NEW FINDINGSStudy published in CANCER (12/2008) reports breast cancer

patients who participate in intensive interventions that reduce stress, improve mood, coping abilities and health behaviors have better survival rates (11 yrs later) than patients who do not receive such an intervention.

Patients in the intervention group had about half (55%) the risk of recurrence compared to the control patients.

Patients who suffered recurrence had been cancer-free an average of six months longer than controls (45 % reduced risk).

Patients receiving the intervention had less than half the risk (44 percent) of death from breast cancer of controls and a reduced risk of death from all causes, not just cancer.

2

INTRODUCTIONMind Matters Research received Phase I and II

National Cancer Institute-funded grants to develop, clinically test, and market quality-controlled imagery rehabilitation interventions for cancer survivors.

The programs reduce stress, improve mood state, coping abilities and health behaviors and address the long-term and late-term effects of cancer treatment.

Primary product: “Envision The Rhythms of Life” Program for breast cancer survivors.

We seek partners to host delivery of the “Envision the Rhythms of Life” intervention.

3

TOTAL AVAILABLE MARKET: U.S.

There are 9.8 million cancer survivors in the U.S.

Breast cancer survivors make up the largest group of cancer survivors (22%, or 1.9 million)

One in 8 women will be diagnosed with breast cancer.

The breast cancer survivor market is the ‘fastest growing club no one ever wanted to belong to.”

4

THE PAIN:Side Effects of Cancer Treatment

Quality of Life issuesCognitive Functionality (chemobrain)FatigueStress/PTSDDepression, somatization, anxietySleep Disturbance

Spiritual issues raised by diagnosis and treatment

5

THE CHALLENGEWhat is Needed What MMR Provides

An intervention that provides a ‘complete rehabilitation package;’

A clinically tested program;Consistent outcomes;Quality control standards;Updated and current;Delivered live or at a

distance;Assures patient satisfaction;

All content, materials, trainers, and equipment;

A clinically tested program, utilizing quality standards to produce consistent outcomes;

Program is updated annually, based on evolving research and in-house retesting outcomes;

Program can be delivered in person or via videoconferencing;

Patient satisfaction surveys are conducted as part of training.

6

7

PRIMARY PURPOSE OF THIS PROGRAMTo trigger a transformative “Phoenix Experience”----Using cancer as an opportunity to create psychological wisdom, physiological strength, and learn new life skills, while short-circuiting the potential for post-traumatic stress disorder (PTSD)

8

EnvisionThe Rhythms

of Life(ERL)

ENVISION(Imagery)

RHYTHMS LIFE(Quality of)

Smell

Taste

Sight/Visualize

Sound

Touch/Move

Emotion

HRV

Brain

Hormonal/Chemical

TEMP

Sleep

Music/Sound

Circadian/Ultradian

CognitiveMental

Function

EmotionalMoodState

PhysicalEnergy

SpiritualExpression

+ =

Breath

Self-Esteem

PROGRAM FEATURES AND DESCRIPTION

•What is included in the ERL intervention?•How does it work?

9

Phase I Within Group DesignAt eight weeks post-treatment, N=34, clinically

and statistically significant improvements. Physical well being (.005)Emotional well-being (<.001)Functional well-being (<.001)Social/family well-being (.05)Spiritual well-being (.008)Breast-cancer specific symptoms of well-being

(<.001)Depression (.028)Anxiety (.005)Somatization (.002) and global severity index (<.001)

10

Phase II Between Group135 breast cancer survivors in Alaska & Seattle

OPTION 1: 45 participants in room with instructorOPTION 2: 45 participants instructed on camera. WAITLIST CONTROL: 45 participants (after

Waitlist, 23 trained by OPTION 1; 22 by OPTION 2, and all compared to extended baseline.

Primary Measures: FACT-B/SP; BSI; BFI; PDQI;SF-36; ERP (evoked response potentials)

Secondary Measures: Qualitative Focus Group (description of how

imagery evolved, and its effects). Outcomes and Likert-scale ratings, stress

reduction and imagery vividness/engagement ratings.

11

VALUE PROPOSITIONTO PATIENTS

Improvements in long-term and late-term effects:•Improved cognitive function•Reduced fatigue and stress•Improved sleep•Elevated self-esteem•Reduced depression, somatization, and anxiety.•Addressed spiritual concerns•Other: workplace concerns

12

Value Proposition Provide an innovative, effective,

clinically tested, and quality controlled mind-body cancer rehabilitation program;

Maximize patient satisfaction; Assure consistent intervention

outcomes class after class; Potentially reduce the risk of cancer

recurrence (new findings)13

Patient Experience“This program changed my life. I no longer felt

like a victim, but like someone with the power to take control, manage my own health, and improve my life.”

“The scientific information was easy to understand, and was crucial in helping me believe that my own imagery can affect my health, and my happiness.”

“This program should be offered to every person diagnosed with cancer—and to their family members too! It can make all the difference in helping us recover from the traumatic experience of cancer.”

14

Candace Pert, Ph.D.,Researcher/ Discoverer of Neuropeptides

I have authored a book entitled “Molecules of Emotion” which explains my theory of the importance of neuropeptides and their receptors as the biochemicals of emotion, based on over 200 scientific papers I published as a section chief at the NIH.

I have met with Lyn, attended her scientific presentation at an NCI meeting and am extremely excited about being asked to participate in her project [Envision the Rhythms of Life ]. 

Lyn is an extremely well-respected scientist and author of the best selling research-based [Mosby] textbook on Alternative & Complementary Mind-Body Medicine.

Her Phase I pilot data suggests that Dr. Freeman is poised to produce the most meticulous, compelling and clinically important study in the history of mind-body medicine. Of course, I am extremely enthusiastic to be able to lend my support.

15

Lorenzo Cohen, Ph.D./ResearcherSection Chief/Director, Integrative Medicine, MD Anderson Cancer Center, Houston TX

As an NCI-funded mind-body researcher, I am aware of the important role that psychological factors play in improving cancer patients’ outcomes from a psychological, physiological, biological, and clinical perspective.

Relaxation and imagery have gained some acceptance within standard medical practice as a way to reduce treatment and disease-related symptoms and improve quality of life. 

Dr. Lyn Freeman is a leader in the field and the imagery program she has developed [Envision the Rhythms of Life] is unique in that it engages all the senses and incorporates passive, active, and targeted forms of imagery. 

The Envision the Rhythms of Life program will ultimately benefit patients battling any form of cancer.  Data from the phase I trial is very encouraging and the program will be easy to implement nationwide.

16

Partnership ModelMMR provides:

Intervention content and training materials;Intervention tools;Certified intervention trainers.

Partner provides:Participant enrollment servicesBilling and collection of participant feesOn-sight meeting facilitator

Revenue is shared, as negotiated

17

Delivery OptionsFive classes delivered in 4-hour weekly sessions;Distance delivery

Partner provides a videoconferencing center compatible with Polycom Equipment OR

Required On-sight Resources Option 768 KBPS upstream and downstream connectivity High definition projection or LCD screen Polycom Equipment (Can be provided by MMR) Requires on-site IT/ equipment support

Live certified trainer and equipment recommended for initial program delivery.Optional for the complete program

18

CONTACT INFORMATIONLyn Freeman, Ph.D., CEOMind Matters Research LLC7926 Port Orford DriveAnchorage, AK 99507Phone: (907) 868-7737Fax: (907) 344-4537E-mail: lfreeman@mindmattersresearch.comCell: (907) 727-6296

19

20

21

Total Available Market: Washington State

Between 1992 and 2005, 51,074 women were diagnosed with breast cancer; 8,007 died, and 43,067 of those patients are still alive. This does not include female breast cancer patients with more than one primary site, nor those diagnosed since 2005.

Washington State has the highest number of breast cancer diagnoses, per capita (134 per 100,000), adding an estimated 8,000 breast cancer survivors per year.

Statistics provided by Mahesh Keitheri Cheteri, Washington State Cancer Registry, December 23, 2008. [DOH.WA.GOV] and the American Cancer Society.

TAM 50,000, x $500 fee=market potential of $25 million

22

Total Available Market:State of Alaska

Between 1996 and 2006, 4507 women were diagnosed with breast cancer; 846 are deceased and 3661 are surviving.

This does not include breast cancer patients with multiple sites, nor those diagnosed after 2006.

There are an estimated 400 additional breast cancer diagnoses per year.

Statistics provided by David O’Brian, Alaska Cancer Registry, DOHSS, 12/15/2008.

TAM 4000 x $500= $2 million potential market

23

Other OptionsOnce a successful partnership is established

and tested, franchise agreement may be pursued. Models:1. MMR trains & annually recertifies local

trainers employed by MMR to deliver training at Partner organization (preferred option) OR

2. MMR trains and recertifies local trainers who are employed by the Partner organization.

In this scenario, a no-compete contract is required of the partner organization;

Certification and annual testing of trainers is required to maintain Product quality.

24

NOTE:The project described was supported by

Award Number R44CA117597 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.

25

Publications Freeman, L.W., Cohen, L., Stewart, M., White, R., Link, J., Palmer,

J.L., & Welton, D.L. (2008). An Imagery Intervention for Recovering Breast Cancer Patients: A Phase I Clinical Trial of Safety and Efficacy Journal of the Society for Integrative Oncology.6 (2), 67-75.

Freeman, L.W., Cohen, L., Stewart, M., White, R., Link, J., Palmer, J.L., Welton, D.L., McBride, L., & Hild, C. (2008). Qualitative Analysis of Breast Cancer Survivor Imagery: Themes Leading to Improved Quality of Life. Oncology Nursing Forum, 35, (6), E116-E121.

Freeman, L.W .& Dirks L. (2006). Mind-Body Imagery Practice Among Alaska Breast cancer Patients: A Case Study. Alaska Medicine, 48 (3), 74-84.

26

Total Available Market:State and County

Number of California women diagnosed with primary invasive breast cancer estimated to be alive in January , 2009: 272,800

Approximately 70,928 are in Los Angeles CountyApproximately 10,492 are in are San Francisco

CountyThese figure do NOT include in-situ, which would

significantly increase the number of survivors in each category . (California Cancer Registry, Brenda M Hofer, Research Scientist I, February 3,

2009.)

27