multiple epiphyseal dysplasia
DESCRIPTION
Multiple Epiphyseal Dysplasia. Multiple Epiphyseal Dysplasia. Normal. What is Multiple Epiphyseal Dysplasia?. Multiple epiphyseal dysplasia (MED) is a common form of skeletal dysplasia, and it is characterized by variable degrees of epiphyseal* abnormality. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/1.jpg)
Multiple Epiphyseal Dysplasia
![Page 2: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/2.jpg)
Multiple Epiphyseal Dysplasia
Normal
![Page 3: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/3.jpg)
What is Multiple Epiphyseal Dysplasia?
Multiple epiphyseal dysplasia (MED) is a common form of skeletal dysplasia, and it is characterized by variable degrees of epiphyseal* abnormality.
* epiphysis is an either end of a long bone
![Page 4: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/4.jpg)
But in fact, it’s rather a group of diseases. Mutations in six non-allelic genes are associated with MED (COMP, DTDST, MATN3, COL9A1, COL9A2 and COL9A3)
...and depending on which gene is affected presentation of MED may vary
...however, radiologic diagnosis of MED is possible
![Page 5: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/5.jpg)
![Page 6: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/6.jpg)
![Page 7: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/7.jpg)
![Page 8: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/8.jpg)
MED may be uncommon in physician’s daily practice, and not all of doctors are able to recognize it.
![Page 9: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/9.jpg)
RadiographsSpine
T12/L1 notching and deformed ring apophysisHands
short, carpal bones more delayed than phalangeal epiphysis,
Hipsirregular thigh bone which is bilateral and
symmetricKnees
knock-knee or bow-leggedness
![Page 10: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/10.jpg)
How about teaching computer to recognize multiple epiphyseal dysplasia?
![Page 11: Multiple Epiphyseal Dysplasia](https://reader036.vdocuments.net/reader036/viewer/2022081502/5681651c550346895dd79b71/html5/thumbnails/11.jpg)
Thanks for Your attention!!