Page 2

NeoGenomics Laboratories offers testing services that address diagnosis, prognosis and therapy selection for hematologic and solid tumor cancers.

FISH• 1p/19q Deletion (Glioma)

• ALK, RET, & ROS1 for NSCLC

• BCL2

• Bladder Cancer FISH

• BRAF Translocation (Brain & Other)

• DDIT3 (CHOP)

• EGFR Amplification (Solid Tumors)

• EWSR1

• HER2 (Breast, Breast Equivocal,Non-Breast)

• Hematologic Panels

- ALL, Adult & Pediatric

- AML

- CLL

- Eosinophilia

- High-Grade/Large B-CellLymphoma

- Low-Grade/Small B-CellLymphoma FISH Panel

- MDS

- MM/MGUS

- High Risk MM

- MPN

- NHL

- Plasma Cell Myeloma RiskStratification

- SS18 (SYT)

- TCL1

• MDM2 (Liposarcoma)

• MET

• MYCN Amplification (Solid Tumors)

• NeoSITE™ B.E (Barrett’s Esophagus)

• NeoSITE™ Cervical FISH Panel

• NeoSITE™ Melanoma

• PDGFRA Amplification (Brain)

• PTEN (Prostate & Other)

• RARA Break-Apart FISH

• RET

• XY (Engraftment)

• Comprehensive Menu of IndividualHematologic FISH Probes

Flow Cytometry• CD52 Campath® Sensitivity

• Comprehensive Leukemia/Lymphoma Analysis

• DNA Content & Cell Cycle Analysis

• PNH: High Sensitivity Evaluation

• V-Beta T-Cell Clonality

• ZAP-70 Lymphoid Panel

Cytogenetics• Oncology Chromosome Analysis

- Reflex to FISH

- AML reflex to NeoTYPE™ AML Profile

• Products of Conception

- Reflex to NeoARRAY™SNP/Cytogenetic Profile

Molecular Testing• ABL1 Kinase Domain

• ASXL1

• ATRX

• B-Cell Gene Rearrangement

• B&T Cell Gene Rearrangement

• BCL1, t(11;14)

• BCL2, t(14;18)

• BCR-ABL1, t(9;22)

• BRAF

• BTK Inhibitor Acquired Resistance Panel

• BTK Inhibitor Primary SusceptibilityPanel

• BTK

• CALR

• CARD11

• CBL

• CD79B

• CEBPA

• Chimerism/DNA Fingerprinting

• CSF3R

• CXCR4

• DNMT3A

• EGFR

• ETV6

• ETV6-RUNX1 (TEL-AML1), t(12;21)

• EZH2

• FLT3

• GNAS

• HOXB13 Genotyping

• HRAS

• IDH1

• IDH2

• IgVH

• inv(16), CBFB-MYH11

• JAK2 V617F

• JAK2 Exon 12-14

• KIT

• KRAS

• KRAS Exon 4

• MET (c-MET)

• MGMT Methylation

Page 3

• Microsatellite Instability

• MLH1 Methylation

• MPL

• MPN Extended Reflex Panel

• MPN Standard Reflex Panel

• MYD88

• NPM1

• NOTCH1

• NRAS

• PDGFRa

• PIK3CA

• PLC-Gamma-2

• PML-RARA, t(15;17)

• PTEN

• PTPN11

• RUNX1 Mutation

• RUNX1-RUNX1T1 (AML1-ETO), t(8;21)

• SETBP1

• SF3B1

• SRSF2

• STAT3

• T-Cell Gene Rearrangement

• TET2

• TP53

• TPMT Genotyping

• U2AF1

• UGT1A1 Genotyping

• WT1

• ZRSR2

Other Testing/Cancer Profiles• Hereditary Cancer Testing - Multiplex

Panels

- BRCA1/2

- Comprehensive HereditaryBreast-Ovarian Cancer Panel

- Inherited Bone MarrowFailure Panel

- Lynch Syndrome

• Hereditary Cancer Testing - SingleGene Tests

- BRCA1

- BRCA2

- EGFR T790M Germline

- EPCAM

- MLH1

- MSH2

- MSH6

- PMS2

• NeoARRAY™ SNP/Cytogenetic Profile

• NeoLAB Liquid Biopsy for HematologicDiseases - Multiplex

- AML Profile

- BTK Inhibitor AcquiredResistance Panel

- MDS/CMML Profile

- Myeloid Disorders Profile

• NeoLAB Liquid Biopsy for HematologicDiseases - Single Gene

- FLT3

- IDH1

- IDH2

- inv(16), CBFB-MYH11 Translocation

- KIT (c-KIT)

- KRAS

- NPM1

- NRAS

- PML-RARA Translocation, t(15;17)

- RUNX1-RUNX1T1 (AML1-ETOTranslocation, t(8;21)

• NeoLAB™ Prostate – Liquid Alternativeto Biopsy

• NeoLAB™ Solid Tumor Monitor

• NeoSEQ™ NGS Services

• NeoTYPE™ CUP Consult

• NeoTYPE™ Hematology Profiles

- AML Favorable-Risk

- AML Prognostic

- CLL Prognostic

- JMML

- Lymphoma

- MDS/CMML

- MPN

- Myeloid Disorders (54 genes)

• NeoTYPE™ Solid Tumor Profiles

- Brain

- Breast

- Cervical

- Colorectal

- Discovery (315 genes)

- Endometrial

- Esophageal

- Gastric

- GIST

- Head & Neck

- Liver/Biliary

- Lung

- Melanoma

- Other Solid Tumor

- Ovarian

- Pancreas

- Precision (48 genes)

- Soft Tissue

- Thyroid

• NeoTYPE™ Cancer Exome Profile

• NGS Fusion Profiles

- ALK, RET, ROS1 Fusion Profile

- ALK, NTRK, RET, ROS1 Fusion Profile

- Sarcoma Fusion Profile

• RAS/RAF Panel

Page 4

• AACT (Alpha-1Antichymotrypsin)

• AAT (Alpha-1-Antitrypsin)• ACTH (Adrenocorticotropin

Hormone)• Actin MSA (Muscle

Specific Actin)• Actin SMA (Smooth Muscle

Actin)• Adenovirus• AFP (Alpha Fetoprotein)• ALK (Anaplastic

Lymphoma Kinase)• ALK1• Alpha Synuclein• Amyloid A• Amyloid P• Androgen Receptor• Annexin A1• AR (Androgen Receptor)• Arginase 1• B72.3• BCA225• BCL-1 (Cyclin D1)• BCL-2• BCL-6• BerEP4• Beta Amyloid• Beta-Catenin• Beta-HCG• BG8 (Blood Group Related

Antigen)• BOB-1• BRAF V600E• BRCA1• Breast Triple Stain

(CK5+p63+CK8/18)• CA125• CA19-9• CAIX (Carbonic

Anhydrase)• Calcitonin• Caldesmon• Calponin-1• Calretinin

Immunohistochemistry (IHC) Antibody Library

• CAM 5.2• Cat Scratch• Cathepsin D• CD10• CD117• CD11c• CD123• CD138• CD14• CD15• CD163• CD19• CD1a• CD2• CD20• CD21• CD22• CD23• CD25• CD3• CD30• CD31• CD33• CD34• CD35• CD38• CD4• CD42b• CD43• CD44• CD45 LCA• CD45RB• CD45RO• CD5• CD56• CD57• CD61• CD68• CD7• CD71• CD79a• CD8• CD99• CDK4

• CDX2• CDX2/CK7 Double Stain• CEA Monoclonal• CEA Polyclonal• Chromogranin A• CK 10/13 (Cytokeratin 10/13)• CK AE1/AE3 (Pan Cytokeratin)• CK HMW (CK903/34βE12)• CK HMW/CK LMW Double Stain• CK OSCAR (Pan Cytokeratin)• CK14 (Cytokeratin 14)• CK17 (Cytokeratin 17)• CK18 (Cytokeratin 18)• CK19 (Cytokeratin 19)• CK20 (Cytokeratin 20)• CK5 (Cytokeratin 5)• CK5/6 (Cytokeratin 5/6)• CK7 (Cytokeratin 7)• c-MET• CMV (Cytomegalovirus)• c-MYC• Collagen Type IV• COX-2• COX2 (Cyclooxygenase-2)• cREL• CXCR4• Cytokeratin 17• Cytokeratin 19• Cytokeratin 20• Cytokeratin 5/6• Cytokeratin 7• Cytokeratin 8/18• Cytokeratin 903

(CK34BE12 HMW)• Cytokeratin AE1 (LMW)• Cytokeratin AE1/AE3• D2-40• DBA.44• DCC (Deleted in Colorectal

Cancer Protein)• Desmin• DOG-1• DPC4 (SMAD4)• EBV (LMP1)

• E-Cadherin• EGFR (E746_A750del specific)• EGFR (Epidermal Growth

Factor Receptor)• EGFR (L858R mutant specific)• elF4E• EMA (Epithelial Membrane

Antigen)• ER (Estrogen Receptor)• ERCC1• ERG• Factor VIII• Factor VIIIa• Factor VIII-RA• Fascin• FLI1• FOX P1• FOX P3• FSH (Follicle Stimulating

Hormone)• Galectin-3• Gastrin• GATA-3• GCDFP15 (Gross Cystic

Disease Fluid Protein)• GCET1• Geminin• GFAP (Glial Fibrillary Acidic

Protein)• GH (Growth Hormone)• Glucagon• GLUT1• Glycophorin A• Glypican 3• Granzyme B• GST π (Glutathione S

Transferase π)• H. Pylori (Helicobacter Pylori)• HBME-1• HCGβ (Human Chorionic

Gonadotropin Beta)• Helicobacter Pylori• Hemoglobin A• Hep Par 1• Hepatitis B Core Antigen

Page 5

• Hepatitis B SurfaceAntigen

• HepPar1• HER-2• HGAL• HHV8 (Human Herpesvirus,

Type 8) (KSHV)• HHV-9• HLADR• HMB-45• HPL (Human

Placental Lactogen)• HPV (Human

Papilloma Virus)• HSV 1 (Herpes

Simplex 1 Antigen)• HSV 2 (Herpes

Simplex 2 Antigen)• HSV I/II• IDH1• IgA (Immunoglobulin A)• IgD (Immunoglobulin D)• IGF-1R• IgG (Immunoglobulin G)• IgG4 (Immunoglobulin G4)• IgM (Immunoglobulin M)• Inhibin• iNOS• Insulin• Kappa Ig Light Chain• Ki-67• Ki67/Caspase 3 Double

Stain• Lambda Ig Light Chain• Laminin• Langerin• LEF1• LH (Luteinizing Hormone)• LMO2• Lysozyme• Mammaglobin• Mammaglobin A• MART-1/Melan A• Mast Cell Tryptase• MDR1 (Multi Drug

Resistance Protein 1)

• Melan A (Mart1)• Mesothelin• MET• MGMT• MITF• MLH1• MMR Panel by IHC (MLH1,

MSH2, MSH6, PMS2)• MOC-31• MPO (Myeloperoxidase)• MSA• MSH2• MSH6• MUC1• MUC2• MUC5• MUC6• MUM1• MyoD1• Myogenin• Myoglobin• Napsin A• NB (Neuroblastoma)• NeuN• NF (Neurofilament)• NKX2.2• NKX3.1• NSE (Neuron Specific

Enolase)• Oct-2• OCT4• p120 Catenin• p16• P21• p27• p40• P501S (Prostein)• P504S (AMACR)• p53• p57• p63• pAKT (Phosphorylated AKT)• Pancreatic Polypeptide (PP)• Pan-Cytokeratin Plus

(AE1/AE3 + CK 8/18)• Pan-Keratin (AE1/AE3/PCK26)

• Pan-Melanoma (MART-1/MelanA + HMB-45 + Tyrosinase)

• Pan-Melanoma (S100 + MelanA + Tyrosinase)

• Parvovirus• PAX2• PAX-5• PAX-8• PD-1• PDGFR Alpha (Platelet Derived

Growth Factor Receptor Alpha)• PDGFR Beta (Platelet Derived

Growth Factor Receptor Beta)• PD-L1• PD-L1 22C3 FDA (Keytruda®)• PD-L1 28-8 FDA (Opdivo®)• Perforin• PGP9.5• PgR• PHH3• PIN-4 (CK 903 +p63 + p504s)• PLAP (Placental Alkaline

Phosphatase)• PMS2• Pneumocystis jiroveci (carinii)• PR (Progesterone Receptor)• Prealbumin (TTR)• Prolactin• Prostate Triple Stain (p63/

CKHMW/P504S)• PSA (Prostate Specific

Membrane Antigen)• PSAP• PTEN• PTH (Parathyroid Hormone)• PU.1• RB (Retinoblastoma Protein)• RCC• ROS1• S-100• S100P• SALL4• Serotonin• SF1 (Steroidogenic Factor-1)• Simian Virus 40 (SV40)• SMA• SMM

• SMMHC (Smooth MuscleMyosin, Heavy Chain)

• Smoothelin• Somatostatin• SOX-11• SOX2• Spirochete• Surfactant• Surfactant Apoprotein A• Survivin• Synaptophysin• TAG 72• Tau• TCL1 (T Cell Leukemia/

Lymphoma Protein 1)• TCRβF1• TdT• TFE3• TGF Alpha (Transforming

Growth Factor Alpha)• Thrombomodulin• Thyroglobulin• TIA-1• TLE1• Toxoplasma• TRAcP• TRAP (Tartrate-Resistant

Acid Phosphatase)• Tryptase• TS (Thymidylate Synthase)• TSH (Thyroid Stimulating

Hormone)• TTF-1• Tuberculosis• Tyrosinase• Uroplakin• Uroplakin II• Uroplakin III• Varicella Zoster Virus (VZV)• Vascular Endothelial

Growth Factor (VEGF)• VEGFR-2• Villin• Vimentin• WT-1• ZAP70

Page 6

Cytochemical Stains• MPO

• Wright-Giemsa

Special Stains• AFB (Acid-Fast Bacilli)

• Alcian Blue

• Alcian Yellow

• Colloidal Iron

• Congo Red/Amyloid

• GMS

• Iron (Prussian Blue)

• Mucicarmine

• PAS

• Reticulin

• Trichrome

• Warthin-Starry

In Situ Hybridization (ISH)• CMV

• EBER

• HER2 Dual

• HPV

• Kappa/Lambda

MultiOmyx™ MultiplexedImmunofluorescence• Ang2

• Arginase I

• BOB1

• BTLA/CD272*

• CCR4/CD194

• CD11b

• CD11c

• CD137*

• CD14

• CD15*

• CD16

• CD163

• CD19

• CD20

• CD27

• CD3

• CD30

• CD31

• CD33

• CD34*

• CD39

• CD4

• CD40

• CD45

• CD45RA

• CD45RO

• CD56

• CD57

• CD68

• CD69

• CD73

• CD79a

• CD8

• cMet

• Collagen IV

• CTLA4/CD152*

• CXCR4/CD184

• Cytokeratin AE1

• Cytokeratin PCK26

• DC SIGN/CD209

• ECAD

• EGFR

• ER

• FGFR1

• FGFR2

• FGFR3

• FOXP3

• GALECTIN 3

• GALECTIN 9

• GITR*

• Glut-1

• GranzymeB

• HBcAg

• HBsAg

• HER2

• HER3

• HLA I ABC

• HLA II DR

• ICOS/CD278

• ICOS L/CD275

• IDO1

• IGF1R

• iNOS

• Ki67

• LAG3/CD223

• mTOR

• NaKATPase

• NFkB RelA

• Notch1

• NRP1

• OCT2

• OX40/CD134

• OX40L/CD252*

• pAKT

• PANCAD

• PAX-5

• PD-L1/CD274

• PD-L2/CD273*

• PD1/CD279

• PDGFR-beta

• pEGFR

• pERK1_2*

• pHER2

• pmTOR

• PI3K p110a

• PR

• PTEN

• Ron

• S6

• S100

• SDF-1

• SMA

• STAT3

• pSTAT3

• SYNDECAN 1

• Tie2

• TIM-3

• VCTN1/B7_H4

• VEGFR1

• VEGFR2

• VEGFR3

• Vimentin

• vonWillibrandFactor

*The marker is offered as Primary/Secondary staining

Note: Please inquire if you do not see the marker you need, over 200 additional markers have been tested in MultiOmyx.

Page 7

• Acute Leukemia: CD3, CD7, CD20, CD34, CD45 LCA, CD56, CD117, MPO, PAX-5, TdT

• Adenocarcinoma vs. Mesothelioma: Pan-Cytokeratin Plus, CEA (Monoclonal), MOC-31, BerEP4, TTF-1, Calretinin, WT-1

• B-Cell Lymphoma: BCL-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD23, CD30 Ki-67, MUM1, PAX-5

• Bladder vs. Prostate Carcinoma: Pan-Cytokeratin Plus, CK 7, CK 20, PSAP, PIN-4

• Breast Panel: ER, PgR, HER2, Ki-67 with or without p53, Reflex to HER2 FISH after HER2 IHC available

• Burkitt vs. DLBC Lymphoma: BCL-2, c-MYC, Ki-67

• Carcinoma Unknown Primary Site, Female (CUPS-Female): CK 7, CK 20, Mammaglobin, ER, TTF-1, CEA, CA19-9, S100,Chromogranin A, WT-1

• Carcinoma Unknown Primary Site, Male (CUPS=Male): CK 7, CK 20, TTF-1, PSAP, CEA (Monoclonal), CA19-9, S100, Chromogranin A

• Cholangiocarcinoma: CK 7, CK 19, MOC-31, CEA (Monoclonal), CAM 5.2, p53, CA19-9, CK 903

• GIST: CD117, DOG-1, CD34, Desmin, S100

• Hepatocellular Carcinoma: Hep Par 1, Glypican 3, CEA (Polyclonal), CD34, CAM 5.2, c-MET, AFP

• Hepatocellular Carcinoma vs. Metastatic Adenocarcinoma: AFP, Hep Par 1, CDX2, CK 7, CK 20, CAM5.2, TTF-1, CEA (Monoclonal)

• High-Grade/Large B-Cell Lymphoma: BCL-2, BCL-6, CD10, Ki-67, MUM1, and c-MYC

• Hodgkin vs. NHL: BOB-1, BCL-6, CD3, CD10, CD15, CD20, CD30, CD45 LCA, CD79a, MUM1, OCT2, PAX-5, EBER ISH

• Lung Cancer: Chromogranin A, Synaptophysin, CK 7, p63, TTF-1

• Lung vs. Metastatic Breast Carcinoma: TTF-1, Mammaglobin, GCDFP-15, ER

• Lymphoma Phenotype: BCL-1, BCL-2, BCL-6, CD3, CD4, CD5, CD7, CD8, CD10, CD15, CD20, CD30, CD79a, CD138, Ki-67,MUM1, PAX-5, TdT, EBER ISH

• Lymphoma vs. Carcinoma: Pan-Cytokeratin Plus, Chromogranin A, TTF-1, CD56, CD45 LCA

• Lymphoma vs. Reactive Hyperplasia: BCL-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD23, CD43, Ki-67

• Melanoma vs. Squamous Cell Carcinoma: Pan-Melanoma, Pan-Cytokeratin Plus

• Mismatch Repair Proteins (MMR/Colon Cancer): MLH1, MSH2, MSH6, PMS2

• Neuroendocrine Neoplasm: CD56, Chromogranin A, TTF-1, Pan-Cytokeratin Plus

• Plasma Cell Neoplasm: BCL-1, CD20, CD38, CD56, CD79a, CD138, MUM1, kappa/lambda ISH

• Prostate vs. Colon Carcinoma: Pan-Cytokeratin Plus, CDX2, CK 7, CK 20, PSAP

• Soft Tissue Tumor: Pan-Cytokeratin Plus, SMA, Desmin, S100, CD34, Vimentin, Factor XIIIa

• T-Cell Lymphoma: ALK1, CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD20, CD21, CD30, CD56, TdT, EBER ISH

• T-LGL Leukemia: CD3, CD8, granzyme B, TIA-1

• Undifferentiated Tumor: Pan-Cytokeratin Plus, S100, CD45, Vimentin

IHC Panels

For additional information, please contact Ashi Malekafzali at ashi.malekafzali@neogenomics.com, 650.787.6074 or reach out to our client services team at www.neogenomics.com, or toll free at 866.776.5907.

NeoGenomics Laboratories • Clarient© NeoGenomics Laboratories, Inc.

© 2016 Clarient Diagnostic Services, Inc.

All Rights Reserved.

MultiOmyx™ is a registered trademark of NeoGenomics Laboratories, Inc., which holds a license from GE Healthcare BioSciences Corp. Rev. 051616

1271 Commonwealth Drive, Suite 9Fort Myers, FL 33913Phone: (886)776-5907Fax: (239) 768-0711www.neogenomics.com