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NAVIGATE WITH PRECISION, CONFIDENCE and CONFORMABILITY
1. Stent Positioning Marker A fluoroscopic guide helps provide precise deployment
at the aneurysm neck
2. Enhanced closed cell design The closed cells were redesigned allowing the stent
to better expand and contract in vessel tortuosity, optimizing wall apposition
3. Recapturable stent The closed cell design allows for deployment and
recapture, facilitating precise placement
4. .021” Microcatheter delivery Allowing easy, precise navigation 99.8% of the time1
5. Stent markers New solid platinum stent markers with increased
radiopacity provide clear visibility of the device during and after deployment
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4
5
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KEY FEATURES
2. Codman Neuro Enterprise® 2 Vascular Reconstruction Device
1King B, et al. J NeuroIntervent Surg 2014;0:1–5. doi:10.1136/neurintsurg-2014-011457(Data in this study is based on experience with the original CODMAN ENTERPRISE® Vascular Reconstruction Device).
ENHANCED CONFORMABILITY
3.Codman Neuro Enterprise® 2 Vascular Reconstruction Device
Allows the stent to elongate on the outside radius of the bend
Allows the stent to compress on the inside radius of the bend
Variable strut width allows easy navigation and conformability
Enhanced closed cell design
Based upon the principles of the original CODMAN ENTERPRISE® stent design, the CODMAN ENTERPRISE® 2 Vascular Reconstruction Device has been enhanced to improve conformability and wall apposition while maintaining the significant benefits of its closed cell design.
Images courtesy of Dr. Masahiro Yoshida, Osaki Citizen Hospital, Japan
Pre treatment: Unruptured Basilar Tip Aneurysm
Pre Treatment: Unruptured ICA Aneurysm
CODMAN ENTERPRISE® 2 deployed
CODMAN ENTERPRISE® 2 deployed
OUTSTANDING COIL MASS SUPPORT
The CODMAN ENTERPRISE® 2 Stent has the highest point load force measurements, demonstrating its ability to effectively support the coil mass.
Advanced closed cell stent designThe CODMAN ENTERPRISE® and CODMAN ENTERPRISE® 2 Vascular Reconstruction Devices were designed to better approximate the aneurysm neck and reduce the likelihood of coil compartmentalization and herniation into the lumen.
Point Load Force
1King B, et al. J NeuroIntervent Surg 2014;0:1–5. doi:10.1136/neurintsurg-2014-011457(Data in this study is based on experience with the original CODMAN ENTERPRISE® Vascular Reconstruction Device).2Codman Neuro internal testing report 103111155.
4. Codman Neuro Enterprise® 2 Vascular Reconstruction Device
Point Load Force2
Forc
e (g
)
25
20
15
10
5
0ENTERPRISE® ENTERPRISE® 2 Neuroform™ Solitaire™ Lvis® Jr
Studies support higher complete occlusion rates and lower recanalization rates compared to Neuroform.1
CODMAN ENTERPRISE® 2 (closed cell design) Neuroform™ (open cell design)
POIN
T LO
AD
PRECISE AND STABLE PLACEMENT
Minimal foreshortening The CODMAN ENTERPRISE® Stent deploys with minimal foreshortening4.
Stent Positioning Marker The CODMAN ENTERPRISE® Stent Positioning Marker helps position the stent precisely at the neck of the aneurysm.
Stable placement Chronic Outward Force (COF) may help the stent resist migration.
3 % foreshortening calculated from data in Lvis™/ Lvis™ Jnr Intraluminal Support Device Instructions for Use 2014-064 Codman Neuro internal testing report 103111155* Images above table from Codman Neuro internal testing report 103111155
5.Codman Neuro Enterprise® 2 Vascular Reconstruction Device
Chronic outward force4
Pres
sure
(m
mH
g)
30
25
20
15
10
5
0
ENTERPRISE® 2ENTERPRISE® Neuroform™ Solitaire™ 2/FR Lvis® Jr
CODMAN ENTERPRISE®
Stent positioning marker
NEUROFORM
No stent positioning
marker
Stent Positioning
Marker
23mm CODMAN ENTERPRISE® Device
23mm LVIS® Jr.
undeployed
undeployed
1.2mm
or
4.9%
6mm
or
19%3
Deployed
3mm dia.
Deployed
3mm dia.
PROVEN CLINICAL PERFORMANCE
A literature review representing the largest and most robust comparison of stent assisted coiling to
date, reports better performance of the CODMAN ENTERPRISE® Vascular Reconstruction Device. The CODMAN ENTERPRISE® VRD provides reliable performance that you can trust.
Source: King B, et al. Journal of Neuro-Interventional Surgery 2014; 0:1–5. doi:10.1136/neurintsurg-2014-011457(Data in this study is based on experience with the original ENTERPRISE® stent)
6. Codman Neuro Enterprise® 2 Vascular Reconstruction Device
80,0%
75,0%
70,0%
65,0%
60,0%
55,0%
50,0%
74,7%
61,1%
ENTERPRISE® NEUROFORM™
Complete Occlusion of the aneurysm at last follow-up (p < 0,001)
4,0%
3,0%
2,0%
1,0%
0,0%
1,6%
3,4%
ENTERPRISE® NEUROFORM™
Lower rates of ICH (P=0.001)
16,0%
12,0%
8,0%
4,0%
0,0%
10,6%
13,9%
ENTERPRISE® NEUROFORM™
Lower rates of recanalization (P = 0.02)
Higher rates of complete occlusion (P<0.001)
PROVEN CLINICAL PERFORMANCE
* TE events defined as TIA stroke, or development of asymptomatic thrombus during procedure.(Data in this study is based on experience with the original ENTERPRISE® stent)
7.Codman Neuro Enterprise® 2 Vascular Reconstruction Device
100,0%
80,0%
60,0%
40,0%
20,0%
0,0%
99,8% 97,7%
ENTERPRISE® NEUROFORM™
7%
6%
5%
4%
3%
2%
1%
0%
5,9% 6,7%
ENTERPRISE® NEUROFORM™
1,2%
1,0%
0,8%
0,6%
0,4%
0,2%
0,0%
1,0% 1,2%
ENTERPRISE® NEUROFORM™
Higher rates of deployment success (P<0.001)
Lower rates of thromboembolic events* (P=0.37)
Lower rates of in-stent stenosis (P=0.75)
47 peer-reviewed studies
4,238 aneurysms
4,039 patients
14.1 months mean follow-up
Studies from 2004 through March, 2014
IMPROVED EASE OF USE
Recapturability The closed cell design of the CODMAN ENTERPRISE® stent / ENTERPRISE® 2 stent allows you to deploy and recapture with confidence for when you need that second chance.
CODMAN ENTERPRISE®
Stent
NEUROFORM
Stent
CODMAN ENTERPRISE® Stent CODMAN ENTERPRISE® 2 Stent
Improved Stent markersNew solid platinum markers provide increased radiopacity during and after deployment.
Fully insert the introducer and flush simultaneously
Heparinized saline enters through these holes
Saline exits here
• Self-flushing introducer facilitates ease of use • Tapered distal end to match PROWLER SELECT® Plus Microcatheter
New Self Flushing Introducer
8. Codman Neuro Enterprise® 2 Vascular Reconstruction Device
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Codman Neuro is a trading division of Johnson & Johnson Medical Ltd.Registered Office: PO Box 1988, Simpson Parkway, Livingston, West Lothian, EH54 0AB, Registered in Scotland, No.SC 132162 This publication is not intended for distribution in the USA.
Johnson & Johnson Medical Ltd. Pinewood Campus, Nine Mile Ride Wokingham, RG40 3EW United Kingdom
Medos International SARLChemin-Blanc 38 CH-2400 LeLocle Switzerland
Codman NeuroScience SARLRue Girardet 29 CH-2400 LeLocle Switzerland
Products may be manufactured at one of the following: Codman & Shurtleff, Inc.325 Paramount DriveRaynham, MA 02767-0350USA
www.depuysynthes.com
Over 110,000 CODMAN ENTERPRISE® Stent units have been distributed globally since 2006*.
PROWLER SELECT Plus Microcatheter is the only microcatheter tested for compatibility with the CODMAN ENTERPRISE® 2 Stent. The CODMAN ENTERPRISE® 2 Stent requires a 0.021” microcatheter inner diameter.*Codman shipment data as per 30/10/2015
MICROCATHETER COMPATIBILITY
PRODUCT SPECIFICATIONS
PROWLER SELECT® Plus Microcatheters
Catalog Codes Shape OD (prox./distal)
ID (inches)
Usable Length (cm)
Distal Length (cm)
Tip Markers
606S255X Straight 2.8F/2.3F 0.021 150 5 2
606S255FX 45 2.8F/2.3F 0.021 150 5 2
606S255MX 90 2.8F/2.3F 0.021 150 5 2
606S255JX J 2.8F/2.3F 0.021 150 5 2
CODMAN ENTERPRISE® 2 Vascular Reconstruction Device
Distal TipCatalog Code
No Distal TipCatalog Code
Min. Indicated Parent Vessel Diameter (mm)
Max. Indicated Parent Vessel Diameter (mm)
Length at Max Indicated Parent Vessel Diameter
ENC401612 ENC401600 2.0 4.0 16
ENC402312 ENC402300 2.0 4.0 23
ENC403012 ENC403000 2.0 4.0 30
ENC403912 ENC403900 2.0 4.0 39