. Oncogene. 27. Anti‐Cancer DHuman Patholol. British Journal. Seminars in Dobet D* et al. Joal. Human Pathbet D et al. Labol. Internationall. Modern Pathbet D et al. Archl. Journal of Pa

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et‐Navas* et al.ell. 159:1461‐75ecular and Cellcine. 20:1130‐7& Developmental of Pathologyal. Jounal of Immcience. 125:192athology. 43:630‐81. 2011 Laboratory Invernal of Pathologrican Journal ofrnal Of Cancer.chows. 456:39‐4ood. 113:4595‐American Journnical Pathology.d Quantitative 7:2513‐24. 2008Drugs. 19:115‐12ogy. 39:994‐10al of DermatoloDiagnostic Pathoournal of Biologology. 37:1465oratory Investigl Journal of Gynhology. 18:719‐hiv Virchows. 44thology. 204:56

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nyer Award of Bis. 2010

. Genome Rese5. 2014 ular Biology. 347. 2014 t. 28:765‐82. 20. 183:277‐87. 2munology. 189:29‐44. 2012 32‐43. 2012

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ext, I joined theo study stem ceor Regenerative

elevant iPSCs. In

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ore recently, I amed iCRISPR. To address the furoughput gene

y main researcPSC). Pancreatancer death by f this disease.

Using iCRISPR, equentially genading to PDACrganoids. This aarly detection, eat PDAC patie

sumen del ChD in Science, master in Biologyegree in Biology

esearch activity

pril 2011 to prer. Danwei Huan

008 to April 201f the Swiss Nati

007. Post‐doc i

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GONZALRYC‐2014

a: Biomedicnico: gon

nitiation throug

a Memoria: PhD in the labgy and geneticonsible for the lo

e laboratory of ll biology and re Medicine in B

n 2009, I publish

the laboratoryg reprogramminthis process. Ther approaches

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ch line is to mic ductal adeno2030. Unfortun

I propose to cerating the muC and assess thapproach will gand easily perfnts.

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y

esent Pongfu. Sloan‐Kett

11. Post‐doc at onal Science Fo

n the Gene Ex

A VIDAD

LEZ GRASSI,4‐16751 cina zalf1@mskc

gh gene editing

boratory of Drcs and publisheong‐range regu

Prof. Juan Carloregenerative marcelona (CMR

hed one of the

y of Dr. Huangfung. I showed thhis study is thefor creating iPS

novel platform allows modifyinmplex gene netwhPSCs.

model and studocarcinoma (PDnately, no avail

create a PDAC utations characheir function ingreatly improveform drug or g

Vitae: y, Department f Geneva‐SwitzGeneva‐Switze

ost‐doc in the Dtering Institute

the Centre of Roundation (SNS

pression Labor

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, FEDERICO

c.org

g in hPSCs

. Duboule lab ed several artiulation of Hox g

os Izpisúa Belmedicine, first atB) (Barcelona,

first strategies

u as a New Yorhat DNA damag first report ideSCs.

for rapid, efficg the genome works altered i

y pancreatic dDAC) has a dismlable human m

initiation modcterizing differen vivo, throughe our understangenetic screens

of Zoology anderland, 1998 rland, 1996

evelopmental BMSKCC, New Y

Regenerative MSF).

ratory. Prof. Jua

S RAMÓN YOCATORIA

de acceso g

(University of cles uncoveringenes during de

monte as a postt The Salk InstitSpain). My wo

allowing the ge

rk State Stem Cge is increasedentifying reprog

cient and inducof hPSCs with uin multigenic d

ductal adenocamal 5‐year survivmodels of PDAC

del by introducent stages of Ph injection intonding of the eas using CRISPR

Animal Biology

Biology ProgramYork, USA. New

Medicine. Prof. J

an Carlos Izpis

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general

Geneva, Switzg the identificevelopment.

doctoral fellowtute for Biologicrk focused on d

eneration of �

Cell (NYSTEM) S during reproggramming as a

cible genome eunprecedenteddiseases such a

rcinoma (PDACval rate of 6% ainitiation recap

cing single or mDAC initiation, o recipient micarly steps of thilibraries, provi

y, University of

m York State Stem

Juan Carlos Izpi

ua Belmonte a

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SDE

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erland) where ation and char

w of the Swiss Ncal Studies (La Jdeveloping stra

�transgene‐free

cience fellow. Iramming, and major trigger o

editing of humd ease and effics cancer, and h

C) initiation usind is projectedpitulate the gen

multiple PDAC I will be able tce or in vitro, is disease, allowding new thera

Geneva‐Switze

m Cell (NYSTEM

sua Belmonte a

at The Salk Inst





I acquired a sracterization o

National ScienceJolla, USA), andategies to gene

e� iPSCs.

I addressed thehomologous reof DNA damage

an pluripotentciency. It providhas the potent

ing human Plud to be the seconetic context fo

initiating mutto recapitulatethrough generwing identifyinapeutic approa

erland (2000‐20

M) Science fello

at CMRB, Barce

titute, La Jolla,


ENERAL CNOLOGÍA

NERAL IÓN

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solid backgrounof remote enha

e foundation (Sd then at the Cerate therapeut

e role of DNA recombination ge and contribut

stem cells (hPdes an effectivetial to support

ripotent Stem ond leading cauound in early st

ations in hPSCe the genetic evration of pancrg biomarkers faches to detect

006)

w.

elona, SPAIN. Fe

USA. Fellow o

nd in ancer

NSF), enter tically

repair genes tes to

PSCs), e tool high‐

Cells use of tages

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996 ‐ 1998. Masrof. Denis Dubo

ost relevant pu

hu, Z. *, Gonzaethods in enzy

onzalez, F. *, Zhducible genom

ndrey, G., Monetween topolog

onzalez, F., GeoNA repair genes

onzalez, F., Bouev Genet 12, 23

onzalez, F., Barelmonte, J.C. (2roc Natl Acad Sc

onzalez, F., Dub59.

pitz, F., Gonzaleuster. Cell 113,

pitz, F., GonzaleoxD complex se

atents ub. No.:WO/20tle: "Generatio

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cience Foundat

006. Post‐doc iRLAND

PhD in the Loule at Universit

ster in the Labooule at Universit

ublications

alez, F. *, and mology 546, 21

hu, Z. *, Shi, Z.e editing in hum

ntavon, T., Masgical domains u

orgieva, D., Vas play a critical

ue, S., and Izpis31‐242.

rragan Monaste2009). Generatici U S A 106, 89

boule, D., and

ez, F., and Dub405‐417.

ez, F., Peichel, Ceparate an ance

10/105257 n of mouse ind

A VIDAD

ion (SNSF).

n the Laborato

Laboratory of Mty of Geneva, S

oratory of Molety of Geneva, S

Huangfu, D. (15‐250.

D. *, Lelli, K., Vman pluripoten

screz, B., Gonznderlies HoxD

noli, F., Shi, Z.Drole in reprogr

ua Belmonte, J

erio, M., Tiscoron of mouse‐in918‐8922.

Spitz, F. (2007)

boule, D. (2003

C., Vogt, T.F., Destral regulator

duced pluripote

AYUDASCONVO

Turno d

ory of Molecul

Molecular EmbrySWITZERLAND.

ecular EmbryogSWITZERLAND.

2014). The iCR

Verma, N., Li, Qnt stem cells. Ce

alez, F., Noordgenes collinear

D., Stadtfeld, Mramming to a pl

.C. (2011). Met

rnia, G., Montsnduced pluripot

). Transgenic a

). A global cont

Duboule, D., anry module from

nt stem cells by

S RAMÓN YOCATORIA

de acceso g

ar Embryogene

yogenesis and M

enesis and Mo

RISPR Platform

Q.V., and Huangell stem cell 15,

dermeer, D., Lerity in mouse lim

M., Ludwig, T., luripotent state

thods for makin

serrat Pulido, Ntent stem cells

nalysis of Hoxd

trol region def

d Zakany, J. (20m evolutionary i

y transient exp

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general

esis and Morp

Morphogenesis

rphogenesis

for Rapid Gen

gfu, D. (2014). A, 215‐226.

eleu, M., Tronombs. Science 34

Jasin, M., and e. Cell reports 3

ng induced plur

N., Vassena, R., by transient ex

d gene regulati

fines a chromos

001). Large scannovations. Ge

ression of a sin

SDD

SDE

DDC

SDP

hogenesis. Pro

s

nome Editing i

An iCRISPR plat

o, D., Spitz, F., 40, 1234167

Huangfu, D. (23, 651‐660.

ipotent stem ce

Batlle Morera,xpression of a s

on during digit

somal regulato

le transgenic aenes Dev 15, 22

gle non‐ viral p





of. Denis Dubo

in Human Plur

tform for rapid

and Duboule,

2013). Homolog

ells: reprogram

, L., Rodriguez single nonviral p

t development.

ory landscape c

and cluster dele209‐2214.

polycistronic ve


ENERAL CNOLOGÍA

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ule at Universi

ripotent Stem

, multiplexable

D. (2013). A sw

gous recombin

mming a la carte

Piza, I., and Izpolycistronic ve

. Dev Biol 306,

containing the H

etion analysis o

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ity of

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sumen de lay research carend developed desticide residueatalytic mechachniques. Durignal transductioe efector respystallization of

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sumen del Coy licenciada enalencia (UPV), rngel Maquieiraontinuación, reaoquímica en laiptófano sintetacromoléculas ecanismo de troquímica. Adeolecular en la rimera estructuutofosforilaciónetabólica heredontinué con el umano, resolvieología fundamología Molecustudios, he consaralelo relacion

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CASINO RYC‐2014

a: Biomedicnico: pcfc

y applied to the

a Memoria: eer comprises wdifferent skills. Aes in water andnism of the tng my PhD stuon systems (TCponse regulatorf membrane his

man non‐collagning the structue la Cierva to weins related wG_207 involved ch line that I hsduction pathwectors producins and I have doe histidine kinamonstration ofur just in transstructural char

derstand the spvation state. Aof TCS, howevmplex TCS, presantibiotic and/o

Currículum Vn Ciencias Químrespectivament poniendo a pualicé una estana Universidad asa, publicandodel Dr. Albertransducción demás, realicé uUniversidad m

ura cristalina den en cis en hisditaria dirigido estudio de TCendo la estrucental y de sistelar de Barceloseguido resolvenados con TCS,

A VIDAD

FERRANDO4‐16490 cina [email protected]

e study of bacte

working periodAfter my bached soil samples. tryptophan synudies I worked CS) performing r. Within the Pstidine kinases

genous domainures NC112, NCwork with Prof.with motility anin virulence. have developedway in bacteriang adaptative one pioneer coase HK853 andf cis‐autophosp. Later, I solvedracterization. Fecificity in the fter all these yer, there are stsent mainly in or antifungal ac

Vitae: micas (1997) y Cte. Realicé el grunto inmunoenncia predoctorade California do tres artículosto Marina en e señales en losn estancia de

médica de Masse un TCS formadstidina quinasapor el Dr. VicenCS y comencé tura cristalina emas), en el lana, CSIC estuder la estructuren colaboració

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ds in several naelor, I worked wAfterwards, I dnthase bienzymwith Dr. Albertfunctional and PhD studies peusing deterge

s of collagen ty566, NC1, NC2, Ignacio Fita innd virulence in

d during the las. TCS are key rresponses. I hontributions in t its cognate rephorylation in d the first crysturthermore, I srecognition betyears of researtill many questfungi. All this tivity, as TCS ar

Ciencia y Tecnorado (tesina) ennsayos enzimátal de dos años de Riverside (Es. Como becariael Instituto des sistemas de ddos meses en sachusetts en Wdo por una hists. Desde Diciente Rubio en elnuevos estudide varios NCs.boratorio del Ddiando la maqa cristalina de ón con el Dr. M

S RAMÓN YOCATORIA

de acceso g

A

nsduction and r

ational and intewith Prof. Ángedid a predoctorme complex uto Marina to d crystallographeriod I did a thnts. As a postd

ype IV chains 1, NC3, NC4 andn the Institute n Mycoplasma

st twelve yearsregulators of bhave studied ththe field solvinesponse regulathistidine kinasetal structure ofsolved structurtween a HK witrch, I have acqtions left behinstructural knowre absent in hu

logía de los alimn Químicas en eticos (ELISA) pa(2001‐2002) eEE.UU). Duranta FPI, en 2003 e Biomedicina dos componentel laboratorioWorcester (EE.tidina quinasa yembre 2007 hal Instituto de Bios estructurale. En Mayo 201Dr. Ignacio Fitauinaria de mola fosfatasa MGMichael T. Laub

Y CAJAL A 2014

general

are diseases

ernational laborel Maquieira to ral stay of two using stopped‐decipher the mic studies on thhree months stdoc, I worked f

1‐6 involved in NC5, as well aof Molecular Ba genitalium, o

s is the study obacterial and fuhe three basic ng the first crystor RR468 whices, a breakthrof a HK performres of rewired Hth its RR as weluired a great kd, therefore, I wledge will sermans (in mamm

mentos (2000) el Departamenra la determin

en el laboratorite este periodcomencé la tesde Valencia, Ctes (TCS), medi del Dr. Bert V.UU). Fruto de y un regulador asta 2012, fui omedicina de Ves de los dom12 comencé una en el Departaovilidad de MyG207 implicadab del Instituto t

SDD

SDE

DDC

SDP

ratories where develop immuyears with Prof‐flow rapid kinolecular and stheir componentay in Dr. Bert for the CIBERER

the rare diseass I continued wBiology of Barceobtaining as a

of the moleculaungal life actingreactions thattal structure ofch gave novel ough in the fieming cis‐autophoHK853 and RR4l as the structuknowledge in sam pursuing nerve as a platformals, in general

por la Universidto de Química ación de plaguo del Dr. Micho realizacé estsis doctoral en CSIC. El objetiviante una aproVan den Berg emis estudios dde la respuestacontratada CIBValencia, CSIC. Cinios no colagen contrato postamento de Biolcoplasma genita en virulencia. ecnológico de





I have learnt dunoassays for thf. Michael F. Dnetics and divtructural basesnts, the sensor van den Berg R performing s

ses Goodparturworking in TCS. elona (CSIC) woresult the 3‐

ar and structurag as sensors oft catalyze simpf a complex bemechanistic clueld since autoposphorylation, 468 alone and res of the DNAstructural bilogew projects, rerm for the ratil).

dad de Valencide la UPV bajo

uicidas, publicanhael F. Dunn detudios enzimátel laboratorio vo de mi tesis oximación en bien el Departamde doctorado (a y se demostróBERER del progComo investigaenosos (NC) dtdoctoral Juan logía Estructuratalium. Como A su vez, he reMassachusetts


ENERAL CNOLOGÍA

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ÉCNICA


different technhe determinatiounn to work overse spectross of two‐compohistidine kinaselab to work in

structural biolo

re�s and AlpoSince 2012, I haorking on strucD structure of

al bases of TCSf the environmple TCS in ordetween the cataues of this systhosphorylationa reaction thain complex tha‐binding RRs Ogy and in enzymelated basicallyional design of

a y la Politécnico la dirección dendo dos artículel Departamentticos con la ende Cristalograffue el estudio

iología estructumento de Med(2008) se obtuó por primera vgrama de Medadora post‐doctel colágeno tipde la Cierva (Áal en el Institutresultado de ealizado estudios en Boston (EE

iques on of n the copic onent e and n the ogy in

ort�s ave a ctural f the

S, the ental er to alytic tems, n was t has t has mpR, matic with f new

ca de el Dr. os. A to de nzima fía de o del ural y dicina vo la vez la dicina toral, po IV Área: to de estos os en E.UU)

sohireMpeunloalt

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cimiento en TCa en cis‐autofoy OmpR. turos son ampdominios senson estructural y smos, por elloíficos.

A VIDAD

S y en colaboraosforilación, así

pliar el conocimores, catalíticosfuncional. Esto

o, dicho estudi

AYUDASCONVO

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ación con el Drí como las est

miento en el ms y reguladoresos sistemas, noo presenta ta

S RAMÓN YOCATORIA

de acceso g

r. Alberto Mariructuras crista

mecanismo de ts que imponen o presentes en hambién importa

Y CAJAL A 2014

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ina que ha dadlinas del domi

transducción mun nivel superhumanos, estánancia para el

SDD

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mediado por TCrior de regulación implicados endesarrollo rac





rimera estructuactivado de dos

CS más compleón en microorgn procesos de gcional de nuev


ENERAL CNOLOGÍA

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ura cristalina des reguladores

jos, resultado ganismos, medgran relevanciavos antimicrob

e una de la

de la iante para ianos

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sumen de lahe candidate hauring the last foook chapters, 1ecognized qualiarted his PhD pázquez. In an eas quoted by ostdoctoral perrofessor Tamasorresponding au

andidate returnwn project as Period, the candicolás et al., 20areer of the caadership and su

sumen del CScientific contrtotal of 32 scieientific publicaathogens, Arth

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NICOLASRYC‐2014

a: Biomedicnico: fnico

of the RNAi mec

a Memoria: as achieved a hourteen years. 1 edited monogty such as NATperiod with thexceptionally coAndrew Z. Firriod was carries Dalmay. Duruthor (Nicolás

ned to Spain wiPrincipal Investidate orientate013, Plos Pathoandidate has reupervision.

Currículum Vributions: entific publicatations reveals tritis Rheum, RN

cts in open and

rva� (Ministrymme Action). Fpossible modalResearch Activitne as Principal International cwas funded wi

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ar�. relevance andhas its own anstudents. The of a total of 3

d three Degree that justified t

m). The candida

A VIDAD

S MOLINA, 4‐15844 cina [email protected]

chanism in eme

ighly successfuIn this trajectographic special TURE, EMBO J,e opening of a ompetitive fieldre when he red out at the Uring this early et al., 2008, RN

ith a �Juan detigator, fundeded the researchgens), producineached a final

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d competitive c

y of Science, SpFive research fities: invited plty: nvestigator) anonsortium SIRith 11.781.445

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sion, 6th frame

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sters and 12 d

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l scientific careory, the candidaissue and 1 ed Nucleic Acids new RNAi resed, the candidateeceived the NoUniversity of Epostdoc, the NA; Nicolás et

e la Cierva� co and granted bh line to the stung extraordinarstage in whic

ific articles, 4 bnal journals of y, etc. A total o

calls: �Senior

pain) and �Maellowships in oenary talks, tal

nd two contractOCCO, which jeuros (725.000

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work) and a �nts 2014 of therces at the Euro

r a total of 930

different subjec

arch group whPrincipal Investding author in A total period oDoctor Degree aed up to 6 invit

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de acceso g

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ns.

eer on the field ate has publishitorial. The list Res, Plos Pathearch line in the managed to obel Prize for ast Anglia (Uncandidate pubal., 2010, Nucl

ontract and sooby the Europeaudy of the role ry high impact ch he has crea

book chapters,widely recogn

of 11 research p

Researcher�

arie Curie� (Eopen and comks, posters, par

ts, all of them gjoined 24 gro0 euros for our

framework) wi

�Marie Curie�e European Comopean level.

0 hours (360 h

cts. Positive ev

hich currently tigator in one 13 publicationof 43 months oand a second ptations to writ

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of RNA interferhed a total of 3of scientific art

hogens, Arthritie molecular gepublish an excehis work in thited Kingdom),blished again hleic Acids Res;

on after, the caan Commissionof RNAi in fungresults (Calo eated a young r

1 edited monnized quality suprojects, 1 of th

(SIROCCO cons

uropean Commpetitive calls. Urticipant, organ

granted by the ups from 11 dr sub‐project). T

th 7000 euros

contract (Euro

mmission, being

hours in the Un

valuation grant

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ns out of a totaf international post‐doctoral stte specialized r

SDD

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rence (RNAi) an32 scientific conticles reveals tos Rheum, RNAenetics group heptional work (he field of RNAworking threehighest qualityNicolás et al.,

andidate obtainn (Marie Curie gal pathogenest al., 2014, NATresearch group

ographic speciauch as Nature,hem as the Prin

sortium, Europe

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nd its applicationtributions: 26 op internationaA, RNA biology,headed by Prof(Nicolás et al., A interferencee and a half yey contributions2013, Arthritis

ned a Marie CuActions). In thsis and mucormTURE). At this p with several

al issue and 1 , EMBO J, Nucncipal Investiga

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ons to human hscientific artical journals of w etc. The candessor Rosa M. 2003; EMBO J)e. The internatears in the grous both as firstRheum). Later

rie contract anis late postdoc

mycosis (reviewphase, the resestudents unde

editorial. The lleic Acids Res,tor. Three diffe

on, 6th framew

ram, UMU Incoientific confereal.

first project is an Commissioned to the cand

contract (SIRO

work program).

�A�, which s

s in Spain) inclu

Spanish positio

aster students,First author iThesis, two My of 3 months iersity of East Aone of them in

ealth les, 4 widely idate Ruiz‐) that tional up of t and r, the

nd his ctoral wed in earch er his

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nal PLOS Pathog

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tions in Thesis Editor). Invitati

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committees. Mions to four ple

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ree scientific ar

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currently lead an international ssociation studiutoimmune diseis disease havemall cohort sizessociated with dependent pop

ability providedossible novel th

sumen del Cthough my scieocused on the s

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n May 2010, I

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heumatology w

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CARMONRYC‐2014

a: Biomedicnico: fdca

immune Diseas

a Memoria: seases are comany discerniblerigger a chronicetween 5‐8% oormalities as a c

d working on th

ópez‐Neyra�, rest in working

lopmental procprevisions by fas of systemic say lead to seve

and coordinatecollaborative

ies is increasingeases, but raree followed a canes. Because of tthe disease (

pulations). The

d by the �Ramherapies.

Currículum Ventific career htudy of the mo

ménez (Departm

Laude Unanimo

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decided to wo

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h Prof. Martin aorm the first lathe understandke GCA have nopproach, and mic component oassociations wsearch line I cu

rogram, would

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cs, University o

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opened and l) to study the dnform our undetific journals an

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when there is ae defence mecfferent organs aWestern countrin of multiple ge

seases in the g

xperience and ntific career unt

cientific produce contributed wf the skin and iyalgia rheumati

and in collaboraarge scale gending of human ot yet taken admost of them wof GCA is not wwere close to urrently lead a

mark a turning

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ed a new resedevelopmental erstanding of end had large me

oined Prof. Jav

line I am involtis. During thisgory) with an avted as first auonal congresse

matology �AC

on Genetics), gaative project (Pm 12 European

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group of Prof. Ja

recognition in ttil them was fo

tivity since I jowith publicationinternal organsica, stroke or b

ation with diffenetic studies ondiseases with a

dvantage of thisere compromiswell understoodthe statisticalnd in which I w

g point in the re

s has been alwaon and gonad d

ain). I obtained

earch line in thbiology of the ye functionalitedia coverage,

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ined Prof. Martns in high impacs, and giant cellindness.

erent internation GCA. The pua complex genes methodology.sed by a consided, and only the significance bwould work on

esearch of the G

ays a common development in

my PhD as �

e group of Provisual system iy, evolution, anreceiving much

group (Institute

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and The Europ

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mune system terence betweeconsequences id by a cascade otors.

báñez (Institute

dex=56). I was mtudy of the mo

tín�s group lact journals to thll arteritis (GCA

onally recogniseublication of reetic componen. To date, all therable low state HLA region haborder and lan the following

GCA genetics, b

topic in my resn mammals, un

�Doctor Europe

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ENERAL CNOLOGÍA

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to the own bodn self and nonn most cases. Tof immunologic

of Parasitology

mostly motivateolecular mechan

argely surpassehe understandiA), an inflamm

ed rheumatoloecent genome‐nt, such as cance genetic studietistical power das been consistcked replicatiog years, if I had

being a referenc

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ollinson (Institual model of dysgease in humanson worldwide.

gy and Biomed

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late systemic a

scientific journ

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with systemic surrently superv

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sease to detecta

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ostdoc, to exploem‐cell environory), 2) NCSs xtrinsically cont014, Cover‐Storanipulated to i

ntend to now ientricular surfaemonstrated, itould repair or eurobiological tostdoc, I will inentricular progeased neuron prond disease.

sumen del Chroughout my c

completed my MEC, Spain). My

y the completiohis work resulteTechnology Pat11 main paperseuropathol.Expell Probes.2009rimary and seco

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PAEZ GORYC‐2014

a: Biomedicnico: patr

brain resident

a Memoria: progress in neu) to generate nses, such as hyenously regulate

research, I first man (J.Neuropween NSC progese and other pamage to the ht provide addion.

urrent NSC tresplantation is

ore alternative nments are critin vivo are captrol stem cell fry). By successfnduce its own r

investigate wheace. The ependt is intricately itransform thetechniques acqnvestigate this enitors/precursoduction. Succe

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on of my PhD, I ed in: ent s: 3 as first autp.Neurol.2005, 9, Acta Neuropaondary within t

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neural stem ce

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ether NSCs anddymal/ventricunvolved in neue ependymal squired during mnew avenue osors for repair ess here will ide

Vitae: has been to unc

he Malaga Uniwas awarded the

had successful

thor (NeurobioActa.Neuropatathol. 2011). The field of neur

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ATRICIA

mail.com

ells control: new

herapy has unvay provide mucince beginning n development

how a single murol. 2005, Neongenital/neuronditions. Seconall (Acta Neuroutic avenues fo

ypically based oduction of cell

�modulating�ng appropriate srating approprrogeny by modting intrinsic NS

d other radial‐glar surface is auropathic/degeurface in dise

my training, as wf research. By of the ependyentify additiona

cover the best w

iversity (Spain),e grade of Outs

ly established a

ol of Disease.20thol.2012), andhe impact factoropathology. In

S RAMÓN YOCATORIA

de acceso g

w future thera

veiled great prch needed therg my career as aand maturation

mutation in NSCeurobiology oodegenerative dly, we observopathologica.20or treatment o

on transplantatls needed by t

� the brain�s osignals for propriate responsesdulating local nSC control, I ha

lial‐like progena critical compenerative proceased/injured cwell as publishresearching thymal ventriculaal processes fo

ways to manipu

, under supervstanding/Summ

a direct relation

006, J.Neuropad 5 as third/miors for these pn addition, some

Y CAJAL A 2014

general

pies by which t

omise for brainapies for patiena research scien in health and

C progenitors lef Disease.2006disease was a

ved that reactiv012). This strof neurodegene

tion and sufferthe host. With

own resident stper NSC functios under differeneuronal circuiave revealed fu

nitors in the venponent of the esses like hydroconditions is ued and unpuble transformatir surface, I wilr clinical interv

ulate NSCs as a

vision of Dr. Fema Cum Laude in

nship between

thol.Exp.Neuroiddle author (Jublications are e of these resu

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n regenerative nts suffering brntist, I have sodisease.

eads to hydroce6, J.Neuropathkey concept te astrocytes acongly suggestedrative disease,

r from very lowknowledge of

tem cells. I haveon and progenyent requirements using laser uture therapies

ntricular niche developing an

ocephalus. Whnknown. Usingished in vitro ave potential ofl move beyondention and trea

tool for brain r

rnandez‐Fígaren 2006.

NSCs and cong

ol.2007), 3 as s.Neuropathol.Emedium to melts were publish





be manipulate

medicine. Harnrain injuries or ought to unders

ephalus and nehol.Exp.Neurol.that provided pcquire attributed that NSCs o beyond the lim

w‐efficiency. Onf this deficienc

e since demony generation (Nnts (Nature 20stimulation (Ns by which the

can be harnessnd mature brahether NSCs ang established assays that I def NSCs as well d the limited satment of neur

regenerative m

es, supported b

genital/neurode

second author Exp.Neurol.200edium/high, anhed as 5 additio


ENERAL CNOLOGÍA

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ed to induce its

nessing adult nneurodegenerastand ways in w

eurodegenerati.2007). This dprecedence fores of the ependor other ventrimited scope of

ne major barriecy, I endeavore

strated that 1) Neuron 2011, C13), and 3) weature Neuroscibrain itself ma

sed for repair oin. As others ad other progendevelopmentaleveloped durinas examining ocope of purelyopathological i

medicine.

by a FPU Fellow

egenerative dis

(Int.J.Dev.Biol.21, 2003, 2009;nd the journals onal articles in

own

eural ative/ which

on in direct r NSC dymal icular f new

er‐to‐ed as

local over‐e can ience ay be

of the and I nitors l and g my other y NSC njury

wship

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2001, ; Mol were open

ac InThsu

I fre‐ N‐ N‐ NI a I hSp Fuan20 Asin intpr Du(Sot

MDY

ccess journals: 2

2008, I startedhe Ruth K. Broupported my ind

focus my postdesident stem ceNeuron 2011 (fiNature 2013 (ToNature Neuroscam also a key au

have received dpain), The Ruth

urthermore, I wn F1000 prime 014; NIH Highlig

s a researcher, scientific meeternational sciresentations.

uring my scientpain), SAS/Juntther institutes a

MINISTERIO


2 as first autho

d a postdoc at oad BRF, Inc adependent rese

doctoral researlls after brain dirst authorship;op Story Neuracience 2014 (firuthor in four ad

different awardK. Broad Biome

was nominated reviewer since ght 2011; Cove

in addition to tetings relevant entific confere

tific career, I hta de Andaluciaand to perform

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r (CSF 2005a,b)

Duke Universitnd was awardearch from 200

rch on developdamage. This w; Neuron Coverl Cells News 20rst authorship; dditional manu

d/fellowships: Redical Research

for Outstandin2010. My reser Story in Neuro

the published pto the neuroscences/symposia

have been essea. Also, I have various teachin

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ty (USA) under ded with the R09‐2011.

ping a new direork has resulter Story; NIH‐Hig013) Nat.Neurosc. Cscripts, one in r

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g Postdoc by Dearch has beenon 2011 and Na

papers (18 totacience audienca (FENS, SFN,

ential contributbeen fortunateng/mentoring d

S RAMÓN YOCATORIA

de acceso g

uthor (CSF 200

Dr. Kuo supervRuth K. Broad

ection for futud in 3 high impghlights.2011),

Cover Story). revision and th

ng Fellowship nc. Fellowship (

Duke Universityn frequently recat.Neurosc. 201

al, 7 first‐authoce, with a totalKeystone Sym

tor on several e to have oppoduties at differe

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general

05c, CSF 2006).

vision. In 2009,International P

ure NSC therapact factor pape

ree are under f

(Beca ColaboraUSA).

y in 2012. I havecognized as top14).

r, 5 second‐aut of 40 contribu

mposia, CSHL m

research projecortunities to deent levels.

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cts funded by evelop fruitful c





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on for submissio

Andalucia), FP

d as a memberory Neural Cell

impact factor),he national scihese contribut

public entities:collaborations


ENERAL CNOLOGÍA

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a grant proposas competitive g

� the brain�s

on.

PU Fellowship (

r of F1000 facus News 2011, 2

, I have participentific level antions, 22 were

: NIH/USA, FIS/with researche

al for grant

own

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pated nd 29 oral

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GONZALRYC‐2014

a: Biomedicnico: elen

pigenetic study

a Memoria: ajectory centeive disease modand first postdell biology conc

international pith the role of odels and humaigoprogenitor rating and diffeing this period.

010, I joined Drafish model witogramming prould start to devand reprogramm). This project¿suisition and mawith this projein, and analyzinso developing ies. ort term goal isfunctional assaic collaboration

ently count onen Enfermedadunding from Gth Dr. M.A. Dolodelling project

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ar last 5 years: tions: 5 ions :2 e: my last high ifactor: 11.22 (1oogle.es/citatio

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r. J. Cibelli¿s grth in vivo labeocess that happvelop an indepeming. I could cos results have baintenance, andect where I wang transcriptionprojects that co

s to generate iays to uncover ns we anticipat

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tic cell reprogra

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aining at Univeell division and

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oup �Cell Repeling of heteroens from adult endent project fontinue it after been publishedd a new reprogant to go deepnal and epigeneouple my know

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amming, and ap

rstanding of hic applications.y of Barcelona 4 indexed publi

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progamming Lachromatin dur somatic cell tofocused into thr I moved to Drd in a high impgramming combper in the repretic characteristwledge of repro

ific cell types aar pathways thry of new drug

disease modelializada)(projectosis modeling rapy for Neuropansplantation i

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human somatic helped me to acations and im

ornia San Francn of neural ste

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ffected in diffehat may explaig targets that m

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it doesnt have

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Michigan Stateming (pendingpotent cell (iPSCnew oocyte‐spn Spain at LARCwing that ASF1escribed. echanisms by eprogramming.d with neurod

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s through ourto FEDER‐INNTEf new altered partment) for Fous system.

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g for potential t

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ENERAL CNOLOGÍA

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herapies.

the applicatio

f a great amoubiomedical rese

ent (2009‐2010elopment, using

ell populations s the major top

MSU). I establishn) and essentia

nd their implicn Laboratory foperone is crucia

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f asymmetric cuman NSCs cuansplantation aanuscript is stilOctober 2010

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my project deaes and I publishPalacin laborain epiblast de

d my first internell division andulture, in vitroand luminiscenll pending for it0, I joined Dr. field. I establishand essentially,

ing this period ation in pluripotell Reprogrammcount on fundines Raras y Medth Dr. M. Doladansplantation inence adquired he biology of Nust obtained toamming and dis

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national postdod differentiatioo differentiationce‐based tumts publication. Cibelli Cell Rehed a transgen I studied the

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of caveolae in aexed articles. ctoral researchd mouse stem

octoral trainingn of neural sten to differentor tracking. W

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MER Cell Therapus system. tdoctoral trainimy knowledgeogramming basg research proje

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g at University oem cells (NSCst neural lineagWe published a

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general

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of California Sa) in glioma devges, mouse con article in a

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e University, wheterochromati adult somatic

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of cell reprograecular and cell started, make





a wide variety o

studying the roication and a

th Dra. Petritsccquired knowleance, brain diournal (Cancer

where I focusein during reproc cells to induc

ning of new oolab in Spain at cience, 2014). n in AMER (Acciple Sclerosis medreich Ataxia

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ENERAL CNOLOGÍA

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of molecular an

ole of the aminosecond article

ch, to study theedge of mousessection, brainCell) and a se

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a Memoria: BS in Environm

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distinction in 2and discontin

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