nanomanufacturing & medtech research at umass lowell
DESCRIPTION
Nanomanufacturing & MedTech Research at UMass Lowell. MassMEDIC April 10, 2007. Nanomanufacturing Programs at UMass Lowell. NSF NSEC Center for High-Rate Nanomanufacturing . 9/04: $12.4MM UMass Lowell ,Northeastern and UNH - PowerPoint PPT PresentationTRANSCRIPT
Nanomanufacturing & MedTech Research at UMass Lowell
MassMEDICApril 10, 2007
Nanomanufacturing Programs at UMass Lowell
• NSF NSEC Center for High-Rate Nanomanufacturing. 9/04: $12.4MM
UMass Lowell ,Northeastern and UNH
• Nanomanufacturing Center of Excellence 12/04: John Adams Innovation Institute $5MM to UMass Lowell.
• New Nano/Bio/Manufacturing Building
4/07 Gov. Patrick commits
$25 MM Cash + $16 MM Bond for
Commercialization of Nanotechnology: Nanomanufacturing is a Vital Component
Flexible Electronics, Sensors, Implants
Biosensors (radiation, cancer, anthrax, insulin...)
New Reinforced Materials
Nano Capsule for Drug Delivery Drugs by
Design
NanoManufacturing
Research
New Fabrics
The Path to Commercialization
Production
NanoscienceScientific discovery, basic theory, test hypotheses
Nanomanufacturing Science
Process science (models, discovery of process methods, reliability
theory, enabling tools) Fundamental science focused on
manufacturing
Nanomanufacturing Center of
Excellence
Product Prototypes, Scalable processes
Specific product process development, “prototype” products
Process Scale upShort production runs, debug
scale up
• Materials suppliers• Process equipment manufacturers• On-line measurement equipment• Products (bio, electronic, automotive, chemical, aerospace…)
NSF NSECCenter for High Rate Nanomanufacturing
Nanomanufacturing at CHN
Biosensors
Memory devices
TemplatesHigh rate
High volume Reliability
Manipulation of billions of atoms and nanoparticles
Informed public and workforce
Environmentally benign processes
CHN
CHN Vision: Guided Self Assembly
Will provide the tools to manufacture a wide range of nanoscale products
Nanomanufacturing Through High-rate/High-volume Templates for Guided Self-Assembly of Nanoelements
microinjection molding machine
Injection Molder
Nanotemplates as tooling surface in high rate process
Nanopatterned Surfaces
Biosensors (radiation, cancer,
anthrax, etc.)+ IgG
NCOE Vision: Capitalize on Polymer Advantages
• Lightweight• Flexible• Biologically compatible• Easily adapted for high
rate processes
Electrospun NanofibersDr. Mead, Plastics Engineering
Inner core •provide mechanical or electrical properties
Outer core•highly absorbent material
Selectively permeable materials•highly breathable•impermeable to liquid water•stretchable•novel textiles•tissue scaffolding
Controlled Patterning of NanoFibersDr. Chen, Mechanical Engineering
High voltagepower supply
Syringe withploymer solution
Shi
ft a
nd s
prea
d of
the
spun
fib
ers
on ta
rget
Rotated discelectrode at syringe
Electrospinning can be used to create submicron diameter fibers with high surface area and fabrics with fine porosity
Greater functionality (and information content) can be achieved through controlled patterns, rather than random mats
1 bilayer
5 bilayers
10 bilayers
Continuous TiO2 on Polyacrylonitrile
TiO2 particles on Functionalized Polyacrylonitrile
Coated Materials include•Polyelectrolytes•Metal Oxides•Conjugated Polymers
Applications include•Photovoltaic Cells•Sensors•Catalysts•Water purification
Layered Materials on NanofibersDr. Kumar, Physics Department
PAHH-PURETCA Fiber
Nanomultilayer CoextrusionDrs. Barry & Mead, Plastics Engineering
• Utilize coextrusion process – Two polymers of dissimilar structure and properties to be combined– Nanolayer laminates with hundreds or thousands of layers– No nanoscale dimensions on tooling– Conventional coextrusion facilities can be used except layer-
multiplying elements
1st3rd
2nd
2nd
4th
Single Screw Extruder
Layer Multiplying
Element (LME)
Feedblock
Single Screw Extruder
Layer Multiplying
Element (LME)
Feedblock
NanocompositesDrs. Barry , McCarthy & Mead, Plastics Engineering
Nanocomposites •High performance properties•Issue is repeatable dispersion in commercially viable process•Study effect of process conditions/material on dispersion
•Nanoclay•Nanoparticulates (alumina, silica, carbon black)
Improved•Barrier properties•Mechanical properties•Flame retardance•Thermal properties
Self-assembled monolayers (SAMs), including alkanethiols adsorbed on gold surfaces
• Thiophene-terminated alkanethiols have been sythesized and used to coat gold nanoparticles.• Organic vapor sensors have been fabricated from the monolayer protected gold nanoparticle films.
0
20
40
60
80
100
0 50000 100000 150000 200000
Rel
ativ
e ch
ange
of
resi
stan
ce (
R/R
o) [%
]
Vapor Concentration (ppm)
TolueneChloroform
Hexane
Ethanol
Change of Resistance vs Organic Vapor Concentration for Films Comprised of Gold Nanoparticles Protected by 12-(3-thienyl)dodecanethiol
*H. Ahn, A. Chandekar, C. Sung and J.E. Whitten, Chemistry of Materials, vol. 16, p. 3274 (2004).
Surface Functionalization and CharacterizationDr. Whitten; Chemistry
Nanospherical Gold Delivery SystemsDr. Braunhut, Biology
“Non-invasive product that kills cancer using localized lethal heat with negligible damage to healthy tissues”
In conjunction with Triton Biosystems of Chelmsford, MA
• Targeted/controlled delivery
Self-assembly in water Optional removal of core
• Core-shell structure
• Shell can be crosslinked
• Core can be selectively removed
• Shell and/or core can be functionalized selectively
Self-assembly of Polymer MicellesBiodegradable Hollow Nanospheres for
Drug DeliveryStephen P. McCarthy, Plastics Engineering, 978.934.3417
Biodegradable Hollow Nanospheres for Drug Delivery
Stephen P. McCarthy, Plastics Engineering, 978.934.3417
Self-assembly in water
Optional removal of core
Self Assembly of Polymer Micelles
•Core-shell structure
• Shell can be crosslinked
• Core can be selectively removed
• Shell and/or core can be functionalized selectively
Typical curve with expected value of cac
RhRH
mica mica mica
Well-defined spherical
nanoparticles observed
Atomic Force Microscopy Analysis of
Nanoparticles
Transdermal Delivery of Insulin with Cationic Shell-xlinked Hollow
Nanospheres in Hyperglycemic Rats
Glucose tolerance test in normal rats
0
50
100
150
200
250
300
350
400
450
0 20 40 60 80 100 120 140
Time, min
Glu
co
se
, mg
/dl
Glucose alone
Insulin in cationic nanospheres
Highlights of Results
Encapsulation of nutrients, such as Vitamin E
Oral and transdermal delivery of insulin
Transdermal delivery of antiinflammatory agents
Encapsulation of hydrophobic and hydrophilic substances
Antibacterial properties of cationic nanospheres
Biodegradable Hollow Nanospheres for Drug Delivery
Stephen P. McCarthy, Plastics Engineering, 978.934.3417
Massachusetts Medical
Device Development Center (M2D2)
UMASS Lowell & UMass Worcester
Connect the resources of the University of Massachusetts
to Medical Device firms within Massachusetts
M2D2 Mission
M2D2M2D2
EducationEducation
ProductProductRealizationRealizationProcessProcess
NetworkNetwork
BusinessBusinessRealizationRealizationProcessProcess
Medical Device Industry Critical to Massachusetts’ Future
What was Once An Economic Engine
Medical Device Employment Trends
75%
80%
85%
90%
95%
100%
105%
110%
115%
120%
2000 2001 2002 2003 2004 2005
CA
MA
MN
NC
US
Is Now Declining Compared to Others
Source: Economy.com 4 digit NAICS code 3391 Employment: Medical Equipment & Supplies Manufacturing
With M2D2 They Can Reach Across
M2D2M2D2
Proof of ConceptBusiness Plan
Team
Inventors
IdeasMock-Ups
Investors
MarketsProducts
Product/Business Realization Process Creates 8-11
Companies/YearSeed Fund
(3-8 mos)Prototyp
e & AnimalTrials
(12 mos)
Human Trials(18-24 mos)
Screening
(2-4 mos)
UnqualifiedLeads
Markets & Investors
Milestone
Competitive Selection
Seed funding obtained & Business Plan
Prototype demonstrated in Animals/Cadavers
FDA Regulatory Submission
8-11300 45 22 11300/yr
15%
50%
50%
75%
17-24 months
M2D2 Helps Entrepreneurs Find Funds
• SBIR grants
• STTR grants
• John Adams Innovation Institute
• Angel investors
Seed Funding process requires 3-8 months Depending on concept quality & funding source
Multiple Companies Already Benefiting
• Perfusion Technology
UMass Lowell Incubator
( SBIR, April 2006, August 2006)
Ultrasound Enabled Drug
Delivery To the Brain
Multiple Companies Already Benefiting
• Spire Biomedical Bedford, MA
(SBIR, December 2006)
Novel Dialysis Catheter
Multiple Companies Already Benefiting
• Vista ScientificAndover, MA
(STTR, April 2007)
Nanosphere-Antibiotic Corneal Contact Lens Delivery System
Multiple Companies Already Benefiting
• VasoTechWorcester, MA
(FastTrack, April 2007)
Biodegradable Drug Eluting Stent
Multiple Companies Already Benefiting
• BosteQBoston, MA
(STTR April 2007)
Vibrotactile Tilt Feedback
for Balance Rehabilitation
and Elderly Fall Reduction
M2D2 Steering Committee• Hooks Johnston, Chair• (SVP, Smith & Nephew, Retired)• Daniel Baril, President & CEO, Baril Die Company• John Brooks III, General Partner, Prism Venture Partners• Thomas Chmura, Vice President for Economic Development, University of
Massachusetts President’s Office• Paul Fenton, President, Axya Medical• Robert Halpin, President & CEO, MVEDC, Inc.• John Konsin, Executive Vice President & General Manager, Accellent
Endoscopy• Peter Litman, Vice President for Business Development and Marketing,
Anika Therapeutics, Inc.• Stephen McCarthy, Co-Director, M2D2, University of Massachusetts Lowell• Sheila Noone, Co-Director, M2D2, University of Massachusetts Worcester• Richard Packer, President & CEO, Zoll Medical Corporation• Thomas Sommer, President, MassMEDIC• Josh Tolkoff, Managing Director, Ironwood Equity Fund LP• Edward C. Williams III, Partner, Brook Venture Partners
Big Things from Small Science
• Continuing the tradition of manufacturing excellence in Lowell region– Education– Research– Service to industry and the
community
• Sustainable economic development for the US