morphology , pathogenesis , treatment andmicrobiology.free.fr/presentations/trypanosomiasis2.pdf ·...
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��Morphology , pathogenesis , treatment and Morphology , pathogenesis , treatment and
prevention are prevention are similar to Trypa similar to Trypa -- GambienseGambiense
��Difference:Difference: it is an acute infection it is an acute infection
��Duration:Duration: from several week to a yearfrom several week to a year
►► Forms:Forms: oval or circle oval or circle
��Trypomastigote:Trypomastigote: in blood circulation.in blood circulation.
��Amastigote:Amastigote: in RESin RES and phagocytesand phagocytes
��a nucleus and kinetoplast. a nucleus and kinetoplast.
AA-- TrypomastigoteTrypomastigote
BB-- amastigoteamastigote
CC-- EpimastigoteEpimastigote
DD-- Trypomastigote gambiense or Rho Trypomastigote gambiense or Rho
Central and south America.Central and south America.
Vector: Kissing bugVector: Kissing bug
Transmission Transmission
♣♣ Cases American trypanosomiasisCases American trypanosomiasis
►►Incubation period:Incubation period: 55--15 days.15 days.
►►Symptoms:Symptoms: Cutaneous or mucous Cutaneous or mucous ChancreChancre with with lymphodenopathy, call lymphodenopathy, call (chagoma).(chagoma).
►►ConjunctivitisConjunctivitis ,generalized lymphodenopathy,generalized lymphodenopathy
►►Myocarditis, headache, malaise, fever Myocarditis, headache, malaise, fever hepatosplenomegaly, meningo cephalitishepatosplenomegaly, meningo cephalitis
Conjunctivitis Conjunctivitis
►►Direct:Direct: Giemza stainGiemza stain (trypomastigote form in blood (trypomastigote form in blood
and amastigote in RES.and amastigote in RES.
►►Motility testMotility test
►►XenodiagnosisXenodiagnosis
►►Indirect:Indirect:
►►Anti bodyAnti body fluorescence test.fluorescence test.
►►CultureCulture
►►Inject of patient blood to animalInject of patient blood to animal
Xeno diagnosisXeno diagnosis
♣♣ NefurtimoxNefurtimox 100mg ,10mg/kgw.b 100mg ,10mg/kgw.b X4X4
..44monthsmonths
☻☻Benznidazole Benznidazole 55--10mg/kgw.b 110mg/kgw.b 1--2 months2 months
☻☻ProcainamidProcainamid
☻☻Qinidin.Qinidin.