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Neurology Oftlclal Journal of the Amerlcan Academy of Neurology JUNE 1976 VOLUME 26, NUMBER 6 - PART 2
United States - Japan Conference on Multiple Sclerosis
A conference sponsored by the National Science Foundation and the Japan Society for the Promotion of Science, under the United States-Japan Cooperative Science Program, and by The Kroc foundation for the Advancement of Medical Science.
February 25 - 27, 1976
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US-Japan Conference on Multiple Sclerosis 1
C. W. M. Adams, M.D. Guy's Hospital Medical School London, England
SPEAKERS John Sever, M.D., Ph.D. National Institutes of Health Bethesda
Milton Alter, M.D., Ph.D. Veterans Administration Hospital Minneapolis
Yoshigoro Kuroiwa, M.D. Ky us hu University Fukuoka, Japan
Hiroshi Shibasaki, M.D. Kyushu University Fukuoka, Japan
Richard Carp, Ph.D. New York State Institute for Basic Research on Mental Retardation Staten Island
Nelson L. Levy, Ph.D., M.D. Duke University Medical Center Durham
Akira Shishido, M.D. National Institute of Health of Japan Tokyo, Japan
Donald Silberberg, M.D. Hospital of the University of Pennsylvania Philadelphia
Ryoichi Mori, M.D. Kyushu University Fukuoka, Japan
Floyd A. Davis, M.D. Rush-Presbyterian-St. Luke's Medical Center Chicago
Lawrence Myers, M.D. University of California Los Angeles
Paul Terasaki, Ph.D. University of California Los Angeles
Roger Detels, M.D. University of California Los Angeles
Yoshitaka Nagai, Ph.D. Tokyo Metropolitan Institute of Gerontology Tokyo, Japan
Wallace W. Tourtellotte, M.D., Ph.D. Veterans Adminstration Wadsworth Hospital Center Los Angeles
Peter Dowling, M.D. Veterans Administration Hospital East Orange
David Poskanzer, M.D. Massachusetts General Hospital Boston
Hilde E. Hirsch, Ph.D. University of California Los Angeles
Yasuo Toyokura, M.D. University of Tokyo Tokyo, Japan
John Prineas, M.D. Veterans Administration Hospital East Orange
Fusahiro Ikuta, M.D. Niigata University Niigata, Japan
Tadao Tsubaki, M.D. Niigata University Niigata, Japan
Augustus S. Rose, M.D. University of California Los Angeles
Frederick Wolfgram, Ph.D. University of California Los Angeles
Hiroshi Iwashita, M.D. Kyushu University Fukuoka, Japan
Eijiro Satoyoshi, M.D. Toho University Tokyo, Japan
Hilary Koprowski, M.D. The Wistar Institute Philadelphia
Takeshi Yonezawa, M.D. Kyoto Prefectural University Kyoto, Japan
2 Neurology, June 1976 - Part 2
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Neurology Official Journal of the American Academy of Neurology JUNE 1976 VOLUME 26-NUMBER 6 PART 2
TABLE OF CONTENTS
Abstract No. Abstract No.
1. Epidemiologic and clinical studies of multiple sclerosis 11. Clinical and immunologic studies on multiple sclerosis in Japan Tadao Tsubaki, Yo Horikawa, lhoko Iwata, and Yoshigoro Kuroiwa and Hiroshi Shibasaki Nobutada Arnaya
2. Relationship of environment, ethnicity, and migration 12. Comparative studies of cerebrospinal fluid proteins of to multiple sclerosis multiple sclerosis patients in Japan and Germany R. Detels, B. Visscher, A. Coulson, R. Malrngren, and Hiroshi Iwashita, Helmut Bauer, and Yoshigoro J. Dudley Kuroiwa
3. Multiple sclerosis among Caucasians and Orientals in Hawaii Hiroshi Shibasaki, Michael M. Okihiro, and Yoshigoro Kuroiwa
4. Studies in the epidemiology of multiple sclerosis in the Orkney and Shetland Islands David C. Poskanzer, Alexander M. Walker, Joanne Yon Kondy, and Jean L. Sheridan
5. Painful tonic seizures in multiple sclerosis Yasuo Toyokura, Manabu Sakuta, and Takao Nakanishi
6. Criteria for the clinical diagnosis of multiple sclerosis Augustus S. Rose, George W. Ellison, Lawrence W. Myers, and Wallace W. Tourtellotte
7. Clinical manifestations and the diagnostic problems of multiple sclerosis in Japan Eijiro Satoyoshi, Akira Saku, Nobuhiko Sunohara, and Masao Kinoshita
13. The role of acid hydrolases in demyelination Hilde E. Hirsch
14. Demyelinating pattern with EAE and EAN antisera studies in vitro: Time lapse cinematographic analysis Takeshi Yonezawa, Takahiko Saida, and Michinori Hasegawa
15. Neural blocking activity of multiple sclerosis and EAE sera F.A. Davis and C.L. Schauf
16. Modulation of the immunologic response of myelin basic protein by extrinsic and intrinsic factors Yoshitaka Nagai
17. Selected immunologic parameters of demyelinative diseases Donald H. Silberberg, Robert P. Lisak, and Burton Zweiman
18. HLA studies on multiple sclerosis in Japan S. Saito, S. Naito, S. Kawanami, and Yl Kuroiwa 8. Distribution of plaques in 70,autopsy cases of multiple
sclerosis in the United States Fusahiro lkuta and H.M. Zimmerrnan 19. HLA antigens in multiple sclerosis
Chairn Brautbar, Milton Alter, and Esther Kahana
20. HLA and the immune response to measles in multiple sclerosis Lawrence W. Myers, George W. Ellison, Mona E. Fewster, Paul Terasaki, and Gerhard Opelz
9. Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions J.W. Prineas and C.S. Raine
10. The progression of the lesion in multiple sclerosis C.W.M. Adarns
4 Neurology, June 1976 - Part 2
Abstract No. Abstract No.
21.
22.
23.
24.
25.
26.
A single mutation hypothesis for multiple sclerosis based on the HLA system Paul Terasaki and Max R. Mickey
Schemes to eradicate the multiple sclerosis central nervous system immune reaction W.W. Tourtellotte, K. Murthy, D. Brandes, N. Sajben, B. Ma, P. Corniso, A. Potvin, A. Costanza, and J. Korelitz
Spinal fluid from patients with multiple sclerosis contains nucleotide-rich material associated with IgG Nelson L. Levy and Thad M. Schoen
Inhibition of experimental allergic encephalomyelitis in guinea pigs by administration of bacterial lipopolysaccharide Kohei Nagasawa and Ryoichi Mori
Serology of demyelinating disease Peter Dowling, Joseph Menonna, and Stuart Cook
Oemyelinating antibodies in multiple sclerosis Frederick Wolfgram and Pierre Duquette
27.
28.
29.
30.
31.
32.
A small virus-like agent found in association with multiple sclerosis material Richard I. Carp, George S. Merz, and Pamela C. Licursi
Multiple sclerosis: Attempts to demonstrate altered immune responses and viruses John L. Sever, David A. Fuccillo, David L. Madden, and Gabriel A. Castellano
An attempt to isolate viruses from multiple sclerosis and neuro-Behcet disease in Japan Fusahiro Ikuta, Hideyuki Kosaka, lwao Takeshita, Hiroshi Ogawa, Takeshi Sato, and Toshiro Kumanishi
Cytotoxic activity of peripheral blood lymphocytes against HeLa cells persistently infected with measles virus: Depressed capacity in multiple sclerosis Ryoichi Mori, Kohei Nagasawa, Kenichi Umene, Junko Miyazono, Hiroshi Shibasaki, and Yoshigoro Kuroiwa
Search for viruses in multiple sclerosis Hilary Koprowski
Encephalomyelitis induced by paramyxovirus in nonhuman primates with a special reference to possible viral etiology of multiple sclerosis Akira Shishido and Kazuya Yamanouchi
US-Japan Conference on Multiple Sclerosis 5
INTRODUCTION
This special supplement of NEUROLOGY contains extended abstracts of a Conference on Multiple Sclerosis that was held on February 25-27, 1976. The conference was sponsored by the Japan Society for the Promotion of Science, The National Science Foundation of the United States, and The Kroc Foundation for the Advancement of Medical Science. The meeting was held in the Santa Ynez Valley of California at the headquarters of the Kroc Foundation, which is located on the J & R Double Arch Ranch of Mr. Ray A. Kroc.
This is the second conference on multiple sclerosis that has been sponsored by the Kroc Foundation. The first one was held in 1972. At the present conference, many new and interesting findings were reported in epidemiology, neuropathology, immunology and immunogenetics, neurochemistry, and virology. Equally important, the conference provided a forum for a detailed examination of the similarities and differences of multiple sclerosis in Orientals and Caucasians.
We acknowledge with gratitude the support of the Japanese and the United States governments through their Cooperative Science Program. The many new friendships that were made at the conference and the quality of the investigations by the scientists of both countries attest to the value of this binational program.
In a special way we wish to thank Mr. Ray A. Kroc for providing the facilities of the Kroc Foundation and for the publication of this supplement. Dr. Robert Kroc and Dr. Peter Amacher were our kind hosts. Thanks are also due to Miss Elaine Price and Mrs. Setsuko Kashitani for editing and typing the abstracts.
Yoshigoro Kuroiwa, M D Frederick Wolfgram, Ph D
US-Japan Conference on Multiple Sclerosis 7
1976;26;8-84 Neurology 26 (6 Part 2)
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