Since 1973 the Royal College of Obstetricians and Gynaecologistshas regularly convened Study Groups to address important growthareas within obstetrics and gynaecology. An international group ofeminent scientists and clinicians from various disciplines is invitedto present the results of recent research and to contribute to in-depth discussions. The resulting volume, containing the paperspresented, is published within a few months of the meeting andprovides a summary of the subject that is both authoritative andup to date.

All healthcare professionals involved in women’s health need tohave an awareness of the special antenatal and postnatal problemsfor the mother having twins or indeed a higher-order multiplepregnancy. There are also particular challenges facing those caringfor neonates born from multiple pregnancies.

Contributions to this volume come from multidisciplinaryhealthcare professionals who are leaders in both the scientificunderstanding and the clinical management of multiplepregnancy. They address not only issues related topathophysiology and delivery in multiple pregnancy but also thevarious potential implications and long-term sequelae for thechildren. The continuing need to support mothers who give birthto multiple pregnancies is also recognised and addressed.

This volume provides an essential overview of the currentliterature to those healthcare professionals working withinobstetrics, midwifery and paediatrics.

Spine Width 14. mm

14 mmSpine Width

MultiplePregnancy

Edited byMark Kilby, Philip Baker,

Hilary Critchley and David Field

2006

Mu

ltiple

Pregn

ancy

Edited by Mark K

ilby, Philip Baker, H

ilary Critchleyand D

avid Field

Multiple Pregnancy Cover 150506 24/5/06 09:53 Page 1

Multiple Pregnancy

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InfertilityEdited by AA Templeton and JO Drife

Intrapartum Fetal SurveillanceEdited by JAD Spencer and RHT Ward

Early Fetal Growth and DevelopmentEdited by RHT Ward, SK Smith and D Donnai

Ethics in Obstetrics and GynaecologyEdited by S Bewley and RHT Ward

The Biology of Gynaecological CancerEdited by R Leake, M Gore and RHT Ward

Multiple PregnancyEdited by RHT Ward and M Whittle

The Prevention of Pelvic InfectionEdited by AA Templeton

Screening for Down Syndrome in the FirstTrimesterEdited by JG Grudzinskas and RHT Ward

Problems in Early Pregnancy: Advances inDiagnosis and ManagementEdited by JG Grudzinskas and PMS O’Brien

Gene Identification, Manipulation and TreatmentEdited by SK Smith, EJ Thomas and PMS O’Brien

Evidence-based Fertility TreatmentEdited by AA Templeton, ID Cooke and PMS O’Brien

Fetal Programming: Influences on Developmentand Disease in Later LifeEdited by PMS O’Brien,T Wheeler and DJP Barker

Hormones and CancerEdited by PMS O’Brien and AB MacLean

The Placenta: Basic Science and Clinical PracticeEdited by JCP Kingdom, ERM Jauniaux and PMS O’Brien

Disorders of the Menstrual CycleEdited by PMS O’Brien, IT Cameron and AB MacLean

Infection and PregnancyEdited by AB MacLean, L Regan and D Carrington

Pain in Obstetrics and GynaecologyEdited by AB MacLean, RW Stones and S Thornton

Incontinence in WomenEdited by AB MacLean and L Cardozo

Maternal Morbidity and MortalityEdited by AB MacLean and J Neilson

Lower Genital Tract NeoplasiaEdited by Allan B MacLean,Albert Singer and Hilary Critchley

Pre-eclampsiaEdited by Hilary Critchley,Allan MacLean,Lucilla Poston and James Walker

Preterm BirthEdited by Hilary Critchley, Phillip Bennett and Steven Thornton

Menopause and Hormone ReplacementEdited by Hilary Critchley,Ailsa Gebbie and Valerie Beral

Implantation and Early DevelopmentEdited by Hilary Critchley, Iain Cameron and Stephen Smith

Contraception and Contraceptive UseEdited by Anna Glasier, Kaye Wellings and Hilary Critchley

Since 1973 the Royal College of Obstetricians andGynaecologists has regularly convened Study Groups to address

important growth areas within obstetrics and gynaecology.An international group of eminent scientists and clinicians from various disciplines is invited to present the results of

recent research and to take part in in-depth discussions.Theresulting volume, containing the papers presented and

also edited transcripts of the discussions, is published within afew months of the meeting and provides a summary of the

subject that is both authoritative and up-to-date.

SOME PREVIOUS STUDY GROUP PUBLICATIONS AVAILABLE

3002 RCOG Multi Preg SG 24/5/06 11:22 am Page ii

MultiplePregnancyEdited by

Mark Kilby, Philip Baker,

Hilary Critchley and David Field

3002 RCOG Multi Preg SG 24/5/06 11:22 am Page iii

Mark D Kilby MD MRCOGProfessor of Maternal and Fetal Medicine, Department of Fetal Medicine, Floor 3, Birmingham Women’sHospital, Birmingham B15 2TG

Philip N Baker DM FRCOGProfessor of Maternal and Fetal Health, Maternal and Fetal Health Research Centre,The University ofManchester, St Mary’s Hospital, Hathersage Road, Manchester M13 0JH

Hilary OD Critchley MD FRCOG FRANZCOGProfessor of Reproductive Medicine and Consultant Gynaecologist, Centre for Reproductive Biology,University of Edinburgh,The Chancellor’s Building, 49 Little France Crescent, Edinburgh EH16 4SB

David J Field MBBS DCH FRCPCH FRCP(Ed) DMProfessor of Neonatal Medicine, University of Leicester, Neonatal Unit, Leicester Royal Infirmary,Infirmary Square, Leicester LE1 5WW

Published by the RCOG Press at the Royal College of Obstetricians and Gynaecologists,27 Sussex Place, Regent’s Park, London NW1 4RG

www.rcog.org.uk

Registered charity no. 213280

First published 2006

© 2006 The Royal College of Obstetricians and Gynaecologists

No part of this publication may be reproduced, stored or transmitted in any form or by any means,without the prior written permission of the publisher or, in the case of reprographic reproduction, inaccordance with the terms of licences issued by the Copyright Licensing Agency in the UK[www.cla.co.uk]. Enquiries concerning reproduction outside the terms stated here should be sent to thepublisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of aspecific statement, that such names are exempt from the relevant laws and regulations and therefore forgeneral use.

While every effort has been made to ensure the accuracy of the information contained within thispublication, the publisher can give no guarantee for information about drug dosage and applicationthereof contained in this book. In every individual case the respective user must check currentindications and accuracy by consulting other pharmaceutical literature and following the guidelines laiddown by the manufacturers of specific products and the relevant authorities in the country in whichthey are practising.

The rights of Mark Kilby, Philip Baker, Hilary Critchley and David Field to be identified as Editors ofthis work has been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988.

ISBN 1-904752-22-5

RCOG Editor:Andrew WelshDesign/typesetting by Karl Harrington, FiSH Books, LondonIndex by Liza FurnivalPrinted by Henry Ling Ltd,The Dorchester Press, Dorchester DT1 1HD

3002 RCOG Multi Preg SG 24/5/06 11:22 am Page iv

Contents

Participants vii

Preface xiii

1 Epidemiology of multiple pregnancy: changing effects of assisted conceptionJennifer J Kurinczuk 1

2 Assisted conception and multiple pregnancies: methods of reducing multiples from assisted reproductionSiladitya Bhattacharya and Zabeena Pandian 29

3 Monochorionic twin placentas: clinical outcome and computer modelling of a high-risk pregnancyPeter GJ Nikkels, Jeroen PHM van den Wijngaard and Martin JC van Gemert 45

4 Anomalous development in twins (including monozygotic duplication)Neil J Sebire 59

5 Genetic aspects of twinningDavid Chitayat and Judith G Hall 89

6 Selective reduction and termination of multiple pregnanciesRuwan C Wimalasundera 95

7 Preterm labour in multiple pregnanciesSheri Lim,TG Teoh and Phillip Bennett 109

8 Twin clinics: a model for antenatal care in multiple gestationsAndrew Carlin and James P Neilson 121

9 Impact of twins on neonatal careDavid Field 139

10 Single-twin demise: consequences for the survivorStephen Ong, Javier Zamora, Khalid S Khan and Mark D Kilby 149

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11 Scientific basis of twin-to-twin transfusion syndromeWilliam JB Dennes, Mark FH Sullivan and Nicholas M Fisk 167

12 Twin-to-twin transfusion syndromeMasami Yamamoto and Yves Ville 183

13 Management of twin reversed arterial perfusion (TRAP) sequenceNeil J Sebire and Waldo Sepulveda 199

14 Management of labour in multiple pregnanciesJon FR Barrett 223

15 Does neonatal and infant neurodevelopment of twins and singletons differ?Neil Marlow 235

16 Epidemiology of cerebral palsy in multiple pregnanciesIsaac Blickstein 245

17 Systematic reviews of research on multiple pregnancy: an overview of their quality and a guide to methodsKhalid S Khan, Pradeep M Jayaram, Caroline Fox and Mark D Kilby 255

18 Effects of the birth of multiples on parents’ psychological wellbeingDebbie Sen and Stephen Robson 267

19 Consensus views arising from the 50th Study Group: Multiple Pregnancy 283

Index 287

vi | CONTENTS

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Participants

Philip BakerConvenor of RCOG Study Groups and Professor of Maternal and Fetal Health,Maternal and Fetal Health Research Centre,The University of Manchester,St Mary’s Hospital, Hathersage Road, Manchester M13 0JH, UK.

Jon FR BarrettAssociate Professor of Obstetrics and Gynaecology, Gynaecology,Women’s CollegeHospital, 60 Grosvenor Street,Toronto, Canada, M5S 1B6.

Phillip BennettProfessor of Obstetrics and Gynaecology, Imperial College Parturition ResearchGroup, Institute of Reproductive and Developmental Biology, HammersmithHospital Campus, Du Cane Road, London W12 0NN, UK.

Siladitya BhattacharyaReader and Honorary Consultant,Acting Head of Department of Obstetrics andGynaecology, University of Aberdeen, Foresterhill,Aberdeen AB25 2ZD, UK.

Isaac BlicksteinProfessor of Obstetrics and Gynecology, High-risk Pregnancy Unit, Department ofObstetrics and Gynecology, Kaplan Medical Center, Rehovot, 76100, Israel.

David ChitayatProfessor and Head,The Prenatal Diagnosis and Medical Genetics Program,Department of Obstetrics and Gynecology, Mount Sinai Hospital, 700 UniversityAvenue, Ontario Power Generation Building, Room 3292,Toronto, Ontario,Canada M5G 1Z5.

Hilary OD CritchleyProfessor of Reproductive Medicine and Consultant Gynaecologist, Centre forReproductive Biology, University of Edinburgh,The Queen’s Medical ResearchInstitute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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David FieldProfessor of Neonatal Medicine, University of Leicester, Neonatal Unit,Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK.

Nicholas M FiskProfessor of Obstetrics and Fetal Medicine, Institute of Reproductive &Developmental Biology, Imperial College London, Hammersmith Campus,Du Cane Road, London W12 0NN, UK.

Khalid S KhanProfessor of Obstetrics, Gynaecology and Clinical Epidemiology, BirminghamWomen’s Hospital, Birmingham B15 2TG, UK.

Mark D KilbyProfessor of Maternal and Fetal Medicine, Department of Fetal Medicine, Divisionof Reproduction and Child Health, Floor 3, Birmingham Women’s Hospital,Birmingham B15 2TG, UK.

Jennifer J KurinczukConsultant Clinical Epidemiologist, National Perinatal Epidemiology Unit,University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK.

Neil MarlowProfessor of Neonatal Medicine,Academic Division of Child Health,University Hospital, Queen’s Medical Centre, Nottingham NG7 2UH, UK.

James NeilsonProfessor of Obstetrics and Gynaecology, Developmental Medicine, University ofLiverpool, Liverpool Women’s Hospital, Crown Street, Liverpool L8 7SS, UK.

Kypros H NicolaidesProfessor and Director, Harris Birthright Research Centre for Fetal Medicine,9 Jubilee Wing, King’s College Hospital, Denmark Hill, London SE5 9RS, UK.

Peter GJ NikkelsPathologist, Department of Pathology, University Medical Centre Utrecht,PO Pox 85500, Utrecht 3508 GA,The Netherlands.

Stephen OngSubspecialty Trainee in Fetal Medicine, Department of Fetal Medicine,Birmingham Women’s Hospital, Birmingham B15 2TG, UK.

Neil J SebireConsultant in Paediatric Pathology, Department of Paediatric Pathology,Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK.

Debbie SenSenior Research Nurse Manager, Clinical Research Facility, 4th Floor, Leazes Wing,Royal Victoria Infirmary, Newcastle upon Tyne, NE2 4LP, UK.

viii | PARTICIPANTS

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Yves VilleProfessor of Obstetrics and Gynaecology and Head of Department,Service de Gynécologie Obstétrique, CHI Poissy Saint Germain en Laye,Université de Paris-Ouest Versailles-St. Quentin en Yvelines,10 Rue de Champ Gaillard, Poissy 78300, France.

Ruwan C WimalasunderaConsultant Obstetrician and Fetal Medicine Specialist, Centre for Fetal Care,Queen Charlotte’s and Chelsea Hospital, Du Cane Road, London W12 0HS, UK.

Additional contributorsAndrew CarlinSubspecialty Trainee in Fetal-Maternal Medicine, Liverpool Women’s Hospital,Crown Street, Liverpool L8 7SS, UK.

William JB DennesSenior Registrar, Centre for Fetal Care, Queen Charlotte’s and Chelsea Hospital,Du Cane Road, London W12 0HS, UK.

Caroline FoxSenior House Officer, Birmingham Women’s Hospital, Birmingham B15 2TG, UK.

Judith G HallProfessor Emeritus of Pediatrics and Medical Genetics, British Columbia’sChildren’s Hospital, Department of Pediatrics, Room L408, 4480 Oak Street,Vancouver, British Columbia, Canada V6H 3V4.

Pradeep M JayaramSenior House Officer, Birmingham Women’s Hospital, Birmingham B15 2TG, UK.

Sheri LimImperial College Parturition Research Group, Institute of Reproductive andDevelopmental Biology, Hammersmith Hospital Campus, Du Cane Road,London W12 0NN, UK.

Zabeena PandianSpecialist Registrar, Department of Obstetrics and Gynaecology,AberdeenMaternity Hospital, Cornhill Road,Aberdeen AB25 2ZL, UK.

Stephen RobsonProfessor of Fetal Medicine, School of Surgical and Reproductive Sciences,3rd Floor, Leech Building, Medical School, University of Newcastle, NewcastleNE2 4HH, UK.

Waldo SepulvedaProfessor of Fetal Medicine, Fetal Medicine Unit, University of Santiago, Chile.

PARTICIPANTS | ix

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Mark FH SullivanSenior Lecturer in Reproductive Biochemistry, Institute of Reproductive andDevelopmental Biology, Imperial College London, Hammersmith Campus,Du Cane Road, London W12 0NN, UK.

TG TeohConsultant Obsterician, St Mary’s Hospital, Praed Street, Paddington, London, UK.

Jeroen PHM van den WijngaardResearch Scientist, Laser Centre,Academic Medical Centre, University ofAmsterdam, Meibergdreef 9,Amsterdam 1105 AZ,The Netherlands.

Martin JC van GemertDirector, Laser Centre,Academic Medical Centre, University of Amsterdam,Meibergdreef 9,Amsterdam 1105 AZ,The Netherlands.

Masami YamamotoUnidad de Medicina Materno Fetal, Clinica Alemana de Santiago y Hospital PadreHurtado, Universidad del Desarrollo, Manquehue Norte 1407,Vitacura, Santiago,Chile.

Javier ZamoraMedical Statistician, Clinical Biostatistics Unit, Hospital Ramon y Cajal, Madrid28034, Spain.

DiscussantJacqui HieslerLay Member, RCOG Consumer’s Forum, Royal College of Obstetricians andGynaecologists, 27 Sussex Place, Regent’s Park, London NW1 4RG, UK.

PARTICIPANTS | xi

DECLARATION OF INTERESTAll contributors to the Study Group were invited to make a specific Declaration of Interest in relationto the subject of the Study Group. This was undertaken and all contributors complied with thisrequest. Philip Bennett holds a patent on the inhibition of nuclear factor kappa B in the preventionof preterm labour and acts as a consultant to pharmaceutical companies that are developing drugs forthe prevention of preterm labour. Nicholas Fisk has consultancies with Ferring International,EUMOM Ltd, the Gerson-Lehrman Group and IC Consultants. He is a member of the Ferring UKObstetric Advisory Board and the Scientific Advisory Board of Omnicyte Ltd, and is an independentmember of the Data Safety and Monitoring Board of the US NICHHD Twin–Twin TransfusionSyndrome Trial. He has a medico-legal consultancy and undertakes private practice on behalf of theInstitute of Obstetrics and Gynaecology Trust, a registered charity. He is a member of the MRCCollege of Experts. He has written numerous chapters, editorials and reviews, generating modesteditorial fees. He holds one patent, and his department holds numerous patents related to obstetricsand gynaecology. Neil Marlow is President of the British Association of Perinatal Medicine and aworking member of the Nuffield Council on Bioethics.

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19Chapter 19

Consensus views arising from the 50th Study Group: Multiple Pregnancy

Consensus expert views relating to clinical practice1. The risk of multiple pregnancy should be reduced by conservative use of

ovarian stimulation with careful monitoring according to published guidelines(RCOG, 1999; NICE, 2004; Grade A).

2. In view of the risks associated with multiple pregnancy, consideration shouldbe given to transferring only a single embryo in women undergoing in vitrofertilisation (Grade A).

3. In view of the changing effects of maternal age and fertility treatment onmultiple pregnancy rates, there needs to be a mechanism for recording theirimpact on the rates of multiple pregnancy.

4. Prepregnancy counselling regarding the risks of multiple pregnancy should begiven to a woman undergoing fertility treatment (Grade C).

5. Parents of high order multiple pregnancies (≥ 3) should be counselled andoffered multifetal pregnancy reduction (MFPR) to twins in specialist centres(Grade B).

6. Long-term neurodevelopmental follow-up studies are needed of survivors ofmultiple pregnancies who have undergone MFPR (Grade C).

7. All women with a multiple pregnancy should be offered an ultrasoundexamination at 10–13 weeks of gestation (Grade B) to assess:(a) viability(b) chorionicity(c) major congenital malformation(d) nuchal translucency for designation of risk of aneuploidy and twin-to-

twin transfusion syndrome.

8. All monochorionic twins should have a detailed ultrasound scan whichincludes extended views of the fetal heart (Grade B).

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9. Monochorionic twins require increased ultrasound surveillance from 16 weeksof gestation onwards to detect twin-to-twin transfusion syndrome and growthdiscordance.This should be offered at an interval of 2 weeks (Grade C).

10. Nuchal translucency based screening should be offered as the preferredmethod of aneuploidy screening in women with multiple pregnancy (GradeB).

11. Monochorionic twins that are discordant for fetal anomaly must be referred atan early gestation for assessment and counselling in a regional fetal medicinecentre (Grade B).

12. Twins that are discordant for fetal anomaly should be managed in fetalmedicine centres with specific expertise (Grade C).

13. Hospitals should organise antenatal and postnatal care around specialist-led,multidisciplinary multiple pregnancy clinics (Grade C).

14. The organisation of antenatal twin clinics should be facilitated by carepathways and allow referral to regional fetal medicine centres whenappropriate (Grade C).

15. The lead clinician for multiple pregnancy clinics should have expertise inultrasound and in the intrapartum care of multiple pregnancies (Grade C).

16. Twin-to-twin transfusion syndrome should be managed in conjunction withregional fetal medicine centres with recourse to specialist expertise (Grade C).

17. Fetoscopic laser ablation is the treatment of choice in severe twin-to-twintransfusion syndrome presenting prior to 26 weeks of gestation (Grade A).

18. Single-twin demise in a monochorionic twin pregnancy should be referredand assessed in a regional fetal medicine centre (Grade B).

19. The survivor after single-twin demise in monochorionic twins should havefollow-up ultrasound and, if normal, an MRI examination of the fetal brain2–3 weeks after the co-twin death. Counselling should include the long-termmorbidity in this condition (Grade C).

20. Vaginal delivery of twins should be performed in a setting with continuousintrapartum monitoring, immediate recourse to caesarean section, appropriateanalgesia and an obstetrician experienced in twin delivery (Grade B).

21. In view of the increased risk of stillbirth in twin pregnancy, elective deliveryis recommended between 37 and 38 weeks of gestation (Grade C).

22. Mothers with a multiple pregnancy have a need for specific information,including discussion of delivery and postnatal wellbeing, includingbreastfeeding (Grade C).

23. The role of midwives and other healthcare specialists is integral to themanagement of multiple pregnancies within specialist clinics (Grade C).

24. Additional support to women is available from TAMBA and the MultipleBirths Foundation, and this should be encouraged (Grade C).

25. There is a need to support women emotionally with multiple pregnancies(Grade A).

284 | CONSENSUS VIEWS ARISING FROM THE 50TH STUDY GROUP

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26 There is a need to recognise early signs of perinatal psychological disturbance,which is increased after multiple births, and to offer treatment (Grade A).

Consensus expert views relating to future research1. The optimum method of delivery of twins at greater than 32 weeks of

gestation is unknown. Continuing research may inform this uncertainty.

2. The optimum treatment of early-stage twin-to-twin transfusion syndrome isunclear.This needs to be informed by further research, preferably in the formof a randomised trial investigating conservative management, amnioreductionor laser ablation and their effects on disease progression.

3. There is a need for further multicentre randomised controlled trials evaluatingeffectiveness and cost effectiveness of a single-embryo transfer policy in in vitrofertilisation.

4. Further research is required to assess the outcome of the single surviving fetusin a monochorionic twin set where in utero therapy has been instigated.

5. Because most epidemiological studies on cerebral palsy were performedbefore the impact of fertility treatment on multiple births, there is a need forupdated surveys to establish the current prevalence of cerebral palsy followingassisted conception.

7. There is a need to understand mechanisms of prematurity in multiplepregnancies.

8. There is a need to explore other interventions with the aim of reducingmaternal psychological distress.

9. Given the uncertainties about many interventions during multiple pregnancy,it is important to encourage clinical research aimed at improving pregnancyoutcome.

Consensus expert views relating to health education/policy1. There is an urgent need for the establishment of a prospective registry of

multiple pregnancies that relates chorionicity to outcome.

2. A prospective cohort registry should evaluate the risks mediating neurologicalmorbidity in multiple pregnancy.

3. The UK regional congenital anomaly registers should collect informationregarding plurality and chorionicity.

4. The general health problems related to twinning should be brought morewidely into the public domain.

5. There is a need to enhance the provision of antenatal education for multiplepregnancies.This should facilitate realistic preparation for birth and parenting,and should aim to meet the needs of the father as well as the mother.

CONSENSUS VIEWS ARISING FROM THE 50TH STUDY GROUP | 285

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Key pre- and postnatal events to be offered in pregnancy

286 | CONSENSUS VIEWS ARISING FROM THE 50TH STUDY GROUP

Dichorionic twins

� Multiples clinic: lead clinician with multidisciplinary team.� Ultrasound at 10–13 weeks: (a) viability; (b) chorionicity; (c) NT:

aneuploidy� Structural anomaly scan at 20–22 weeks.� Serial fetal growth scans e.g 24, 28, 32 and then two- to four-weekly.� BP monitoring and urinalysis at 20, 24, 28 and then two-weekly.� Discussion of woman’s/family needs relating to twins.� 34–36 weeks: discussion of mode of delivery and intrapartum care. � Elective delivery at 37–38 completed weeks.� Postnatal advice and support (hospital- and community-based) to include

breastfeeding and contraceptive advice.

Monochorionic twins

� Multiples clinic: lead clinician with multidisciplinary team.� Ultrasound at 10–13 weeks: (a) viability; (b) chorionicity; (c) NT:

aneuploidy/TTTS� Ultrasound surveillance for TTTS and discordant growth: at 16 weeks and

then two-weekly.� Structural anomaly scan at 20–22 weeks (including fetal ECHO).� Fetal growth scans at two-weekly intervals until delivery.� BP monitoring and urinalysis at 20, 24, 28 and then two-weekly.� Discussion of woman’s/family needs relating to twins.� 32–34 weeks: discussion of mode of delivery and intrapartum care.� Elective delivery at 36–37 completed weeks (if uncomplicated).� Postnatal advice and support (hospital- and community-based) to include

breastfeeding and contraceptive advice.

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