nano-bio: synergy of biology, physics and chemistry yehiam prior dean, faculty of chemistry november...
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Nano-Bio:Synergy of Biology, Physics and Chemistry
Yehiam PriorDean, Faculty of Chemistry
November 2011
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Nano-Bio:Synergy of Biology, Physics and Chemistry
Import and Integrate insights, tools and methodologies from Biology, Physics and Chemistry - to understand material systems on the nano scale and develop new concepts and functionalities
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Henry Moore Top Down
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Bottom up
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Top Down
Microelectronics
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Gordon Moore
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Gordon Moore
Smaller
Difficult
Top Down Fabrication
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Water
Fullerene
Molecules
0.1 1 10 100 1000 10000 100000 Nanometers
PG5 - The largest molecule synthesized
(30 nm diameter)
Bottom up
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May have started “top down” :
“Then the LORD God formed a man fromthe dust of the ground and breathed into his nostrils the breath of life, and the man became a living being.”
Genesis, chapter 2, verse 6
But eventually we (i.e. science) adopted the ‘central dogma’ of molecular biology:
DNARNAProteins….. ….cells organisms
Living Things(or is it “top” down?)
Bottom up
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X1000 times actual size
0.001 inch Diameter
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Chemistry
Material Science
Biology
Physics
Nano-Bio
Electrical EngineeringMechanics
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How can we study this regime?
The Challenges of Nano-Bio Research:
Molecules Bulk Matter?Living things
What is it there – Chemistry? Physics? Biology?
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In microelectronics, complex systems are routinely fabricated
Can we fabricate complex biological entities outside the cell and study them on a chip ?
The Challenges of Nano-Bio Research:
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Biological recognition is very well adapted and extremely specific.
Can we adopt the biological methodology for specific functionalities?
• Bio sensors? • Sensors for Hazardous materials ?• Disease early detection?
The Challenges of Nano-Bio Research:
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• Molecular specificity using biological recognition :
Integrate the electronics and the biological functions into the Nano scale:
• Remote sensing• Independent monitoring
The Challenges of Nano-Bio Research:
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• Further miniaturization is more and more difficult, can we develop molecular computers?
• Can we study the transition from the classical everyday world to the quantum regime, in particular in biological systems?
• How can we learn from Nature’s approach to the assembly of living creatures and apply it to other complex structures?
The Challenges of Nano-Bio Research:
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• Knowledge of scaled up molecular and biological processes
• Exchange of ideas and concepts
• Integrated programs to educate Students and scientists
• Teach - “Biology to non-biologists” - “Chemistry to non-chemists”
- ….......• Infrastructure to fabricate and measure on
the 10-100 nm scale
What is needed?
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• Excellent scientists from the different disciplines
• A culture of no boundaries between departments
• Dedication to Basic Science
• Flexible hiring and readiness to change
Why at Weizmann?
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• Establish a state of the art facility, with a wide variety of instrumentation, and the support of highly trained staff scientists
• Make it available to biologists, physicists, and chemists both within and outside the Institute
• Invite and encourage collaborations
• Wait…
What is the plan ?
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• NMR• AFM• XPS• …….
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