Supplement

Antibiotic search terms: antibiotic OR "Anti-Bacterial Agents"[Mesh] OR "Anti-Bacterial

Agents"[Pharmacological Action] OR 2,4-diacetylphloroglucinol OR 2-deoxystreptamine OR

acedapsone OR actinonin OR actinorhodin OR alamethicin OR albomycin OR amdinocillin OR

amdinocillin pivoxil OR amikacin OR aminosalicylic acid OR amoxicillin OR amphomycin OR

amphotericin b OR ampicillin OR amprenavir OR angustmycin a OR anisomycin OR antibiotic

1233a OR antimycin a OR arsphenamine OR aurodox OR avilamycin OR azithromycin OR

azlocillin OR aztreonam OR bacampicillin OR bacitracin OR bacteriocins OR bambermycins

OR benzathine cloxacillin OR beta-lactams OR bialaphos OR bicozamycin OR blasticidin s OR

bongkrekic acid OR bredinin OR brefeldin a OR broadcillin OR butirosin sulfate OR calcimycin

OR candicidin OR capreomycin OR carbenicillin OR carbenicillin indanyl OR carfecillin OR

cefaclor OR cefadroxil OR cefamandole OR cefamandole nafate OR cefatrizine OR cefazedone

OR cefazolin OR cefdinir OR cefditoren OR cefditoren pivoxil OR cefepime OR cefetamet OR

cefetamet pivoxyl OR cefixime OR cefmenoxime OR cefmetazole OR cefminox OR cefodizime

OR cefonicid OR cefoperazone OR ceforanide OR cefoselis OR cefotaxime OR cefotetan OR

cefotiam OR cefoxitin OR cefpiramide OR cefpirome OR cefpodoxime OR cefpodoxime

proxetil OR cefprozil OR cefsulodin OR ceftazidime OR cefteram pivoxil OR ceftezole OR

ceftibuten OR ceftiofur OR ceftizoxime OR ceftobiprole OR ceftobiprole medocaril OR

ceftriaxone OR cefuroxime OR cefuroxime axetil OR cephacetrile OR cephalexin OR

cephaloglycin OR cephaloridine OR cephalosporins OR cephalothin OR cephamycins OR

cephapirin OR cephradine OR cethromycin OR chelerythrine OR chloramphenicol OR

chloramphenicol succinate OR chlortetracycline OR citrinin OR clarithromycin OR clavulanic

acid OR clavulanic acids OR clindamycin OR clindamycin-2-phosphate OR clofazimine OR

cloxacillin OR colistin OR cyclacillin OR cycloserine OR dactinomycin OR dalbavancin OR

dalfopristin OR dapsone OR daptomycin OR decamethoxine OR demeclocycline OR

desoxyfructo-serotonin OR dibekacin OR dicloxacillin OR dihydrostreptomycin sulfate OR

diketopiperazines OR dirithromycin OR distamycins OR diucifon OR doxycycline OR

dynemicin a OR echinomycin OR edeine OR efrotomycin OR emiglitate OR enviomycin OR

epicillin OR ertapenem OR erythromycin OR erythromycin estolate OR erythromycin

ethylsuccinate OR erythromycin lactobionate OR erythromycin stearate OR essential 303 forte

OR ethambutol OR ethionamide OR filipin OR FK 565 OR florfenicol OR floxacillin OR

fluoroquinolones OR forphenicinol OR fosfomycin OR framycetin OR fumagillin OR fusafungin

OR fusidic acid OR gamithromycin OR GE 2270 A OR gemifloxacin OR gentamicins OR

gramicidin OR grepafloxacin OR hepcidin OR herbimycin OR hygromycin b OR imipenem OR

immunomycin OR isepamicin OR isoniazid OR josamycin OR kanamycin OR kitasamycin OR

KRM 1648 OR KT 5720 OR lactacystin OR lactams OR lacticin 481 OR lactoferricin b OR

lasalocid OR leucomycins OR lincomycin OR lincosamides OR loracarbef OR lucensomycin

OR lydicamycin a OR lymecycline OR maduramicin OR maltotetraose OR manoalide OR

manumycin OR marbofloxacin OR meclocycline OR mepartricin OR meropenem OR

methacycline OR methampicillin OR methicillin OR mevastatin OR mezlocillin OR

micronomicin OR midecamycin OR mikamycin OR minocycline OR miocamycin OR

mocimycin OR moxalactam OR muconomycin a OR mupirocin OR mycobacillin OR n-

methyldeoxynojirimycin OR nafcillin OR narasin OR natamycin OR nebacetin OR nebramycin

OR nebularine OR neomycin OR netilmicin OR netropsin OR nigericin OR nisin OR

nojirimycin OR norfloxacin OR novobiocin OR nystatin OR ofloxacin OR oleandomycin OR

oligomycins OR oxacillin OR oxetanocin OR oxytetracycline OR panipenem-betamipron OR

paromomycin OR pazufloxacin OR pediocin pa-1 OR penicillanic acid OR penicillic acid OR

penicillin g OR penicillin g benzathine OR penicillin g procaine OR penicillin v OR

phenethicillin OR phosphoramidon OR piericidin a OR piperacillin OR piperacillin-tazobactam

OR pivampicillin OR polymyxin b OR polymyxins OR polyoxorim OR PR 39 OR pristinamycin

OR prodigiosin OR propicillin OR prothionamide OR pyrazinamide OR pyrazofurin OR

quinupristin OR quinupristin-dalfopristin OR radezolid OR ramoplanin OR ribostamycin OR

rifabutin OR rifamexil OR rifampin OR rifamycins OR rifapentine OR ristocetin OR

rolitetracycline OR roxarsone OR roxithromycin OR rutamycin OR saframycin a OR

salinomycin OR sangivamycin OR sirolimus OR sisomicin OR SM-4300 OR sodium thiosulfate

OR sparfloxacin OR spectinomycin OR spiramycin OR squalamine OR staphylococcin OR

stigmatellin OR streptogramin a OR streptogramin group a OR streptogramin group b OR

streptogramins OR streptomycin OR streptovaricin OR sulbactam OR sulbenicillin OR

sulfamerazine OR sulfameter OR sulfamethoxypyridazine OR sulfanilamide OR sultamicillin

OR syringomycin OR talampicillin OR teicoplanin OR telithromycin OR temafloxacin OR

temocillin OR tetracenomycin c OR tetracycline OR thalidomide OR thiamphenicol OR

thienamycin OR thienamycins OR thioacetazone OR thiobenzamide OR thiocarlide OR

thiolactomycin OR thiostrepton OR thymopoietin iii OR tiamulin OR ticarcillin OR ticarcillin-

clavulanic acid OR tigecycline OR tilmicosin OR tobramycin OR tomaymycin OR triostin a OR

troleandomycin OR tunicamycin OR tylosin OR tyrocidine OR tyrothricin OR ubenimex OR

undecylprodigiosin OR valinomycin OR vancomycin OR vernamycin b OR viomycin OR

virginiamycin OR aminoglycoside OR carbapenem OR cephalosporin OR macrolide OR

fluoroquinolone OR quinolone OR penicillin OR telavancin OR gentamicin OR rifaximin OR

doripenem OR ceftaroline OR furazolidone OR nitrofurantoin OR linezolid OR flucloxacillin

OR ciprofloxacin OR gatifloxacin OR levofloxacin OR lomefloxacin OR moxifloxacin OR

nalidixic acid OR ofloxacin OR sulfonamide OR sulfadiazine OR sulfamethizole OR

sulfamethoxazole OR ethionamide OR rifampicin OR metronidazole OR trimethoprim OR

tinidazole.

Supplement Naranjo scale:

Are there previous conclusive reports on this reaction?

o Yes (+1) No (0) Do not know/Not measured/Not done (0).

Did the adverse events appear after the suspected drug was given?

o Yes (+2) No (-1) Do not know/Not measured/Not done (0)

Did the adverse reaction improve when the drug was discontinued or a specific antagonist

was given?

o Yes (+1) No (0) Do not know/Not measured/Not done (0)

Did the adverse reaction appear when the drug was readministered?

o Yes (+2) No (-1) Do not know/Not measured/Not done (0)

Are there alternative causes that could have caused the reaction?

o Yes (-1) No (+2) Do not know/Not measured/Not done (0). For alternative causes,

only infections involving the brain (such as meningitis or encephalitis) were

interpreted as “Yes.” Rest were marked as “Do not know/Not measured/Not

done,” as active infection could plausibly considered a potential alternative cause

for altered mental status

Did the reaction reappear when a placebo was given?

o Yes (-1) No (+1) Do not know/Not measured/Not done (0)

Was the drug detected in any body fluid in toxic concentrations?

o Yes (+1) No (0) Do not know/Not measured/Not done (0)

Was the reaction more severe when the dose was increased, or less severe when the dose

was decreased?

o Yes (+1) No (0) Do not know/Not measured/Not done (0)

Did the patient have a similar reaction to the same or similar drugs in any previous

exposure?

o Yes (+1) No (0) Do not know/Not measured/Not done (0)

Was the adverse event confirmed by any objective evidence?

o Yes (+1) No (0) Do not know/Not measured/Not done (0). Abnormalities on EEG

were not counted as objective evidence because of lack of specificity.

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