nematoda intestinal
TRANSCRIPT
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REVISION
Types of Life Cycle in Trematoda and Cestoda
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Life cycle in human trematodes
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Type of life cycles in intestinal cestodes
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Life cycles in human intestinal cestodes
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Life cycles in human larval cestodiases
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Nematoda
Dr. Mohiedden M Abdul-Fattah
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General characters• Cylindrical, round in cross section (round worm).• Body wall is formed of 3 layers• Has body cavity containing fluid, sex organs and intestine.
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• Separate sexes ♀ >♂.• Single set of genitalia
in ♂ and 2 sets in ♀.• Digestive system
begins with;• Mouth with lips,
papillae or buccal capsules, followed by
• oesophagus, then • Intestine and ends by • Anus which opens
ventrally joining the genital tract to form cloaca in ♂. and separately in ♀
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Esophagus types in nematodes
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Adult intestinal nematodes with pre adult larval migratory phase: Ascaris lumbricoides, strongyloides stercoralis, Hookworms
Adult Intestinal nematodes without larval migratory phase: Enterobius vermicularis, Trichostrongylus colubriformis, Capillaria philippinensis and Trichuris trichiura.
Intestinal nematodes with post-adult larval tissue invasion: Trichinella.
Larval tissue nematodiases with developmental arrest: visceral and cutaneous larva migrans.
Adult tissue nematodes: Adult tissue nematodiasis: Dracunculus medinensis and filariae.
Human Nematodes
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Classification of nematodes according to habitat and development.
Adult intestinal nematodes with pre adult larval migratory
phase: ,Ascaris, Hookworms, strongyloides.
Adult Intestinal nematodes without larval migratory phase:
Enterobius, Trichostrongylus, Capillaria and Trichuris.
Intestinal nematodes with post-adult larval tissue invasion:
Trichinella.
Larval tissue nematodes with developmental arrest: visceral
and cutaneous larva migrans.
Adult tissue nematodes: Adult tissue nematodiases:
Dracunculus and filariae.
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Nematodes according to mode of infection
1. Ingestion of eggs: Ascaris, Enterobius, Trichuris.2. Ingestion of larva: Trichostrongylus (on vegetable), Trichinella (in pork),
Dracunculus (in cyclops), Capillaria (in fish).3. Active penetration of skin by larva: Ancylostoma, Necator, Strongyloides.4. Entrance of skin by larva transmitted by insect: Filarial worms : Wucheraria, Onchocerca, Loa,
Acanthocheilonema, Mansonella.
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Nematode infection by ingestion
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Nematode infection via skin
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Intestinal Nematodes: with pre-adult larval lung migratory phase:
Dr Mohieddin M Abdul-Fattah
1. Ascaris
2. Hookworms
3. Strongyloides stercoralis
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I. Biology1.Ascaris lumbricoides
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Ascaris male and female
♂ post end with spicule
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Man related biology
1. Man (especially children) act as final host.
2. Habitat: lumen of small intestine.
3. Diagnostic morphology: Intestinal nematode; 25 cm long, creamy white.
4. Exit stage: fertilized and unfertilized eggs in stool ♀ Ascaris lays 200,000 eggs per day.
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II. Epidemiology Geographical distribution: moist warm
climates and temperate zones. Transmission:.
1. Intermediate host: none
2. Reservoir hosts: None, Human is the only host.
3. Infective stage: egg containing Filariform larvae.
Fertile eggs embryonate optimally in moist, warm, shaded soil and develop infective filariform larva in 2 – 5 weeks.
4. Mode of infection: Ingestion of foods mainly vegetables and carrots contaminated by eggs with (2nd stage) larvae.
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III. Host parasite relationship
Immune responses
1. Adult in the lumen elicits no immune response.
2. Migrating larva stimulates humoral response with an increase of IgE.
3. Migrating larvae in the lung initiate inflammatory cellular response (eosinophilic)
4. The immune responses are not protective as reinfection occurs.
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III. Host parasite relationship
Pathogenesis
1. Larvae in the lung cause pneumonitis (Loffler's syndrome)
2. Heavy worm burden (> 200 eggs/ G feces) causes intestinal obstruction.
3. Parasite secretes trypsin inhibitor, prevents host from digesting proteins → protein-calorie malnutrition.
4. Migrating adult into bile ducts causes obstructive jaundice and pancreatitis
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Inflammatory eosinophilic granuloma around larva in lung
Volvulus
Ascaris extracted from liver
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III. Host parasite relationship Clincal picture:
1. Migratory phase: Loffler’s syndrome: fever, cough, eosinophilia
lung infiltration; (during prepatent period).
2. Intestinal stage: Asymptomatic in light infection. Heavy infection; nausea, vomiting, diarrhea and
abdominal pain. Intestinal obstruction due to intussusception and
volvulus may occur.
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III. Host parasite relationship Erratic movement of the adult: occurs due to its
irritation by fever, anesthesia and drugs: Adult migrate from normal habitat through any opening,
and can even perforate the intestinal wall to:
1. Ampulla of Vater: (pancreatitis).
2. CBD: (obstructive jaundice).
3. Appendix: (appendicitis).
4. Peritoneum: (peritonitis due to intestinal bacteria)
5. Liver: granulomas around eggs and adult ♀.
6. Biliary ducts: biliary ascariasis with recurrent cholangitis.
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IV. Diagnosis Direct methods: Detection of eggs in feces. Egg count by Stoll technique is
needed to estimate worm burden. Detection of larvae in sputum Indirect methods: Eosinphilia. Chest x-ray (lung infiltration). X-ray with Barium meal: filling
defects
ovoid.60 x 45 um
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V. Treatment Albendazole: 200 mg for 3 days. Mebendazole: 100 mg bid for 3 days. Treatment; to be followed by purge to avoid
allergic manifestation.
Alternating streaking filling defects in barium meal
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VI. Control
Personal hygiene Hand washing Vegetable washing Avoid playing in soil. Sanitary disposal of human excreta. Avoid use of human excreta as fertilizer for
vegetables Treatment of patients
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Use of night soil as fertilizer
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2. Hookworms: Ancylostoma and Necator BIOLOGY: Final host: human. Habitat: The adult are usually found in jejunum. Exit stage: Adult females put eggs [20,000/24h;
Ancylostoma, 4000; Necator] in the 4 cell stage. When passed in stool they develop to the morula stage and hatches in 1-2 days.
D. morphology: 9 – 12 mm x 0.4 mm, the head bends back dorsally and has a buccal capsule with teeth [Ancylostoma] or plates [Necator].
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1. Egg in feces2. Rhabditiform larva Hatches
in soil
5. Adults live in small intestine
3. Filariform larva in soil
4. Penetrates skin
Life cycle of Hookworms
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The 1st stage larva develops to the 2nd stage rhabditiform larvae with distal oesophageal bulb
Within 5-8 days it develop to infective 3rd stage non-feeding filariform larvae [800 µm with simple muscular esophagus and protective sheath].
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The larvae penetrate skin, enter blood & migrate to lungs. They enter alveoli, pass up trachea, then swallowed to become mature worms in jejunum that lay eggs
within 5 week period from exposure.
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II. Epidemiology Geographical distribution: Endemic in tropics; favoured by 1. promiscous daefecation.2. moist, shady, warm, sandy soil with decaying vegetation. 3. the presence of dung and stool burying beetles. Prolonged dry and cold climates are unsatisfactory. Transmission: Intermediate host: No. Resevoir hosts: No, Human are the only hosts. Infective stage: Filariform larvae in soil. 1. These larvae survive 3-4 weeks in the soil or moisture
films on the ground. 2. They move towards warmth, moisture, oxygen, and CO2
but away from gravity [larval tropism]. Mode of infection: Filariform larvae in soil penetrate
skin of feet.
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Host-Parasite Relationship
1. Ground itch:
cutaneous penetration; associated with stinging
sensation, followed by local oedema, erythema and
papule formation.
These are more common in repeated infections and
reflect enhanced host immune reaction (type I) to
larval forms. They are more pronounced among the
expatriates.
2. Transient creeping eruption caused by larvae of
Necator americanus.
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Host Parasite Relationship
3. Pulmonary lesions; pneumonitis and eosinophilia occurs during massive migration of larvae in the lung.
If Ancylostoma duodenale infection has occurred orally, pneumonitis is preceded by nausea, salivation, itching of the pharynx and hoarsness [Wakana disease].
4. Intestinal infection & hookworm disease; abdominal pain, diarrhea, less commonly malabsorption,
5. iron deficiency anaemia and chronic protein calorie malnutrition if the infection was heavy (>100 worms). Less than 25 worm load is insignificant.
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Diagnosis Detection of eggs or larvae in faeces. Egg
count by Stoll technique is needed to estimate worm burden. Eosinphilia usually occurs.
Egg characters: thin shelled, colourless, ovoid with blunt ends, 60 x 40 µm and contain an ovum in 4 or 8 cell stage.
Rhabditoid larva: 250 µm with rhabditiform oesophagus, and buccal cavity longer than the width of the head tip.
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Treatment1. Albendazole (Alzental, tablets 100, 200) 200 mg
for 3 days.
2. Mebendazole (Antiver, tablet 100mg) 100 mg twice daily for 3 days.
3. Pyrantel pamoate (Combantrin,tablets; 250, 125), a single dose of 12.5 mg/kg, i.e. 3 tablets
Control:
1.Use footwear.
2.Proper disposal of human waste
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3. Strongyloides stercoralis Biology: Final host: Human. Habitat:. Adult lives and lays egg in mucosa
of small intestine . Exit stage: egg in the mucosa hatches
Rhabditiform larva that escapes into the lumen and is passed in faeces.
Diagnostic morphology: Parasitic female is larger (2.2 mm x 45 µm)
than the free-living worm (1 mm x 60 µm) .The eggs, when laid are 55 µm by 30 µm.
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Life cycle of Strongyloides
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2.Epidemiology:Geographical distribution: endemic in tropics and subtropics with poor sanitation. It has 2 features:
The worm has potential for autoinfection and multiplication within the host.
It has two types of cycles; free living and parasitic.Intermediate host: No.Reservoir host: NoThe infective stage: Filariform larvae.Mode of infection: Filariform larvae can penetrate either by:
The intestinal mucosa (internal autoinfection),The skin of the perianal area (external autoinfection),orContact of the skin of hands and feet with contaminated
soils.
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3. Host parasite relationship: Patients with a low worm burden are asymptomatic,
otherwise; Larva currens:
A. rash caused by chronic cutaneous larval migration localized around the waist and buttocks.
B. It is a serpiginous red line that progresses 1 to 2cm/h for up to 48 h.
Larvae in the lung produce pneumonitis. Adults within the mucosa cause enteritis leading to
diarrhea. Sepsis due to enteric bacteria may occur due to damage
caused by autoinfection. Massive super infection occurs in the immune
compromised (hyper-infection)..
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4.Lab diagnosis: - Detection of larvae in stool sample by direct exam.
Or by Baermann concentration. Eosinophilia in blood count Characters of the rhabditiform larva: Very short buccal cavity. The esophagus has two bulbs with narrow isthmus
between them.
5.Treatment: - Albendazole 5mg/kg/12h peroral (PO) for3d or Thiabendazole 25mg/kg/12h PO for 3d or Ivermctin (Mectizan) 200 µg/kg/d for two days.
6.Control: - Foot wear and proper disposal of human waste.
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Intestinal nematodes with post-adult larval tissue invasion
•Trichinella spiralis
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Trichinella spiralisA.Biology: Final host: Pigs, wild boars, rats, bears, walruses, and
many other carnivores including man. Habitat: -
i. Adult ♂ in Small intestines while females inhabit rows of epithelial cells of the mucosa of duodenum and jejunum.
ii. Larvae live in Striated muscle fibers (cells). Exit stage:
i. Males in the faecal streams.
ii. Larvae have no exit as they encyst in muscle fibers. Morphology: 2.5 mm long ♀ with tapering post. end and
1.2 mm long ♂ with 2 caudal appendages. ♀ puts 5000 larvae each 100 µm long.
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Circulation
5. Larva encysts in striated muscles
3. enter intestinal mucosa
♂ copulates ♀
4.Larva deposited in the mucosa
1. Man ingests encysted larva in undercooked
pork
RodentsCarnivorism
Pigs
Life cycle of Trichinella
1. Encysted larva from pigs
2. Larvae released in intestine, mature to adults
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Trichinella Life Cycle
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Circulation
5. Larva encysts in striated muscles
3. enter intestinal mucosa
♂ copulates ♀
4.Larva deposited in the mucosa
1. Man ingests encysted larva in undercooked
pork
RodentsCarnivorism
Pigs
Life cycle of Trichinella
1. Encysted larva from pigs
2. Larvae released in intestine, mature to adults
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B. Epidemiology: Distribution: Worldwide; prevalent in pork
eating countries (USA and Europe). Transmission: Intermediate host (IH): Pigs. One host may serve as both final and IH. Humans
are dead end IH. Reservoir host: Pigs, wild boars, rats, bears,
walruses, and many other carnivores. Infective stage: Encysted larvae in muscles. Mode of infection: Ingestion of pork infected by
encysted larvae.
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C.Host-parasite relationship:1. Intestinal stage (20-24 hours): eneteritis → nausea,
vomiting, abdominal pain and diarrhea.2. Migratory stage:A.Invading skeletal muscles (1-2 weeks): fever, facial
edema, conjunctivitis, pain, swelling and weakness of the involved muscles.
B.Invading cardiac muscles and CNS (3rd week): Myocarditis and CNS involvement are the most frequent two causes of death in trichinosis.
3.Encapsulation (3w – 4 w): symptoms subside or decrease. Myocarditis persists
and may precipitate congestive heart failure.4. If the infective dose ≥100 larvae morbidity occurs. If it
is ≥300,000 death occurs
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D. Diagnosis: 1. Symptoms. 2. detection of free or encapsulated larvae.
From the 7th day onward a) In compressed (trichinoscopy) or b) Stained biopsy.c) Or digested samples from deltoid, biceps,
gastrocnemius or Pectoralis muscles. d) Or by xenodiagnosis in rats. 3. Immune-diagnosis by a. Bachman intra-dermal skin test (IDT). Or by b. Serology: from 2 weeks in heavy infection and
3-4 w in lighter ones: BFT (2w), IFAT (2-3w) and Sandwich Elisa.
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E.Treatment: Prednisolone 40 mg/day for 5d, with Mebendazole 50 mg/kg/12h PO for 10
days.
F.Control: Properly cooking pork. Feeding pigs on cooked garbage.
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Intestinal nematodes without lung larval migratory phase
Habitat in large intestine:
1. Enterobius vermicularis (Oxyuris)
2. Ttichuris trichiura Habitat in small intestine
1. Trichostrongylus colubriformis
2. Capillaria philipinensis.
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Enterobius vermicularis (Oxyuris)
Final host: Human. Habitat: Cecum
and colon. Exit stage: mature
egg. Diagnostic
morphology: ♀ cylindrical 1 cm with pointed ends. ♂ ½ cm with curved posterior end.
I. BIOLOGY
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II. Epidemiology
Distribution: worldwide. Mostly in children. Transmission: Intermediate host: No. Reservoir host: No. Infective stage: Embryonated egg. Mode of infection: Ingestion of mature eggs fro environment, with
foods, or by hand to mouth. Re-infection (auto infection).
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III. Host-Parasite relationship Peri-anal pruritis and insomnia, Nausea, and loss of appetite Urinary tract infection especially in females. Worm may migrate into ♀ genital tract
inducing bacterial infection, salpingitis.
IV. Diagnosis Eggs are detected in peri-anal skin by Scotch
tape technique. Adult in the stool or diapers. Eggs are detected in stool accidentally, in 3%
of patients
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V. Treatment
Mebendazol 200 mg/12 hours for one day, repeated after one week.
If aged < 2 years, piperazine; 0.3ml/kg/day for 7 days. Treat the whole family
VI. Control
Personal cleanliness. Hygiene is more important than drugs as
adults die after 6 weeks. Continued symptoms means re-infection
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Trichuris Trichiura
Final host: Man Habitat: Large
intestine with ant end embedded in the intestinal wall.
Exit stage: one cell immature egg.
Morphology: Whip like with narrow ant part is half the length of thick posterior part in ♂ and double the length in ♀.
I. BIOLOGY
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II. Epidemiology Distribution: worldwide, esp. in the
tropics. Transmission: Intermediate host: None. Reservoir host: None. Infective stage:
embryonated egg with 2nd stage larva.
Mode of infection: Ingestion of soil, food or drinks contaminated with embryonated egg.
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III. Host Parasite Relationship
1. Mild infection is asymptomatic, 2. In heavy infection: Penetration of mucosa may predispose to 2ry
bacterial infection, appendicitis and peritonitis. Bleeding from friable mucosa → hypochromic
iron deficiency anemia and growth retardation in children.
Megaloblastic (hyperchromic) anaemia may occur
3. Severe infection: dysentery→ frequently lead to rectal prolapse
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IV. Diagnosis
Detection of typical eggs in stool sample.
Counting eggs with Stoll technique
Characters of egg:
1. 50 x 25 µm,
2. Barrel shaped with mucoid plug at both ends,
3. brownish, 4. unsegmented with one cell
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V. Treatment
Mebendazole 200 mg/ 12h pero–oral (PO) for 6 days
VI. Control Personal hygiene Proper disposal of human faeces
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Capillaria Philippinensis
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1. Man or birds ingest larvae in fish & larvae develop to adults in intestinal mucosa
2.♀ lay Immature eggs3. Mature egg
4. Infective larva develops in fish
5. Some ♀ lay larvae 6.These reinvade mucosa & develop to adults
Internal auto- infection
Capillaria Philippinensis Life Cycle
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C. philippinensis
Final host: Humans, fish.
Habitat: mucosa of the small intestine (the jejunum).
Exit stage: Eggs, larvae, and adults passed in feces.
Basic morphology and life cycle: adult 2-4 mm long.
I. BIOLOGY
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II. Epidemiology
Distribution: worldwide but more in the Orientals ;
Philippines and Thailand. TransmissionI. Reservoir hosts: Fish and Birds.
II. Intermediate hosts: fish
III. Infective stage: infective larva in the mucosa of fish.
IV. Mode of infection: ingestion of undercooked fish infected with the larvae or by internal autoinfection.
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III. Host Parasite Relationship
1. Watery diarrhea with excessive fluid loss.
2. Malabsorption with weight loss, abdominal
distension, oedema and muscle wasting.
3. Death due to heart failure, pneumonia or
hyperkalaemia in severe infection.
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IV. Diagnosis Clinical picture in endemic areas gives a clue
to diagnosis. Detection of eggs in the stool:1. Thick shelled with polar plugs 2. 40x20µ in size. Detection of larvae or adults in stool.
V. Treatment Mebendazole: 400mg daily for 20 days
VI. Control Health education, proper cooking of fish.
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Trichostrongylus
Final host: - herbivorous animals (sheep, goats). Occasionally, found in man.
Habitat:- small intestine; with anterior end embedded in the mucosa.
Exit stage: Egg with 16 -32 cell morula stage. Morphology: 4mm long ♂, 8mm long ♀, slender hair like
worm with narrow anterior extremity. Male adult is with post. copulatory bursa.
I. Biology
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I. Biology: Life cycle
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II. Epidemiology Distribution: Middle East and Far East. Transmission:1. Intermediate host: No.2. Reservoir host:- Sheep, camels and
goats.3. Infective stage:- Filariform larvae on
vegetables.4. Mode of infection:- Ingestion of
vegetables contaminated with filariform larvae.
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III. Host-Parasite relationship Slight enteritis and diarrhea
IV. DiagnosisDetection of typical eggs in stool sample.
Characters of egg: 90 x 45 µm, thin shelled, pointed at one end, brownish, and segmented embryo with 16 -32 cells.
V.Treatment: Mebendazole 200 mg/ 12h peroral (PO) for three days.
VI.Control:- Personal hygiene, washing vegetables and water sanitation