New Technologies in Toxicology and

Environmental Health

PANWAT Regional Chapter Meeting

Oregon State University

Corvallis, OR

September 29-30, 2016

PANWAT greatly appreciates the generous support of our

2016 Meeting Sponsors Mt. Hood (Platinum): $3000+

Columbia Gorge (Gold): $2,000-2,999

Lewis & Clark (Silver): $1,000-1,999

Chinook (Bronze): up to $999

Oregon State University Superfund Research Program

Oregon State University Environmental and Molecular Toxicology Department

Oregon State University Research Office

Endowment Fund Contributors PANWAT greatly appreciates the generous contributions to the Endowment

Fund.

Mt. Hood (Gold): $2,000 - $2,999

Lewis & Clark (Silver): $1,000 – $1,999

Rafael Ponce Katie Sprugel Robert Tanguay

Chinook (Bronze): $250 - $999

Cecile Krejsa Dennis M. Miller Linda L. Carlock

Friends of PANWAT: Up to $250

Abigail Brewer Angie Wong Anne Johnston Annette Myers Anonymous Donor Beth Wong Bukunmi Gesunde Cathie Adams

Christopher M. Carosino Dawn Hayes Jane Heffernan Matt Kadlec Paramita Mookherjee Rosita Rodriguez Siba Ranjan Das Stephen W. Frantz

2016–2017 PANWAT Officers

President: Mike Templin, PhD, DABT SNBL USA, Ltd.

Vice President: Susan Tilton, PhD Oregon State University

Vice President-Elect: Nadia Moore, PhD, DABT, ERT Veritox Inc

Secretary/Treasurer: Rebecca Watson, PhD, DABT Alder Biopharmaceuticals

Past President: Russel Eyre, PhD, DABT Acucela Inc

Senior Councilor: Barbara Mounho-Zamora, PhD, DABT, Fellow ATS ToxStrategies, Inc.

Junior Councilor: Christopher Carosino, PhD Seattle Genetics

Outreach Coordinator: Paramita Mookherjee, PhD, DABT Acerta Pharma

Postdoctoral Representative: Pamela Roque, PhD University of Washington

Junior Graduate Student Representative: Matthew Slattery Oregon State University

Corvallis Map

PANWAT Reception and Registration, Thursday September 29th: The Vue 517 SW 2nd Street Corvallis, OR 97330

Conference Hotel:

Hilton Garden Inn 2500 SW Western Blvd Corvallis, OR 97333

PANWAT Conference and Registration, Friday September 30th:

LaSells Stewart Center OSU campus 875 SW 26th St Corvallis, OR 97333

Oregon State University Campus Map, Directions and Parking LaSells Stewart Center

The LaSells Stewart Center is located on the Oregon State University campus in Corvallis, Oregon. Corvallis is located 90 minutes South of Portland and 45 minutes North of Eugene. Corvallis is served by the Portland International Airport (PDX) and the Eugene Regional Airport (EUG). Find directions to below:

Driving Directions

From Portland International Airport (PDX):

• Exit the airport traveling east on NE Airport Way toward I-205. • Merge onto I-205 toward Salem • Continue on I-205 for about 24 miles. • Merge onto I-5 south toward Salem. • Continue on I-5, traveling south for about 60 miles. • Take the OR-34 exit, Exit 228, toward Corvallis. • Turn right onto OR-34 toward Corvallis/Newport. • Continue on OR-34 for about 10 miles. • Turn left onto OR-34 Bypass/Corvallis-Newport Hwy. toward

Philomath/Newport/Reser Stadium (At the light right before going over the bridge into Corvallis).

• Continue on OR-34 for about 2 miles (Hwy. 20/34/Philomath Blvd.) • Turn right onto 26th Street.

• Proceed to next intersection. The Hilton Garden Inn will be on your right, across Western Blvd. on the right is The LaSells Stewart Center and the CH2M HILL Alumni Center.

From I-5:

• From I-5, take Exit 228. • Turn west onto Highway 34 towards Corvallis/Newport. • Continue on OR-34 for about 10 miles. • Take the OR-34 exit, Exit 228, toward Corvallis. • Turn right onto OR-34 toward Corvallis/Newport. • Continue on OR-34 for about 10 miles. • Turn left onto OR-34 Bypass/Corvallis-Newport Hwy. toward

Philomath/Newport/Reser Stadium (At the light right before going over the bridge into Corvallis).

• Continue on OR-34 for about 2 miles (Hwy. 20/34/Philomath Blvd.) • Turn right onto 26th Street. • Proceed to next intersection. The Hilton Garden Inn will be on your right, across

Western Blvd. on the right is The LaSells Stewart Center and the CH2M HILL Alumni Center.

Visitor Parking

The LaSells Stewart Center is located directly across the street from the Hilton Garden Inn conference hotel. For those driving to the PANWAT meeting, there is ample parking across 26th street in the Reser Stadium parking lot and north of LaSells Stewart Center in the parking structure. These campus parking lots are pay lots from 7 am to 5 pm Monday through Friday. Visitor parking permits are available from automated Pay Station kiosks (kiosk instructions) located in the lots or by ORDERING a Parking Pass Here! For more information visit OSU Parking Services.

Oregon State University LaSells Stewart Center Floor Plan Conference Registration (9/30 only): Myrtle Tree Alcove Symposium: Construction & Engineering Hall Lunch: Giustina Gallery Poster Session: Agriculture Production Room

2016 Regional Chapter Meeting

New Technologies in Toxicology and

Environmental Health

Thursday September 29th, 2016

The Vue 517 SW 2nd Street, Corvallis, OR

Friday September 30th, 2016

LaSells Stewart Center Oregon State University, Corvallis, OR

Thursday, September 29th The Vue, Corvallis, OR Throughout Day Work-Shadow Mentoring Program

Sponsored by Oregon State University Superfund Research Center and PANWAT

5:30 - 6:00 PM REGISTRATION 6:00 - 8:30 PM WELCOME RECEPTION Friday, September 30th LaSells Stewart Center, Oregon State University 7:30 - 8:30 AM REGISTRATION AND CONTINENTAL BREAKFAST POSTER SET-UP Agriculture Production Room, LaSells Stewart Center 8:30 - 8:40 AM Welcome Remarks and Conference Overview by PANWAT President Dr. Mike Templin, SNBL

MORNING SYMPOSIUM 8:40 - 9:40 AM KEYNOTE SPEAKER Recent Advances and Applications on Sequencing Based

Circulating MicroRNA Analysis Dr. Kai Wang, Principal Scientist, Institute for Systems Biology, Seattle, WA

9:40 - 10:15 AM Organs on Chips & Reducing the Need for Animal Studies

Dr. Edward J. Kelly, Department of Pharmaceutics, University of Washington, Seattle, WA

10:15 - 10:30 AM COFFEE BREAK AND POSTER VIEWING 10:30 - 11:05 AM Cancer Prevention with Diet and Epigenetics: Role of lncRNA

Dr. Laura Beaver, School of Public Health, Oregon State University, Corvallis, OR

11:05 - 11:20 AM Targeting Therapy Resistant Cancer through Bcl-2 Family of

Proteins Martin Pearce, Molecular and Cellular Biology Program, Oregon State

University, Corvallis, OR 11:20 - 11:35 AM Use of Chemometrics and Computational Chemistry in Non-Targeted

and Targeted Analysis of PAH Transformation Products in Various Environmental Matrices

Ivan Titaley, Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR

11:35 - 12:05 PM Poster Flash Talks

LUNCH AND POSTER SESSION 12:05 - 12:35 PM LUNCH Giustina Gallery, LaSells Stewart Center 12:35 - 1:45 PM POSTER ATTENDANCE/VIEWING Agriculture Production Room, LaSells Stewart Center

AFTERNOON SYMPOSIUM 1:45 – 2:20 PM Mass Spectrometry Imaging: Revealing Tissue Secrets for Early

Drug Efficacy and Risk Assessment Dr. Stefan T. Linehan, Director of North America and Japan, ImaBiotech

2:20 - 2:55 PM Aryl Hydrocarbon Receptor in Liver Fibrosis and Regeneration

Dr. Kristen A. Mitchell, Department of Biological Sciences, Boise State University, Boise, ID

2:55 - 3:10 PM Safety assessment of Polymyxin B structural variants using a 3D

nephrotoxin-sensitive microphysiological system Elijah Weber, Department of Pharmacuetics, University of Washington, Seattle, WA

3:10 – 3:25 PM Characterization of a Conserved Long Noncoding RNA regulated by

the Aryl Hydrocarbon Receptor Gloria Garcia, Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR

3:25 – 3:40 PM Hepatic mRNA Expression Varies in Three Genetically Distinct

Zebrafish Strains Lindsay Holden, Department of Biology, Portland State University,

Portland, OR 3:40 – 3:55 PM Developmental Toxicity and Differential Gene Expression of Nitrated

PAHs Anna Chlebowski, Environmental and Molecular Toxicology Department,

Oregon State University, Corvallis, OR 3:55 - 4:15 PM COFFEE BREAK AND POSTER VIEWING 4:15 - 5:00 PM PANWAT 2015 TOXICOLOGY ACHIEVEMENT AWARD PRESENTATION

Dr. Terrance J. Kavanagh, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA

5:00 - 5:10 PM Work Shadow Program Overview

Dr. Stacey Harper, Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR

5:10 - 5:25 PM Awards

Susan Tilton, PANWAT Vice-President, Oregon State University

5:30 PM Meeting Closeout and Announcements Mike Templin, PANWAT President, SNBL