ncbi national center for biotechnology information

28
NCBI NCBI National Center for Biotechnology Information

Upload: walter-fletcher

Post on 17-Dec-2015

218 views

Category:

Documents


3 download

TRANSCRIPT

Page 1: NCBI National Center for Biotechnology Information

NCBINCBI

National Center for Biotechnology Information

Page 2: NCBI National Center for Biotechnology Information

Cytochrome c Oxidase

subunits I and II

Picture: http://www.ks.uiuc.edu/Research/bio_ener/cco/Source: www.pdb.org/pdb/static.do?p= education_discussion/molecule_of_the_month/pdb5_1.html

Controls the last step in the oxidation of food. This

enzyme add electrons and hydrogen to oxygen to form

water.

Page 3: NCBI National Center for Biotechnology Information

http://www.ncbi.nlm.nih.gov

//

Page 4: NCBI National Center for Biotechnology Information
Page 5: NCBI National Center for Biotechnology Information

Cytochrome c Oxidase subunit 1

mt

Page 6: NCBI National Center for Biotechnology Information
Page 7: NCBI National Center for Biotechnology Information
Page 8: NCBI National Center for Biotechnology Information
Page 9: NCBI National Center for Biotechnology Information
Page 10: NCBI National Center for Biotechnology Information
Page 11: NCBI National Center for Biotechnology Information

Clustalw2

Page 12: NCBI National Center for Biotechnology Information

Go back to your

download. Copy and

paste into this box.

Page 13: NCBI National Center for Biotechnology Information
Page 14: NCBI National Center for Biotechnology Information

Scroll down to Submit.Click, then

wait.

Page 15: NCBI National Center for Biotechnology Information
Page 16: NCBI National Center for Biotechnology Information
Page 17: NCBI National Center for Biotechnology Information
Page 18: NCBI National Center for Biotechnology Information
Page 19: NCBI National Center for Biotechnology Information
Page 20: NCBI National Center for Biotechnology Information

Phylogram is a branching diagram (tree) assumed to be an estimate of a phylogeny, branch lengths are proportional to the amount of inferred evolutionary change.

A Cladogram is a branching diagram (tree) assumed to be an estimate of a phylogeny where the branches are of equal length, thus cladograms show common ancestry, but do not indicate the amount of evolutionary "time" separating taxa.

FROM EMBL-EBI

Page 21: NCBI National Center for Biotechnology Information

Go back to the download and annotate with the scientific name. Research and add the common name. Does this tree agree with

what you assumed about these organisms?

Page 22: NCBI National Center for Biotechnology Information

Pan troglodyte- ChimpanzeeCanis lupus familiaris- Dog

Bos taurus-CattleMus musculus-

MouseRattus norvegicus-Brown RatGallus gallus- ChickenDanio rerio-Zebrafish

Drosophila melanogaster-Fruit FlyAnopheles gambiae-

MosquitoCaenorhabditis elegans-nematodeSchizosaccharomyces pombeFission Yeast

Saccharomyces cerevisiae-buddingBudding yeast Kluyveromyces lactisLactose converting yeast

Ashbya gossypiiFilamentous fungusArabidopsis

thalianaMouse ear cress

Oryza sativa Indica Group-RicePlasmodium falciparum-malaria

protozoans

Page 23: NCBI National Center for Biotechnology Information

Choose your own Choose your own proteins and proteins and organismsorganisms

Page 24: NCBI National Center for Biotechnology Information
Page 25: NCBI National Center for Biotechnology Information

Insulin is a good Insulin is a good searchsearch

Page 26: NCBI National Center for Biotechnology Information

Copy the FASTA codeCopy the FASTA code

Page 27: NCBI National Center for Biotechnology Information

Into notepadInto notepadStart with three proteins. Add one or two at

a time . Hypothesize the relationship.

Page 28: NCBI National Center for Biotechnology Information

Check in ClustalW2Check in ClustalW2