Introduction of

National Engineering Research Center

for Biomaterials (NERCB)

07/06/2015

OUTLINE

The first national institute for biomaterials approved

by Ministry of Science & Technology in 2000, an

independent legal entity, relying on Sichuan

University

An innovation-platform of Sci. & Tech. for biomedical

engineering, set by Ministry of Education

The “International Sci. and Tech. cooperation and

exchange base for Biomedical Materials” in the

Ministry of Science and Technology.

Functions: research, education, industrial

incubator…

OUTLINE

NERCB

Chinese Committee for Biomaterials (CCBM)

Testing & Evaluation Center for Medical Devices &

Biomaterials (STEC-MDB)

R & D Department

Clinical

Application

Department

Business Dep.

& Information

Department

Dep. of

Middle Scale

Manufacturing

GMP scale

supporting organization established by

4

Staff & Students

Associate Prof.

Professor

Lecturer & Assistant R & D, Administration

Total staff: 120

Ph. D. Student

MS Student

Post Dr

458

65

58

25

1621

Total students: 118

All Professors have overseas background.

Current Research Projects

Provincial

National18

53

International

Provincial

Ongoing Projects (26)

Ministry of Science & Technology (MOST)

1 National Basic Research Program of China (973 Program)

3 National High Technology Research & Development

Programs (863 Program)

NSFC: 3 Key Research Programs

5 International Collaboration Programs

Products

HA Ceramic

Dental Implants

with HA Coating PLGA Barrier Film

PLA Adhesion-proof velum

HA powders Osteoinducing Ceramic

Artificial Hip Joint

with HA Coating

6 class III Products approved by CFDA

International Collaboration

Worldwide academic exchanges and

collaboration with key international institutes

on biomaterials have been established.

UK

Italy

Finland

Germany

The Netherlands

Sweden

USA

Australia

India

Japan

Korea

……

8

Honorary & Visiting Prof.

Honorary Professors

Prof. D. Williams, Liverpool University, UK

Prof. W. Bonfield , Cambridge University, UK

Prof. C. J. Kirkpatrick, Johannes Gutenberg University,

Germany, Chairman of ESB

Prof. K de Groot, University of Leiden, the Netherlands

Prof. JCY Leong, Academician of Chinese Academy of Science,

University of Hongkong

Prof. J. Kopecek, Univ. of Utah, USA

Prof. E. Wagner, University of Munich

Visiting Professors

U. Gross , Professor, Free University of Berlin, Germany

JCY Cheng, Professor, Chinese University of HK

PJ Li, Senior Material Scientist, DePuy Co.( Johnson &

Johnson), USA

Educations

9

An international committee for Ph. D dissertation defense

(China, Japan, Australia)

The Ph. D. candidate Co-supervised by XD Zhang &

Leiden Univ.

Graduate students

Co-advisors with famous oversea universities

Academic Collaboration

10

Zhang signed cooperationAgreement with J. Tanaka

Zhang, Bonfield, K.de GrootCooperation agreement onresearch & education

C.J. Kirkpatrick awardedthe Honorary Prof. of SCU

Gu signed cooperation Agreement with R. Brown in UCL

J. Kopecek (U Utah) awardedthe Honorary Prof. of SCU

RESEARCH AREA--1

Tissue Inducing Biomaterials

Bone inducing biomaterials

Calcium phosphate ceramics with a specific

composition and structure

Non-osseous tissue inducing biomaterials

Natural polymer composites for cartilage inducing

11

RESEARCH AREA 2

Biomaterials for drug/gene delivery and

molecular imaging

Intelligent with sensitivities of temperature, pH or

bio-molecules

Targeting drug delivery systems of cellular-

specific

Novel Carriers

Polymeric micelles

Nanocapsules

Liposomes

Hydrogels

Hollow Nanoparticles

Peptide dendrimers12

RESEARCH AREA--3

Surface/Interface Modification

Bioactivation of Titanium surface Plasma Sprayed HA Coating

Liquid Phase Plasma Spray

Electrochemistry

Alkali-heat Treatment

Chlorine Group Immobilization (to inhibit bacterial growth)

Functionalization of Magnetic Nano-particles Interaction of functional groups with specific cells

Detection & separation of bio-molecules

Anti-thrombosis of Titanium Surface Plasma immersion ion implantation

Endothelium of surface

13

RESEARCH AREA--4

Novel Biomaterials: Molecular Design &

Controllable Preparation

Multifunctional peptide dendrimers Imaging probes

Drug delivery system

DNA vector for gene therapy

Biologic separation & detection

Supramolecular nano-hydrogel Drug delivery system

Tissue repair

Nano-biomaterals Composites of natural polymers and hydroxyapatite for

tissue regeneration, drug delivery and DNA vectors

Magnetic Nanoparticles for tissue repair, separation &

detection, targeting DDS, DNA vectors14

RESEARCH AREA--5

Biomaterials for Tissue EngineeringDesign & Synthesis of Novel Biodegradable

Polymers

Polyesters, Polycarbonate, Polypeptides and their

copolymers, Hydrogels, Natural Polymers

Bulk & Surface Modification of Biodegradable

Polymers

Fabrication of Tissue Engineering Scaffolds

Vascular Network

Cartilage

Bone

Cell-Scaffold Interactions

15

Chinese Committee for Biomaterials (CCBM)

16

Academic organization under the direction of the Chinese

Association for Sci. & Tech.

One of the six founders of International Union Society for

Biomaterials Science & Engineering (IUS-BSM)

Hosting & co-organizing international academic symposia

China-Europe Symposium on Biomaterials (once every two years)

Asian Symposium on Biomaterials (once every two years)

9th WBC (2012, Chengdu)

2014 National Nano-Biological and Medical conference

Testing & Evaluation Center for Medical Devices & Biomaterials (STEC-MDB)

17

An independent national evaluation center, founded by

NERCB

Issuing test reports with legal authority in both China &

abroad

Service items

Class III & part of class II medical devices & biomaterials

Biocompatibility tests and evaluations according to ISO10993

Physical and chemical tests

Consulting services for product testing, standards set-up &

amendment, various training courses

Potential Collaboration

Scientific Collaboration To apply joint funding

To hold the Thematic Workshop

To build joint lab

Education Cooperation To supervise graduate students jointly and exchange

young scientists Short term: 1-3 months (Summer school etc.)

Long term: 1-3 years (Sandwich PhD etc.)

Industrial Cooperation To jointly establish biomaterials factories or provide

advanced manufacturing technique

Testing and Evaluation Center Support for research and product development

Results recognized by most organizations

19

Thank you

Welcome to Chengdu and NERCB