movement of melanosomes
DESCRIPTION
MOVEMENT OF MELANOSOMES. FORMATION OF MELANOSOMES. MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE). HUMAN SKIN. MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS. MELANOBLASTS DIVIDE TO FORM MELANOCYTES. - PowerPoint PPT PresentationTRANSCRIPT
MOVEMENT OF MELANOSOMES
FORMATION OF MELANOSOMES
MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE)
HUMAN SKIN
MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS
MELANOBLASTS DIVIDE TO FORM MELANOCYTES
AN AUTO - IMMUNE DISEASE IN WHICH SOME MELANOCYTES ARE DESTROYED BY THE IMMUNE SYSTEM
MELANSOMES ARE TAKEN UP BY PHAGOCYTOSIS INTO THE LOWER KERATINOCYTES
INACTIVE TYROSINASE DUE TO MUTATION
MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.
BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.
CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE.
SO MISDIRECTED AT TRANS-GOLGI SYSTEM
MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.
LACK OF TYROSINE TRANSPORT SYTEM IN MELANOSOME MEMBRANE.
LACK OF FUNCTIONAL TYROSINASE
LACK OF TRANSFER TO KERATINOCYTES