my academic career - utokyo tv€¦ · organosilicon chemistry prof. renji okazaki...
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My Academic CareerNagoya University
Department of Chemistry
Yasuyuki Yamada
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(1997. 4 – 1998. 3)for bachelorʼs degreeOrganosilicon chemistryProf. Renji Okazaki(Organoheteroatom chemistry lab.)
Research in the University of Tokyo
(1998. 4 – 2000. 3)for masterʼs degreeOrganometallic polymerProf. Hiroshi Nishihara (Inorganic chemistry lab.)
(2000. 4 – 2003. 3)for doctorʼs degreeArtificial metallo-DNAProf. Mitsuhiko Shionoya (Bioinorganic chemistry lab.)
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Way to an Academic Position
Academic position
(I) Be an assistant professor just after graduation (Direct path)(II) Be a postdoctral fellow or go to a company (Indirect path)
Postdoctral fellow (sometimes considered as ʻA Period for Trainingʼ)(i) Limited-term job(ii) A good chance to expand your background. to learn some new techniques. to change your research field.
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My Thoughts aboutSearching for a Post-Doc Position
• Peptide chemistry • Medicinal chemistry
Internet PapersMagazinesLectures
Informationresources
In Japan or Abroad (USA, Europe, etc.) ??
• Organic synthesis • Young professor
Key words I decided on
Big guy
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How I Applied for a Foreign Post-Doc Position
Found an article about a young professor (C&E news) Jean A Chmielewski (Purdue University)· Drug discovery · Drug delivery systems · Bio-nanotechnology
based on peptide chemistry
Sent an e-mail· Curriculum vitae · Recommendation letter · My own academic papers
One post-doc position was available. several days
Got more information From Prof. Hisakazu Mihara (Tokyo Institute of Technology)
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Introduction of Purdue University
West Lafayette
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My Activities in Chmielewski Lab
Self-Replicating Peptide System
• Lab seminar• Organic reaction mechanism meeting
What was expected?
• Research report• Literature report (topics relates to peptide chemistry)
Work hard!!Discussion
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A Way Back to Japan
• An E-mail from Prof. Shionoyaa limited-term position as an assistant professor was available.Faculty of Pharmaceutical Sciences, Tokyo University of Science (Prof. Shin Aoki, Bioorganic Chemistry Lab.)
Can I survive in the Faculty of Pharmaceutical Sciences?A good chance to expand my background.
• Sent my curriculum vitae with recommendation letters
• Telephone interview
• Got a call from Prof. Aoki
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Faculty of Pharmaceutical Sciences
Tokyo University of ScienceFaculty of Pharmaceutical Sciences, Noda, Chiba
Chemistry
5 Groups
Biology
9 Groups
EnvironmentalHygiene
3 Groups
Healthcare
11 Groups
7 Professors(3 of them were the licensed pharmacists)
My job• Teaching (Some Organic Chemistry Classes)• Research in the lab
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Start a New Research
Something New, Originality• New Concept, Function, Structure, etc.
Where should I begin?
Something related to medicinal chemistry was better.
Focused on well-established zinc cyclen chemistry.
Start my original work. Find something new.
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Redox Properties of Flavins (Vitamin B2)
Yellow
N
N O
O
N
NCOOH N
HN O
O
N
NH
COOH
E0ʼ = –0.24 V vs. SHE
Reduction
+2e–, +2H+
(Na2S2O4, DTTred, etc.)
Oxidation
–2e–, –2H+
(O2, H2O2, etc.)
Oxidized form Reduced form
Almost colorlessFluorescent (Φf = 0.16) Non-fluorescent (Φf ~ 0)
λex = 365 nm
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Redox Potential in Living Cells
SHR SR S R–2e–, –2H+
2e–, 2H+
E (Cytosol) = –0.28 ~ –0.22 V vs. SHE at pH 7.0
Thiol–disulfide redox equilibrium
Oxidized flavins can be reduced by thiols.
Flavins can be used for monitoring the redoxpotential in living cells?
Kept by the redox homeostasis mechanisms.
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What Should We Rely on?
Knowledge and Experience of Chemistry Methodology to make molecules. to analyze molecules. to treat molecules.
Our Sword and Shield
Find something new
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Nagoya University
Trying to find something newin the Department of Chemistry !
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Acknowledgement
Prof. Mitsuhiko Shionoya (Univ. of Tokyo)
Prof. Shin Aoki (Tokyo Univ. of Sci.)
Prof. Jean A. Chmielewski (Purdue Univ.)
Prof. Hiroshi Nishihara (Univ. of Tokyo)
Prof. Renji Okazaki (Univ. of Tokyo)
Prof. Eiichi Nakamura (Univ. of Tokyo)
Prof. Takashi Kato(Univ. of Tokyo)
Prof. Tetsuya Hasegawa (Univ. of Tokyo)