2ND ESO-ESMO-RCE CLINICAL UPDATE

ON RARE ADULT SOLID CANCERS

2-4 December 2017 Milan, Italy Chairs:

J.Y. Blay, FR

P.G. Casali, IT

R. Stahel, CH

In the framework ofHeld in collaboration with

INTRODUCTIONRare cancers make up as many as one fifth of all new cancer cases. Amongst them, pediatric cancers and rare hematologic neoplasms are often covered by dedicated educational events, while rare adult solid cancers are hardly grouped together and approached as a collective group of neoplasms. Indeed, they account for as many as 15% of all new cancer cases, thus being the main group within rare cancers. This Course is aimed at dealing with them on an annual basis, to provide the community of clinical oncologists specialising in these tumors with a regular update of recent advances in this specific area. The ultimate goal is to strengthen the educational coverage of a group of cancers which may be neglected in spite of their collective incidence. According to the RARECARE project, which provided a definition and a list of rare cancers, rare adult solid cancers include the following big families of tumors, each of them being therefore covered by a corresponding educational session within this Course:

• Rare skin cancers & non-cutaneous melanoma• Rare thoracic tumors • Rare female genital cancers• Neuroendocrine tumors • Endocrine gland tumors • Sarcomas • Digestive rare cancers • Rare urological and male genital tumors • Central nervous system neoplasms • Head & neck cancers

Any educational effort in the rare cancer area makes little sense if disconnected from a networking environment.

This year we are amid the process of creation of the new European Reference Networks (ERN) on rare diseases, including rare adult solid cancers, with the ERN named EURACAN. Many speakers and moderators will thus come from EURACAN and definitely will be happy to meet Oncologists working within it or in collaboration with it.

From the educational point of view, one cannot expect that even experienced clinical oncologists are knowledgeable about all these tumors. For this reason, the European Faculty of this Course is asked to focus on most recent advances always trying to put them into the context of state-of-the-art treatment of these tumors, with a special view to ESMO Clinical Practice Guidelines.

FACULTy

M. Angi, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

S. Bielack, Klinikum Stuttgart Olgahospital, Stuttgart, DE

J.y Blay, Centre Léon Bérard, Lyon, FR

p.G. Casali, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

F. De Braud, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

A.p. Dei Tos, Azienda ULSS9, Treviso, IT

C. De La Fouchardière, Centre Léon Bérard, Lyon FR

F. De Lorenzo, European Cancer Patient Coalition, Brussels, BE

M. Deraco, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

N. Fazio, Istituto Europeo di Oncologia, Milan, IT

S. Ferrari, Istituti Ortopedici Rizzoli, Bologna, IT

A.M. Frezza, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

M. Garassino, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

J.A. Gietema, University Medical Center, Groningen, NL

R. Glynne-Jones, Mount Vernon Centre for Cancer Treatment, London, UK

V. Gregoire, Universitè Catholique, Louvain, BE

S. Grisanti, A.O. Spedali Civili, Brescia, IT

A. Gronchi, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

C. Lebbé, Hopital St. Louis, Paris, FR

S. Leboulleux, Institut Gustave Roussy, Villejuif, FR

L. Licitra, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

D. Lorusso, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

V. Mazzaferro, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

A. Necchi, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

N. Nicolai, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

K. Oliver, International Brain Tumour Alliance, Tadworth, UK

F. peccatori, European School of Oncology, Milan, IT

C. piazza, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

G. pravettoni, Istituto Europeo di Oncologia, Milan, IT

F. Raspagliesi, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

I. Ray-Coquard, Centre Léon Bérard, Lyon, FR

M. Seckl, Hammersmith Campus, London, UK

C. Simon, Université de Lausanne, CHUV Lausanne, CH

R. Soffietti, AOU San Giovanni Battista, Torino, IT

S. Stacchiotti, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

R.A. Stahel, Cancer Center University Hospital, Zurich, CH

D. Talbot, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

J.C. Tonn, University of Munich, Munich, DE

A. Trama, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT

M. Van den Bent, Erasmus MC Cancer Institute, Rotterdam, NL

S. Villà, Hospital Universitari Germans Trias i Pujol, Badalona, ES

M. Wartenberg, Sarcoma Patients EuroNet, Wölfersheim, DE

L. Wyrwicz, Curie Institute of Oncology, Warsaw, PL

2ND ESO-ESMO-RCE CLINICAL UPDATE ON RARE ADULT SOLID CANCERS2-4 December 2017, Milan, Italy

Please fill in this form in BLOCK CAPITALS and send by the deadline to:European School of Oncology - Via Turati 29 - 20121 Milan - Italy

Fax: +39 02 85464545 - E mail: raretumours@eso.net

ONLINE REGISTRATION AT WWW.ESO.NET

PARTICIPANT'S DETAILSDr. Prof. Mrs. Mr.

Surname NameInstituteDepartmentStreet Zip Code Town CountryPhone Fax MobileEmailProfession Specialisation Main fieldVAT number (compulsory for self-employed persons)

Fiscal code (Italian residents only)

Are you an ESMO Member? YES NOIf YES: Membership ID: Expire date (DD/MM/YYYY):

If your invoice details are different to those above, please complete the following section:

Invoice contact personAddressPhone emailVAT number (compulsory for self-employed persons)

Fiscal Code (Italian residents only)

REGISTRATION FEES:Rates are quoted in Euro and include VAT.

Early Late(by 31 October 2017) (from 1 November 2017)

Registration fee EUR 200 EUR 250Club ESO Members EUR 150 EUR 250ESMO Members EUR 150 EUR 250

PAYMENT DETAILS:The registration is processed when payment accompanies the form (credit card details or copy of bank transfer)

Visa/Mastercard Card Number / / / Expire date / CV2 codeHolder’s name: and signature

BANK TRANSFER with no cost to the beneficiary (please provide a copy of the bank transfer): Bank: Banca Popolare di Milano, Agenzia 24 - Milan, ItalyAccount holder: European School of OncologyNumber: No. 16333 IBAN: IT96G0558401624 0000000 16333 - BIC: BPMIITMMXXXReference: "Rare Tumours" + participant’s name

I authorize the European School of Oncology to use my personal data according to what is specified inArticle 13 DLGS 196, available at www.eso.net or on request at fax number +39 02 8546 4545.

Signature Date

Flyer Rare Tumours_screen 11.07.2017 16:13 Pagina 1

pROGRAMME

Saturday, 2 December 2017 9:00 Registration and coffee entry INTRODUCTION (plenary session*) Moderators: J.Y. Blay, FR - P.G. Casali, IT - R. Stahel, CH 9:45 Welcome from ESO and ESMO F. Peccatori, IT - R. Stahel, CH 10:00 The problem of rare cancers P.G. Casali, IT 10:15 The epidemiology of rare cancers A. Trama, IT 10:30 The pathologic diagnosis in rare cancers A.P. Dei Tos, IT 10:45 The European Reference Networks J.Y. Blay, FR 11:00 Discussion pATIENT EMpOWERMENT IN RARE CANCERS (plenary session *)Moderators: F. De Lorenzo, BE - M. Wartenberg, DE 11:30 Patient empowerment in rare cancers: a consensus G. Pravettoni, IT 11:45 The EU scenario F. De Lorenzo, BE 12:00 Patient advocacy on rare cancers as a resource M. Wartenberg, DE 12:15 Patient involvement in clinical trials K. Oliver, UK 12:30 Discussion 13:00 Lunch RARE THORACIC CANCERS Moderators: M. Garassino, IT - R. Stahel, CH 14:00 The epidemiology of mesothelioma A. Trama, IT 14:15 Mesothelioma R. Stahel, CH 14:30 Thymic tumors M. Garassino, IT 14:45 DiscussionNEUROENDOCRINE TUMORS Moderators: D. Talbot, UK - F. De Braud, IT 15:15 Thoracic neuroendocrine tumors D. Talbot, UK 15:30 Gastroenteropancreatic neuroendocrine tumors N. Fazio, IT 15:45 Surgery in neuroendocrine tumors V. Mazzaferro, IT 16:00 Discussion 16:30 Coffee breakDIGESTIVE RARE CANCERS Moderators: V. Mazzaferro, IT - L. Wyrwicz, PL 17:00 Biliary tumors F. De Braud, IT 17:15 Anal carcinoma R. Glynne-Jones, UK 17:30 Peritoneal mesothelioma & pseudomyxoma M. Deraco, IT 17:45 Discussion

Sunday, 3 December 2017 CNS TUMORS Moderators: R. Soffietti, IT - M. van den Bent, NL 8:30 The frontiers of neurosurgery of brain tumors J.C. Tonn, DE 8:45 The frontiers of radiation therapy of brain tumors S. Villà, ES 9:00 Gliomas: state-of-the-art approach M. van den Bent, NL 9:15 Precision medicine in brain tumors R. Soffietti, IT 9:30 Discussion 10:00 Coffee breakSARCOMAS Moderators: P.G. Casali, IT - A. Gronchi, IT 10:30 The variegated pathology of sarcomas A.P. Dei Tos, IT

10:45 The surgical margin in sarcomas A. Gronchi, IT 11:00 Medical therapy of adult soft tissue sarcomas P.G. Casali, IT 11:15 Medical therapy of GIST J.Y. Blay, FR 11:30 Ewing sarcoma S. Ferrari, IT 11:45 Osteosarcoma S. Bielack, DE 12:00 “Rare” sarcomas S. Stacchiotti, IT 12:15 Histiocytic/dendritic cell neoplasms A.M. Frezza, IT 12:30 Discussion 13:00 LunchRARE FEMALE GENITAL CANCERS Moderators: F. Raspagliesi, IT - M. Seckl, UK 14:00 Vulvar and vaginal cancers F. Raspagliesi, IT 14:15 Rare endometrial cancers D. Lorusso, IT 14:30 Uterine sarcomas P.G. Casali, IT 14:45 Non-epithelial ovarian tumors I. Ray-Coquard, FR 15:00 Trophoblastic tumors M. Seckl, UK 15:15 Discussion 15:45 Coffee breakRARE UROGENITAL CANCERS Moderators: J.A. Gietema, NL - N. Nicolai, IT 16:15 Testicular cancer A. Necchi, IT 16:30 Penile cancers J.A. Gietema, NL 16:45 Discussion RARE SKIN TUMORS & UVEAL MELANOMA Moderators: M. Angi, IT - C. Lebbé, FR 17:15 The integrated approach to uveal melanoma M. Angi, IT 17:30 Merkel cell carcinoma C. Lebbé, FR 17:45 Skin adnexal tumors L. Licitra, IT 18:00 Discussion

Monday, 4 December 2017 HEAD & NECK CANCERS Moderators: V. Gregoire, BE - L. Licitra, IT 8:30 Natural history of H&N cancers C. Simon, CH 8:45 The potential of radiation therapy for H&N cancers V. Gregoire, BE 9:00 Surgery in H&N cancers and its innovations C. Piazza, IT 9:15 Laryngeal & hypopharyngeal carcinoma L. Licitra, IT 9:30 Oropharyngeal carcinoma V. Gregoire, BE 9:45 Nasopharyngeal carcinoma L. Licitra, IT 10:00 Oral cavity tumors C. Simon, CH 10:15 Salivary gland tumors L. Licitra, IT 10:30 Discussion 11:00 Coffee break ENDOCRINE GLAND TUMORSModerators: S. Leboulleux, FR - L. Licitra, IT 11:30 Adrenal cancer S. Grisanti, IT 11:45 Thyroid cancer S. Leboulleux, FR 12:00 Anaplastic thyroid carcinoma C. De La Fouchardière, FR 12:15 Discussion 12:45 Closing remarks, with a view to networking… P.G. Casali, IT (Plenary*)

*Linked to Rare Cancer Patient Advocates pilot training course

GENERAL INFORMATION

ORGANISING SECRETARIATEuropean School of OncologyRare Tumours Programme c/o Fondazione IRCCS Istituto Nazionale dei TumoriVia G. Venezian, 1 - 20133 Milan – ItalyFax +39 0223902531 – www.eso.netEmail: raretumours@eso.net

Rates are quoted in Euro and include VAT.Registration grants participation in all sessions, coffee breaks and lunches as indicated in the programme.

TRAVEL GRANTSTravel grants are made available on a competitive basis thanks to the support of Rare Cancers Europe. Priority will be given to younger candidates and low/middle income Countries. To submit the Travel Grant application please complete the online form and upload your Curriculum vitae and motivation letter by 1st October.All applicants will be contacted by 15th October. Unselected applicants will still be able to register with the early rate fee (deadline: 31st October).

Participants coming from:Italy € 500 (plus free registration)Southern and Western Europe € 700 (plus free registration)Northern, Central and Eastern Europe € 800 (plus free registration)Other and overseas € 1000 (plus free registration)

VENUEFondazione Cariplo Conference CenterVia Romagnosi, 8Milan, Italywww.centrocongressifondazionecariplo.it

REGISTRATIONRegister online at www.eso.net

Early (by 31 October) Late (from 1 November)

Registration fees EUR 200 EUR 250

Club ESO members EUR 150 EUR 250

ESMO members EUR 150 EUR 250

ACCREDITATION

Application for CME recognition will be submitted to the European AccreditationCouncil for Continuing Medical Education (EACCME) and to the Italian CME accreditation system. EACCME credits are recognised by the American Medical Association towards the Physician’s Recognition Award (PRA).Information on the status of the applications can be obtained from the organising Secretariat.

CANCELLATION OF REGISTRATION OR REpLACEMENTCancellation should be notified to ESO in writing. In case of cancellation without replacement, the fee less handling charges of EUR 80 will be refunded after the event, provided that the cancellation is received by ESO before 2 November.Replacements will be possible till 2 November.

BADGEThe badge is the only official evidence of registration and should be worn at all times during the event.

INSURANCE The organisers bear no responsibility for untoward events in relation to the participation in the Course. Participants are advised to take out their own personal and travel insurance.

OFFICIAL LANGUAGE The official language will be English. No translation will be provided.

ACKNOWLEDGEMENTESO wishes to express its gratitude toFondazione Cariplo - Iniziative patrimoniali S.p.A.for their support in hosting the course in its premises

IMpORTANT DEADLINES TRAVEL GRANTS: 1 October 2017

EARLY REGISTRATION: 31 October 2017LATE REGISTRATION: from 1 November 2017

2ND ESO-ESMO-RCE CLINICAL UPDATE ON RARE ADULT SOLID CANCERS2-4 December 2017, Milan, Italy

Please fill in this form in BLOCK CAPITALS and send by the deadline to:European School of Oncology - Via Turati 29 - 20121 Milan - Italy

Fax: +39 02 85464545 - E mail: raretumours@eso.net

ONLINE REGISTRATION AT WWW.ESO.NET

PARTICIPANT'S DETAILSDr. Prof. Mrs. Mr.

Surname NameInstituteDepartmentStreet Zip Code Town CountryPhone Fax MobileEmailProfession Specialisation Main fieldVAT number (compulsory for self-employed persons)

Fiscal code (Italian residents only)

Are you an ESMO Member? YES NOIf YES: Membership ID: Expire date (DD/MM/YYYY):

If your invoice details are different to those above, please complete the following section:

Invoice contact personAddressPhone emailVAT number (compulsory for self-employed persons)

Fiscal Code (Italian residents only)

REGISTRATION FEES:Rates are quoted in Euro and include VAT.

Early Late(by 31 October 2017) (from 1 November 2017)

Registration fee EUR 200 EUR 250Club ESO Members EUR 150 EUR 250ESMO Members EUR 150 EUR 250

PAYMENT DETAILS:The registration is processed when payment accompanies the form (credit card details or copy of bank transfer)

Visa/Mastercard Card Number / / / Expire date / CV2 codeHolder’s name: and signature

BANK TRANSFER with no cost to the beneficiary (please provide a copy of the bank transfer): Bank: Banca Popolare di Milano, Agenzia 24 - Milan, ItalyAccount holder: European School of OncologyNumber: No. 16333 IBAN: IT96G0558401624 0000000 16333 - BIC: BPMIITMMXXXReference: "Rare Tumours" + participant’s name

I authorize the European School of Oncology to use my personal data according to what is specified inArticle 13 DLGS 196, available at www.eso.net or on request at fax number +39 02 8546 4545.

Signature Date

Flyer Rare Tumours_screen 11.07.2017 16:13 Pagina 1

2ND ESO-ESMO-RCE CLINICAL UPDATE ON RARE ADULT SOLID CANCERS2-4 December 2017, Milan, Italy

Please fill in this form in BLOCK CAPITALS and send by the deadline to:European School of Oncology - Via Turati 29 - 20121 Milan - Italy

Fax: +39 02 85464545 - E mail: raretumours@eso.net

ONLINE REGISTRATION AT WWW.ESO.NET

PARTICIPANT'S DETAILSDr. Prof. Mrs. Mr.

Surname NameInstituteDepartmentStreet Zip Code Town CountryPhone Fax MobileEmailProfession Specialisation Main fieldVAT number (compulsory for self-employed persons)

Fiscal code (Italian residents only)

Are you an ESMO Member? YES NOIf YES: Membership ID: Expire date (DD/MM/YYYY):

If your invoice details are different to those above, please complete the following section:

Invoice contact personAddressPhone emailVAT number (compulsory for self-employed persons)

Fiscal Code (Italian residents only)

REGISTRATION FEES:Rates are quoted in Euro and include VAT.

Early Late(by 31 October 2017) (from 1 November 2017)

Registration fee EUR 200 EUR 250Club ESO Members EUR 150 EUR 250ESMO Members EUR 150 EUR 250

PAYMENT DETAILS:The registration is processed when payment accompanies the form (credit card details or copy of bank transfer)

Visa/Mastercard Card Number / / / Expire date / CV2 codeHolder’s name: and signature

BANK TRANSFER with no cost to the beneficiary (please provide a copy of the bank transfer): Bank: Banca Popolare di Milano, Agenzia 24 - Milan, ItalyAccount holder: European School of OncologyNumber: No. 16333 IBAN: IT96G0558401624 0000000 16333 - BIC: BPMIITMMXXXReference: "Rare Tumours" + participant’s name

I authorize the European School of Oncology to use my personal data according to what is specified inArticle 13 DLGS 196, available at www.eso.net or on request at fax number +39 02 8546 4545.

Signature Date

Flyer Rare Tumours_screen 11.07.2017 16:13 Pagina 1