nanoscan family new - medisovisipaque human clinical x-ray contrast agent during continuous i.v....
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the next generation four modality preclinical imaging platform
nanoScan® products are No.1 in the following:
IMAGIN
G FO
R SCIENCE
Family
- achieve the breakthrough 10,000 cps/MBq SPECT sensitivity
- 275 µm SPECT resolution measured with Derenzo phantom
- 700 µm PET resolution measured with Derenzo phantom
- quantification accuracy over 97% for SPECT & PET
- in-line SPECT/MRI multimodality system
- in-line PET/MRI multimodality system
CT
MRI
SPECT PET
SPECT PET
CT
MRI
SPECT PET
Kép csere!!!
the next generation four modality pre-clinical imaging platform
SPECT/MRI, PET/MRI, SPECT/CT, PET/CT
Egész test??
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Pursuit of perfection in technology to serve perfection in science
Always eager to find an even better solution, Mediso constantly strive to develop the highest
level medical imaging technologies possible.
We wish to serve the scientific community with our core value: supreme image quality with
quantification.
MEDISO Medical Imaging Systems
Mediso Medical Imaging Systems with headquarters in Budapest is a dynamic supplier of nuclear medicine and modern
hybrid imaging techniques to healthcare and research institutes around the world. The company was founded in 1990
by experts of the leading research and manufacturing company of the region carrying on their proficiency in developing
and producing nuclear equipment since 1960. At present Mediso continue its legacy in researching innovative medical
imaging technologies and developing cutting edge preclinical and clinical imaging systems.
www.cromedresearch.hu www.scanomed.hu (persze humán képpel)
vagy logoval? képeken még gondolkodni, hogy jól nézzen ki! szerintem több kicsi is szóba jöhet a díjaknál
Note: images should be the picture of the building and CROmed logo?
Tradition in research and development
Clinical diagnostic and CRO partners
Mediso have developed special partnership with pre-clinical imaging contract research organizations and leading
molecular imaging centers in both preclinical and clinical domain around the world.
Partnership with CROmed, Karolinska Institute, Semmelweis University in preclinical field and Scanomed, University of
Debrecen Medical School and Hungarian National Institute of Neuroscience in clinical area represent vital drive to
Mediso's developments as well as invaluable feedback and better insight into users’ needs.
Customer focused support
Mediso-affiliated subsidiaries and world-wide distributor network with strong factory support ensure close contact
with our customers and quick, professional response to their requests not only in technical but also in application
related issues. We at Mediso are proud to serve physicians and researchers at more than 100 preclinical and 900 clinical
system installations in 86 countries.
Some awards and partners:
www.cromedresearch.com www.scanomed.hu
Latest awards
New Product Innovation Award
2011 - Grand Prize of Innovation 2010
2008 - Frost & Sullivan 2008 European Medical Imaging
Entrepreneurial Company of the Year Award
2006 - Grand Prize of Innovation 2006
2012 - Frost & Sullivan 2012 European Preclinical Imaging
Customerfocusedfactorysupport
Improvedimaging
performance
Increasedproduct
variability
100% customer satisfaction for all usersnanoScan®
3®*NanoSPECT/CT
Various upgrade opportunities for existing *NanoSPECT/CT® users
SPECT PET
CT
MRI
Imaging facilities already using the world market leader *NanoSPECT/CT systems (manufactured by Mediso) - to be
able to keep up with the pace of development of technology (like the nanoScan Family) - are provided with the
unique opportunity of upgrading onto the next level of multi-modality imaging.
® TM*NanoSPECT/CT and NanoPET/CT are registered U.S. trademarks of Bioscan, Inc., which does not sponsor, authorize or endorse this site or any of
MEDISO’s services or goods. There is no affiliation or relationship between Bioscan, Inc. and MEDISO.
®
®
Unique versatility in molecular imaging modalities
SPECT PET
CT
MRIMembers of the nanoScan® Family combine the industry’s highest performing microscopy
level of NM imaging supported by excellent MRI and CT performance.
The ultimate versatility and in-line combinations of the systems are based on common
software, common animal handling platform and easy on-site upgrade possibility, thus
fulfil all demands of your growing and long term research requirements.
nanoScan® - the four modality in vivo molecular imaging platform
With the
with shared components and flexible upgrade possibilities. Exclusive features only from the Mediso :
nanoScan® Family Mediso designed a platform that can satisfy the increasing needs of any research institute
nanoScan® Family
Benefits of joining the nanoScan® Family:
TM- New patented* Tera-Tomo 3D SPECT on the fly
Monte Carlo based multi-pinhole reconstruction
- Improved SPECT quantification accuracy by scatter and
CT based attenuation correction
- List-mode SPECT acquisition and processing for heart,
brain and other applications
- New patented** non-multiplexed M pinhole apertures
for artifact-free imaging
*
3 TM
Family concept
- Two MRI and two CT based bimodal solutions
- Highest visible resolution in NM modalities: 275 µm SPECT and 700 µm PET
- Highest PET and SPECT quantification accuracy: over 97% in both modalities
- Dynamic list mode acquisition for both PET and SPECT
- Fulfiling low to high budget requirements with continuous on-site upgrade path
- Worldwide exclusive factory support throughout the equipment lifetime (guaranteed for moreTM
than 10 years for all systems including NanoSPECT/CT and NanoPET /CT)®
UP
GR
AD
E
* patent pending*
Family
- 30 µm resolution- 80 W X-ray power- ultra low dose acquisition protocol
- 100 µm resolution- 500 mT/M gradient- maintenance free magnet
- 275 µm visible resolution- over 97% quantification accuracy- up to 10,000 cps/MBq sensitivity by 100 pinholes
SPECT
MRI*
CT
SPECT PET
CT
MRI
nanoScan® SPECT/CT
nanoScan® SPECT/MRI
4
1
5
6
7
8
nanoScan® PET/MRI
nanoScan® PET/CT
PET
SPECT PET
CT
MRI
- 700 µm visible resolution- over 97% quantification accuracy- 9% maximal sensitivity
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Common Versatile Platform
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3
4
1. MRIMRI of a 30 g Nu/Nu mouse with flank tumor xenograft imaged post i.v. injection of iron oxide particulate contrast agent using a T1-weighted GRE sequence, imaging duration 6.5 min.
2. PET/MRI18F-FDG PET in a 30 g Nu/Nu mouse with flank tumor xenograft imaged in the last 10 minute frame of a 60 min. dynamic scan post i.v. injection of 4 MBq of radioactivity. MRI acquisition details as in image 1.
3. PET18F-FDG biodistribution image in a 32 g mouse during a 5 minute scan, immediately after i.v. injection of 3.4 MBq of radioactivity. Vascular system is visible.
4. PET/CTGated cardiac PET/CT image of a 14 g Balb/c mouse
18injected with 6.7 MBq of F-FDG. 20 min. gated PET acquisition immediately post injection, heart rate was over 500 bpm. CT acquired with 55 kVp during 9 min. with real-time reconstruction.
5. CT440 g Wistar rat, injected with a total of 6 mL of Visipaque human clinical X-ray contrast agent during continuous i.v. infusion, CT scan with 45 kVp, total CT duration 13.5 min. using real-time reconstruction.
6. SPECT/CT23 g Nu/Nu mouse, injected with 45.5 MBq
99mof Tc-Human Serum Albumin imaged for 30 minutes in SPECT 10 min. post injection. CT scan with 45 kVp, total CT duration 7.5 min. using real-time reconstruction.
7. SPECT347 g Wistar rat, injected with 68.6 MBq of 99mTc-Human Serum Albumin, imaged for 60 minutes in SPECT 5 minutes post injection.
8. SPECT/MRITransaxial plane view of 34 g mouse brain, injected
123with 7.4 MBq of I-NNC13-82431 compound, imaged for 30 minutes, 3h post injection. MRI acquisition: T2 weighted FSE.
1., 2. Images courtesy of Helmholtz-ZentrumDresden-Rossendorf. 3., 4., 5., 6., 7., 8. Images courtesy of CROmed Ltd.
Cover page: SPECT/MRI, SPECT/CT images courtesy of CROmed Ltd., PET/CT image courtesy of Helmholtz-Zentrum Dresden-Rossendorf, PET/MRI image courtesy of Karolinska Institute
nanoScan® SPECT/CT/PET
TM*M2 MRI from Aspect Imaging
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Shared components
TMNucline 2.0 - all modality acquisition software
- Common user friendly acquisition platform for all four modalities
- Integrates wide range of functionalities of acquisition,
calibration, data management, reconstruction and
visualization.
- DICOM standard images stored in DICOM server
- Flexible and easily customizable daily workflow protocols.
- Software solutions
TMInterView FUSION - post processing and analysing software
- Supports DICOM, Analyze 7.5, RAW import/export as
well as exporting still images (DICOM SC, JPEG, PNG)
and movies (AVI)
- Supports dual, triple and quadruple fusion of
PET/SPECT/MRI/CT images
- Provides GPU accelerated 3D MIP, Volume Rendering
and Surface Rendering Techniques.
- Multiple statistics of Time Activity Curve (TAC) can be
derived from 4D dynamic PET and SPECT studies
(with MS Excel compatible export)
TMTera-Tomo 3D SPECT / PET - reconstruction software
- Multi GPU based data reconstruction with multi-Teraflop Computing
- Wide range of corrections such as detector geometry, Monte Carlo DOI estimation, object attenuation
and scatter, randoms, dead time and partial volume.
- Results are ultra-fast, quantitative and provide excellent visual quality reconstructed images.
TMTera-Tomo 3D SPECT reconstruction principle
with on the fly system matrix generation
position dependentintrinsic resolution
PSF model
Monte Carlodetector
crystal model
realistic pinholecollimatorsimulation
attenuation andscatter within
the object
GPU-basedadvanced 2D
and 3D filtering
TMTera-Tomo 3D SPECT reconstruction principle
with on the fly system matrix generation
Monte Carloattenuation &
scatter correction
Monte Carlopinhole
modeling
Regularizediterative
reconstructioncycle
Multi-GPU3D iterative
reconstruction
TMTera-Tomo 3D SPECT reconstruction principle
with on the fly system matrix generation
Photon transport modeling
(attenuation, scatter)
Monte Carlobased pinhole
edge penetration modeling
Monte Carlobased crystalinteractionmodeling
Regularized OSEMreconstructionimplemented on multi GPU
High precision, quantitative,fast 3D SPECTreconstruction
PSF-based intrinsic
resolution modeling
Releasebutton
Automatic disattachment
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Data Workflow / Workstations
head positioning by ear bars
inhalation through tooth bar
anesthesia gas absorption by nose cone
respiratory gating by breath sensor
temperature control by integrated hot-air channels
- Multimodality imaging for
- Multipurpose applications 4D-, 5D
imaging by one-click connection
PET+CT+SPECT+MRI modalities (full compatibility)
MultiCell™ Imaging bed
- Multiple mouse scanning in one scan
(optional)
- Multifunctioning preparation station
for the imaging cells
TMMultiCell Animal Anesthesia / Imaging Chamber
Control / Equipment Room
Multimodality Acquisition / Processing Workstations
Multimodal image visualization
Post processing features after acquisition
DICOM 3.0 and CFR21 part 11 compliant
data handling
PET/CT acquisition and control
NuclineMain Console WS
TM
Tera-Tomo - Real 3D Reconstruction WS
TM
PET
Dual monitor WS with touchscreen
- Intel® Core™ i7 platform @ 3.4 GHz
- Non-stop operating WS through liquid cooling
- Safe data handling by 0,5 TB SSD
- GPU based on the fly volume rendering
- Ease of use CT scout for positioning
- 24” + 17” (on the gantry) LCD monitor
- Multitask 64 bit OS by MS Windows 7
- Intel® Core™ i7 platform up to 4.5 GHz
- Cutting edge computing with liquid cooling
- Safe raw data backup by 0.5 TB SSD
- GPU cluster with 6 GB memory
- Mainstream data transfer through dual 10 GbE
- Realtime 64 bit OS by Linux
PET real-time 3D reconstruction
On the fly system matrix generation
Real time image correction
Post-reconstruction image manipulation
after acquisition
1/10 Gb Ethernet
Supercomputer with embedded
Teraflop Computing
10 Gb Ethernet
Acquisition / Processing WSTM- Nucline
TM- Tera-Tomo 3D SPECTTM- Tera-Tomo Real time CT
- InterViewTM FUSION
Post-processing WSTM - InterView FUSION
TM- Tera-Tomo 3D SPECT
Post CT
- Online archiving
TM- Tera-Tomo
TMTera-Tomo 3D PET - Real WS
TMTera-Tomo 3D PET
„real“ reconstruction
TMTera-Tomo 3D PET
„post“ reconstruction
Win
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Linux
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odal
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Real time acquisition /Processing /
reconstruction unit
Post-processing /reconstruction /archiving unit
- Multimodality imaging for
- Multipurpose 4D, 5D imaging by one-click connection
- Multiple mouse imaging in one scan (optional)
- Multifunction preparation station for the imaging cells
PET+CT+SPECT+MRI modalities (full compatibility)
applications
TMTera-Tomo 3D PET - Post WS
SZÉLES!!!
Conformance Statement
Product design, development, production and services comply with ISO 9001:2001 and with ISO 13485:2004.
The nanoScan® multimodality molecular imaging system conforms to EC Directive 93/42/EEC; Annex II, Article 3 Full Quality Assurance
System Medical Devices Design and safety testing has been performed in accordance with IEC 60601-1 and IEC 60601-1-2 EMC standards.
Safety labels are attached to appropriate places on equipment and appear in all operation manuals. The supplied software conforms to DICOM and CFR 21 part 11 standard.
The technical information provided here is not a detailed specification.
For exact details and up to date information please contact your local distributor or Mediso Medical Imaging Systems.
MEDISO Medical Imaging Systems
1022 Budapest, Alsótörökvész 14. Hungary
Phone.: +36-1-399-3030
Fax.: +36-1-399-3040
E-mail: [email protected]
Web: www.mediso.com
MEDISO reserves the right to change data without notice © MEDISO 2013. NSFB 08/13
®nanoScan is registered trademark of MEDISO Medical Imaging Systems.
TM TM TM TM TMNucline , InterView FUSION, Tera-Tomo 3D PET, MultiCell , PrepaCell are trademarks of MEDISO
Medical Imaging Systems.
TMcore i7 is trademark of Intel.
®
Windows is registered trademark of Microsoft.
®
NanoSPECT/CT is registered trademark of BIOSCAN.
TMCUDA is trademark of NVIDIA. This product was partially established by the support of the National Development Agency of Hungary
using funds of the Research and Technology Fund (code: TeraTomo).
More than 100 pre-clinical and 900 clinical MEDISO manufactured systems were installed worldwide
86 countries100+ preclinical systems900+ clinical systems
Worldwide installed base of preclinical and clinical systems developed and manufactured by Mediso
Conformance Statement
Quality management system operated by Mediso Medical Imaging Systems complies with Council Directive 93/42/EEC Annex II.
Product design, development, production and services comply with EN ISO 13485 and EN ISO 14971.
Safety labels are attached to appropriate places on equipment and appear in all operation manuals.
The supplied software complies with DICOM standard.
The technical information provided here is not a detailed specification.
For details and up to date information please contact your local distributor or Mediso Medical Imaging Systems.
Trademarks:
is registered trademark of MEDISO Medical Imaging Systems.
TM TM TM 3 TM TM TMNucline , InterView FUSION, Tera-Tomo 3D, M pinhole , MultiCell , PrepaCell are trademarks of MEDISO Medical Imaging Systems.
®nanoScan
®TMNanoPET /CT is trademark, NanoSPECT/CT is registered trademark of Bioscan.