natural selection and evolution. what is this all about? video
TRANSCRIPT
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Natural selection and Evolution
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What is this all about? video
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Traits
• Traits are passed from one generation to the next
• That means that all the information to produce all of your traits was contained within the single cell that was you when you were conceived.
• What determines your traits?
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Proteins
• Proteins determine our traits• Each protein is a sequence of amino
acids. Which amino acids and in which order determines the structure and function of the protein.
• How are proteins produced?
Val His Leu Thr Pro Glu Lys … 139 more
Hemoglobin: a protein that is 146 amino acids long
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DNA
• DNA is the blueprint or recipe book for making proteins (and therefore traits). This is what is passed on from one generation to the next.
• How does DNA code for proteins, thus traits?
Proteins
DNA Traits
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•It is composed of four types of nucleotides:
A Adenine
T Thymine
G Guanine
C Cytosine
From this four letter alphabet different amino acids are specified.
DNA is arranged as a double helix
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Nucleotides
• DNA is composed of nucleotides: the information part of the DNA. There are only 4 types of nucleotides in DNA: A, T, G, and C
A = adenineT = thymineG = guanineC = cytosine
• From this four letter alphabet different amino acids are specified
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More on DNA
• A - T every three nucleotides• A - T (codon) codes for one of
the• T - A 20 amino acids• C - G (and there are 1000s• G - C of nucleotides in a• T - A strand of DNA)There are also sequences of 3 nucleotides that specify
where to start and where to stop reading along the DNA to make the protein. This is called translation.
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THE GENETIC CODE
Thymine (T) is replaced with Uracil (U) in messenger RNA.
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More on DNA
• A - T So another definition • A - T of DNA is a sequence• T - A of 1000s of nucleotides• C - G in a double strand that• G - C is the recipe for amino• T - A acids and therefore
proteins
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Three processes
• REPLICATION– Synthesis of two
DNA molecules from DNA template
• TRANSCRIPTION– Synthesis of RNA
molecule from DNA template
• TRANSLATION– Synthesis of a
protein from RNA template
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Genes are translated into proteins based on a triplet code
Transcription
Codon = 3 bases
Translation
Amino acidProtein = many amino acids strung together
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Recap• DNA is composed of
nucleotides– There are only 4 types of
nucleotides
• Every 3 nucleotides codes for an amino acid– There are 20 different
amino acids
• Strands of amino acids form proteins
• Proteins are responsible for traits and adaptations…
Video on DNA translation
Video2 on DNA translation
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Chromosomes
• So what is a chromosome?
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Chromosomes• So what is a chromosome?
– Strands of DNA, all tightly wrapped up and existing in a cell’s nucleus
• [Humans have 46 chromosomes, 23 from each parent?]
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Genes
• So what is a gene?
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Genes are a particular segment of DNA, that code for a protein (usually).
Junk DNA
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Genes
• So what is a gene?– A section of DNA that encodes
information for building a protein (or RNA molecule)
– Each chromosome can have thousands of genes on it.
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Mutations
• What is a mutation?
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Mutations• What is a mutation?
– A change in the sequence of nucleotides in a gene.
– They are random, caused by• Chemicals, radiation, copying errors
– They change the protein that is specified• May be beneficial, neutral, harmful, or lethal
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Alleles are variants of genes
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Sickle cell disease• Occurs due to a mutation in the gene that
codes for the hemoglobin protein. protein that carries oxygen in red blood cells.
• Causes the normally round red blood cell to change into a sickle shape that no longer carries oxygen as well. This can be lethal. Red blood cells of affected individuals distort in shape, break down or clog blood vessels and cause pain, poor circulation, etc
Val His Leu Thr Pro Glu Lys … 139 more
Val His Leu Thr Pro Val Lys … 139 more
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Sickle cell disease
• Alleles: different versions of genes.– Sickle cell allele (h)– “normal” allele (H)– Sickle Cell Anemia (hh): often lethal– Sickle Cell Trait (Hh): symptoms vary,
usually very little effects.
H h
H HH Hh
h Hh hh
Mom
Dad
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Sickle cell disease• Is having the sickle cell allele good or
bad?
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Sickle cell disease
• Is having the sickle cell allele good or bad?– It depends on the environment!!– The sickle cell allele confers genetic
resistance to malaria, one of the biggest killers of infants in areas with malaria.
• So, where do you think you find populations with the highest incidence of the sickle cell allele? Malaria areas
PBS Video
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Some more genetic diseases mapped
List
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Gene pool
• Gene Pool: all of the alleles and their proportions in a population.
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Gene pool
• Gene pools change over time.
0% 100%
80% 20%
Environmental Change – Pesticide introduced
Resistant Gene
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Gene pool
• A change in a gene pool over time is called what?
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Evolution
• Genetic Evolution: a change in a gene pool– Note: this operates at the population level!
Another definition is a genetic change in a population.
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Mechanisms of evolution
• What causes gene pools to change?
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Mechanisms of evolution
• What causes gene pools to change over time?
• 1. Mutations: produce new alleles and new genes.– are random– cannot be predicted ahead of time– create genetic variety– may be beneficial, neutral, or harmful to the
individuals that inherit them
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Mechanisms of evolution
2. Migration (immigration/emigration).– Technical term is gene flow.– The movement of alleles between
populations as a result of movement of individuals from one population to another.
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Mechanisms of evolution
3. Chance: when chance, rather than traits determine reproductive success. Example: disaster that kills part of a population. Small populations are more susceptible to big evolutionary change due to chance. Technical term is Genetic Drift.
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Mechanisms of evolution
• 4. Natural Selection. When traits determine reproductive success; traits in more reproductively successful individuals get passed on more into the next generation.
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Natural Selection
• Natural Selection. Alleles that confer “success” are more likely to be passed on to future generations and will increase their % relative to other alleles over time. Technical term for “success” is differential reproductive success.
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Example of Natural Selection
• Gene pools change over time.
0% 100%
80% 20%
Environmental Change – Pesticide introduced
Resistant Allele
Non-Resistant Allele
Alleles
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Example of natural selection• Beetles and pesticide resistance
– The resistant and non-resistant alleles were due to past mutations that created genetic variety in the beetles but were neutral until now (pesticide spraying time).
– The pesticide acted as a new environmental selection pressure that selected for the resistant allele.
– This selection pressure, causing individuals with the resistant allele to out-survive and out-reproduce individuals without the resistant allele, resulting in an increase in individuals with the resistant allele in the next generation.
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Natural Selection
http://evolution.berkeley.edu/evolibrary/article/0_0_0/evo_14
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Natural selection flowchart
Mutation New Genes Random
Recombination New combinations of existing genes Sexual reproduction
Genetic Variability—Gene Pool Current mix of genes in population
Environmental Selection Pressures Examples: climate, predation, mate selection
Differential Survival Some genes and gene combinations help the individual survive better than other individuals.
Differential Reproduction Some genes and gene combinations help the individual reproduce better than other individuals
Rep
rod
uce
d
Gen
es
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Natural selection flowchart
• Mutation and recombination create genetic variety in gene pool of a population.
• Mutations: create new alleles/genes.• Recombination: sexual reproduction
mixes alleles and creates new combinations of alleles.
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Variationarises from
Mutation:new genes
Sexual Recombination: new gene combinations
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Natural selection flowchart
• Environmental selection pressure: affects the survival and reproduction of individuals in a population differently (think back to the beetles)
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Natural selection flowchart
• Environmental selection pressure leads to differential survival and differential reproduction of individuals with more successful alleles. This is passed on to future generations and changes the gene pool through time.
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“evolution: survival of the fittest”
• Isn’t that what we were taught in school? Well, its wrong.
• This is an example of science being misinterpreted by the public.
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“evolution: survival of the fittest”
• What does fittest mean?– To a biologist?– To the public?
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“evolution: survival of the fittest”
• What does fittest mean?– To a biologist?
• = differential reproductive success
– To the public?• = biggest, strongest, ….
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“evolution: survival of the fittest”
• What does fittest mean?– To a biologist?
• = differential reproductive success
– To the public?• = biggest, strongest, ….
• ALL that really matters is whether or not your genes are passed on to future generations ….
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Artificial Selection
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Types of evolution
• 1. Divergent evolution• 2. Convergent evolution• 3. Co-evolution
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Divergent Evolution
• 1. Divergent evolution– Two different populations of a species that
experience different selection pressures may as a result become genetically different from one another• Once in a very great while, the two populations
will become so different that they cannot reproduce together anymore (this then becomes speciation).
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Divergent Evolution
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Divergent Evolution
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Divergent Evolution
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One or more populations whose members actually or potentially interbreed under natural conditions and that are reproductively isolated from other such groups.
Species and Speciation
Review: Definition of Species:
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Divergent Evolution
http://www.biology-online.org/images/darwin_finches.jpg
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Divergent Evolution
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• 2. Convergent evolution– Start with two very different species;
they experience similar selection pressures and through time come to look and/or behave similarly.
Convergent Evolution
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Convergent Evolution
Fish Reptile MammalWhat is the similar selection pressure?
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Convergent Evolution
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Convergent Evolution
What is the similar selection pressure?
http://www.votawphotography.com/photo/Animals/animals.htm
http://www.hundekosmos.de/images/greyhound_517.jpg
Speed to catch prey (cheetah) and speed to win races and be bred.
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Convergent Evolution
MarsupialMammals
Placental Mammals
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Convergent Evolution
“Ant eaters” of the world
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Convergent Evolution
Many plants look like cacti because they also have evolved to store and defend water but they are not cacti – for example, the ocotillo is not a cactus, it is a shrub in a different plant family.
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Types of evolution• 3. Co-evolution
– Two species that interact with each other (predator/prey; mutualistic; parasite/host; …) and act as selection pressures on one another
– “Evolutionary Arms Race”
Long legsGood hearing
Sharp eyesight
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Coevolution
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CoevolutionBird Bites
Eye Spot
Real Eye
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What type of myth does this illustrate?
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What type of myth does this illustrate?
• That need creates the genetic change
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What type of myth does this illustrate?
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What type of myth does this illustrate?
Good and bad gene myth. (only differential reproductive success).
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Vicious cycle
• Pesticide resistance cycle• Antibiotic resistance cycle