18 - 22 JUNE 2018 BELGRADE, SERBIA18 - 22 JUNE 2018 BELGRADE, SERBIABELGRADE BIOINFORMATICS CONFERENCE

MUSCLE MODEL WITH NET OF FIBERS USED FOR MODELLING CELL MIGRATIONMUSCLE MODEL WITH NET OF FIBERS USED FOR MODELLING CELL MIGRATION

Bogdan Milićević 1, Miljan Milošević1,2, Vladimir Simić1 And Miloš Kojić1,3,4*Bogdan Milićević 1, Miljan Milošević1,2, Vladimir Simić1 And Miloš Kojić1,3,4*1 Bioengineering Research And Development Center Bioirc Kragujevac, Prvoslava Stojanovića 6, 3400 Kragujevac, Serbia

2 Belgrade Metropolitan University, Tadeuša Košćuška 63, 11000 Belgrade, Serbia3 Houston Methodist Research Institute, The Department Of Nanomedicine, 6670 Bertner Ave., R7-117, Houston, TX 77030, United States

4 Serbian Academy Of Sciences And Arts, Knez Mihailova 35, 11000 Belgrade, Serbia

Protrusion.Rear of cell is attached to the wall, strong attachment,front part free. Normal strain rate are generated in

1. Introduction 3. Materials and methods

Maxwell cell model We use material model for continuum independently of muscle model.Then, we have summation of stresses for calculation of nodal forces as

front part free. Normal strain rate are generated infrontal part.

ContractionFront part is fixed, strong attachments. Rear part is free.Internal activation, with anisotropic fibers in x-ydirections. Propagation of activation wave is generated.

RelaxationRear part is fixed. Front part is free to move. Cell

Use of reference points of fibers

Hill muscle model

Rear part is fixed. Front part is free to move. Cellapproximately recover intial shape.

4. Results4. Results5. Conclusion

2. Aim In numerical example we demonstrated how

Model cell migration using finite element analysis. Use Hill’s muscle model with net of fibers, in order to describe contraction of cell during cell migration. Cell moves within fluid and interacts with the surrounding deformable cells. Strong coupling between solid and fluid is used. The methodology is implemented in our FE software PAK.

we demonstrated how cells migrate, through a continuum taken as viscous fluid and interacting with the surrounding cells.

AcknowledgementsResearch supported by the grants III41007 and OI174028 Ministry of Education, Science andTechnological Development of Serbia.

implemented in our FE software PAK.