1

More Natural Approaches to Cancer Treatment

Workshop

Speaker: Serge Jurasunas

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3

Serge Jurasunas N.D. MD (Hom)

- 40 years of practice, research and development of innovative medicine and alternative therapies in cancer.

Speciality: Nutrition, orthomolecular medicine, oxidative stress and antioxidant therapy, stem cells therapy, detoxification, mitochondrial repair, peripheral blood analysis.

Holiterapias

Institute

of

Integrative

MedicineLisbon

-

Portugal

Member: Society

of

Integrative

Oncology

(USA), AAAA Medicine

(USA), International

delegate

WOSAM

4

More natural therapies

in the

treatment

of

cancer

1 –

Adjuvant

clinical

nutrition

–

Nutritherapy

2 –

Targeting

cancer

through

natural angiogenic

inhibitor

5

Some common characteristics of cancer patients

- Antioxidants-vitamins, enzymes deficiency accentuated by chemotherapy.

- Wrong food diet.

- Poor appetite, poor digestion, malabsorption.

- Anorexia, malnutrition, decreasing quality of life, increasing mortality.

- Immune cells cannot function without vitamins, acidic milieu, poor oxygen.

-

Negatively affected or damaged GUT system (bacteria or yeast movement into blood stream).

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Our body needs for an healthy function and life survival

Daily

needs

of

50 essential

nutritional

factors

- 8 aminoacids

(11 in

premature

child

born)- 13 vitamins

(100 milligrams)

- 20 minerals

(10 grams)- 20 trace elements

(60 milligrams)

- 12 to 15 grams

of

2 eventual fatty-acids- 1 source

of

energy

(carbohydrates, 400 grams)

Water

-

Oxygen

-

Light

Parallel

source

of

substances

normally

produced

by

the

body

but

beneficial for our

health:

-

Glutathione, coenzyme

Q10, SOD, N-cysteine, orotic

acid, choline, inositol and

nucleic

acids.

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Peripheral Blood Analysis (nutritional and antioxidants deficiency)

- Abnormal, damages shape red cells

- Platelets aggregation

- Lipid ribbon and plaque

- Fragile and disintegrate WBC’s

- Red cells in rouleau

- Bacterial/fungal invasion

- Microclots

- Liver stress

- Kidney failure

Serge

Jurasunas

2008

Health status – Before and after chemotherapy

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Photo 1 – vitamins-antioxidants deficiency.

Photo 2 – Large lipid ribbon after chemotherapy (colon cancer.

Dr. Serge

Jurasunas

–

Holiterapias

2006

9

Photo 3 - Red cells with strong rouleau (drug intoxication after chemotherapy)

Photo 4 – large compact lipid plaques – yeast form like candida invasion – after chemotherapy

Photo 5 – large colony of yeast- form like candida (PLFs) with compacted microclots.

Photo 6 – large colony of yeast form like budding sphere (overgrowth) impaired immune system – oxygen deficiency – bad cancer case

Dr. Serge

Jurasunas

–

Holiterapias

2006

10

Photo

7 -

Advanced

liver

cancer

treated

by

chemotherapy. Broken’s

RBC’s

–

rouleau

–

Platelets

aggregation

–

yeast-form

like

candida

invasion

spread

everywhere.

Photo

8 –

Agglutinate

red

cells

and

platelets

to form

a thrombus

(cancer).

Dr. Serge

Jurasunas

–

Holiterapias

2006

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Enzyme Yeast Cells preparation as anticancer food supplementation36 years of experience

Attribution: Natural composition

Biological sources

Orthomolecular composition

High bioavailability

Rich in active enzymes

Developed by Dr. Siegfried Wolz –

Co-worker Nobel Prize Prof. Lunnen

(Germany)

-

Immunonutrition

-

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Enzyme Yeast Cells Process

Enzyme Yeast cells is a pure liquid strain made from a fermentation process at low temperature (32º) using saccharomyces cerevisiaie, fresh fruit juices, essential fatty acid, oxygen to enhance the formation of krebs cycle substrate and respiratory chain enzymes in the mitochondria of the yeast cells.

Enzyme yeast cells preparation contain several billions of enzymatic mitochondria.

Each 10ml contain 100 billions of active yeast cells.

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Oxygen

E

B2

B12

B1

< 32ºC

17 vitamins –

14 minerals16 amino acids, enzymes of the redox system, biocatalysors

Proteins –

46/50g for 100g of dried yeastParticularly rich in vitamin B complexB1, B2, B3, B5, B6, B12.

Iodine, potassium, magnesium, copper, selenium, zinc, iron, chromium, phosphoric acid.

-Activation of Krebs cycle-Stimulation immune defense-Activation metallic enzymes-Against infection

Enzyme Yeast Cells contain a balanced combination

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Food

Aerobic Anaerobic

Glycolysis Glycolysis

Mitochondria

Cellularrespiration

PyruvateOxidation

Citric

Acidcyle

Respiratory

chain

Complete oxidationwaste

products

H2O

36 moles ATP

80% Energy672 calories

Fermentationreaction

cytosol

Blockage

of

the

respiratory

chain

Incomplete

oxidation

Waste products = carbon compound (lactic acid, CO2

2 moles ATP

20% energy35 calories

AcetylCoenzyme A

Oxphos

Complex IIIIIIIV

Complex VATP synthase

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16

Nutritional elements found in Enzyme Yeast Cells

Dr. Moerman

(Nederland

) isolate

the

particular nutritional

elements

responsible for building

the

immune

system

and

activate

the

respiratory

chain

in

the

mitochondria.

1 –

Vitamina A2 –

Vit. B complex

3 –

Vitamin

C4 –

Vitamin

E

5 –

Citric

acid6 -

Iodine

7 –

Iron8 –

Sulphur

Vitamin

A 50,000 U To 100,000 I.U.B Complex 2 tablets

per

day (10g per

day)

Vitamin

C 1.250 mg 5-10g per

dayVitamin

E 400 I.U. 2,200 I.U.

Citric

acid 3 tablespoons

solution 2,200 I.U.Iodine 3 teaspoons

solution 2,200 I.U.

Iron 3 teaspoons

solution 2,200 I.U.

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Enzyme Yeast Cells contain

Particularly high in active glutathione

(10mg/100ml of yeast preparation)methionine

Detox

–

antioxidant –

redox

value

cysteine

Particularly high in Q10 –

critical to mitochondria–

Booster of energy

–

Powerful liposoluble

antioxidant

Cytochrome

oxidase, coenzyme A, NADH, Superoxide dismutase (SOD)

Rich in nucleic acid, nucleus building substances: adenine nucleotides, ribonucleic acids –

Nucleotides repair damaged DNA and enhance T-cell

maturation, function, enhance NK cell activity.

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Enzyme Yeast Cells enhance immune systemMembrane contain defined polyssacharide

1-3D-glucan. (29-64%) –

(1-6)40% mannan)

1 –

macrophages (bind to macrophage beta-glucan

receptors)2 –

Lymphocytes

3 –

Natural Killer cells (N.K) -

Support the production of cytokines -

Tumor necrosis factor alpha (TNFa)

-

Interleukine

1 –

beta (Il-1-B)

Potent

macrophages

activator

A strong

Biological Response Modifier

Activate

the

regranulation

of

NK cells

and

restore

their

function.

Significantly

reduce

the

infection

related

mortality

rate in

cancer

patients

(4.8% vs 30% control

group

from

studies

in

Japan)

Immunomodulating

effects

–anti-inflammatory and bacterial property.

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Activation of macrophage cells by Beta 1-3-D - glucans

YY

Interferon

–

Gamma

(IFN)

T.N.F.a

Interleukine

1 –

Beta (1L-1B)

T-cells Activating

a specific response building

special

antibodycommunication

Macrophages

(big

eater)

Receptors

Dextin 1

Complement3 receptor

Destroy

foreign

bodies, bacterias, fungi, necrotic

tissues, dead

tumor cells

Activate Natural Killer cells

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Application in cancer

1 –

Combination

Beta-glucan

+ antineoplasic

agentPotentialize

the

anti-tumor effect

2 –

Contreact

chemotherapy-induced

immunosuppressionResulting

in

higher

mortality

3 –

Protect

cancer

patients

from

5 –

Fluorouracil

induced

leukocytopenia

4 –

Contreact

corticosteroid

hormones

induced

immunosuppressive

effects

in cancer

patients.

5 –

Beta-glucans

can

affect

biological

responsed

to bacterial lipopolyssacharide

(LPS) inducing

pro-inflammatory

mediators

–

immunosuppressor

–

angiogenesis

–

P53 down-regulation.

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LitteratureBeta-Glucan, a specific

biologic

response modifier

that

uses antibodies

to target

tumors

–

J.Immunol.1999.

The

beta-Glucan

receptor, dectin

1, is

predominantly

expressed

on

the

surface

of

cells

of

the

J. Immunol.2002.

Abel G., Czop

I.K. (1992) stimulation

of

human

monocyte

B-glucan

receptors

by

glucan

particules

induces

production

of

TNFa

and

IL 1B. Int.J. Immunopharmacol. 14-1363-1373.

Mansell

P.W.A., ichinose

H., Reed

R.J. Krementz

E.T., Mc

Names

R., Di

Luzio

N.R. (1975) Macrophages

–

mediated

destruction

of

human

malignant

cells

in

vivo –

J. Natl

Cancer

Institute

54-571-580.

Williams D-L Ha-T-Li

C. Kalbfleish

J.H., Laffan

JJ, Ferguson

D.A. (1999) Inhibiting

early

activation

of

the

tissue

nuclear factor –

KB and

nuclear factor Interleukin

6 with

(1→3) –

B-

D glucan

increases

long-term

survival

in

polymicrobial

sepsis

–

Surgery

126-54-65.

Duan

X, Acherly

M., Vivier

E, Anderson P. (1994) Evidence

for involvement

of

beta-glucan

–

binding

cell

surface

lectins

in

human

natural killer

cell

function

–

cell

immunol. 157: 393-

402.

Lee

D.Y., Ji

I.H., Chang

H.I., Kim

C.W. (2002) High

Level

TNF alpha

secretion

and

macrophage

activity

with

soluble

beta-glucans

from

saccaromyces

cerevisae

–

Biosci

–

Biotechnol

–

Biochem

66: 233.238.

22

NK cells are able to destroy cancer cells by attaching to the cell’s membrane and injecting cytoplasmic granules. A NK cell destroy in 5 minutes time a cancer cell and move to another.

A single NK cell can repeat this process with up to 27 cells in its lifetime.

Regranulation of NK cells by beta-glucan retore their ability to destroy cancer cells.

However, when the NK cell is weak, the cancer cell can also destroy white cells.

Therefore it needs to be activated and addition of Enzyme Yeast Cells may increase their activity.

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One activate NK cell attacking 3 cancer cells

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Results

of the

Freiburg university study

Myoglobin ug/l 1 h post

560

194

- 65 %

Before

the

intake

of Enyzme

Yeast

Cells

After six

weeks

of Enyzme

Yeast

Cells

intake

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Results

of the

Freiburg university study

Muscle stressTotal-Creatinkinasis U/l 1 h post

Fibrinogen mg/dl 1 d post

Before

the

intake

of Enzyme Yeast

CellsAfter six

weeks

of Enzyme Yeast

cells

intake

253135 199314

- 64 % - 27 %

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Enzyme Yeast Cells

Protection of DNA and cell membrane

Protection of mitochondria

Repair damaged DNA

Increase cell respiration

Yeast cells are identical to the human body cell by 70% with the same repair mechanism.

Enzyme yeast cell

Human cell

SODCatalaseGlutathioneCytochromeOxidaseNADHCoenzyme A

Mitochondria

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Enzyme Yeast Cells Preparation

-Contain thiny

and fragile walled young oxygen yeast cells.-

Uniformly formed cells –

clearly cells

wall on which light is reflected.

Orally administered enzyme yeast cells reach the small intestine, open, release billions of enzymes, including natural vitamins, minerals etc. for fast absorption, body’s nourishment.

Total Biological Rejuvenation

Photo taken from a drop of the liquid enzyme yeast cells preparation

Serge

Jurasunas

2008

28

Indication of Enzyme Yeast cells

Enzyme Yeast

Cells

-Restore nutritional status

-Improve oxygen supply to tissue

-Restore damaged intestine –

Regulation of bowel function

-Strengthen the immune system

-Anti-inflammatory effect –

Reduce excessive fibrogenesis – prevent thrombosis

-Increase energy level and prevent fatigue (during chemo)

-Stimulation of the nerve resistance –

Reduce depression

-Promote detoxification

-Increase cellular respiration

-Prevent or counteract anorexia

Overall increase Quality of

Life

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Conclusion

-Enzyme yeast cells preparation is not a simply mixed combination ingredients but are simply integrated in the cells with high

bioavailability.

-Enzyme yeast cells natural ingredients work in synergy with each other and as an “Whole food” to increase the body’s defense

resistance and inhibit some factors of tumor growth.

Enzyme yeast cells are the perfect anticancer food

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A new approach to cancer: Angiogenesis

-Angiogenic

agents to target proangiogenic

factors.

-Inhibit vascularization

of the tumor and destroy by apoptosis existing vessels.

-Selective therapy to tumor

-Result reduced tumor resistance

-Overall increasing effectiveness of standard chemo-

regimen

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Abnormal vessels make trouble

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1 - The effect of the liquid cartilage extract (LCE) as an angiogenic inhibitor

-A concentrate hydrosoluble extract of liquid cartilage using special patented technique.

-Contain biologically active mucopolysacharides and proteins with strong antiangiogenic property.

-Orally taken shown to be biovailable and non-toxic on long term administration on the contrary of Avastin or Thialidomide.

LCE targets many different aspects of the angiogenic cascade

Interfere with VEGF binding and signaling to VEGF receptor.Inhibit MMP’s

–

2.9.12 activity.Stimulate apoptosis of endothelial cells.Promote angiostatin

production in the vicinity of tumor.

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Tumor

Liquid Cartilage Extract InhibitAngiogenic Cascade

MMP’SInhibition of MMP’S

(L.C.E.)

Apoptosis

ofexisting

vesselsL.C.E.

MMP’S

Receptor

Inhibition

of

the

VEGF receptor

VEGF

L.C.E.

Angiogenicfactors

COX2 ActivityInhibition byAntioxidants

Inflammation

Decreasing

Macrophages

Increased

Oxidative

Stress

Increase

Signals

toCancer

Cells

Conjointly

Professor Serge

Jurasunas

2008

Promote

angiostatin

production

in

vicinity

of

tumor

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Does antiangiogenic therapy enhance the effectiveness of cytotoxic drugs?

Yes, it does!1 –

Animal studies show that radiotherapy is enhanced by

antiangiogenic

therapy (1).

2 –

Experimental animal studies show that cytotoxic

chemotherapy can be enhanced by combining it with antiangiogenic

therapy (2).

3 -Anti-angiogenesis therapy increase flow and oxygen delivery as well as a drug delivery to a tumor (3)

(1)

Teicher

BA, Dupuis

N., Kusumuto

T, Robinson

MF, Liu

F, menon

K, -

Antiangiogenic

agents

can

increase

tumor oxygenation

and

response to radiation

therapy

–

Radiation

Oncology

Investigation

2 –

269 –

276 –

1995.(2)

Teicher

BA, Holden

AS, Ara G, Sotomayor

EA, Huang

ZD –

Potentiation

of

cytotoxic

cancer

therapies

by

TNP –

470 alone

and

with

other

anti-angiogenic

agents

–

Int. J. Cancer

57.920-925.1994.(3) Teicher

BA, Dufins

NP, Robinson

MF, Emi

Y. Golff

D. Antiangiogenic

treatment

(TNP –

470/Minocyline) increases

tissue

levels

of

anticancer

drugs

in

mice

L.L.C. lung

carcinoma –

Oncol

Res

27:237.243 -

1995

35

Comparable

effects

of

chemotherapy

with

a direct

targeting of

cancer

by

a antiangiogenic

therapy

Chemotherapy Radiation60 days30 90

days30 60 90

Antiangiogenic therapy

Cancer

cells

recover

increase

their

resistance

make

more vascularization

Less

vascularization

inhibition

-

starving

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Clinical application of L.C.E. at Holiterapias Institute with successful response in cancer patient during a 12 years period.This include a wide variety of different cancer types such: prostate, multiple myeloma, lung, colorectal, breast, ovaries, melanoma pancreas.

-Benefit survival extension.

-Significative

reduction of tumor size.

-Decrease of metastasis specially bone metastasis.

-Elimination of secondary nodules.

-Our patients take L.C.E. during several years without toxicity.

-Suggested in anti-cancer dormancy therapy

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Therapy Posology Produced by

Enzyme

Yeast

CellsImmunokomplex

with

additional

concentrate wild

fruits, vegetables

extracts, betacarotene

40 to 60ml per

day

(up

to 600 billions

of

enzyme

yeast

cells) mixed

in beetroot

juice, apple

juice. Divided

in

3 intake per

day.

Dr. Wolz. Zell GmbhGermany

Liquid

Cartilage

Extract Frozen

vial

of

30ml concentrate

1 vial

under

the

tongue each

morning

before

breackfast

Atrium

BiotechnologiesQuebec

-

Canada

The two natural products work with synergistic effects with various therapeutic options. The anticancer diet by Serge Jurasunas is suggested to combine more effectiveness.

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Example of clinical improvement of a patient with liver metastasis and chemotherapy doing our anticancer food treatment including

Enzyme Yeast Cells2/12/08

3/26/08

Dr. Serge

Jurasunas

–

Holiterapias

2006

39

Patient

female

–50 years

old

with

a metastasic

recurrency

from

breast cancer

(2000) in

2004 with

multiple

lesions

dissiminated

in

the

skeleton.

Strong

pains

and

after

one

year

of

a new

protocol

of

chemotherapy

a new bone

scan

(May

2005) showed

more lesions

disseminated

in

comparaition

of

2004. Poor

response and

evolution

of

the

disease.

The

complete case fully

illustrated

is

available

in

English

and

French.

X ray of the spine

After 3 months of combined therapy + chemotherapy.

Total elimination of the very large lesions in the illium and spine.

Dr. Serge

Jurasunas

–

Holiterapias

2006

40

10/11/2005 – bad physical condition – metastases to bone skeleton – PSA 354 nl/ml Treatment – L.C.E. (Comitris) – Antioxidant compound (Anoxe) 18g per day – Enzyme Yeast cells.

12/01/2006 - PSA 53.6 nl/ml - after 3 months PSA 1.4 nl/mlAfter 5 months elimination of almost all the bone metastases.

Patient male – 73 years old – Prostate Cancerclinical story: adenocarcinoma of the prostate – Gleason 7 (3+4) - Advanced case – No surgery or chemotherapy/radiation.

Dr. Serge

Jurasunas

–

Holiterapias

2006

41

Patient female – 62 years oldClinical story: carcinoma left breast 1988Partial resection– chemotherapy

2005 – Recurrence: Lung metastasis – However the patient refuse more chemotherapy with the alternative option of CAM.

22/11/2005 - CA 15.3 – 617-U/ml - ACE – 1.25 ng/ml

15/09/2005 – CA.15.3 – 446 U/ml - ACE – 1.23 ng/ml

25/09/2006 – CA 15.3 – 50.2 U/ml - RBC - 5.16 – Hemo 14.9 – WBC’s 4700

06/02/2007 – CA 15.3 – 32 U/ml - RBC - 5.16 – Hemo 14.9

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Female

52 years

(pharmacist)

Clinical

story: February

2004 - Pancreatic

cancer

with

abdominal

large

metastasis, multiple

liver metastasis.

Under

chemotherapy: Follow

our

strategy

program

including

L.C.E., Enzyme

Yeast

Cells

and

antioxidants

(no adverse effects).

3 April

2008: Good

physical

condition, good

quality

of

life

New

hospital check-up shown

total elimination

of abdominal and

liver

metastasis

and

reduce

pancreatic

tumor.

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For more information:

-Liquid Cartilage Extract as a natural nutritional adjuvant to conventional therapies: Serge Jurasunas –

8th Congress for Nutri x Phytotherapy –

March 2007

–

Brussels –

Belgium.

-The therapy of Enzyme Yeast Cells in cancer disease, CFS and Aging process. Serge Jurasunas –

Booklet.

-Mitochondria and Cancer –

Townsend letter –

August/Sept 2006 –

Serge Jurasunas.

-A new combination therapy as support to conventional treatment –

Townsend Letter –

Special issue “Alternative Therapies for cancer”

-More clinical cases.

Holiterapias InstituteRua da Misericórdia, 137 –

1º -

Lisbon

–

Portugal

Tel: 00351 213471117 –

Fax: 00351 213471119Email: info@sergejurasunas.com

www.sergejurasunas.com