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Pioneer in Natural Health- since 1923

Bioforce Canada Inc.66 Brunswick Blvd., Dollard-des-Ormeaux

QC, Canada H9B 2L3 • 1-800-361-6320 www.avogel.ca

Points to Remember1. Echinaforce is the only product approved by Health Canada for both

prevention and treatment of cold and flu.

2. Echinaforce can be safely taken for up to 4 months to effectively prevent cold and flu.1

3. For maximum effectiveness you need both root and herb: Antiviral properties are located in the herb and anti-inflammatory properties are located in the roots.

Echinaforce is composed of 5% root and 95% herb extract.5

4. Fresh plant extract is more effective.5-8

5. Acute Treatment with Echinaforce: Start at first signs of infection and use the higher indicated dosage.

6. Echinaforce Hot Drink has the same concentration as Echinaforce Extra, with the added benefit of organic elderberry.

7. Having a hot drink is in itself an effective treatment for common cold symptoms.9

References(1) Jawad M et al. Safety and Efficacy profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double

Blind, Placebo-Controlled Trial. eCAM 2012(2) Schapowal A.Efficacy and safety of Echinaforce® in respiratory tract infections. Wien Med Wochenschr.2013;163(3-4):102-5(3) Shah SA, et al. Evaluation of Echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet

Infect Dis. 2007;7(7):473-80.(4) Brinkeborn R, et al. Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold: A

randomized, placebo controlled, doubleblind clinical trial. Phytomedicine. 1996(1):1-6.(5) Vimalanathan S, et al. Optimisation of Echinacea purpurea extraction and processing to yield high potency antiviral activity.

2013 (poster).(6) Vimalanathan S, et al. (2005). Pharm. Biol 12;43(9):740-745.(7) Chicca A, et al. Synergistic immunopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int

Immunopharmacol. 2009;9(7-8):850-8.(8) Tobler M, et al. Swiss J Integr Med. 1994;5:257-266.(9) A. Sanu and R. Eccles. The effects of a hot drink on nasal airflow and symptoms of common cold and flu. Rhinology, 46,

271-275, 2008.

New Echinaforce Extra “Hot Drink”

The cold and flu relief you need. The comfort you crave.

Same medicinal concentration as Echinaforce Extra (1200 mg) with the added benefit of tasty elderberry

Scientific Evidence

In addition to the clinical proof of safety and efficacy of Echinaforce, there is actual evidence of the efficacy of a hot drink.

A 2008 study conducted by the Common Cold Centre at Cardiff University concluded that there was evidence to support the folklore that “A hot tasty drink is a beneficial treatment for relief of most symptoms of common cold and flu”.

The study showed that subjects with cold infections who consumed a hot drink showed a subjective but significant improvement in their symptoms (runny nose, cough, sore throat, fatigue) versus subjects given the same drink at room temperature.

700

476

11

Minute Training

Echinaforce® Latest News!

Echinaforce is the only product approved by Health Canada for both prevention and treatment of cold and flu.

For professional use only

NEw StudiES, NEw product,

NEw claim

caution:Consult a healthcare practitioner prior to use if taking an immunosuppressant (including Imuran, Simulect, Neoral, Sandimmune, Zenapax, OKT3, Orthoclone OKT3, CellCept, FK506, Prograf, Rapamune, prednisone and other corticosteroids) or if you have a progressive systemic disease such as tuberculosis, leucosis, collagenosis or multiple sclerosis. Discontinue immediately in case of hypersensitivity/allergic reaction. Do not use if you have an allergy to Asteraceae/Compositae (daisy) family or elderberries or in case of known allergy to any of the ingredients in the product. Consult a healthcare practitioner if symptoms persist or worsen.

medicinal ingredients:

EACH TEASPOON (5 ML) CONTAINS: Fresh organic Echinacea (Echinacea purpurea) - Herb tincture (ratio 1:12) - 1,140 mg, equivalent to 95 mg of dried herb - Root tincture (ratio 1:11) - 60 mg, equivalent to 5.5 mg of dried root Fresh organic European Elderberry (Sambucus nigra) - Fruit extract (ratio 1.4:1) - 1,370 mg, equivalent to 1 910 mg of dried fruit.

N.B. there is no danger of cyanogenic toxicity, which results in weakness, dizziness, numbness and stupor with Echinaforce Extra Hot drink. it is made with the ripe fruit of Elderberry, which does not contain cyanogenic glycosides.

Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.

Max

imum

Inhi

bito

ry

Dilu

tion

(1/x

)

9000

8000

7000

6000

5000

4000

3000

2000

1000

0

Table 2. Superiority of fresh Echinacea preparations

The anti-viral activity of Echinacea is located in the herb (green plant parts).

Max

imum

Inhi

bito

ry

Dilu

tion

(1/x

)

9000

8000

7000

6000

5000

4000

3000

2000

1000

0

Table 1. Localization of the anti-viral activity in Echinacea

above-ground plant parts

green plant parts

flowerheadspetalsroots

dried roots Echinaforce® from dried

plants

fresh roots Echinaforce®

from fresh plants

fresh herbdried herb

Table 3

pg/m

l

LPS = Lipopolysaccharide

LPS control

Herba tincture

Roots tincture 1:20 dilution

Echinaforce® (95% Herba, 5% Roots)

4500

4000

3500

3000

2500

2000

TNF-α

*

Echinaforce® is the only medicine licensed by Health Canada for both the prevention and the treatment of the common cold Largest study on Echinacea completed in 20121

Scientists at the Common Cold Centre at Cardiff University’s School of Biosciences conducted the world’s largest clinical study on Echinacea purpurea. The double-blind, placebo-controlled study unequivocally demonstrates that Echinaforce is effective both in the prevention and treatment of colds and flu and that it is safe even for long-term use. In particular, Echinaforce offers much-needed support to those whose immune systems may be depleted from stress, insufficient sleep or smoking.

proven long-term prevention.755 subjects were treated with either Echinaforce or placebo over 4 months.

Latest research in EchinaceaResearch in plant extracts is quite different from pharmaceutical research. The base material is a complex of many molecules in various concentrations which depend on weather, time of harvest, the particular section of the plant being used/analyzed and freshness. In some cases, known benefits are linked to specific plant parts; for example: it is the fatty acid content in the fruit of the saw palmetto plant that helps with prostate hyperplasia, hypericin in the flower heads of St-John’s Wort is responsible for its anti-depressant action. In the case of Echinacea Purpurea, a plethora of products are available, some containing dry extract, root only extract, whole fresh plant, mixed varietals of echinacea, and so on. The picture has never been clear… until now.

Antiviral activity in EchinaceaIn their latest study, Vimalanathan S et al., evaluated different types of echinacea purpurea extracts for relative antiviral activities.5

The authors separately investigated ethanol extracts (65% V/V) of roots, herb (aerial part without flowers), flower heads and petals. Minimal inhibitory concentrations (MIC) were measured quantitatively by means of standard plaque assays with influenza virus type A, H3N2.6

No antiviral activity was found in the roots and the petals (MIC > 1 mg/ml); but extracts of the herb and of the flower heads were active (MIC < 26.5μg/ml). (Table 1)

In addition there was a substantial difference between the freshly processed herb providing tinctures with MIC < 2.3 μg/ml in comparison to dried herb tincture with MIC equal to 16.8 μg/ml. (Table 2)

Anti-inflammatory activity in EchinaceaIn 2009, Chicca A, et al. demonstrated that alkylamides are the key to the anti-inflammatory effect of echinacea purpurea.7 Their study showed how alkylamides regulate inflammation by influencing the levels of immune mediators (e.g. TNF-a) (Table 3)

Get Real! When choosing an Echinacea product, look for a fresh plant extract, combining root and herb.

« Combination of anti-viral and anti-inflammatory therapies is the best hope for intervention after the onset of cold symptoms »

Johnston SL. Trends in Microbiology. 1997;5(2):58-63

The plant’s roots hold the highest concentration of alkylamides. In a previous study, Tobler et al. showed that fresh plant extract contains significantly more alkylamides than dried plant extract.8 (Table 4)

90

80

70

60

50

40

30

20

10

0

+32%

+66% +68%

+82%

Risk

of

plac

ebo

grou

p vs

. Ec

hina

forc

e® (

%)

> 2 colds/year

Stress Lack of sleep Smoking

Higher risk of cold episodes without Echinaforce

60

50

40

30

20

10

0

+26%

+59%+52%

Risk

of

plac

ebo

grou

p vs

. Ec

hina

forc

e® (

%)

Cold episodesCold days

Recurrentinfections

Risk without Echinaforce

Co-medication episodes

New evidence for stressed immune systems5-2

Effective treatment Significant reduction of symptoms and symptom duration3-4

For acute treatment with Echinaforce: • Start at first signs of infection (itchy/sore throat, sneezing, runny nose)• Use the higher indicated dosage

Sym

ptom

sev

erity

Symptom duration

Placebo Echinaforce®

Schematic illustration of Echinaforce® effects

–62.7%reduction

of symptom severity7

–1.5 daysreduction of

symptom duration6

Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.

Max

imum

Inhi

bito

ry

Dilu

tion

(1/

x)

9000

8000

7000

6000

5000

4000

3000

2000

1000

0

Table 2. Superiority of fresh Echinacea preparations

The anti-viral activity of Echinacea is located in the herb (green plant parts).

Max

imum

Inhi

bito

ry

Dilu

tion

(1/

x)

9000

8000

7000

6000

5000

4000

3000

2000

1000

0

Table 1. Localization of the anti-viral activity in Echinacea

above-ground plant parts

green plant parts

flowerheadspetalsroots

dried roots Echinaforce® from dried

plants

fresh roots Echinaforce®

from fresh plants

fresh herbdried herb

Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.

Max

imum

Inhi

bito

ry

Dilu

tion

(1/

x)

9000

8000

7000

6000

5000

4000

3000

2000

1000

0

Table 2. Superiority of fresh Echinacea preparations

The anti-viral activity of Echinacea is located in the herb (green plant parts).

Max

imum

Inhi

bito

ry

Dilu

tion

(1/

x)

9000

8000

7000

6000

5000

4000

3000

2000

1000

0

Table 1. Localization of the anti-viral activity in Echinacea

above-ground plant parts

green plant parts

flowerheadspetalsroots

dried roots Echinaforce® from dried

plants

fresh roots Echinaforce®

from fresh plants

fresh herbdried herb

The anti-viral activity of Echinacea is located in the herb (green plant parts).

Freshly harvested Echinacea herb contains 10 times more anti-viral activity than dried ones.

Table 3

pg/m

l

LPS = Lipopolysaccharide

LPS control

Herba tincture

Roots tincture 1:20 dilution

Echinaforce® (95% Herba, 5% Roots)

4500

4000

3500

3000

2500

2000

TNF-α

*

table 4. Fresh plant/dried plant comparison for Echinacea purpurea herbs (in Echinaforce)

Alkylamide (VC = 0.9%)

mg/

100g

cal

cula

ted

on th

e ba

sis

of th

e dr

ied

plan

t

80

70

60

50

40

30

20

10

0Fresh

79.9

dried

30