Nasir RajpootComputational Biology & Bioimaging (COMBI)

A new branch of computational biology concerned with the study of concepts and techniques for acquisition, visualization, processing, analysis, and dissemination of biological images.

Exciting developments in imaging hardware and image informatics algorithms make it possible to study biology in a new light

Advantages: Handling too much-data (Information overload) Extracting useful objective information Spatiotemporal localisation High throughput Reduced subjectivity in analysis, resulting in: Reproducible research (Acceptability of your research

depends on this)

Some Recent Projects

Vinay Kalasannavar, MSc Dissertation (Distinction), September 2010

in collaboartion with Department of Biological Sciences, University of Warwick

Irfan Butt, MSc Dissertation (Best Dissertation Prize), September 2009Accepted for publication in Pattern Recognition, 2011

Noisy Denoised Thresholded

PC Suraj Bangalore-Nagaraj, MRes Project, 2009-10

in collaboartion with

PC Suraj Bangalore-Nagaraj, MRes Project, 2009-10

Myosin proteins aremotor proteins (GREEN spots) which travel onActin Filaments (roadnetworks shown inRED) within the cells.

in collaboartion with

Arif, Rajpoot et al., Journal of Biotechology, 2011

in collaboartion with

Project Ideas for 2010-11

Task: Track the sliding long thin microtubules (railway lines within the cell) in a video sequence contaminated with acquisition noise.

in collaboartion with

in collaboartion with

Task: Track the expanding long thin microtubules (railway lines within the cell) in a video sequence contaminated with acquisition noise.

Schubert et al.,Nature Biotech., 2006

Multi-channel fluorescence microscopy,

a fairly recent development

The Toponome Imaging System (TIS)at Warwick HRI

in collaboartion with

Images from a Colon cancer TIS stack by Mike Khan’s group at Warwick

Find multi-protein signatures of cancer cells Identify molecular characteristics of stem

cells that can differentiate to cancer cells

Some Ground Rules

An exciting CS dissertation (elements of Image Processing, Computer Vision, and Pattern Recognition) with a Biology application

Lots of fun toying with cutting edge technologies in microscopy imaging

Space in the lab

Working with some of the top scientists in their field

Potential candidacy for PhD at Warwick or elsewhere

Contribution to Science

Good background in Mathematics Good know-how of image processing Fluency in MATLAB and/or C++

Willingness to put in that much extra effort A serious attitude towards research and

science

Email me your CV, with specific mention of:

Relevant courses taken at your UG/PG levels

Relevant programming experience

Say a few words about your motivation for working in this area

Deadline: 5pm, Tuesday 23 Nov, 2010.