Mutations

Disorder clips presentation.pptx

Human GeneticsMutation - a spontaneous change in DNATypes of mutations -- gene or base: caused by a single base errorchromosome mutation: a part of a chromosome is to blamenon-disjunction: a whole chromosome is involved.Disorder: a negative result of a mutation

Mutation - a spontaneous change in DNATypes of mutations -- gene or base: caused by a single base errorsubstitution (point): one base replaces anotheraddition: one base is inserteddeletion: one base is deletedchromosome mutation: a part of a chromosome is to blamedeletion: part of a chromosome is missingduplication: part of a chromosome is duplicatedinversion: part of a chromosome breaks off and reinserts backwardstranslocation: part of a chromosome from an unrelated chromosome attachesnon-disjunction: a whole chromosome is involved.Disorder: a negative effect of a mutation

Normal: MEN ARE ALL WAY TOO SAD ANY ONE DAY1. MEN ARE ALL WAY TOO SAD YAD ENO YNA2. MEN ARE ALL WAY TOO3. MEN ARE ALL WAY TOO SAD ANY ONE DAY ANY ONE DAY4. MEN ARE ALL WAY TOO SAD ANY ONE DAY ONE FLY CAN5. MEN ARE ALL WAY TOO SAP ANY ONE DAY6. MEN ARE ALL WAP YTO OSA DAN YON EDA Y7. MEN ARE ALL WAT OOS ADA NYO NED AY

Normal DNA: TAC CGC TTC GGC ATCNormal mRNA: AUG GCG AAG CCG UAGAmino acids:

Normal DNA: TAC CGC TTC GGC ATCNormal mRNA: AUG GCG AAG CCG UAGAmino acids: Met Ala Lys Pro stop

Normal DNA: TAC CGC TTC GGC ATCMutation 1: TAC CGC TTC GGT ATCType of mutation:

Normal DNA: TAC CGC TTC GGC ATCMutation 2: TAC CGC ATT CGG CAT CType of mutation:

Normal DNA: TAC CGC TTC GGC ATCMutation 1: TAC CGC TTC GGT ATCType of mutation: substitution aka pointmRNA: AUG GCG AAG CCA UAGMutant protein: Met Ala Lys Pro stop(Normal protein: Met Ala Lys Pro stop)

Normal DNA: TAC CGC TTC GGC ATCMutation 2: TAC CGC ATT CGG CAT CType of mutation: additionmRNA: AUG GCG AAG CCA UAGMutant protein: Met Ala stop(Normal protein: Met Ala Lys Pro stop)

Normal DNA: TAC CGC TTC GGC ATCMutation 3: TAC TGC TTC GGC ATCType of mutation:

Normal DNA: TAC CGC TTC GGC ATCMutation 3: TAC TGC TTC GGC ATCType of mutation: point aka substitutionmRNA: AUG ACG AAG CCA UAGMutant protein: Met Thr Lys Pro stop(Normal protein: Met Ala Lys Pro stop)

Normal DNA: TAC CGC TTC GGC ATCMutation 4: TAC CGC _TCG GCA TC(not on sheet)

Type of mutation:

Normal DNA: TAC CGC TTC GGC ATCMutation 4: TAC CGC _TCG GCA TC(not on sheet)

Type of mutation: deletionmRNA: AUG GCG AGC CGU AGMutant protein: Met Ala Ser Aug (Normal protein: Met Ala Lys Pro stop)

Chromosome mutation: deletion

Chromosome mutation: deletion and duplication

Chromosome mutation: inversion

Chromosome mutation: translocation

Down Syndrome Klinefelter Syndrome Turner Syndrome

Non-disjunction: when chromosomes don't separate correctly in meiosis, resulting in a gametes with too many or too few chromosomes. If such a gamete is involved in fertilization, the zygote (and baby if it develops) will have too few or too many chromosomes.

Attachments

Disorder clips presentation.pptx