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“The Role of Research Universities for the Regional Economy Dr Martin Hinoul Moscow, december 10 th , 2013 Business Development Manager KU Leuven R&D a case study The Leuven Model

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Page 1: Moscow 10 december 2013

“The Role of Research Universities

for the Regional Economy

Dr Martin Hinoul

Moscow, december 10th , 2013

Business Development Manager KU Leuven R&D

a case studyThe Leuven Model

Page 2: Moscow 10 december 2013

World’s GDP and R&D Budgets !

500 Bi $ versus 360 Bi $ ?

16,5 tr $ 18 tr $

1,5 tr $

6,4 tr

$ 5 tr $

Source : The World Bank-Reshaping Economic Geography, Hinoul

1,74 tr $

2 tr $

3 % R&D -

500 BI dollar

2% R&D-

360 Bi dollar

M.Hinoul

Page 3: Moscow 10 december 2013

SIR* World Report 2012

• 3290 Research Institutions (strong criteria)

• more than 80% of the world scientific output (2006-2010)

(Global Ranking KU Leuven 68 (universities 32) - European Ranking KU Leuven 5)

*Scimago Institutions Rankings

INDICATORS

• Output

• International Collaboration

• Normalized Impact

• High Quality Publications

• Specialization Index (Gini

index)

• Excellence Rate

M.Hinoul

Page 4: Moscow 10 december 2013

Barosso’s dream (or nightmare)

for 2020

75% of the active population should be employed in 2020 –Today in

2013 it is only 66%- A long way to go.

3% of the European GDP should be spent on R&D .

Today it is only 1,9%

One percent extra means an extra of 180 Bi€

One percent means also an extra 700.000 engineers and scientists.

R&D fine but how good is the valorization of the European research?

20/20/20 in 2020:

Reducing green house gas emissions with 20% (level 1990)

Energy reduction minus 20%

Alternative Energy plus 20%

M.Hinoul

Page 5: Moscow 10 december 2013

Economic growth and the

Knowledge Economy Regions

M.Hinoul

Page 6: Moscow 10 december 2013

Globally there are more than 50 well

developed knowledge economy regions

M.Hinoul

Page 7: Moscow 10 december 2013

Source : Harvard Business Review July-August2012 – p.26

M.Hinoul

Page 8: Moscow 10 december 2013

M.Hinoul

Page 9: Moscow 10 december 2013

“Third Generation Universities”Some examples

KU LeuvenCambridge

Stanford University, Palo Alto MIT

Page 10: Moscow 10 december 2013

February 2009:

• 25.800 companies founded by MIT alumni

• 3.3 mi employees

• Annual sales : 2 trillion $

• 17th largest economy in the world

Impact on ecosystem:

• < 10% MIT students are from Ma state

BUT: > 30% firms started in Ma by MIT

alumni

• > 50% firms started by foreign students

are located in the US

Location Total

United States 2,340

Europe 790

Latin America 495

Asia 342

Estimated Number Of

Companies Founded

By “Foreign” MIT

Alumni

Source: Bankboston Report (Kauffman Foundation)

Massachusetts Institute

of Technology - MIT

Vannevar Bush M.Hinoul

Page 11: Moscow 10 december 2013

Stanford University at the basis of

Silicon Valley

Leland Stanford governor of California

1887 first stone of the university

1891 (March 22) opening – 559 students

David Starr Jordan – first rector

Frederick Emmon Terman

Start setting up companies such as Hewlett Packard, Varian, etc.

Build the first research parks

First Venture Capital which became later the famous Sand Hill

venture capital Road

27 Nobel Prizes, a lot of National Medals and other distinctions

Silicon Valley – more than 8000 high tech companies – hundred

thousands of new jobs

M.Hinoul

Page 12: Moscow 10 december 2013

Regional Knowledge Economy

It all started with professor Fred Terman at the

Stanford University in 1939

Page 13: Moscow 10 december 2013

Silicon Valley today

A State of Mind

Page 14: Moscow 10 december 2013

Stanford – Fred Terman

Silicon Valley – A complex Network of Clusters

Nano-electronics-Bio Silicon

Internet – Google – e-Bay –Yahoo-

Amazon.com - Facebook

Semiconductors – Shockley –-Intel

Software -Oracle

Computers – Apple Computer - Sun

Electronics – Hewlett Packard -

Varian

Networks – Cisco - Juniper

(Bosack,Lerner& Troiano -1984)

2005

2000

1980

1975

1955

1939R

oute

101 –

Route

280 -

Sta

te o

f min

d

VC

–K

lein

er P

erk

ins C

aulfie

ld…

NA

SD

AQ

Silic

on V

alle

y J

oin

t Ventu

re N

etw

ork

Sta

nfo

rdU

niv

ers

ity–

UC

SF

-B

erk

ele

y

Clean Technology

M.Hinoul

Page 15: Moscow 10 december 2013

Source: Silicon Valley 150

The Mercury News – May 2013

The Power of

Silicon Valley Cies

2012

RankCompany

2012

Sales – Bn $2012

Net Profit – Bn$

Market Value

Bn $

March 31 2012

1 Apple 164,7 42 416

2 Hewlett-Packard 119 -12 46

3 Intel 53 11 108

4 Google 51 10 262

5 Cisco Systems 47 9 111

6 Oracle 37 10 152

7 eBay 14 3 70

8 Synnex 10,3 0,159 1,4

9 Gilead Sciences 10 2,6 75

10 Applied Materials 8,1 - 16

Total 514 88 1258

*GDP Be 444 Bn $

GDP Netherland 743 Bn $

M.Hinoul

Page 16: Moscow 10 december 2013
Page 17: Moscow 10 december 2013
Page 18: Moscow 10 december 2013
Page 19: Moscow 10 december 2013

The “Echoes” of Silicon Valley are Everywhere

Page 20: Moscow 10 december 2013

An Ancient yet Hi-Tech and Modern City

804 year old University

Cambridge

Page 21: Moscow 10 december 2013

The Cambridge Phenomenon

50 years young

5,000 companies founded since 1960

1400 truly “HiTech”companies today. 2,500 Total Tech.

45,000 jobs

Ten $1 billion dollar companies

Two $10 billion dollar companies

Roads, airports, guided bus, rail transportation

Attracting up to 20% of European Early Stage VC

Page 22: Moscow 10 december 2013

Key Components of the Entrepreneurial Eco-system

Cambridge

University

1960

1970

MRC

Laboratory

of Molecular

Biology

CAD

Centre

Sinclair

Radionics

CCL

Barclays Bank

1980

Cambridge

Interactive

System

Cambridge

Science Park

Acorn

PA

TechnologyEicon

Research Ltd

Sinclair

Research Ltd

1990

Analysys

Olivetti Research

Laboratory

(acquired by

AT&T in 1999)

Judge Business

SchoolSt. John

Innovation

Centre

Scientific

Generics

The Technology

Partnership

TTP

Cambridge Research and

Innovation Ltd (CRIL)

Institute of

Biotechnolog

y

Cantab

Pharmaceuticals

Hitachi

Cambridge

Laboratory

Nickerson

Biotech

Laboratory

Glaxo

2000

Toshiba

Cambridge

Research

Laboratory

Seiko Epson

Research

Lab

Unilever Cambridge

Centre for Molecular

Informatics

Cambridge

NetworkInstitute of

Manufacturing

Amadeus Capital

Partners

TTP Ventures

Microsoft Research

(previously Entropic

Research)

Glaxo Institute

of Applied

Pharmacology

BP

CfEL (previously

CEC)

Cambridge

Enterprise

CUE, Biology

in Business

CMI

Avlar

ET Capital

Cambridge

Gateway

3i Create

Partners

Cambridge

Angels

GEIF

Library

House

Cambridge

Capital Group

ERBI

Philip

s

EPSON

The Wellcome

Trust Sanger

Babraham

Bioincubator

Cambridge

Research

Park

Granta Park

CHASE

Enterprise Link

Page 23: Moscow 10 december 2013

Until 1985

1986-1990

1991-1995

1996-2000

2001-2002

Cambridge

University

AcornHermann

Hauser

Acquired by

Olivetti

Olivetti

Research LabAndy Hopper

Adaptive

Broadband

Cambridge

BroadbandAcquired by American

Microwave

Acquired by

Western

Multiplex

Corp

Andy Hopper

Peter Warton

IPV (Telemedia

Systems)

Andy Hopper

Virata(ATML)

Hermann Hauser

Andy Hopper

Merged with

Globespan

Acquired by AT &T

RealVNC

Virtual Network

Computing Level5NetworkAndy Hopper

ANTAlex van Someren

Nicko van Someren

nCipherAlex van Someren

Nicko van Someren

NetchannelHermann Hauser

Jack Lang

Acquired by

NTL

ARMElement 14

Stan Boland

Simon Knowles

Acquired by

Broadcom

Amadeus Capital PartnersHermann Hauser

IQ BioHermann Hauser, Chris Keightley

Part of DAKO

Diagnostics DakoCytomation -

Merged with

Cytomation Inc

CDT

Richard Friend

Richard Friend Plastic Logic

Analysys

David Cleevely

Cambridge

Network

David Cleevely

Hermann Hauser

Alec Broers

Cambridge

3G

David Cleevely

CPSPeter Duffett-Smith

Polight

Technologies

Stephen Elliott

Pavel Krecmer

ART

Daniel Hall

Pilgrim BeartActiveRF

Pilgrim Beart

Antenova

Zeus

Technology

Adam Twiss

David Reeves

Cambridge

Semiconductor

Gehan Amaratunga

Florin Udrea

MuscatJohn Snyder

Martin Porter Enterprise

AcceleratorJohn Snyder

John SnyderWebtop

Smartlogik

Acquired by Dialog

Small

World

Richard Green

Authur Chance

Dick Newell

CADShape Data

Charles Lang

Acquired by

GE

TensailsRichard Green

VBN

online

TerraPrise

Ubisense

Andy Hopper

Steve Pope

Andy Hopper

Andy Ward

Pete

StegglesSimon Elliott

David Cleevely

Electronic Share

InformationAcquired by

E* Trade

Hermann Hauser

Jack LangTop

expressJack Lang

Splashpower

Lily Chang

James Hay

Saviso Group

Adam Twiss

Bryan Amesbury

Innovia

Collin Ager

Garraint Davies

Cambridge Interactive Systems

Hermann Hauser

Mike Muller

Tudor Brown

Jamie Urquhart

Dick Newell, Tom Sancha

The hi-tech start-ups and Networks associated with the Cambridge University

Stan Boland

Simon Knowles

Icera

Laser-ScanR. O. Frisch

M-Spatial

Adrian Cuthbert

Jon Billing

version (Sept 2005) – not to be used or copied without permission

Copyright – Y.M.Myint - [email protected], Dr. Shailendra Vyakarnam -

[email protected]

Page 24: Moscow 10 december 2013

Until 1985

1986-1990

1991-1995

1996-2000

2001-2002

AGC

1984Alan

Goodman

ATMAlan

Goodman

Salix

pharmaceutical

Alan

Goodman

Peptide

Therapeutics

Now Acambis

Daniel Roach

Alan

Goodman

AmuraAlan

Goodman

Avlar

BioVenturesAlan Goodman

Daniel Roach

Oxford

BimedicaAlan

Goodman

LiDCO

Alan

Goodman

Terry O’Brien

Alan Goodman

CORE

CeNes

Daniel Roach

Alan Goodman

ChiroscienceChris Evans

Alan Goodman

Enzymatix

Chris Evans

Merged by

Celltech

Group

Rapigene

ChiroTech

Enviros

Chris Evans Chris Evans

CerebrusToad

Chris Evans

Chris Evans Chris Evans

Merlin Ventures

Celsis

Amedis

pharmaceutic

al

William Bains

John Caldwell

Axis Genetcs Iain Cubitt

Iain CubittPestex Changed its name

to MicroBio Group

Acquired by

Becker

Underwood

MRC LMB

1960s

Greg Winter

Daivd ChiswellCAT

Greg WinterDiversys

RiboTargets

Simon Sturge

Celltech

Cambridge

University

Martin Davies

BioRobotics

Cantab

Pharmaceuticals

Alan Munro

Merged with

Xenova

Group Ltd

Chris Lowe

J. McCann

Cambridge

Sensors

Affinity chromatography

Chris Lowe

Ken Jones

Acquired by

Prometic

Biosciences

Inc

HolometricaRoger MillingtonAbcam

Jonathan Milner

David Cleevely

AdproTechPeter Lachmann

Biotica TechnologyPeter Leadlay

Jim StauntonKudos

PharmaceuticalsStephen Jackson

Hexagen. Mark Bodmer

Mark Bodmer Lorantis

Acquired by Incyte

Sense

ProteomicsJonathan Blackburn

De NovoPhilip Dean

David Bailey

Paradigm

TherapeuticsMark Carlton

Metris

TherapeuticsStephen Smith

Steve Charnock-Jones

Smart

Holograms

Chris Lowe

Purely

Proteins

Chris Lowe

David Bailey

DaniolabsPaul Goldsmith Akubio

MC

David Klenerman, Tony Minson

Astex

Technology

Tom Blundell

Chris Abell

Harren Jhoti

SolexaShankar

Balasubramanian

David Klenerman

Vernalis

Arakis

Andy

RichardsCyclacelMicroscience

Ark Therapeutics

VecturaReNeuron

Biovex

Genzyme

(UK) -

1985

Chris Evans

Chris Lowe

Merlin BiosciencesChris

Evans

Cambridge Theranostics

Jonathan Milner

David Cleevely

Ivan Petyaev

And a similar Network for Biosciences

Page 25: Moscow 10 december 2013

Leuven, a region for

innovation & high-tech

entrepreneurship

Page 26: Moscow 10 december 2013

The Leuven Region

Close to Brussels

Leuven Region: 95.000 habitants

Brussels

Airport Leuven

Page 27: Moscow 10 december 2013

An old young city

Page 28: Moscow 10 december 2013

The Leuven Case

Brewery Den Hoorn

Stella

AB Inbev

Stanford University (1891)

Fred Terman-1939

Hewlett, Packard,Varian(s)

IPTEC Price

IMECFamous researchers

• Mercator

• Vesalius

• Frisius

• Ortelius

Education Research Exploitation research

• 137 spin offs

• 300 tech companies

• 7000 researchers

• 7000 high tech jobs

• Research Parks

• Incubators

KU Leuven R&D

Transfer OfficeFoundation

KU Leuven

M.Hinoul

Page 29: Moscow 10 december 2013

Knowledge Centers

664 mi€ R&D, 6400 Researchers

High Tech Industrie

Life Sciences Nanotechnology Mechatronics Cleantech Clusters

300 Technology Cies, 135 spin offs

Technology Platforms

Research Parks

University Leuven

Networks

Haasrode Arenberg Leuven Noord Genk THOR Tienen FFH

IMEC

M.Hinoul

Page 30: Moscow 10 december 2013

KU Leuven Research & Development

Technology Transfer Office

A Bridge between research and industry

Page 31: Moscow 10 december 2013

© 2007 LRD

K.U.Leuven Research & Development received the

2008 IPTEC Tech Transfer Award

Nominated:

•K.U.Leuven R&D (Winner 2008)

•Columbia University (USA)

•Imperial Innovations (UK)

•MIT (USA)

•Wisconsin Alumni Research Foundation (USA)

Received the award :

•2006 : Stanford University (USA)

•2007 : Tsinghua University (China)

Page 32: Moscow 10 december 2013

“Promoting and supporting knowledge and technology transfer between

university and industry”

LRD: Mission

Researchers

Companies

• Research collaboration

• Spin-offs and regional development

• IP protection and licenses

Page 33: Moscow 10 december 2013

What is LRD?

• LRD consists of:

o Central multidisciplinary staff

• Supports researchers in knowledge and technology transfer

o Research divisions

• 1,422 researchers & 397 supporting

• Embedded in university via matrix structure

• Virtual organisations in which (groups of)

researchers (from different faculties

or departments) can group their

applied research, commercial-

industrial and exploitation activities.

Page 34: Moscow 10 december 2013

Intellectual property

• What do we do?

o Creating awareness and transferring knowledge

o Assessing the feasibility, patentability and market potential of

an invention

o Determining a protection strategy

o Drafting and filing a patent application

o Following up on patent procedures and costs

o Negotiating and drafting NDAs, MTAs

and license agreements

o Finding industrial partners

Page 35: Moscow 10 december 2013

LRD research divisions

Faculties, departments, research groups:

quality in research and educational activities

LRD divisions/projects:

Contract and budgetary

autonomy and flexibility

incentives

Page 36: Moscow 10 december 2013

Research collaboration

(17)

• advice• contract R&D• projects with government support (IWT, EC, etc.)

• Close interaction and collaboration between

different units

• Regional and international networking

Organisation

Intellectual property rights

(12)

• intellectual property rights • licensing

Spin-off & innovation

(9)

• spin-off creation & growth• networks & regional development• KU Leuven Association

Finance, HR & logistics

(39)

• financial administration

• HRM

administration

Management (2)

Page 37: Moscow 10 december 2013

Activities

• Research collaboration

• Protection and exploitation of intellectual property

• Spin-off creation & innovation

• Support of regional development

• Stimulation of entrepreneurship through

network initiatives

Page 38: Moscow 10 december 2013

Examples of technology transfer

Page 39: Moscow 10 december 2013

Research collaboration

• Oldest activity of LRD

• Performing research & services for companies or

governments

• What do we do?

o Creating awareness and transferring knowledge

o Providing advice

o Negotiating contracts

o Following up on contracts

o Managing research files financially

o Offering administrative support

o Preparing legal documents

Page 40: Moscow 10 december 2013

Contract Research

54.332

70.193

87.908

97.844

121.653126.807

144.802

€ 0

€ 20.000

€ 40.000

€ 60.000

€ 80.000

€ 100.000

€ 120.000

€ 140.000

€ 160.000

2004 2005 2006 2007 2008 2009 2010

tho

usa

nd

s

160.000

2011

Page 41: Moscow 10 december 2013

Intellectual property

• Internal specialised office: protection and exploitation of intellectual property rights

• Network of formal collaborations with different European patent attorneys

• Patent Fund: selective support of research groups to

help them cover their initial costs and expenses related

to patenting needs

Page 42: Moscow 10 december 2013

Intellectual property

• 156 patent applications in 2011

o 496 active patent families

o 49 PCTs

• 60 million euro license-income (71 million in 2012)

• Attributed patent is often the basis for setting up a

spin-off company

In numbers 2011

Reported findings 154

Priority submissions 156

New patents 33

Page 43: Moscow 10 december 2013

Spin-offs & innovation

• What do we do?

o Developing business plans

o Validating business models and the market

o Offering legal support

o Putting together a competent team

o Finding investors

o Finding infrastructure

o Managing growth of spin-offs

o Promoting valorisation and

entrepreneurship

o Stimulating regional development,

networks and clusters

Page 44: Moscow 10 december 2013

Knowledge

Centers

Mixed Innovative Cies

Attraction Innovative

Cies

Creation Innovative

Cies

Network relatedCies

(VC, Seed, IP, Legal..)

Definition of a Technology Cluster

M.Hinoul

Page 45: Moscow 10 december 2013

Mechatronica

Alnaco

Donaldson

Dynamotor

Decoster

Tecmate

Intl.

Robert Bosch

AffilipsSouth Lancs

Belgium

Flexlink

Systems

SST

Food Mach

Camco

Techn

Partec Eng

ACE Electronics

Ora Machines B.E.S.T.

Stas

Electrical & Mech. Design

DV Consulting IPCOS

Krypton

Luyten Automation

PEC EME

Entecom Systems

M&M Corporation

Data Analys Products

CSILMS

D2S International

Atos Engineering

Metris

Somatech

Optidrive

Materialise

Barco Aarschot

WTCM Air Beraing Prec. Techn.

Scala Consultants

KULeuven

K.U.Leuven

Dept. Mechanics

Researh groups

K.U.Leuven

Dept of Metall. & Mater. Eng

Lab Agric Mach & Proc

Kenniscentra

Centers of

excellence

Pure innovatieve

bedrijven

Mixed innovatieve

bedrijven

Page 46: Moscow 10 december 2013

Biotest Seralco

Benelux

Terumo

Europe

Autocyte

Europe

Conti BPC

Ortec

VWR InternationalCentocor

Malaise&co

IVIA

Medvision

Benelux

Norgine

Dermat

E.S.R.I.

Deckers Div

Dakocytomation

Cochlear

M-Elect

Custom8

@Medical Techn.

New Standard Eng.

Materialise

MXS

QMedit

PatientWeb

Thrombogenics

ReMynd

Algonomics

BioTie Therapies Corp.

Tigenix

IDT(RNA-TEC)

Medicim

Life Science Cluster

K.U.Leuven

L-MTC

Univ hospitals

K.U.Leuven

Rega Institute

CEHA

Lab of Exp. Genetics & Transgenese

VIB

VIGOUR

Kenniscentra

Centers of

excellence

Puur innovatieve

bedrijven

Gemengd innovatieve

bedrijven

Diatos

Onco Methylome

Neurogenetics

FugeiaRegenesys

M4S

Formac

PharmaceuticalsCMPG

Page 47: Moscow 10 december 2013

A Top Technology Region

Page 48: Moscow 10 december 2013

Much more

than the 3 % Lisbon target

Page 49: Moscow 10 december 2013

49

Kenniscentra en

centers of excellence

Pure innovatieve

bedrijven

Mixed innovatieve

bedrijven

Netwerken*

HIGH TECH SYSTEMS & MATERIALENSpecialisatie en pieken: Selectie en typologie belangrijkste actoren

KUleuven

U HasseltU Luik

Imec

TTR België

TTR Duitsland

TTR Nederland

KUL

Imec

U Hasselt

U Luik

Ford Werke

Borealis Polymers

Epiq

DOW Belgium

Tessenderlo

chemie

nv Graco

Vista nv

Alro Holdings

LAG

Trailers

Spaas

Kaarsen

Heraeus

Electro-Nite

InternationalRWTH

Aachen

Forschungszentrum Jülich

Hochschule

NiederrheinContinental

Philips (licht)/ Philips

Onderzoeksinstituut

Siempelkamp

Trützschler

Oerlikon Textile

Schumag AG

CAR e.V.

Pierberg

Campus

Eindhoven

Philips

Campus

Geleen

Philips

DAF

Siemens VDO

Bosch

PackagingBosch Hydraulic

Stork food

systems en

printing

Vanderlande

IndustriesAgoria

Flanders

Drive

DSP ValleySirris

Walonie

Espace

FMTC

(mechatronica)

FLAMAC

(materialen

onderzoek)

Nederlandse

vereniging

voor rubber

en

kunststoffen

Vereniging

van de

Nederlandse

Chemische

Industrie

Netherlands

Aerospace

Group (NAG)

Chemelot

Nederlandse

Vereniging

voor Precisie-

technologie

Verband der

Chemischen

industrie (VCI)

Cluster Chemie/

Kunststoffe

Mitteldeutschland

Verbundinitiative Automobil

Nordrhein-Westfalen (VIA NRW)

Verband der

Elektrotechnik

(VDE)AUNDE

3M

ATC

Eindhoven

Fraunhofer Institut

Cerobear

FEV

Motorentechnik

Prüfcentrum Siemens

transportation Systems

Munters Euroform

INTRA e.V.

Voith Paper

Scheidt & Bachmann

Nedcar

ASML

DSM

Akzo Nobel

Océ

* Internationaal netwerk: Automotive.net

Page 50: Moscow 10 december 2013

K.U.Leuven Spin offs

0

10

20

30

40

50

60

70

80

90

100

1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010

Gemma Frisius-Seed Capital

2x 12,5 m€

2012

Page 51: Moscow 10 december 2013

Spillovers and multipliers

• Spin-offs between 2006 - 2010:– K.U.Leuven direct investments: 4,7 M€

– Gemma Frisius Fund investments: 12 M€

– Other third party investments: 476 M€

Page 52: Moscow 10 december 2013

Perennial topics

Euro

Investment in spin-offs 2005 - 2012

7 453 606 14 591 843

631 426 634

0

100 000 000

200 000 000

300 000 000

400 000 000

500 000 000

600 000 000

700 000 000

KU Leuven GFF derden

Page 53: Moscow 10 december 2013

Seed Capital – Venture Capital – 500 million €

Risicokapitaal Arr. Leuven (2002) : 200 miljoen euro

Quest

Management

20%Softw are Holding

& Finance

8%

Beluga

12%

Stonefund

19%

Servifund

12%

Gemma Frisius

Fonds 1

7%

Gemma Frisius

Fonds 2

7%

Capricorn Venture

Partners

12%

IMEC

Incubatiefonds

3%

Page 54: Moscow 10 december 2013

Spillovers and multipliers

• Patent portfolios:

– K.U.Leuven R&D, 454 active patent families of which 90%

economically exploited

– Multiplier effects of patent portfolios of spin-off companies

sectoral multipliers of 3 to 4

Page 55: Moscow 10 december 2013

Examples in Life Sciences KU Leuven

Page 56: Moscow 10 december 2013

Spin-off companies: some examples

• Engineering

• Micro-electronics & ICT

Page 57: Moscow 10 december 2013

Spin-off companies: examples

• Consultancy

• Biomedical

Page 58: Moscow 10 december 2013

Incubation & seed financing

• Gemma Frisius Fund KU Leuven (GFF)

o Seed capital for spin-off companies

o GFF founded in 1997 & GFF II in 2002

• At the end of 2009 GFF and GFF II merged into one single fund

o Partners:

• KU Leuven (20% of capital)

• Two banks: KBC Private Equity (40%) and BNP Paribas Fortis Private

Equity (40%)

o Combination between:

• Knowledge and technology transfer expertise

(university)

• Financial expertise (financial partners)

o Not restricted to one technology domain

o 25 million euro invested in 38 spin-off

companies

Page 59: Moscow 10 december 2013

Regional and interregional development

• Partners: o City of Leuven

o Province of Flemish Brabant

o Vinnof

o CREA - European Commission

o KBC Private Equity

o BNP Paribas Fortis Private Equity

o imec

o VIB

• ELAt: Eindhoven - Leuven - Aachen triangleo Cross-border and interregional network

o Stimulation of knowledge economy

• HAE : Health Axis Europe (Heidelberg, Leuven, Cambridge)

Page 60: Moscow 10 december 2013

Networks

• Stimulating knowledge exchange and partnering with

other high-tech businesses (both SMEs and large

companies) and innovation actors

• Horizontal networks:

o Leuven.Inc

o Flanders Smart Hub

Page 61: Moscow 10 december 2013

Networks

• Vertical networks:

o DSP Valley

o LSEC

• Thematic centres:

o CD3

o L-MRC

o L-MTC

o LICT

o PharmAbs

o NERF

o LFoRCe

Page 62: Moscow 10 december 2013

Science parks, business centres

& incubators

• Arenberg Science Park

• Haasrode Science Park

• Leuven Noord Science Park

• Waterschei - Genk Science Park

• Tienen Science Park

• Ubicenter

• Remy Campus

• Leuven Business Centre

Page 63: Moscow 10 december 2013

Science parks, business centres

& incubators

• Leuven Bio-Incubators

• Tienen Biogenerator

• KU Leuven Innovation & Incubation Centre (I&I)

• Kortrijk Innovation & Incubation Centre (IICK)

Page 64: Moscow 10 december 2013

Multilevel interaction

LRD

GFF

Leuven.Inc

Science

Parks

KU LEUVEN

RegionFinancial

world

Industry

Page 65: Moscow 10 december 2013

1. Basis is a critical mass of high quality research

2. Create an appropriate entrepreneurial climate in a university

context

3. Create a legal framework with respect to exploitation of

academic research

4. Clear incentives and policies to encourage research groups and

departments to actively seek knowledge transfer opportunities

5. Create a professional Interface Unit – An Integrated approach on

research valorisation: multidisciplinary team & “high value” services

6. Create a Seed Capital and/or Venture Capital Fund

12 Lessons from Leuven

Page 66: Moscow 10 december 2013

7. Foster spin-offs from your university research

8. Clear ownership of Intellectual Property

9. Improving awareness among federal, regional and local

shareholders

10. Supporting a forum for business, academia, government and

supporting organisations to build partnerships by sharing new

ideas and best practices. Importance of the networks.

11. Focus on Focus and Enthusiasm

12. Quality of life

12 Lessons from Leuven

Page 67: Moscow 10 december 2013

Success factors

• A critical mass of high quality research

• Multidisciplinary team & high value support

• Clear incentives to encourage researchers and research

groups

• Favourable entrepreneurial climate within the university

• Legal context in Flanders

• Instruments and networks that further professionalise

technology transfer support

Page 68: Moscow 10 december 2013

Towards an

Entrepreneurial Society

“The rise of the entrepreneur is not just about

economics.

It reflects profound changes from individual

careers to the social contract.

It signals the birth of an entrepreneurial society”

-The Economist-March 14, 2009

Page 69: Moscow 10 december 2013

The Value Chain is the barometer

1. Knowledge Centers

2. Entrepreneurs

3. Role Models

4. Money

5. Capital Markets

6. Infrastructure

7. Cluster Policy

8. International Companies

9. Networks

10.Government

11.Quality of Life

Source : Hinoul, Gibbons, Saxenian

Page 70: Moscow 10 december 2013

What makes a region attractive for talent?

Location – such as Silicon Valley, California – Sophia Antipolis, Mediteranée –

Heidelberg Old University

Universities or Research Centers - Magnets for talent

See Jiao Tong University League e.g. Stanford, Harvard, Princeton, IMEC

Leuven, LETI Grenoble, CERN Geneva.

Presence of top Succesful Companies -

Microsoft, Intel, Google, ASML, LMS…

Presence of Strong Individuals – Role Models

Bill Gates, Steve Jobs, Larry Page and even Nobel price winners.

Presence of Successful Clusters

San Diego Biotech-Golden Triangle – North Carolina Research triangle

Fiscal System – Salaries, tax incentives, research budgets

Quality of Life – Leisure, Housing, Medical care, International schools, culture…

Source: M. Hinoul – 7th Annual Conference – Technopolicy Network –

Heidelberg 2010

Page 71: Moscow 10 december 2013

Towards a new Form of Culture

CULTURE

All things are possible attitude

Co-competition

Stock options

Based on Meritocracy

Time for the next big thing

Cross-pollination

Cross-investments

State of mind

Failure Badge of meritJumping on the Next Curve (Oracle)

Networking

Inflection Point (Andy Grove)

SerialEntrepreneurs

Risk TakingWe have not enoughspin-offs who fail

±Source : M. Hinoul

Page 72: Moscow 10 december 2013

75

Flemish Entrepreneurs

The old generation

Lieven Gevaert

Leo Leander Bekaert

Leo H. Baekeland

Page 73: Moscow 10 december 2013

76

Flemish Visionaries

Paul Janssen

Gaston Geens

Roger Van OverstraetenMarc Van Montagu Walter Fiers

John Cordier

Page 74: Moscow 10 december 2013

Leuven Entrepreneurs

A new generation

A.OOSTERLINCK D. COLLEN S. BIJNENS

P. STOFFELS

J. CALLEWAERT

J. DEJAEGER

.

U. VAN DEURZEN B. VAN COPPENOLLE

F. VAN CRAEN

T. DE PROFT

Page 75: Moscow 10 december 2013
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Page 77: Moscow 10 december 2013

Interdisciplinary Research

Clusters and Research DirectionsS

tem

cells

Bio

Info

rmatics

Dru

gD

eliv

ery

Medic

al devic

es

Nucle

ar

Medic

ine

Sm

all

sa

telli

tes

Pla

tfo

rm &

pa

y lo

ad

Suborb

ital

Sp

ace

flig

hts

Gro

un

d N

avig

atio

n

Inte

rpla

ne

tary

S

pa

ce

Flig

hts

Com

pone

nts

Clo

ud c

om

puting

Mic

ro e

lectr

onic

s

Da

ta s

cre

en

ing

Spe

ech r

ecog

nitio

n

Confidential-M.Hinoul

Page 78: Moscow 10 december 2013

5 Research Programs

(Clusters)

Research Centers

Interdisciplinary

approach

A close interaction

between different

research divisions

Technopark

(a state of the art

infrastructure)

Russian &

International Cies

Russian & International

Research Centers

Research Collaboration

IPR(Royalties,Licencing)

Spin offs – Start ups

Finance (Seed, VC, IPO)

DirectorTTO

Clusters and Interdisciplinary Research

at Skolkovo

Page 79: Moscow 10 december 2013

Dual Incentive Mechanism

TechnoparkSIST

Striving for scientific excellence

Gearing this excellence towards application and

technological innovation

Creation of the Knowledge Economy Region Skolkovo

Russian & International

Universities

Russian & International

Cies

Page 80: Moscow 10 december 2013

Contact

KU Leuven Research & Development (LRD)

Waaistraat 6 – box 5105

3000 Leuven, Belgium

Tel.+32 16 32 65 00

[email protected]

lrd.kuleuven.be