CY NHU

Nhm 53Dng Th Anh KhoaL Th Phng HngLm Th Ngc Tho

CY NHU(Morinda citrifoliaL.)

THC VT HCH Rubiaceae (C ph,Thin tho)Tn khoa hc Morinda citrifolia Linn.Tn Vit Nam: Cy Ngao, Nhu ni, Giu, Nhu ln, Nhu rng.B phn dng:R, qu, l v v cy ( Radix, Fructus, Foliumet Cortex Morindae citrifoliae). R hay dng nht di dng phi hay sy kh. Cc b phn dng khc dng ti.

Cy thn mc, cao 6-8m, l mc i hnh bu dc, mp c rng ca, c 6-7 gn l.Hoa hnh ng loa kn, mu trng mc thnh chm nch l, n vo thng 12.Qu hnh trng, di 4-5cm, mc thnh chm, qu non mu xanh khi chn c mu vng, chn vo thng 7.

THNH PHN HA HC

AnthraquinonMorinda citrifolia L. cha: Anthraquinon, polysaccharid, coumarine, acid hu c, vitamin v khong cht, alkaloid.

Hm lng mt s thnh phn ho sinh trong qu Nhu

Cu trc ca cc polysaccharid phn lp c t nhu

ArabinosePolysaccharidRhamnoseGlucuronic acidGalactose

7

Glycosid

Amin acid

Vitamin

Flavonoid

Saponin

CourmarinUrsolic acidAracetinScopolectinAscorbic acidCitrifolinosidAsperulosidid acidCaprylic acidCaprolic acid

TC DNG DC L1/ Theo Ty y

C men Xanthine oxidase km hm chc nng gen ras-genprosertonin xeronin 1-methoxy-2-formyl-hydroxyanthraquinone enzym

Cc ch phm t nhu:

2/ Theo y hc c truynCc b phn cy nhu c dng lm thuc:

Cng dng trong dn gianQu nhu n vi mui d tiu, nhun trng, lm thuc iu kinh, tr bng huyt, bch i, ho, cm hen, thng, au gn, i ng (i tho). Nng chn n cha lR nhunhum mu qun o, vi la. Nhn dn Vit Nam thi nh, sao vng ngm ru, ung cha bnh nhc mi, au lng (c th dng qu nhu non, thi mng sao kh thay r ny)L nhugi nt, p cha mn nht, lm chng ln da. Sc ung cha l i ngoi, cha st v lm thuc b. Liu dng 8 10g sc vi 500ml nc chia lm 2 ln ung trong ngy ( cha nhng ngi hay nhc u chng mt).

1 - Cha nhc u kinh nin, au na u:- R Nhu 24g -Mung tru 12g.- Ci xay 12g -Rau m 12g.- C gu (sao, tm ng tin) 08g. 500ml nc, sccn 250ml. Chia lm 2 ln ung trong mt ngy, ung lc thuc cn nng. 2 - Cha mt ng, suy nhc thn kinh, huyt p cao:- R Nhu 24g -Tho quyt minh (sao thm) 12g.- Rau m 08g -Th phc linh 08g.- V bi 06g.- Gng sng 03lt 500ml nc, sccn 250ml. Chia lm 2 ln ung trong mt ngy, ung lc thuc cn nng.

Mt s bi thuc t cy nhu:

3 - Cha huyt p cao:Rnhu30-40g/ngy, sc ung thay nc ch, sau 2 tun l c kt qu, sau gim bt liu, ung lin tc 2,3 thng.4 - Nhc mi tay chn, au lng:Qu nhu non thi mng sao kh, 300g ngm trong 2 lt ru 30-40 sau 2 tun, ung ngy 2 ln, ln 1 ly con 30-40ml.5 - Cha l, tiu chy, cm st:L nhu ti 3 - 6 l ti ra sch nu vi 500 ml nc cn 200 ml chia 2 ln ung/ngy. Ung lin tc 2-5 ngy.

PHNG PHP KIM NGHIM DC LIU m: khng qu 12%Tro ton phnKhng qu 10% tp chtTp cht khc: khng qu 1%T l ht: khng qu 30%Dc liu phi cha khng t hn 17 % hm lng cht chit c.

nh tnh cc hp cht trong cao chit Nhu:Quy trnh chit xut theo phng php ca trng H Dc khoa Rumani

1- AlcaloidAlcaloid to kt ta vi cc thuc th sau:Thuc th Bouchardat:Phn ng vi alcaloid cho trm hin mu nu.Thuc th Mayer:Phn ng vi alcaloid cho trm hin mu vng nhtThuc th HagerPhn ng vi alcaloid cho trm hin mu vng. Cht th c ha tan trong HCl 1%, un nh 80oC trong 1h , lc ly dung dch, cho 1ml dung dch cht th vo ng nghim lm mu th. Cho vi git thuc th vo ng nghim cha mu th. Nu xut hin kt ta l phn ng dng tnh.

nh tnh

2- Flavonoid

Phn ng dng tnh th hin qua mu sc c trng d dng quan st bng mt thng. Th nghim cho php d on thnh phn flavonoid n trong dch chit phn lp v dch chit flavonoid tng s ca qu Nhu.nh tnh

Diazo ha cho mu thm, coumarin b thng hoa khi nung nng. 3- Coumarin4- AnthraquinonePhn ng Borntrager cho mu lp kim pha di.Phn ng vi Magnesi acetate dung dch c mu nu .Sc k lp mng- Bn mng: silicagel GF 254- H dung mi: benzene - chloroform - acid acetic (9:1.5:0.5)- Dch chm sc k: anthraquinon ha tan trong methanol.nh tnh

Tnh to btSc k lp mng5- Saponinnh tnh- Bn mng: Silica gel G60F254- H dung mi : Benzen - ethyl acetat a. formic (80 : 19 : 1)- Dung dch th: 5 g bt dc liu kh + 30 ml ethanol 96%

PP dng Soxhlet

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